Leptospirosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly. (Human Disease Ontology, DOID_2297)
External Link https://www.disgenet.org/browser/0/1/0/C0023364
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Genes

68 genes associated with the disease Leptospirosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACHE acetylcholinesterase (Yt blood group)
ADA adenosine deaminase
ANK1 ankyrin 1, erythrocytic
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
AZU1 azurocidin 1
BCHE butyrylcholinesterase
CADM1 cell adhesion molecule 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CD40LG CD40 ligand
CES1 carboxylesterase 1
CISH cytokine inducible SH2-containing protein
CLYBL citrate lyase beta like
CRP C-reactive protein, pentraxin-related
CST9 cystatin 9 (testatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
ELMOD3 ELMO/CED-12 domain containing 3
F10 coagulation factor X
FAM109A family with sequence similarity 109, member A
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GEM GTP binding protein overexpressed in skeletal muscle
HAP1 huntingtin-associated protein 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP haptoglobin
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL12RB1 interleukin 12 receptor, beta 1
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL22 interleukin 22
IL6 interleukin 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
LAMB1 laminin, beta 1
LBP lipopolysaccharide binding protein
LGALS3 lectin, galactoside-binding, soluble, 3
LRG1 leucine-rich alpha-2-glycoprotein 1
MAT1A methionine adenosyltransferase I, alpha
MME membrane metallo-endopeptidase
NOD2 nucleotide-binding oligomerization domain containing 2
REN renin
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SCRN1 secernin 1
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPTB spectrin, beta, erythrocytic
SUMF2 sulfatase modifying factor 2
TCOF1 Treacher Collins-Franceschetti syndrome 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TTR transthyretin
TYRP1 tyrosinase-related protein 1
VDAC1 voltage-dependent anion channel 1
WDR26 WD repeat domain 26