Lenalidomide (hemihydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRP1 neuropilin 1 0.0709763
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0679329
TMEM156 transmembrane protein 156 0.0665755
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0656419
EXT1 exostosin glycosyltransferase 1 0.0605986
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0591365
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0545506
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0516215
NRIP1 nuclear receptor interacting protein 1 0.0495241
ASPH aspartate beta-hydroxylase 0.044141
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0435609
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0426324
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0419693
WWTR1 WW domain containing transcription regulator 1 0.0395315
FNDC3B fibronectin type III domain containing 3B 0.0393592
NPAS2 neuronal PAS domain protein 2 0.0388713
APLP2 amyloid beta (A4) precursor-like protein 2 0.0383131
AKAP12 A kinase (PRKA) anchor protein 12 0.0370804
VEGFC vascular endothelial growth factor C 0.0367292
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0366939
EPS8 epidermal growth factor receptor pathway substrate 8 0.0353534
NTN4 netrin 4 0.0349806
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0347966
SVIL supervillin 0.0345009
DOCK5 dedicator of cytokinesis 5 0.0344241
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337201
FNDC3A fibronectin type III domain containing 3A 0.0322148
PTK2 protein tyrosine kinase 2 0.0309924
ELL2 elongation factor, RNA polymerase II, 2 0.0301537
RASAL2 RAS protein activator like 2 0.0295464
MCTP2 multiple C2 domains, transmembrane 2 0.0293059
SEPTIN9 septin 9 0.0287476
RICTOR RPTOR independent companion of MTOR, complex 2 0.0285708
RAB10 RAB10, member RAS oncogene family 0.0281234
WNK1 WNK lysine deficient protein kinase 1 0.0278645
LTBP1 latent transforming growth factor beta binding protein 1 0.0274314
ANKRD28 ankyrin repeat domain 28 0.0270678
PALLD palladin, cytoskeletal associated protein 0.0266988
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0264714
AREG amphiregulin 0.0263202
DUSP5 dual specificity phosphatase 5 0.0257695
ESYT2 extended synaptotagmin-like protein 2 0.0252689
RNF145 ring finger protein 145 0.0248445
MBNL1 muscleblind-like splicing regulator 1 0.0245565
RUNX1 runt-related transcription factor 1 0.0245353
HIPK2 homeodomain interacting protein kinase 2 0.0243074
SIK3 SIK family kinase 3 0.0241402
EGFR epidermal growth factor receptor 0.0236912
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0233073
CAB39 calcium binding protein 39 0.0232507
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0231712
DPY19L1 dpy-19-like 1 (C. elegans) 0.0228935
SLC38A2 solute carrier family 38, member 2 0.0228026
KMT2E lysine (K)-specific methyltransferase 2E 0.022709
PDLIM5 PDZ and LIM domain 5 0.0227059
ITGA1 integrin, alpha 1 0.0226051
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0225957
SMAD3 SMAD family member 3 0.0224728
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0224107
ERBIN erbb2 interacting protein 0.0223076
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0222332
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0221917
CD109 CD109 molecule 0.0221494
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0219637
ZSWIM6 zinc finger, SWIM-type containing 6 0.021875
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0218623
ZC3H12C zinc finger CCCH-type containing 12C 0.0213603
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0213449
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0212934
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0211375
LIMCH1 LIM and calponin homology domains 1 0.0210148
SAMD4A sterile alpha motif domain containing 4A 0.0208625
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0204712
OSMR oncostatin M receptor 0.0204103
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0203857
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0197076
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0195623
ATXN1 ataxin 1 0.0195204
MED13 mediator complex subunit 13 0.0194089
RAB31 RAB31, member RAS oncogene family 0.0193918
ZNF638 zinc finger protein 638 0.0193106
ETNK1 ethanolamine kinase 1 0.0191326
SPRED2 sprouty-related, EVH1 domain containing 2 0.0189563
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0188949
SIRT1 sirtuin 1 0.0188668
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0187053
DUSP16 dual specificity phosphatase 16 0.0182725
USP12 ubiquitin specific peptidase 12 0.0179711
PCBP2 poly(rC) binding protein 2 0.0178953
MSN moesin 0.0178303
FOSL2 FOS-like antigen 2 0.017828
CSNK1A1 casein kinase 1, alpha 1 0.0174561
RTN4 reticulon 4 0.0174273
ITGB5 integrin, beta 5 0.017304
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0172025
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0171968
TMEM165 transmembrane protein 165 0.0171531
AOPEP aminopeptidase O (putative) 0.0170829
KIAA1217 KIAA1217 0.0169429
FHL2 four and a half LIM domains 2 0.0168414

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.276551
FN1 fibronectin 1 -0.218707
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.182628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1657
NRG1 neuregulin 1 -0.159981
PTMA prothymosin, alpha -0.137974
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123364
SQSTM1 sequestosome 1 -0.121869
CANX calnexin -0.118177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101217
HLA-B major histocompatibility complex, class I, B -0.0892662
TMSB10 thymosin beta 10 -0.0716616
TPT1 tumor protein, translationally-controlled 1 -0.0697271
TMSB4X thymosin beta 4, X-linked -0.0640352
S100A6 S100 calcium binding protein A6 -0.0544339
FTH1 ferritin, heavy polypeptide 1 -0.0504028
CALR calreticulin -0.0481701
RPS24 ribosomal protein S24 -0.0481293
NAMPT nicotinamide phosphoribosyltransferase -0.0445992
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.043497
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0428375
RPL26 ribosomal protein L26 -0.0415345
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0408393
SOD2 superoxide dismutase 2, mitochondrial -0.0408351
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0397074
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0374509
CALU calumenin -0.0372988
TMEM263 transmembrane protein 263 -0.0371859
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0369015
IER3 immediate early response 3 -0.0364799
KDM3A lysine (K)-specific demethylase 3A -0.03614
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0355798
SYT1 synaptotagmin I -0.0347231
GNAS GNAS complex locus -0.0344522
CXCL8 chemokine (C-X-C motif) ligand 8 -0.034306
RAB1A RAB1A, member RAS oncogene family -0.0341902
HDLBP high density lipoprotein binding protein -0.033876
AEBP2 AE binding protein 2 -0.0336324
RACK1 receptor for activated C kinase 1 -0.0331865
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0327969
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0324425
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0319924
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.031499
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0308011
LRRC23 leucine rich repeat containing 23 -0.0304267
RAD21 RAD21 homolog (S. pombe) -0.030109
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0295071
H1-0 H1.0 linker histone -0.0293608
RPL12 ribosomal protein L12 -0.0291105
RPS27A ribosomal protein S27a -0.0289486
P4HB prolyl 4-hydroxylase, beta polypeptide -0.028419
AHNAK2 AHNAK nucleoprotein 2 -0.0283138
TNS3 tensin 3 -0.0279557
RPL31 ribosomal protein L31 -0.0274236
KDM5B lysine (K)-specific demethylase 5B -0.0270016
FAM20C family with sequence similarity 20, member C -0.0268553
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0268281
RPS3 ribosomal protein S3 -0.0263585
HLA-A major histocompatibility complex, class I, A -0.0259901
TFPI2 tissue factor pathway inhibitor 2 -0.0259736
SPDYA speedy/RINGO cell cycle regulator family member A -0.0259242
MKI67 marker of proliferation Ki-67 -0.0256551
RPS19 ribosomal protein S19 -0.025473
CENPF centromere protein F, 350/400kDa -0.025381
TAS2R14 taste receptor, type 2, member 14 -0.0252212
RPL37A ribosomal protein L37a -0.0250599
RPL34 ribosomal protein L34 -0.0247085
MT2A metallothionein 2A -0.0246272
GLIS3 GLIS family zinc finger 3 -0.0246137
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0243682
IFRD1 interferon-related developmental regulator 1 -0.0242614
RRBP1 ribosome binding protein 1 -0.0241834
APP amyloid beta (A4) precursor protein -0.0241221
RPL35A ribosomal protein L35a -0.0238641
RPLP1 ribosomal protein, large, P1 -0.0238093
RPS29 ribosomal protein S29 -0.0237924
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0237466
LCORL ligand dependent nuclear receptor corepressor-like -0.0231543
ZNF217 zinc finger protein 217 -0.0231103
RPS25 ribosomal protein S25 -0.0228797
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0226869
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0225979
SOX5 SRY (sex determining region Y)-box 5 -0.022567
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0220199
CADM1 cell adhesion molecule 1 -0.0219614
SPAG9 sperm associated antigen 9 -0.0218176
PDIA4 protein disulfide isomerase family A, member 4 -0.0216203
RPH3AL rabphilin 3A-like (without C2 domains) -0.0215214
RPL11 ribosomal protein L11 -0.0213726
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0212777
SKP1 S-phase kinase-associated protein 1 -0.0212458
FBXO32 F-box protein 32 -0.0211693
LMNA lamin A/C -0.0211589
ARF1 ADP-ribosylation factor 1 -0.0211048
AHRR aryl-hydrocarbon receptor repressor -0.0210207
MBD5 methyl-CpG binding domain protein 5 -0.0208853
FTL ferritin, light polypeptide -0.020633
RPL38 ribosomal protein L38 -0.0205224
RBM39 RNA binding motif protein 39 -0.0204864
RPS12 ribosomal protein S12 -0.0203112