Lenalidomide (hemihydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.108033
ACTG1 actin gamma 1 0.0902726
AREG amphiregulin 0.0793316
TPT1 tumor protein, translationally-controlled 1 0.0736972
EGFR epidermal growth factor receptor 0.0700318
LMO7 LIM domain 7 0.0687474
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0615356
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0615119
AKAP9 A kinase (PRKA) anchor protein 9 0.0474572
RPS8 ribosomal protein S8 0.0453755
FHL2 four and a half LIM domains 2 0.0421655
NUP50 nucleoporin 50kDa 0.0405977
EMP1 epithelial membrane protein 1 0.0402568
JARID2 jumonji, AT rich interactive domain 2 0.0391837
RPS21 ribosomal protein S21 0.0373252
EIF1 eukaryotic translation initiation factor 1 0.036362
RPLP0 ribosomal protein, large, P0 0.0361551
DOCK5 dedicator of cytokinesis 5 0.0352732
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0346635
RPL35A ribosomal protein L35a 0.033238
HMGA2 high mobility group AT-hook 2 0.0329881
GPC5 glypican 5 0.0321112
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0319933
RNF43 ring finger protein 43 0.0319615
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0308916
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0302455
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.030008
NDRG1 N-myc downstream regulated 1 0.0297328
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296753
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0292587
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0291194
FBXO11 F-box protein 11 0.0274124
FTL ferritin, light polypeptide 0.027127
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0269162
SNX9 sorting nexin 9 0.0267212
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0266352
GCLC glutamate-cysteine ligase, catalytic subunit 0.0264906
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0263269
MACF1 microtubule-actin crosslinking factor 1 0.0261891
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0261621
DPY19L1 dpy-19-like 1 (C. elegans) 0.0255133
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0253827
RPL9 ribosomal protein L9 0.0250671
KLK10 kallikrein-related peptidase 10 0.0250306
MYO5B myosin VB 0.0249438
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248551
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0246675
DSCAM Down syndrome cell adhesion molecule 0.0244952
TMSB10 thymosin beta 10 0.0244649
YAP1 Yes-associated protein 1 0.0238124
RPL7 ribosomal protein L7 0.023721
RPS17 ribosomal protein S17 0.023523
SGMS2 sphingomyelin synthase 2 0.023117
RPS12 ribosomal protein S12 0.0229626
KLF5 Kruppel-like factor 5 (intestinal) 0.0225264
WWC1 WW and C2 domain containing 1 0.0224538
EFNB2 ephrin-B2 0.022322
IER3 immediate early response 3 0.0221802
EXT1 exostosin glycosyltransferase 1 0.0220281
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0220022
SERTAD2 SERTA domain containing 2 0.0218468
UBN2 ubinuclein 2 0.0214345
KLF6 Kruppel-like factor 6 0.0214267
UBC ubiquitin C 0.020879
PGK1 phosphoglycerate kinase 1 0.0207661
RPS16 ribosomal protein S16 0.0207145
HOMER1 homer scaffolding protein 1 0.0206907
SIK3 SIK family kinase 3 0.0205063
KTN1 kinectin 1 (kinesin receptor) 0.0204777
APLP2 amyloid beta (A4) precursor-like protein 2 0.0203894
RPL31 ribosomal protein L31 0.0203158
RPS29 ribosomal protein S29 0.0202861
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0202599
COG6 component of oligomeric golgi complex 6 0.0201124
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0200411
AGTPBP1 ATP/GTP binding protein 1 0.0200285
JMJD1C jumonji domain containing 1C 0.0198833
SLC38A2 solute carrier family 38, member 2 0.0197215
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0195143
RPS27A ribosomal protein S27a 0.0191935
DCLK1 doublecortin-like kinase 1 0.0191293
ANKRD12 ankyrin repeat domain 12 0.0190627
NHSL1 NHS-like 1 0.018989
TTC3 tetratricopeptide repeat domain 3 0.0189079
SLC30A10 solute carrier family 30, member 10 0.0189023
CDCP1 CUB domain containing protein 1 0.0188685
RPS25 ribosomal protein S25 0.0187515
ZFAND3 zinc finger, AN1-type domain 3 0.018751
MRPS6 mitochondrial ribosomal protein S6 0.0186025
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0182188
SEC31A SEC31 homolog A (S. cerevisiae) 0.0181254
POTEF POTE ankyrin domain family, member F 0.0180567
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0176739
MOSPD1 motile sperm domain containing 1 0.0176561
WSB1 WD repeat and SOCS box containing 1 0.0176075
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0175477
FBXL17 F-box and leucine-rich repeat protein 17 0.0173864
RPL27 ribosomal protein L27 0.0173566
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0172809
CSNK1A1 casein kinase 1, alpha 1 0.0172255

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.194828
PTMA prothymosin, alpha -0.186942
CD36 CD36 molecule (thrombospondin receptor) -0.180574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.133439
FHIT fragile histidine triad -0.114598
RAD51B RAD51 paralog B -0.107725
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0979986
HDAC2 histone deacetylase 2 -0.091564
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0912487
GPHN gephyrin -0.0720771
EEF2 eukaryotic translation elongation factor 2 -0.0648671
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0628162
MTAP methylthioadenosine phosphorylase -0.0582168
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0532853
ANXA1 annexin A1 -0.0531105
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0509422
FAT1 FAT atypical cadherin 1 -0.0495818
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0478801
ANXA2 annexin A2 -0.0466361
MBNL1 muscleblind-like splicing regulator 1 -0.0466239
OSBPL3 oxysterol binding protein-like 3 -0.0447574
RUNX2 runt-related transcription factor 2 -0.0447551
SERINC5 serine incorporator 5 -0.044606
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0437587
NFIA nuclear factor I/A -0.0434583
FERMT1 fermitin family member 1 -0.0425204
CUX1 cut-like homeobox 1 -0.0422821
LRPPRC leucine-rich pentatricopeptide repeat containing -0.040878
DENND1A DENN/MADD domain containing 1A -0.0403466
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0389392
ANLN anillin, actin binding protein -0.0376126
THSD4 thrombospondin, type I, domain containing 4 -0.0374131
EWSR1 EWS RNA-binding protein 1 -0.0371609
PHF14 PHD finger protein 14 -0.0369023
MKI67 marker of proliferation Ki-67 -0.0361298
OXR1 oxidation resistance 1 -0.0358123
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0354091
NF1 neurofibromin 1 -0.0343959
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0342013
CANX calnexin -0.033663
EXOC4 exocyst complex component 4 -0.0331968
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0327131
ADGRA3 adhesion G protein-coupled receptor A3 -0.0322184
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0321121
RPS2 ribosomal protein S2 -0.0318216
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0317914
EZR ezrin -0.0314637
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0311339
YBX1 Y box binding protein 1 -0.0306666
CCSER1 coiled-coil serine-rich protein 1 -0.0306004
AOPEP aminopeptidase O (putative) -0.0304497
ACTN4 actinin, alpha 4 -0.0303189
SKAP1 src kinase associated phosphoprotein 1 -0.0302428
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0299359
CEP152 centrosomal protein 152kDa -0.029927
NEK7 NIMA-related kinase 7 -0.0296766
EHBP1 EH domain binding protein 1 -0.0296727
PDLIM5 PDZ and LIM domain 5 -0.0295317
SBF2 SET binding factor 2 -0.0294568
WDR43 WD repeat domain 43 -0.0294112
ZBTB7C zinc finger and BTB domain containing 7C -0.0293341
FAF1 Fas (TNFRSF6) associated factor 1 -0.02893
PUM2 pumilio RNA-binding family member 2 -0.0288614
APP amyloid beta (A4) precursor protein -0.0288077
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0286914
FAR1 fatty acyl CoA reductase 1 -0.0285349
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0282996
TCF12 transcription factor 12 -0.0282393
RCC1 regulator of chromosome condensation 1 -0.0279898
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0275835
RPL3 ribosomal protein L3 -0.0274067
VCL vinculin -0.0273678
DIAPH2 diaphanous-related formin 2 -0.0272717
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0270112
PATJ PATJ crumbs cell polarity complex component -0.026834
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0268334
MDN1 MDN1, midasin homolog (yeast) -0.0268269
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0265259
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0263629
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0262437
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0256595
CSDE1 cold shock domain containing E1, RNA-binding -0.0253483
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0250733
CD9 CD9 molecule -0.0250451
RNF145 ring finger protein 145 -0.0250217
TOP1 topoisomerase (DNA) I -0.0249517
ITGB4 integrin, beta 4 -0.0248337
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0247535
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0245206
TNS3 tensin 3 -0.0244646
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.024452
FMNL2 formin-like 2 -0.0241771
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0240587
USP34 ubiquitin specific peptidase 34 -0.0239085
DSPP dentin sialophosphoprotein -0.0238985
KRT18 keratin 18, type I -0.0235969
TMEM123 transmembrane protein 123 -0.0235593
FLOT1 flotillin 1 -0.0235246
PARD3 par-3 family cell polarity regulator -0.0234356
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0233168