Lenalidomide (hemihydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.153787
YAP1 Yes-associated protein 1 0.0799803
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0699471
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.069384
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.065818
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0588153
NKD1 naked cuticle homolog 1 (Drosophila) 0.0587111
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0579785
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0576731
MED13 mediator complex subunit 13 0.0552354
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0550297
SDK1 sidekick cell adhesion molecule 1 0.0549308
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0546672
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0531232
OXR1 oxidation resistance 1 0.0494261
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0491612
RAD51B RAD51 paralog B 0.0487766
MYO1D myosin ID 0.0474216
CD46 CD46 molecule, complement regulatory protein 0.0461921
GPHN gephyrin 0.0453896
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0451222
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0450193
DST dystonin 0.044916
ANKRD17 ankyrin repeat domain 17 0.0446385
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0442905
ZNF638 zinc finger protein 638 0.0433073
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0406413
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0391787
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0386581
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0384705
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0380607
BMP5 bone morphogenetic protein 5 0.0380401
KLF12 Kruppel-like factor 12 0.0379379
AOPEP aminopeptidase O (putative) 0.0378249
DIAPH3 diaphanous-related formin 3 0.0378014
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0372457
PHIP pleckstrin homology domain interacting protein 0.0357355
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0352314
DSPP dentin sialophosphoprotein 0.0350632
BPTF bromodomain PHD finger transcription factor 0.0349263
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.034609
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0342238
CDK8 cyclin-dependent kinase 8 0.0341039
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0339728
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0334262
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332276
SET SET nuclear proto-oncogene 0.0330089
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0325847
LIMS1 LIM and senescent cell antigen-like domains 1 0.0325564
RBP1 retinol binding protein 1, cellular 0.0324633
JMJD1C jumonji domain containing 1C 0.0318606
WWOX WW domain containing oxidoreductase 0.0318387
SAMD4A sterile alpha motif domain containing 4A 0.0317777
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0306947
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0303914
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0299479
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0299456
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0297434
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0295308
RAB10 RAB10, member RAS oncogene family 0.0287735
MCC mutated in colorectal cancers 0.0286706
RPLP0 ribosomal protein, large, P0 0.0286417
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0282571
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0282356
TAOK1 TAO kinase 1 0.028125
DIAPH2 diaphanous-related formin 2 0.0279909
SPIDR scaffolding protein involved in DNA repair 0.0278955
SBF2 SET binding factor 2 0.0277437
PROX1 prospero homeobox 1 0.0276578
SRPK2 SRSF protein kinase 2 0.0276438
ECT2 epithelial cell transforming 2 0.0276089
KDM6A lysine (K)-specific demethylase 6A 0.0269811
PIAS1 protein inhibitor of activated STAT, 1 0.0268827
SESN3 sestrin 3 0.0268238
PCLO piccolo presynaptic cytomatrix protein 0.026793
C2CD5 C2 calcium-dependent domain containing 5 0.0266828
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264791
FAF1 Fas (TNFRSF6) associated factor 1 0.0264063
ADAM10 ADAM metallopeptidase domain 10 0.0263129
SCAF11 SR-related CTD-associated factor 11 0.0262489
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0259342
MBNL1 muscleblind-like splicing regulator 1 0.0258863
WDPCP WD repeat containing planar cell polarity effector 0.0256146
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0256144
DARS1 aspartyl-tRNA synthetase 1 0.0251369
SH3D19 SH3 domain containing 19 0.0250033
SLC35F5 solute carrier family 35, member F5 0.0245677
ASPH aspartate beta-hydroxylase 0.0244233
FOXP1 forkhead box P1 0.0240756
MATR3 matrin 3 0.0240457
PITPNB phosphatidylinositol transfer protein, beta 0.0237309
PHF14 PHD finger protein 14 0.0235704
TBC1D5 TBC1 domain family, member 5 0.0234605
ARHGAP12 Rho GTPase activating protein 12 0.0233776
STAG2 stromal antigen 2 0.0233565
ZNF148 zinc finger protein 148 0.0233155
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0233127
CCND1 cyclin D1 0.0232812
CAMKMT calmodulin-lysine N-methyltransferase 0.0230734
PTBP2 polypyrimidine tract binding protein 2 0.0230038

decreased expression

Symbol Name Standardized Value
EZR ezrin -0.158629
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.126919
CDH13 cadherin 13 -0.116794
TPT1 tumor protein, translationally-controlled 1 -0.111008
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.101836
RPL35A ribosomal protein L35a -0.0948709
NDRG1 N-myc downstream regulated 1 -0.0928481
ANXA2 annexin A2 -0.0910656
AKAP12 A kinase (PRKA) anchor protein 12 -0.0907941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0776111
TMSB10 thymosin beta 10 -0.0681627
PLEC plectin -0.0664868
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0642596
CDK6 cyclin-dependent kinase 6 -0.0642195
MT2A metallothionein 2A -0.0638029
RPS19 ribosomal protein S19 -0.0632806
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0583501
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0554479
MRPS6 mitochondrial ribosomal protein S6 -0.055195
RPLP2 ribosomal protein, large, P2 -0.0531969
ITGB4 integrin, beta 4 -0.0527939
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0526498
MORF4L2 mortality factor 4 like 2 -0.0521547
LMO7 LIM domain 7 -0.0521
LOC112694756 uncharaterized LOC112694756 -0.0499569
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0488111
ANO1 anoctamin 1, calcium activated chloride channel -0.0479409
FTL ferritin, light polypeptide -0.0475138
EEF2 eukaryotic translation elongation factor 2 -0.0449806
RPS29 ribosomal protein S29 -0.0444406
RASA3 RAS p21 protein activator 3 -0.0433381
TRIO trio Rho guanine nucleotide exchange factor -0.0427554
BIRC6 baculoviral IAP repeat containing 6 -0.0424829
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.041984
IER3 immediate early response 3 -0.0396964
RPL32 ribosomal protein L32 -0.0391419
NAV2 neuron navigator 2 -0.0389895
ARF4 ADP-ribosylation factor 4 -0.0380595
RPL28 ribosomal protein L28 -0.0378564
RPS3 ribosomal protein S3 -0.0375079
CMIP c-Maf inducing protein -0.0371886
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0369866
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0361357
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0358091
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0357053
RPS23 ribosomal protein S23 -0.0356494
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0355077
PDGFA platelet-derived growth factor alpha polypeptide -0.0352653
NACA nascent polypeptide-associated complex alpha subunit -0.0348995
FOSL1 FOS-like antigen 1 -0.0344202
FTH1 ferritin, heavy polypeptide 1 -0.0342021
VMP1 vacuole membrane protein 1 -0.0340459
STK17A serine/threonine kinase 17a -0.0338858
SPDYA speedy/RINGO cell cycle regulator family member A -0.0334197
EMP1 epithelial membrane protein 1 -0.0330198
KDM3A lysine (K)-specific demethylase 3A -0.032804
VDAC1 voltage-dependent anion channel 1 -0.0325324
KLF5 Kruppel-like factor 5 (intestinal) -0.0321545
HDAC4 histone deacetylase 4 -0.0320759
RPL38 ribosomal protein L38 -0.03185
SQSTM1 sequestosome 1 -0.031651
CHD4 chromodomain helicase DNA binding protein 4 -0.0316055
MAML2 mastermind-like 2 (Drosophila) -0.0312104
IRS2 insulin receptor substrate 2 -0.0310695
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0310188
BACE2 beta-site APP-cleaving enzyme 2 -0.0310005
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0309796
RPL26 ribosomal protein L26 -0.0305037
RPL23 ribosomal protein L23 -0.0303351
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0301539
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0298932
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0295563
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0294368
RPS13 ribosomal protein S13 -0.0292881
RACK1 receptor for activated C kinase 1 -0.0292432
VIM vimentin -0.0291511
MYOF myoferlin -0.0289026
TIMP2 TIMP metallopeptidase inhibitor 2 -0.028552
RPL8 ribosomal protein L8 -0.028408
TFRC transferrin receptor -0.0281659
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0278469
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.027697
RPL12 ribosomal protein L12 -0.0276304
RUNX1 runt-related transcription factor 1 -0.0275151
LDHA lactate dehydrogenase A -0.0273953
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.0272916
ACTN4 actinin, alpha 4 -0.0271888
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0271607
ZMYND8 zinc finger, MYND-type containing 8 -0.0269694
PPARG peroxisome proliferator-activated receptor gamma -0.0265555
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0263765
RPL7A ribosomal protein L7a -0.0262855
SLC38A1 solute carrier family 38, member 1 -0.0262636
RPS12 ribosomal protein S12 -0.0261565
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0258323
IGF2 insulin-like growth factor 2 -0.0256716
RPL36 ribosomal protein L36 -0.0256046
CUL4A cullin 4A -0.0251819
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0250112
HM13 histocompatibility (minor) 13 -0.0245339