Leptospirosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly. (Human Disease Ontology, DOID_2297)
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Genes

190 genes co-occuring with the disease Leptospirosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.533
TLR2 toll-like receptor 2 2.448
CRP C-reactive protein, pentraxin-related 2.447
ALB albumin 2.44
LCE1A late cornified envelope 1A 2.409
F2 coagulation factor II (thrombin) 2.334
NXN nucleoredoxin 2.256
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.247
TLR4 toll-like receptor 4 2.223
F3 coagulation factor III (thromboplastin, tissue factor) 2.212
PFKL phosphofructokinase, liver 2.21
HNF1A HNF1 homeobox A 2.184
ERV3-1 endogenous retrovirus group 3, member 1 2.174
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.173
PLG plasminogen 2.167
ERVW-1 endogenous retrovirus group W, member 1 2.164
IL10 interleukin 10 2.158
IFNG interferon, gamma 2.149
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.141
TNF tumor necrosis factor 2.106
IL6 interleukin 6 2.105
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.071
FN1 fibronectin 1 2.034
IL1B interleukin 1, beta 2.014
CKB creatine kinase, brain 2.004
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.002
CKMT1B creatine kinase, mitochondrial 1B 2.001
CKM creatine kinase, muscle 2.0
CD4 CD4 molecule 1.954
C4B complement component 4B (Chido blood group) 1.954
UBE2K ubiquitin-conjugating enzyme E2K 1.95
LCN2 lipocalin 2 1.942
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.936
C3 complement component 3 1.904
IL4 interleukin 4 1.871
CXCL8 chemokine (C-X-C motif) ligand 8 1.863
ERVMER34-1 endogenous retrovirus group MER34, member 1 1.826
AFF2 AF4/FMR2 family, member 2 1.821
C4A complement component 4A (Rodgers blood group) 1.808
PXDNL peroxidasin-like 1.779
PXDN peroxidasin 1.778
TLR5 toll-like receptor 5 1.75
SENP8 SUMO/sentrin specific peptidase family member 8 1.741
CCL2 chemokine (C-C motif) ligand 2 1.713
HP haptoglobin 1.707
HAVCR1 hepatitis A virus cellular receptor 1 1.7
MB myoglobin 1.695
IL1A interleukin 1, alpha 1.674
CD8A CD8a molecule 1.671
TLR1 toll-like receptor 1 1.647
TRAPPC2L trafficking protein particle complex 2-like 1.644
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.636
LCE1B late cornified envelope 1B 1.626
CXCL10 chemokine (C-X-C motif) ligand 10 1.625
CCL5 chemokine (C-C motif) ligand 5 1.601
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.598
IL2 interleukin 2 1.594
IL18 interleukin 18 1.589
VTN vitronectin 1.584
PTX3 pentraxin 3, long 1.573
ELN elastin 1.566
CCL3 chemokine (C-C motif) ligand 3 1.55
IL17A interleukin 17A 1.517
AZU1 azurocidin 1 1.499
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.494
STRBP spermatid perinuclear RNA binding protein 1.491
VWF von Willebrand factor 1.48
MYD88 myeloid differentiation primary response 88 1.478
DEFA1 defensin, alpha 1 1.474
AVP arginine vasopressin 1.474
CP ceruloplasmin (ferroxidase) 1.47
CFHR1 complement factor H-related 1 1.469
NPPB natriuretic peptide B 1.468
HEMK1 HemK methyltransferase family member 1 1.467
HTRA1 HtrA serine peptidase 1 1.461
COL18A1 collagen, type XVIII, alpha 1 1.46
R3HCC1L R3H domain and coiled-coil containing 1-like 1.455
ETFB electron-transfer-flavoprotein, beta polypeptide 1.445
TGFB1 transforming growth factor, beta 1 1.436
AQP1 aquaporin 1 (Colton blood group) 1.434
NRL neural retina leucine zipper 1.431
NOD1 nucleotide-binding oligomerization domain containing 1 1.42
ICAM1 intercellular adhesion molecule 1 1.42
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.42
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.399
PI3 peptidase inhibitor 3, skin-derived 1.399
G6PD glucose-6-phosphate dehydrogenase 1.391
LY96 lymphocyte antigen 96 1.381
CNTD1 cyclin N-terminal domain containing 1 1.37
DEFA1B defensin, alpha 1B 1.368
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.348
PRTN3 proteinase 3 1.346
IL13 interleukin 13 1.339
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.334
MPO myeloperoxidase 1.32
ACE angiotensin I converting enzyme 1.32
CFH complement factor H 1.31
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.31
POLK polymerase (DNA directed) kappa 1.308
AQP2 aquaporin 2 (collecting duct) 1.299
MBL2 mannose-binding lectin (protein C) 2, soluble 1.299
SP100 SP100 nuclear antigen 1.293
LRG1 leucine-rich alpha-2-glycoprotein 1 1.292
CDH5 cadherin 5, type 2 (vascular endothelium) 1.285
TLR6 toll-like receptor 6 1.282
CSF3 colony stimulating factor 3 (granulocyte) 1.28
ADA adenosine deaminase 1.273
NOD2 nucleotide-binding oligomerization domain containing 2 1.272
TBL1X transducin (beta)-like 1X-linked 1.268
CCL4 chemokine (C-C motif) ligand 4 1.268
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.265
MFSD11 major facilitator superfamily domain containing 11 1.264
HSPE1 heat shock 10kDa protein 1 1.256
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.245
RPLP2 ribosomal protein, large, P2 1.236
LIPM lipase, family member M 1.226
PPAN peter pan homolog (Drosophila) 1.225
INS insulin 1.224
DNAH8 dynein, axonemal, heavy chain 8 1.221
SCART1 scavenger receptor protein family member 1.218
CST3 cystatin C 1.213
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.205
LGALS9 lectin, galactoside-binding, soluble, 9 1.199
IL5 interleukin 5 1.196
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.194
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.194
LBP lipopolysaccharide binding protein 1.192
PNLIP pancreatic lipase 1.192
GNLY granulysin 1.191
SDC1 syndecan 1 1.189
ACTB actin, beta 1.181
HLA-A major histocompatibility complex, class I, A 1.177
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.173
SAMM50 SAMM50 sorting and assembly machinery component 1.165
IL12RB1 interleukin 12 receptor, beta 1 1.163
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.163
ACE2 angiotensin I converting enzyme 2 1.154
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.147
LEP leptin 1.146
TNNI3 troponin I type 3 (cardiac) 1.142
LTB lymphotoxin beta (TNF superfamily, member 3) 1.139
OGA O-GlcNAcase 1.138
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.128
APOA1 apolipoprotein A-I 1.125
TYRP1 tyrosinase-related protein 1 1.123
TLR9 toll-like receptor 9 1.122
CWC15 CWC15 spliceosome-associated protein 1.119
VKORC1 vitamin K epoxide reductase complex, subunit 1 1.118
MYOM2 myomesin 2 1.117
FBXO41 F-box protein 41 1.113
IL7 interleukin 7 1.112
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.108
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.098
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.096
YBX3 Y box binding protein 3 1.096
TLR7 toll-like receptor 7 1.095
IFNA1 interferon, alpha 1 1.08
SH2D3A SH2 domain containing 3A 1.077
MAPK1 mitogen-activated protein kinase 1 1.073
IL15 interleukin 15 1.066
APCS amyloid P component, serum 1.065
CXCL9 chemokine (C-X-C motif) ligand 9 1.064
SENP6 SUMO1/sentrin specific peptidase 6 1.061
APOH apolipoprotein H (beta-2-glycoprotein I) 1.061
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.054
TLR10 toll-like receptor 10 1.053
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.052
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.052
METTL23 methyltransferase like 23 1.051
ENDOG endonuclease G 1.048
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.046
ADCY10 adenylate cyclase 10 (soluble) 1.042
ENG endoglin 1.042
ICAM3 intercellular adhesion molecule 3 1.04
CD209 CD209 molecule 1.039
ZNF174 zinc finger protein 174 1.038
CLU clusterin 1.036
FLII flightless I homolog (Drosophila) 1.033
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.031
PON1 paraoxonase 1 1.03
CBS cystathionine-beta-synthase 1.028
FBXL13 F-box and leucine-rich repeat protein 13 1.028
JUN jun proto-oncogene 1.027
NLRP3 NLR family, pyrin domain containing 3 1.027
REN renin 1.027
RPP40 ribonuclease P/MRP 40kDa subunit 1.027
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 1.017
ANGPT2 angiopoietin 2 1.008
AKAP4 A kinase (PRKA) anchor protein 4 1.005
SELE selectin E 1.002