Leprosy Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. (Experimental Factor Ontology, EFO_0001054)
External Link https://www.disgenet.org/browser/0/1/0/C1562585
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Genes

247 genes associated with the disease Leprosy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ACTBL2 actin, beta-like 2
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGB androglobin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ANXA2 annexin A2
ANXA6 annexin A6
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
ARG1 arginase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF6 activating transcription factor 6
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBS9 Bardet-Biedl syndrome 9
BCHE butyrylcholinesterase
BCL10 B-cell CLL/lymphoma 10
BMS1 BMS1 ribosome biogenesis factor
BTNL2 butyrophilin-like 2
C1D C1D nuclear receptor corepressor
C1ORF141 chromosome 1 open reading frame 141
C1ORF228 chromosome 1 open reading frame 228
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC122 coiled-coil domain containing 122
CCDC88B coiled-coil domain containing 88B
CCL17 chemokine (C-C motif) ligand 17
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD163 CD163 molecule
CD1D CD1d molecule
CD209 CD209 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD68 CD68 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CDH18 cadherin 18, type 2
CFH complement factor H
CFP complement factor properdin
CHERP calcium homeostasis endoplasmic reticulum protein
CIITA class II, major histocompatibility complex, transactivator
CNBP CCHC-type zinc finger, nucleic acid binding protein
COX4I1 cytochrome c oxidase subunit IV isoform 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DEFB1 defensin, beta 1
DPEP1 dipeptidase 1 (renal)
EBNA1BP2 EBNA1 binding protein 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMC3 ER membrane protein complex subunit 3
ERBB2 erb-b2 receptor tyrosine kinase 2
F2R coagulation factor II (thrombin) receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FHL5 four and a half LIM domains 5
FILIP1 filamin A interacting protein 1
FLNA filamin A, alpha
FMNL1 formin-like 1
FOXP3 forkhead box P3
GAL3ST4 galactose-3-O-sulfotransferase 4
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GSTM1 glutathione S-transferase mu 1
HAMP hepcidin antimicrobial peptide
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HMOX1 heme oxygenase 1
HP haptoglobin
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL26 interleukin 26
IL2RA interleukin 2 receptor, alpha
IL32 interleukin 32
IL33R interleukin 33 receptor
IL37 interleukin 37
IL4 interleukin 4
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
IRGM immunity-related GTPase family, M
ISG20 interferon stimulated exonuclease gene 20kDa
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LRP1 low density lipoprotein receptor-related protein 1
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK1 mitogen-activated protein kinase 1
MASP2 mannan-binding lectin serine peptidase 2
MAVS mitochondrial antiviral signaling protein
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MFN2 mitofusin 2
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPZ myelin protein zero
MRC1 mannose receptor, C type 1
NEBL nebulette
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NR1I2 nuclear receptor subfamily 1, group I, member 2
NT5C3A 5'-nucleotidase, cytosolic IIIA
NUPR1 nuclear protein, transcriptional regulator, 1
OMD osteomodulin
PACRG PARK2 co-regulated
PAEP progestagen-associated endometrial protein
PARK2 parkin RBR E3 ubiquitin protein ligase
PARL presenilin associated, rhomboid-like
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PINK1 PTEN induced putative kinase 1
PLIN1 perilipin 1
PLIN2 perilipin 2
POLG polymerase (DNA directed), gamma
POTEM POTE ankyrin domain family, member M
PREP prolyl endopeptidase
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAB32 RAB32, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RBM45 RNA binding motif protein 45
RIPK2 receptor-interacting serine-threonine kinase 2
RMI2 RecQ mediated genome instability 2
RPSA ribosomal protein SA
S100A1 S100 calcium binding protein A1
S100A6 S100 calcium binding protein A6
S100B S100 calcium binding protein B
SCAF1 SR-related CTD-associated factor 1
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIGLEC5 sialic acid binding Ig-like lectin 5
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SNX20 sorting nexin 20
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG8 sperm associated antigen 8
SRA1 steroid receptor RNA activator 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STING1 stimulator of interferon response cGAMP interactor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TOLLIP toll interacting protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1B torsin family 1, member B (torsin B)
TP63 tumor protein p63
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
UBASH3B ubiquitin associated and SH3 domain containing B
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
ZNF410 zinc finger protein 410