Lenalidomide (hemihydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.178656
NALF1 NALCN channel auxiliary factor 1 0.108236
CD44 CD44 molecule (Indian blood group) 0.104002
MYO10 myosin X 0.1038
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.092425
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.090085
EXT1 exostosin glycosyltransferase 1 0.0826408
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0788782
NAV1 neuron navigator 1 0.0775822
VCL vinculin 0.0768574
FNDC3B fibronectin type III domain containing 3B 0.072699
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0723581
ZSWIM6 zinc finger, SWIM-type containing 6 0.0673854
EGFR epidermal growth factor receptor 0.0590705
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0568936
ASPH aspartate beta-hydroxylase 0.0563762
GLIS3 GLIS family zinc finger 3 0.0563433
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0563292
FNDC3A fibronectin type III domain containing 3A 0.0558213
COL6A3 collagen, type VI, alpha 3 0.0513708
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0494868
SLC38A2 solute carrier family 38, member 2 0.0489602
INTS6 integrator complex subunit 6 0.0481367
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0460748
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0448039
NOTCH2 notch 2 0.0447343
RUNX1 runt-related transcription factor 1 0.042827
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0427968
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0425331
PDLIM5 PDZ and LIM domain 5 0.0416767
PRELID2 PRELI domain containing 2 0.0403063
LTBP1 latent transforming growth factor beta binding protein 1 0.0383683
TIMP1 TIMP metallopeptidase inhibitor 1 0.0382464
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381827
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0365543
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0352439
TGFBI transforming growth factor, beta-induced, 68kDa 0.0349972
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0346979
COL5A3 collagen, type V, alpha 3 0.0338716
PDE8A phosphodiesterase 8A 0.0338151
ANKRD28 ankyrin repeat domain 28 0.0333756
SH3RF1 SH3 domain containing ring finger 1 0.0326501
VEGFC vascular endothelial growth factor C 0.0322738
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0322544
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0319228
WWTR1 WW domain containing transcription regulator 1 0.0310515
PICALM phosphatidylinositol binding clathrin assembly protein 0.0307751
JARID2 jumonji, AT rich interactive domain 2 0.0302257
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0300912
RCOR1 REST corepressor 1 0.0293759
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0286301
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0280167
RAD51B RAD51 paralog B 0.0270536
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0270443
ZNF638 zinc finger protein 638 0.0267382
ARHGAP31 Rho GTPase activating protein 31 0.0262108
WNT2B wingless-type MMTV integration site family, member 2B 0.0261396
NABP1 nucleic acid binding protein 1 0.0260453
CLIC4 chloride intracellular channel 4 0.0259031
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0258588
ITGAV integrin, alpha V 0.0257885
ANO6 anoctamin 6 0.0256136
MBD5 methyl-CpG binding domain protein 5 0.0249031
MAML2 mastermind-like 2 (Drosophila) 0.0246798
ZBTB20 zinc finger and BTB domain containing 20 0.0246434
BPTF bromodomain PHD finger transcription factor 0.024521
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.02445
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0238818
EGR1 early growth response 1 0.0238535
CXCL8 chemokine (C-X-C motif) ligand 8 0.0236427
HIPK2 homeodomain interacting protein kinase 2 0.0235125
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0234965
FER fer (fps/fes related) tyrosine kinase 0.0233007
SMYD3 SET and MYND domain containing 3 0.0231625
SPRED2 sprouty-related, EVH1 domain containing 2 0.0230401
CALD1 caldesmon 1 0.0229509
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0228837
CLIP2 CAP-GLY domain containing linker protein 2 0.022649
JAG1 jagged 1 0.0221395
PALLD palladin, cytoskeletal associated protein 0.021845
SFPQ splicing factor proline/glutamine-rich 0.0217248
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0217174
KLF12 Kruppel-like factor 12 0.0213693
EPAS1 endothelial PAS domain protein 1 0.0211606
NRP1 neuropilin 1 0.0211029
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0210797
ARHGAP24 Rho GTPase activating protein 24 0.0208697
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0208435
PTK2 protein tyrosine kinase 2 0.020832
MSN moesin 0.0205908
PCBP2 poly(rC) binding protein 2 0.0205503
YAP1 Yes-associated protein 1 0.0204645
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0203994
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0201197
ITPRID2 ITPR interacting domain containing 2 0.020033
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0200323
MYO1D myosin ID 0.0200295
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.019985
FOXP1 forkhead box P1 0.0199334
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0197778

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.265239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.23225
MMP1 matrix metallopeptidase 1 -0.210453
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.151756
COL1A1 collagen, type I, alpha 1 -0.0747314
FTL ferritin, light polypeptide -0.0713942
TPT1 tumor protein, translationally-controlled 1 -0.0683656
GREM1 gremlin 1, DAN family BMP antagonist -0.0666911
CAVIN1 caveolae associated protein 1 -0.0620673
FAM13A family with sequence similarity 13, member A -0.0616649
GOLGA4 golgin A4 -0.0599171
ADM adrenomedullin -0.0585229
PTMA prothymosin, alpha -0.0558654
TMSB10 thymosin beta 10 -0.0547226
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0532626
NDRG1 N-myc downstream regulated 1 -0.0529783
TPM4 tropomyosin 4 -0.0511514
CALR calreticulin -0.0504641
COL6A2 collagen, type VI, alpha 2 -0.0419762
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0410916
IER3 immediate early response 3 -0.0406682
CANX calnexin -0.0405965
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0383944
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0368301
RPLP1 ribosomal protein, large, P1 -0.0358991
TFPI2 tissue factor pathway inhibitor 2 -0.0358621
S100A6 S100 calcium binding protein A6 -0.0354429
HILPDA hypoxia inducible lipid droplet-associated -0.0352205
KDM3A lysine (K)-specific demethylase 3A -0.0329974
NAMPT nicotinamide phosphoribosyltransferase -0.0326139
COL3A1 collagen, type III, alpha 1 -0.0320258
CALU calumenin -0.0318355
PRKG1 protein kinase, cGMP-dependent, type I -0.0316363
ANXA2 annexin A2 -0.0300642
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0290797
MXI1 MAX interactor 1, dimerization protein -0.0279881
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0279522
RPL35A ribosomal protein L35a -0.0277733
RAB1A RAB1A, member RAS oncogene family -0.0272206
LCORL ligand dependent nuclear receptor corepressor-like -0.0272044
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0271218
WSB1 WD repeat and SOCS box containing 1 -0.0270514
USP3 ubiquitin specific peptidase 3 -0.0269033
GNAS GNAS complex locus -0.0268775
INSIG1 insulin induced gene 1 -0.0266252
HLA-E major histocompatibility complex, class I, E -0.026139
STC1 stanniocalcin 1 -0.025797
RPS3 ribosomal protein S3 -0.0257698
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0257505
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0256243
FTH1 ferritin, heavy polypeptide 1 -0.0254912
TM4SF1 transmembrane 4 L six family member 1 -0.0254137
SOD2 superoxide dismutase 2, mitochondrial -0.0254072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0252654
KPNB1 karyopherin (importin) beta 1 -0.0251567
RLF rearranged L-myc fusion -0.0251037
PRRX1 paired related homeobox 1 -0.0248416
LMNA lamin A/C -0.024824
LMAN1 lectin, mannose-binding, 1 -0.0245162
RPL34 ribosomal protein L34 -0.0240682
OGA O-GlcNAcase -0.0237275
RPL26 ribosomal protein L26 -0.0234692
HLA-B major histocompatibility complex, class I, B -0.023344
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0233158
WDR45B WD repeat domain 45B -0.023158
CLINT1 clathrin interactor 1 -0.0225245
NOP58 NOP58 ribonucleoprotein -0.0224183
NPEPPS aminopeptidase puromycin sensitive -0.0223841
BTG1 B-cell translocation gene 1, anti-proliferative -0.022163
RPS27A ribosomal protein S27a -0.0220134
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0218008
RPS6 ribosomal protein S6 -0.0217133
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0216169
CSDE1 cold shock domain containing E1, RNA-binding -0.0212522
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0212102
RPL13A ribosomal protein L13a -0.0212042
RPL12 ribosomal protein L12 -0.0211127
HDLBP high density lipoprotein binding protein -0.0210994
FGFR1 fibroblast growth factor receptor 1 -0.0210979
COL4A2 collagen, type IV, alpha 2 -0.0209692
YBX1 Y box binding protein 1 -0.0206991
RAD21 RAD21 homolog (S. pombe) -0.0205352
RPS24 ribosomal protein S24 -0.0204931
MORF4L2 mortality factor 4 like 2 -0.0201563
LOC112694756 uncharaterized LOC112694756 -0.0201384
RPS12 ribosomal protein S12 -0.0199086
EIF1 eukaryotic translation initiation factor 1 -0.0198588
SUCO SUN domain containing ossification factor -0.0197237
FAM162A family with sequence similarity 162, member A -0.0195333
LAMB3 laminin, beta 3 -0.019492
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0194444
TMSB4X thymosin beta 4, X-linked -0.0194044
YBX3 Y box binding protein 3 -0.0194002
RAI1 retinoic acid induced 1 -0.0190977
ARHGAP35 Rho GTPase activating protein 35 -0.0190116
DDIT4 DNA-damage-inducible transcript 4 -0.0189185
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0186806
COPB1 coatomer protein complex, subunit beta 1 -0.0186286
FRMPD4 FERM and PDZ domain containing 4 -0.0185632
SERF2 small EDRK-rich factor 2 -0.0183329