Leprosy Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. (Experimental Factor Ontology, EFO_0001054)
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Genes

76 genes associated with the disease Leprosy in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.041
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.041
CYLD cylindromatosis (turban tumor syndrome) 2.037
NOD2 nucleotide-binding oligomerization domain containing 2 2.037
RIPK2 receptor-interacting serine-threonine kinase 2 2.033
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.019
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.019
LRRC8C-DT LRRC8C divergent transcript 2.019
C1ORF141 chromosome 1 open reading frame 141 2.002
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 2.002
IL23R interleukin 23 receptor 2.002
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.999
CCDC122 coiled-coil domain containing 122 1.999
SNX20 sorting nexin 20 1.99
NKD1 naked cuticle homolog 1 (Drosophila) 1.99
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.986
ENOX1 ecto-NOX disulfide-thiol exchanger 1 1.965
RAB32 RAB32, member RAS oncogene family 1.873
ADGB androglobin 1.873
IL18RAP interleukin 18 receptor accessory protein 1.824
IL18R1 interleukin 18 receptor 1 1.824
IL36R interleukin 36 receptor 1.824
IL33R interleukin 33 receptor 1.824
LITAF lipopolysaccharide-induced TNF factor 1.649
PRM1 protamine 1 1.649
TNP2 transition protein 2 (during histone to protamine replacement) 1.649
RMI2 RecQ mediated genome instability 2 1.649
PRM2 protamine 2 1.649
PRM3 protamine 3 1.649
ESRRA estrogen-related receptor alpha 1.585
FKBP2 FK506 binding protein 2, 13kDa 1.585
BAD BCL2-associated agonist of cell death 1.585
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 1.585
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 1.585
CATSPERZ catsper channel auxiliary subunit zeta 1.585
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 1.585
CCDC88B coiled-coil domain containing 88B 1.585
KCNK4 potassium channel, two pore domain subfamily K, member 4 1.585
GPR137 G protein-coupled receptor 137 1.585
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 1.585
PRDX5 peroxiredoxin 5 1.585
HLA-C major histocompatibility complex, class I, C 1.502
HLA-B major histocompatibility complex, class I, B 1.502
BBS9 Bardet-Biedl syndrome 9 1.332
BMPER BMP binding endothelial regulator 1.332
ZNF175 zinc finger protein 175 1.169
SIGLEC14 sialic acid binding Ig-like lectin 14 1.169
SIGLEC6 sialic acid binding Ig-like lectin 6 1.169
SPACA6 sperm acrosome associated 6 1.169
HAS1 hyaluronan synthase 1 1.169
SIGLEC5 sialic acid binding Ig-like lectin 5 1.169
TNC tenascin C 1.078
CDH18 cadherin 18, type 2 1.078
IL12B interleukin 12B 1.023
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.814
EGR2 early growth response 2 0.747
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.747
CCHCR1 coiled-coil alpha-helical rod protein 1 0.703
C6ORF15 chromosome 6 open reading frame 15 0.703
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.703
POU5F1 POU class 5 homeobox 1 0.703
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.703
MUC22 mucin 22 0.703
TCF19 transcription factor 19 0.703
MED30 mediator complex subunit 30 0.671
DEFB135 defensin, beta 135 0.671
EXT1 exostosin glycosyltransferase 1 0.671
CTSB cathepsin B 0.671
DEFB136 defensin, beta 136 0.671
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.671
BATF3 basic leucine zipper transcription factor, ATF-like 3 0.577
NSL1 NSL1, MIS12 kinetochore complex component 0.577
ATF3 activating transcription factor 3 0.577
TATDN3 TatD DNase domain containing 3 0.577
SYN2 synapsin II 0.562
PPARG peroxisome proliferator-activated receptor gamma 0.562