Lethargy Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating. (Human Phenotype Ontology, HP_0001254)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D053609
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Genes

350 genes/proteins associated with the disease Lethargy from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ABAT 4-aminobutyrate aminotransferase 2.88009
IL1B interleukin 1, beta 2.88009
TNF tumor necrosis factor 2.27582
CAT catalase 2.21926
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.20959
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.20328
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.17561
FOS FBJ murine osteosarcoma viral oncogene homolog 2.13835
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.11798
CXCL8 chemokine (C-X-C motif) ligand 8 2.08705
IL6 interleukin 6 2.08488
IFNG interferon, gamma 2.07709
IL10 interleukin 10 2.05906
MAPK3 mitogen-activated protein kinase 3 2.01622
MAPK1 mitogen-activated protein kinase 1 2.00703
PRL prolactin 2.00689
BDNF brain-derived neurotrophic factor 1.98153
NOS2 nitric oxide synthase 2, inducible 1.97785
BAX BCL2-associated X protein 1.97742
BCL2 B-cell CLL/lymphoma 2 1.97185
FGF2 fibroblast growth factor 2 (basic) 1.93024
MPO myeloperoxidase 1.92769
JUN jun proto-oncogene 1.9225
CCL2 chemokine (C-C motif) ligand 2 1.90208
FAS Fas cell surface death receptor 1.88556
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.8736
VEGFA vascular endothelial growth factor A 1.86706
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.86637
TP53 tumor protein p53 1.83895
TAC1 tachykinin, precursor 1 1.83414
CTSL cathepsin L 1.81556
DRD2 dopamine receptor D2 1.80454
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.79637
CLU clusterin 1.7893
HMOX1 heme oxygenase 1 1.78071
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.77936
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.77257
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.76347
REN renin 1.76289
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.75758
EGR1 early growth response 1 1.75301
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.73516
DDIT3 DNA-damage-inducible transcript 3 1.72055
GSTP1 glutathione S-transferase pi 1 1.70761
ICAM1 intercellular adhesion molecule 1 1.69763
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.69597
IL2 interleukin 2 1.669
NPY neuropeptide Y 1.65489
IGF1 insulin-like growth factor 1 (somatomedin C) 1.65402
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.65045
TGFB1 transforming growth factor, beta 1 1.64303
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.61621
CCND1 cyclin D1 1.59943
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.59685
GFAP glial fibrillary acidic protein 1.59427
PARP1 poly (ADP-ribose) polymerase 1 1.58771
OPRK1 opioid receptor, kappa 1 1.57306
CRH corticotropin releasing hormone 1.57257
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.57042
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.56994
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.56214
NGF nerve growth factor (beta polypeptide) 1.55624
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.55084
CNR1 cannabinoid receptor 1 (brain) 1.5462
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.53917
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.5382
INS insulin 1.53086
DUSP1 dual specificity phosphatase 1 1.5113
GSK3B glycogen synthase kinase 3 beta 1.5103
NOS1 nitric oxide synthase 1 (neuronal) 1.48838
CCL3 chemokine (C-C motif) ligand 3 1.47813
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.47813
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.474
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.46754
VCAM1 vascular cell adhesion molecule 1 1.45989
OPRM1 opioid receptor, mu 1 1.45299
GSTM1 glutathione S-transferase mu 1 1.44599
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.43646
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.42562
IL1A interleukin 1, alpha 1.42156
RGS4 regulator of G-protein signaling 4 1.41257
CTSD cathepsin D 1.40925
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.40541
BCL2L1 BCL2-like 1 1.40401
HSPA1A heat shock 70kDa protein 1A 1.40204
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.40204
IL13 interleukin 13 1.3931
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.38974
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.38918
FOSL2 FOS-like antigen 2 1.38412
PENK proenkephalin 1.38213
GSTA2 glutathione S-transferase alpha 2 1.3759
IL4 interleukin 4 1.3736
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.37303
GSTM2 glutathione S-transferase mu 2 (muscle) 1.36447
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.36247
ATF3 activating transcription factor 3 1.36019
MAPK14 mitogen-activated protein kinase 14 1.35877
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.34983
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.34606
JUNB jun B proto-oncogene 1.34547
PLAT plasminogen activator, tissue 1.34082
DRD1 dopamine receptor D1 1.34024
GPX1 glutathione peroxidase 1 1.33731
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.33731
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.33583
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.32726
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.32015
CTSB cathepsin B 1.31867
MGMT O-6-methylguanine-DNA methyltransferase 1.31686
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.31119
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.30788
CD44 CD44 molecule (Indian blood group) 1.30574
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.3036
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.30269
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.30269
GNAS GNAS complex locus 1.30269
OPRD1 opioid receptor, delta 1 1.30056
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.2975
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.29719
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.29533
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.29533
AVP arginine vasopressin 1.29287
LHB luteinizing hormone beta polypeptide 1.29072
CXCL10 chemokine (C-X-C motif) ligand 10 1.29072
CP ceruloplasmin (ferroxidase) 1.28734
CES2 carboxylesterase 2 1.28119
TKT transketolase 1.28027
ASL argininosuccinate lyase 1.27845
ANXA4 annexin A4 1.27378
SOD2 superoxide dismutase 2, mitochondrial 1.27286
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.27193
ACHE acetylcholinesterase (Yt blood group) 1.27132
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.26732
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.26669
GLUL glutamate-ammonia ligase 1.26514
PRKCE protein kinase C, epsilon 1.26514
RB1 retinoblastoma 1 1.26236
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.26175
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.25929
CCNL1 cyclin L1 1.25929
MMP9 matrix metallopeptidase 9 1.25807
IL12B interleukin 12B 1.25713
EPHX2 epoxide hydrolase 2, cytoplasmic 1.25651
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.25369
CALCA calcitonin-related polypeptide alpha 1.25369
PTK2B protein tyrosine kinase 2 beta 1.25245
GSTT1 glutathione S-transferase theta 1 1.25059
SIGMAR1 sigma non-opioid intracellular receptor 1 1.24655
INHBE inhibin, beta E 1.24655
TGFBR1 transforming growth factor, beta receptor 1 1.24655
FABP1 fatty acid binding protein 1, liver 1.24591
FSHB follicle stimulating hormone, beta polypeptide 1.2456
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24181
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.24087
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.23962
HSPA8 heat shock 70kDa protein 8 1.2393
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.23806
KRT8 keratin 8, type II 1.23552
CSF3 colony stimulating factor 3 (granulocyte) 1.23552
GAP43 growth associated protein 43 1.2352
TOP2A topoisomerase (DNA) II alpha 170kDa 1.23011
IL18 interleukin 18 1.23011
CCL5 chemokine (C-C motif) ligand 5 1.22948
POMC proopiomelanocortin 1.22948
SOD1 superoxide dismutase 1, soluble 1.21855
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.21855
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.21501
GRIK5 glutamate receptor, ionotropic, kainate 5 1.21435
S100A4 S100 calcium binding protein A4 1.21304
NUPR1 nuclear protein, transcriptional regulator, 1 1.21173
PDE4B phosphodiesterase 4B, cAMP-specific 1.21043
SREBF1 sterol regulatory element binding transcription factor 1 1.21043
CREM cAMP responsive element modulator 1.20751
TIMP1 TIMP metallopeptidase inhibitor 1 1.2046
IL12A interleukin 12A 1.20394
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.19835
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.19737
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.19477
NRP1 neuropilin 1 1.19477
CD47 CD47 molecule 1.19312
CDK4 cyclin-dependent kinase 4 1.19014
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.18981
POLR1B polymerase (RNA) I polypeptide B, 128kDa 1.18882
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.18751
GADD45A growth arrest and DNA-damage-inducible, alpha 1.18718
NOS3 nitric oxide synthase 3 (endothelial cell) 1.18326
NFE2L2 nuclear factor, erythroid 2-like 2 1.18326
POR P450 (cytochrome) oxidoreductase 1.18193
OXT oxytocin/neurophysin I prepropeptide 1.17993
PRLR prolactin receptor 1.17993
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.173
BMP4 bone morphogenetic protein 4 1.17034
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.17034
IL1R1 interleukin 1 receptor, type I 1.16567
MAPK8 mitogen-activated protein kinase 8 1.16269
F2 coagulation factor II (thrombin) 1.16104
KLF6 Kruppel-like factor 6 1.16104
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 1.1607
LBP lipopolysaccharide binding protein 1.15458
PER1 period circadian clock 1 1.15458
EFNA2 ephrin-A2 1.15256
SELL selectin L 1.14816
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.14747
SST somatostatin 1.14507
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.14507
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.14507
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.14268
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 1.13963
SDC4 syndecan 4 1.13862
EFNA1 ephrin-A1 1.13862
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.13862
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.13552
PDIA4 protein disulfide isomerase family A, member 4 1.13552
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.13449
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.13109
BBC3 BCL2 binding component 3 1.12973
CYP3A cytochrome P450, family 3, subfamily A 1.1294
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.1294
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.1294
NTF3 neurotrophin 3 1.12634
CREB1 cAMP responsive element binding protein 1 1.12599
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.1253
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.12495
SDS serine dehydratase 1.12495
ANXA5 annexin A5 1.12357
UGDH UDP-glucose 6-dehydrogenase 1.12323
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.12014
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.11741
TEX261 testis expressed 261 1.11606
EDN1 endothelin 1 1.11536
EZR ezrin 1.11466
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.11431
CFLAR CASP8 and FADD-like apoptosis regulator 1.11325
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.1129
OTC ornithine carbamoyltransferase 1.11116
RRM2 ribonucleotide reductase M2 1.11116
CDK5 cyclin-dependent kinase 5 1.10665
GRN granulin 1.10596
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.10353
ECH1 enoyl CoA hydratase 1, peroxisomal 1.10317
MARCKS myristoylated alanine-rich protein kinase C substrate 1.10317
VIM vimentin 1.10246
BAG3 BCL2-associated athanogene 3 1.10033
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.10033
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 1.09927
EDNRB endothelin receptor type B 1.09927
ILK integrin-linked kinase 1.09786
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.09786
PGRMC1 progesterone receptor membrane component 1 1.09786
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 1.09786
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.09751
PDPK1 3-phosphoinositide dependent protein kinase 1 1.09751
BRCA1 breast cancer 1, early onset 1.09751
BAK1 BCL2-antagonist/killer 1 1.09541
MCL1 myeloid cell leukemia 1 1.09506
MAPRE3 microtubule-associated protein, RP/EB family, member 3 1.09154
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.0894
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.0894
SGK1 serum/glucocorticoid regulated kinase 1 1.08584
TPD52 tumor protein D52 1.08513
TRHR thyrotropin-releasing hormone receptor 1.08478
ADCY8 adenylate cyclase 8 (brain) 1.08442
PLCL1 phospholipase C-like 1 1.08442
PRPF38B pre-mRNA processing factor 38B 1.08407
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.08372
UNG uracil-DNA glycosylase 1.08372
STAR steroidogenic acute regulatory protein 1.08231
THRSP thyroid hormone responsive 1.08126
ERBB2 erb-b2 receptor tyrosine kinase 2 1.0784
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.07696
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 1.07696
CKB creatine kinase, brain 1.0734
GSTM3 glutathione S-transferase mu 3 (brain) 1.07305
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.07269
TH tyrosine hydroxylase 1.07234
ADORA2A adenosine A2a receptor 1.07093
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 1.07093
EFNA5 ephrin-A5 1.07022
HSPB1 heat shock 27kDa protein 1 1.06987
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.06917
ATM ATM serine/threonine kinase 1.06734
DRD3 dopamine receptor D3 1.06588
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.06515
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 1.06479
ALB albumin 1.0637
SCARB1 scavenger receptor class B, member 1 1.0637
ACIN1 apoptotic chromatin condensation inducer 1 1.06261
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.06044
MSMO1 methylsterol monooxygenase 1 1.05828
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.05828
GRM5 glutamate receptor, metabotropic 5 1.05721
DPYD dihydropyrimidine dehydrogenase 1.05573
BID BH3 interacting domain death agonist 1.05461
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.05312
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.05312
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.04978
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.04978
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.04941
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 1.04941
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.04684
MVP major vault protein 1.04611
FMO1 flavin containing monooxygenase 1 1.04574
HTRA1 HtrA serine peptidase 1 1.04574
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.04574
PRKCD protein kinase C, delta 1.04465
FGFR1 fibroblast growth factor receptor 1 1.04352
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.04352
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.04352
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.04276
CYCS cytochrome c, somatic 1.04088
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.03864
NUCLEOLIN nucleolin multifunctional protein 1.03864
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.03864
RELN reelin 1.03864
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.03864
HOMER1 homer scaffolding protein 1 1.03864
IFNGR1 interferon gamma receptor 1 1.03864
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.03752
THNSL2 threonine synthase-like 2 (S. cerevisiae) 1.03678
HSPA1L heat shock 70kDa protein 1-like 1.0353
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.0353
CDK2 cyclin-dependent kinase 2 1.03493
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.03493
APP amyloid beta (A4) precursor protein 1.03456
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.03382
PCNA proliferating cell nuclear antigen 1.03345
TYMS thymidylate synthetase 1.03235
CRTC3 CREB regulated transcription coactivator 3 1.03235
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.03159
EIF5A eukaryotic translation initiation factor 5A 1.03159
GRIK2 glutamate receptor, ionotropic, kainate 2 1.03084
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.02971
FN1 fibronectin 1 1.02971
EGR2 early growth response 2 1.02708
ADORA1 adenosine A1 receptor 1.02708
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.02447
IGFBP3 insulin-like growth factor binding protein 3 1.0241
G6PC glucose-6-phosphatase, catalytic subunit 1.02262
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.02114
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 1.02114
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.0189
ARHGAP5 Rho GTPase activating protein 5 1.01852
JUND jun D proto-oncogene 1.01814
EGR3 early growth response 3 1.01776
PPARD peroxisome proliferator-activated receptor delta 1.01776
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 1.01437
CD81 CD81 molecule 1.01324
SYP synaptophysin 1.01137
TGIF1 TGFB-induced factor homeobox 1 1.01099