Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2433
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Genes

600 genes differentially expressed during Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
PGM1 phosphoglucomutase 1 4.08879
RPL18A ribosomal protein L18a 3.47539
RPL26 ribosomal protein L26 3.37339
METTL5 methyltransferase like 5 3.20945
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.18029
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 3.03284
RPS14 ribosomal protein S14 2.95815
RPL7A ribosomal protein L7a 2.9472
RPS11 ribosomal protein S11 2.9128
GLTSCR2 glioma tumor suppressor candidate region gene 2 2.88369
RPS7 ribosomal protein S7 2.86925
RPL28 ribosomal protein L28 2.86884
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.842
RPL38 ribosomal protein L38 2.803
PCDH18 protocadherin 18 2.80141
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.79631
LPAR3 lysophosphatidic acid receptor 3 2.73286
FBXL20 F-box and leucine-rich repeat protein 20 2.64924
PCDHB5 protocadherin beta 5 2.61614
TDP1 tyrosyl-DNA phosphodiesterase 1 2.56094
PHF13 PHD finger protein 13 2.54639
HHAT hedgehog acyltransferase 2.5276
TOP2B topoisomerase (DNA) II beta 180kDa 2.49387
RPL7 ribosomal protein L7 2.48933
KARS lysyl-tRNA synthetase 2.48168
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.47719
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.44658
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.43502
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.38627
GDF3 growth differentiation factor 3 2.36973
APLP1 amyloid beta (A4) precursor-like protein 1 2.32039
RPS10 ribosomal protein S10 2.31599
RPS5 ribosomal protein S5 2.308
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 2.30671
RPL10A ribosomal protein L10a 2.29204
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.25675
FRS3 fibroblast growth factor receptor substrate 3 2.25583
RPS23 ribosomal protein S23 2.25399
TXNRD3 thioredoxin reductase 3 2.24231
NACA nascent polypeptide-associated complex alpha subunit 2.24055
RPS15 ribosomal protein S15 2.24054
RNF165 ring finger protein 165 2.23638
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.22906
RPS8 ribosomal protein S8 2.22478
MDM4 MDM4, p53 regulator 2.21865
TP73 tumor protein p73 2.21276
RPL15 ribosomal protein L15 2.19304
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 2.15709
LYRM7 LYR motif containing 7 2.15015
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.14386
CKAP5 cytoskeleton associated protein 5 2.12094
RPL3 ribosomal protein L3 2.10281
SARNP SAP domain containing ribonucleoprotein 2.09733
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.09621
EIF3I eukaryotic translation initiation factor 3, subunit I 2.07703
ANKRD24 ankyrin repeat domain 24 2.05131
SYTL3 synaptotagmin-like 3 2.04428
POLR1C polymerase (RNA) I polypeptide C, 30kDa 2.03557
RPL11 ribosomal protein L11 2.03005
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.02657
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.02468
RPS17 ribosomal protein S17 2.01161
PRKCZ protein kinase C, zeta 2.00317
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.00183
PRSS41 protease, serine, 41 1.97557
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 1.95834
TGFA transforming growth factor, alpha 1.95193
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1.94703
HAUS2 HAUS augmin-like complex, subunit 2 1.93628
CES5A carboxylesterase 5A 1.91284
TSHZ2 teashirt zinc finger homeobox 2 1.90747
RUNDC1 RUN domain containing 1 1.90446
FGFR3 fibroblast growth factor receptor 3 1.89422
GPR63 G protein-coupled receptor 63 1.89262
DTWD1 DTW domain containing 1 1.88315
E4F1 E4F transcription factor 1 1.87059
CCDC3 coiled-coil domain containing 3 1.85416
ATXN7L3 ataxin 7-like 3 1.85054
MAPK12 mitogen-activated protein kinase 12 1.84309
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.8293
CIAO1 cytosolic iron-sulfur assembly component 1 1.82605
HARBI1 harbinger transposase derived 1 1.81643
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 1.81347
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1.79728
WAC WW domain containing adaptor with coiled-coil 1.79488
PTCH1 patched 1 1.78469
IGHMBP2 immunoglobulin mu binding protein 2 1.78392
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.78203
BTBD2 BTB (POZ) domain containing 2 1.7803
ZNF512 zinc finger protein 512 1.77684
GAS2L2 growth arrest-specific 2 like 2 1.77489
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 1.7695
GPKOW G patch domain and KOW motifs 1.76615
SLTM SAFB-like, transcription modulator 1.76012
C6ORF141 chromosome 6 open reading frame 141 1.75304
LYG2 lysozyme G-like 2 1.75108
DNAI1 dynein, axonemal, intermediate chain 1 1.74955
EPPIN-WFDC6 EPPIN-WFDC6 readthrough 1.7468
HTRA3 HtrA serine peptidase 3 1.74531
SPIRE1 spire-type actin nucleation factor 1 1.73501
METTL20 methyltransferase like 20 1.72936
CCBL1 cysteine conjugate-beta lyase, cytoplasmic 1.72895
RLF rearranged L-myc fusion 1.72835
UBR2 ubiquitin protein ligase E3 component n-recognin 2 1.72662
AMPD2 adenosine monophosphate deaminase 2 1.72635
RPL30 ribosomal protein L30 1.71342
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 1.71161
CCT2 chaperonin containing TCP1, subunit 2 (beta) 1.70944
SPATS2 spermatogenesis associated, serine-rich 2 1.70113
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 1.6989
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.69836
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 1.69415
MED26 mediator complex subunit 26 1.68642
PTCHD3 patched domain containing 3 1.68012
FAM73A family with sequence similarity 73, member A 1.66944
C17ORF99 chromosome 17 open reading frame 99 1.66875
PLEKHA7 pleckstrin homology domain containing, family A member 7 1.6656
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1.6604
CHIC1 cysteine-rich hydrophobic domain 1 1.65594
ACE2 angiotensin I converting enzyme 2 1.65278
CDC23 cell division cycle 23 1.64771
EDNRA endothelin receptor type A 1.64603
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 1.63721
UNC5D unc-5 homolog D (C. elegans) 1.63539
PLCD1 phospholipase C, delta 1 1.63385
ZNF148 zinc finger protein 148 1.6314
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 1.63015
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 1.61579
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 1.61272
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 1.60658
ECE1 endothelin converting enzyme 1 1.59758
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 1.58935
PGAP3 post-GPI attachment to proteins 3 1.58895
C17ORF98 chromosome 17 open reading frame 98 1.58815
EIF3E eukaryotic translation initiation factor 3, subunit E 1.58662
TTN titin 1.58446
ANKRD6 ankyrin repeat domain 6 1.57818
HOXA5 homeobox A5 1.57404
ZNF319 zinc finger protein 319 1.57272
LIMCH1 LIM and calponin homology domains 1 1.56655
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 1.5631
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 1.56152
ELP4 elongator acetyltransferase complex subunit 4 1.55933
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 1.55796
TP53BP1 tumor protein p53 binding protein 1 1.55454
VSX2 visual system homeobox 2 1.54701
PFKP phosphofructokinase, platelet 1.53318
ADGRA1 adhesion G protein-coupled receptor A1 1.53254
ZMYND10 zinc finger, MYND-type containing 10 1.52653
BCL2L2 BCL2-like 2 1.52553
ISX intestine-specific homeobox 1.52196
GSPT1 G1 to S phase transition 1 1.52113
LDB3 LIM domain binding 3 1.52099
RPL10 ribosomal protein L10 1.51449
TBL2 transducin (beta)-like 2 1.51426
TCF15 transcription factor 15 (basic helix-loop-helix) 1.51143
LDHC lactate dehydrogenase C 1.5101
KIF14 kinesin family member 14 1.50817
RPL35A ribosomal protein L35a 1.50487
RPL19 ribosomal protein L19 1.49776
H2BFM H2B histone family, member M 1.49481
MRPL24 mitochondrial ribosomal protein L24 1.49293
FOXP3 forkhead box P3 1.49234
RPS21 ribosomal protein S21 1.49016
CCDC28A coiled-coil domain containing 28A 1.48019
ZNF616 zinc finger protein 616 1.47455
RBM41 RNA binding motif protein 41 1.4721
NXPH4 neurexophilin 4 1.46997
DCST1 DC-STAMP domain containing 1 1.45939
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.44376
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 1.43707
HCRTR1 hypocretin (orexin) receptor 1 1.43619
ZNF318 zinc finger protein 318 1.43223
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.43206
KCNK15 potassium channel, two pore domain subfamily K, member 15 1.43154
PIAS4 protein inhibitor of activated STAT, 4 1.43052
RPS13 ribosomal protein S13 1.43041
EIF3K eukaryotic translation initiation factor 3, subunit K 1.42773
CSNK1G1 casein kinase 1, gamma 1 1.42407
NEUROG3 neurogenin 3 1.42341
RNF222 ring finger protein 222 1.42243
PRR9 proline rich 9 1.42031
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.42009
LEMD3 LEM domain containing 3 1.41655
ASCL3 achaete-scute family bHLH transcription factor 3 1.41567
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 1.41185
TSSK2 testis-specific serine kinase 2 1.40863
ELP3 elongator acetyltransferase complex subunit 3 1.40508
ZNF267 zinc finger protein 267 1.40435
HSPG2 heparan sulfate proteoglycan 2 1.40403
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.3999
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.39978
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.39696
APCS amyloid P component, serum 1.39629
FMO2 flavin containing monooxygenase 2 (non-functional) 1.39345
POLR1D polymerase (RNA) I polypeptide D, 16kDa 1.39032
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 1.38015
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.37562
NUDCD3 NudC domain containing 3 1.37327
ORC5 origin recognition complex, subunit 5 1.37233
NAP1L1 nucleosome assembly protein 1-like 1 1.37156
TUBGCP4 tubulin, gamma complex associated protein 4 1.37017
EDIL3 EGF-like repeats and discoidin I-like domains 3 1.36624
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 1.36622
TSPYL2 TSPY-like 2 1.36587
SHROOM1 shroom family member 1 1.36465
TMEM79 transmembrane protein 79 1.36244
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 1.36014
YIPF2 Yip1 domain family, member 2 1.35833
CCDC167 coiled-coil domain containing 167 1.35826
NMT1 N-myristoyltransferase 1 1.35332
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.35286
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.34833
TMCC1 transmembrane and coiled-coil domain family 1 1.34814
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.34212
SPEF1 sperm flagellar 1 1.33784
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 1.3356
UBE2Z ubiquitin-conjugating enzyme E2Z 1.33504
SPATA7 spermatogenesis associated 7 1.3308
SH2D4A SH2 domain containing 4A 1.33056
CATSPER2 cation channel, sperm associated 2 1.32755
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.32465
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 1.32463
C9ORF142 chromosome 9 open reading frame 142 1.32119
RPL9 ribosomal protein L9 1.31976
SH2D2A SH2 domain containing 2A 1.31971
PAPOLB poly(A) polymerase beta (testis specific) 1.31674
ZC3H14 zinc finger CCCH-type containing 14 1.31636
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 1.31191
TRIM23 tripartite motif containing 23 1.31089
S100PBP S100P binding protein 1.30973
RPL18 ribosomal protein L18 1.30653
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 1.30611
USH1C Usher syndrome 1C (autosomal recessive, severe) 1.30601
ATP9B ATPase, class II, type 9B 1.30316
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 1.30181
TMEM231 transmembrane protein 231 1.30161
ETV2 ets variant 2 1.30149
ZC3H6 zinc finger CCCH-type containing 6 1.30117
INTU inturned planar cell polarity protein 1.29941
OPN4 opsin 4 1.29736
MED30 mediator complex subunit 30 1.29474
DNAAF1 dynein, axonemal, assembly factor 1 1.28474
C1ORF56 chromosome 1 open reading frame 56 1.28247
TREX2 three prime repair exonuclease 2 1.27977
CD300LD CD300 molecule-like family member d 1.27925
NSL1 NSL1, MIS12 kinetochore complex component 1.27823
C8ORF58 chromosome 8 open reading frame 58 1.27733
RETN resistin 1.27691
FOXO1 forkhead box O1 1.27487
SLC38A9 solute carrier family 38, member 9 1.27468
C4ORF47 chromosome 4 open reading frame 47 1.27441
SRL sarcalumenin 1.27317
RPS27A ribosomal protein S27a 1.26987
NRARP NOTCH-regulated ankyrin repeat protein 1.269
C11ORF30 chromosome 11 open reading frame 30 1.26883
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 1.26236
RPL23 ribosomal protein L23 1.26078
CCDC117 coiled-coil domain containing 117 1.26014
POU3F3 POU class 3 homeobox 3 1.25513
ACY3 aminoacylase 3 1.25459
USP48 ubiquitin specific peptidase 48 1.25408
PBLD phenazine biosynthesis-like protein domain containing 1.24903
HELQ helicase, POLQ-like 1.24843
RPL37 ribosomal protein L37 1.24818
HDAC1 histone deacetylase 1 1.24353
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.24312
KCTD2 potassium channel tetramerization domain containing 2 1.24201
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.23697
ZC3H10 zinc finger CCCH-type containing 10 1.23677
TMEM200C transmembrane protein 200C 1.23359
HOXA1 homeobox A1 1.23006
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 1.22707
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.22546
PLRG1 pleiotropic regulator 1 1.2242
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.22402
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 1.22291
MOBP myelin-associated oligodendrocyte basic protein 1.22082
RAD52 RAD52 homolog (S. cerevisiae) 1.21916
RPL7L1 ribosomal protein L7-like 1 1.21568
TGFB2 transforming growth factor, beta 2 1.21461
CCDC53 coiled-coil domain containing 53 1.21364
RBMS2 RNA binding motif, single stranded interacting protein 2 1.21352
SBSN suprabasin 1.21219
RFTN2 raftlin family member 2 1.2109
EIF3G eukaryotic translation initiation factor 3, subunit G 1.20906
SSTR4 somatostatin receptor 4 1.20906
RBL2 retinoblastoma-like 2 1.20888
FUT2 fucosyltransferase 2 (secretor status included) 1.20804
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 1.20773
DESI2 desumoylating isopeptidase 2 1.20413
ZMYM3 zinc finger, MYM-type 3 1.20122
MGARP mitochondria-localized glutamic acid-rich protein 1.20058
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 1.20024
SLC39A5 solute carrier family 39 (zinc transporter), member 5 1.1999
RPS6 ribosomal protein S6 1.19984
TECPR2 tectonin beta-propeller repeat containing 2 1.19782
BAG5 BCL2-associated athanogene 5 1.19054
GIMAP7 GTPase, IMAP family member 7 1.19049
UIMC1 ubiquitin interaction motif containing 1 1.1903

decreased expression

Symbol Name Standardized Value
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -4.032
PPIA peptidylprolyl isomerase A (cyclophilin A) -3.88094
MED29 mediator complex subunit 29 -3.4918
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase -3.42888
NRP2 neuropilin 2 -3.36748
CREB3 cAMP responsive element binding protein 3 -3.2096
RBM24 RNA binding motif protein 24 -3.18517
CHMP3 charged multivesicular body protein 3 -3.11076
C19ORF18 chromosome 19 open reading frame 18 -3.10244
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -3.05792
MED25 mediator complex subunit 25 -3.0414
ILF3 interleukin enhancer binding factor 3, 90kDa -2.98021
PDHX pyruvate dehydrogenase complex, component X -2.95962
DEFB119 defensin, beta 119 -2.91379
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.85001
ERCC3 excision repair cross-complementation group 3 -2.79611
ZNF48 zinc finger protein 48 -2.75341
EXOC5 exocyst complex component 5 -2.71864
MED18 mediator complex subunit 18 -2.68832
LARP4 La ribonucleoprotein domain family, member 4 -2.66634
CFDP1 craniofacial development protein 1 -2.66379
UBE3C ubiquitin protein ligase E3C -2.64933
ANAPC1 anaphase promoting complex subunit 1 -2.60555
RAB23 RAB23, member RAS oncogene family -2.58581
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.57946
TM2D3 TM2 domain containing 3 -2.56986
SNX8 sorting nexin 8 -2.55508
BZW1 basic leucine zipper and W2 domains 1 -2.52861
INTS3 integrator complex subunit 3 -2.51718
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.50435
MAP2K4 mitogen-activated protein kinase kinase 4 -2.48135
AHCYL2 adenosylhomocysteinase-like 2 -2.4732
LIPG lipase, endothelial -2.46937
NAT6 N-acetyltransferase 6 (GCN5-related) -2.45606
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 -2.44913
QSOX2 quiescin Q6 sulfhydryl oxidase 2 -2.44859
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 -2.44422
THOC5 THO complex 5 -2.44179
ZNF248 zinc finger protein 248 -2.44176
ATHL1 ATH1, acid trehalase-like 1 (yeast) -2.4253
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.4039
GMFB glia maturation factor, beta -2.34105
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.32535
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.31604
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -2.30745
TRADD TNFRSF1A-associated via death domain -2.29271
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -2.28394
AVEN apoptosis, caspase activation inhibitor -2.28182
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 -2.27728
NEO1 neogenin 1 -2.24802
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.23764
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.2371
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -2.22933
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -2.22567
PNMT phenylethanolamine N-methyltransferase -2.21788
THOC6 THO complex 6 -2.16957
AAK1 AP2 associated kinase 1 -2.16001
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -2.15586
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -2.14279
AIDA axin interactor, dorsalization associated -2.14152
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.14048
TSPAN33 tetraspanin 33 -2.13525
WDR86 WD repeat domain 86 -2.11875
LRRC14 leucine rich repeat containing 14 -2.11692
OXCT1 3-oxoacid CoA transferase 1 -2.1168
LMAN2L lectin, mannose-binding 2-like -2.10309
FZD3 frizzled class receptor 3 -2.09901
NCDN neurochondrin -2.09155
UXS1 UDP-glucuronate decarboxylase 1 -2.0902
AMACR alpha-methylacyl-CoA racemase -2.0871
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.0859
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.08405
EHBP1 EH domain binding protein 1 -2.07829
POU3F2 POU class 3 homeobox 2 -2.07147
MRFAP1 Morf4 family associated protein 1 -2.07064
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.06939
PRPF4 pre-mRNA processing factor 4 -2.05451
CCM2 cerebral cavernous malformation 2 -2.05128
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.05026
RPUSD1 RNA pseudouridylate synthase domain containing 1 -2.04394
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.0434
ATP13A1 ATPase type 13A1 -2.04141
VPREB1 pre-B lymphocyte 1 -2.0305
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.02479
RAB19 RAB19, member RAS oncogene family -2.0193
APIP APAF1 interacting protein -2.01586
SF3B4 splicing factor 3b, subunit 4, 49kDa -1.98993
MRPL15 mitochondrial ribosomal protein L15 -1.98539
SMYD2 SET and MYND domain containing 2 -1.97388
PPP1R3E protein phosphatase 1, regulatory subunit 3E -1.97117
PRR12 proline rich 12 -1.96285
INTS4 integrator complex subunit 4 -1.96092
ASB6 ankyrin repeat and SOCS box containing 6 -1.95502
UBAC1 UBA domain containing 1 -1.95095
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -1.93557
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -1.93424
HDAC10 histone deacetylase 10 -1.9276
DBNL drebrin-like -1.92433
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -1.922
INADL InaD-like (Drosophila) -1.91264
EXT2 exostosin glycosyltransferase 2 -1.90984
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -1.89945
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -1.89873
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -1.87923
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -1.87285
ORC2 origin recognition complex, subunit 2 -1.87124
C2ORF80 chromosome 2 open reading frame 80 -1.87016
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -1.86756
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 -1.8582
DPP3 dipeptidyl-peptidase 3 -1.85336
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -1.85008
ANAPC11 anaphase promoting complex subunit 11 -1.84131
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -1.84052
TMEM63C transmembrane protein 63C -1.83649
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin -1.83267
NUBP2 nucleotide binding protein 2 -1.83252
TNS4 tensin 4 -1.83238
KLK6 kallikrein-related peptidase 6 -1.82842
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -1.82814
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -1.82164
ZNF433 zinc finger protein 433 -1.81036
DCAF13 DDB1 and CUL4 associated factor 13 -1.80639
EPC1 enhancer of polycomb homolog 1 (Drosophila) -1.80435
CHML choroideremia-like (Rab escort protein 2) -1.79155
TOM1 target of myb1 (chicken) -1.78989
MFSD3 major facilitator superfamily domain containing 3 -1.78635
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -1.78351
VAC14 Vac14 homolog (S. cerevisiae) -1.78127
IPO13 importin 13 -1.76246
TERF2 telomeric repeat binding factor 2 -1.76094
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -1.76078
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -1.75902
LOC101928761 -1.75882
TBC1D13 TBC1 domain family, member 13 -1.74916
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -1.74075
CALB2 calbindin 2 -1.74029
GLE1 GLE1 RNA export mediator -1.73845
COQ4 coenzyme Q4 -1.73682
ADAL adenosine deaminase-like -1.73395
DIEXF digestive organ expansion factor homolog (zebrafish) -1.72718
CDHR1 cadherin-related family member 1 -1.72335
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 -1.71758
PRSS27 protease, serine 27 -1.71273
SNX12 sorting nexin 12 -1.71175
PTCD2 pentatricopeptide repeat domain 2 -1.71046
SAMD7 sterile alpha motif domain containing 7 -1.70889
DLX2 distal-less homeobox 2 -1.70818
PLXNA1 plexin A1 -1.70257
UNC13B unc-13 homolog B (C. elegans) -1.70224
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -1.69812
PGC progastricsin (pepsinogen C) -1.69748
ENTHD2 ENTH domain containing 2 -1.68688
ARL8B ADP-ribosylation factor-like 8B -1.6859
HSF1 heat shock transcription factor 1 -1.68515
STARD3NL STARD3 N-terminal like -1.68329
NCBP1 nuclear cap binding protein subunit 1, 80kDa -1.67749
SAFB scaffold attachment factor B -1.67639
ATXN1L ataxin 1-like -1.66384
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -1.66187
LIM2 lens intrinsic membrane protein 2, 19kDa -1.6609
CXORF56 chromosome X open reading frame 56 -1.65556
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -1.64931
PISD phosphatidylserine decarboxylase -1.64595
ORAI1 ORAI calcium release-activated calcium modulator 1 -1.64533
SNRPN small nuclear ribonucleoprotein polypeptide N -1.63132
OVCA2 ovarian tumor suppressor candidate 2 -1.62571
EIF3B eukaryotic translation initiation factor 3, subunit B -1.62242
EIF1AX eukaryotic translation initiation factor 1A, X-linked -1.62103
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -1.61896
UTF1 undifferentiated embryonic cell transcription factor 1 -1.61475
RAB17 RAB17, member RAS oncogene family -1.61079
PPAP2C phosphatidic acid phosphatase type 2C -1.60819
CD22 CD22 molecule -1.60252
EXOSC10 exosome component 10 -1.60142
HCFC1 host cell factor C1 -1.60046
NRG2 neuregulin 2 -1.59884
PGF placental growth factor -1.59787
ECD ecdysoneless homolog (Drosophila) -1.59739
FAM50A family with sequence similarity 50, member A -1.59513
AIF1L allograft inflammatory factor 1-like -1.59252
GMEB1 glucocorticoid modulatory element binding protein 1 -1.59081
IMPACT impact RWD domain protein -1.59072
MAPK8 mitogen-activated protein kinase 8 -1.59025
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -1.58775
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -1.5877
CSF3 colony stimulating factor 3 (granulocyte) -1.58744
MRPL27 mitochondrial ribosomal protein L27 -1.58696
DUSP8 dual specificity phosphatase 8 -1.5841
TOR2A torsin family 2, member A -1.58312
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -1.57835
ADD2 adducin 2 (beta) -1.57561
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.57192
NBN nibrin -1.57109
LIN52 lin-52 DREAM MuvB core complex component -1.56859
FAM83H family with sequence similarity 83, member H -1.56836
C20ORF196 chromosome 20 open reading frame 196 -1.56582
SNX4 sorting nexin 4 -1.56335
PPP1R16A protein phosphatase 1, regulatory subunit 16A -1.56292
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -1.55983
KIAA0196 KIAA0196 -1.55818
GRB2 growth factor receptor-bound protein 2 -1.55246
CCDC91 coiled-coil domain containing 91 -1.55243
RTN4RL1 reticulon 4 receptor-like 1 -1.5487
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -1.54865
C3ORF67 chromosome 3 open reading frame 67 -1.54659
USP31 ubiquitin specific peptidase 31 -1.5433
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -1.53729
PLXNB3 plexin B3 -1.53713
TNRC6C trinucleotide repeat containing 6C -1.53578
UBL5 ubiquitin-like 5 -1.53375
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -1.53215
CCDC166 coiled-coil domain containing 166 -1.52894
ARL1 ADP-ribosylation factor-like 1 -1.52868
ADSL adenylosuccinate lyase -1.52723
C19ORF24 chromosome 19 open reading frame 24 -1.51964
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -1.51959
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -1.51579
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -1.51411
ZNF672 zinc finger protein 672 -1.50994
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -1.50916
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -1.50836
MAPK10 mitogen-activated protein kinase 10 -1.50714
RTN4IP1 reticulon 4 interacting protein 1 -1.50684
IL17A interleukin 17A -1.50477
SH3RF3 SH3 domain containing ring finger 3 -1.50382
CABIN1 calcineurin binding protein 1 -1.50256
ZBTB37 zinc finger and BTB domain containing 37 -1.50075
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -1.49596
GPR25 G protein-coupled receptor 25 -1.49538
LRPPRC leucine-rich pentatricopeptide repeat containing -1.49366
BRMS1 breast cancer metastasis suppressor 1 -1.49273
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -1.49151
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -1.48834
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -1.48725
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -1.48483
CTSD cathepsin D -1.48351
PHTF1 putative homeodomain transcription factor 1 -1.4821
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -1.48114
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -1.47907
TDRD3 tudor domain containing 3 -1.47338
RBM14 RNA binding motif protein 14 -1.47178
ARHGAP27 Rho GTPase activating protein 27 -1.47159
GAS6 growth arrest-specific 6 -1.47102
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -1.45976
EFNB1 ephrin-B1 -1.45975
MED8 mediator complex subunit 8 -1.45744
CHRD chordin -1.45528
PEX12 peroxisomal biogenesis factor 12 -1.45362
TRAPPC8 trafficking protein particle complex 8 -1.45171
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -1.45107
CALR calreticulin -1.44969
FAF2 Fas associated factor family member 2 -1.44743
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -1.44477
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) -1.44445
CYCS cytochrome c, somatic -1.44322
CCDC64 coiled-coil domain containing 64 -1.44249
CDK7 cyclin-dependent kinase 7 -1.4409
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -1.44057
IDNK idnK, gluconokinase homolog (E. coli) -1.43985
DIABLO diablo, IAP-binding mitochondrial protein -1.439
TMEM65 transmembrane protein 65 -1.43834
TSPAN10 tetraspanin 10 -1.43421
NCAN neurocan -1.42683
GCC2 GRIP and coiled-coil domain containing 2 -1.42626
DENR density-regulated protein -1.42525
FAM20A family with sequence similarity 20, member A -1.425
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -1.42275
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -1.42234
CTNS cystinosin, lysosomal cystine transporter -1.42091
NRXN1 neurexin 1 -1.42057
EPT1 ethanolaminephosphotransferase 1 -1.41996
MYO9B myosin IXB -1.41677
SPDYA speedy/RINGO cell cycle regulator family member A -1.41388
ABHD8 abhydrolase domain containing 8 -1.41377
FBLIM1 filamin binding LIM protein 1 -1.4124
POU4F2 POU class 4 homeobox 2 -1.41194
PAPOLA poly(A) polymerase alpha -1.40466
RNF185 ring finger protein 185 -1.40086
GLMP glycosylated lysosomal membrane protein -1.40011
MEST mesoderm specific transcript -1.39696
MED19 mediator complex subunit 19 -1.3961
MXRA8 matrix-remodelling associated 8 -1.39535
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -1.39515
TFB2M transcription factor B2, mitochondrial -1.39431
TAPBPL TAP binding protein-like -1.39398
PELO pelota homolog (Drosophila) -1.38832
IP6K1 inositol hexakisphosphate kinase 1 -1.38681
PEX1 peroxisomal biogenesis factor 1 -1.3852
CDK5 cyclin-dependent kinase 5 -1.38378
WDR36 WD repeat domain 36 -1.38315
ACSM2A acyl-CoA synthetase medium-chain family member 2A -1.38239
EGLN2 egl-9 family hypoxia-inducible factor 2 -1.38137
FBXO46 F-box protein 46 -1.37992
SAP18 Sin3A-associated protein, 18kDa -1.37973
ELAVL4 ELAV like neuron-specific RNA binding protein 4 -1.37769
NEFH neurofilament, heavy polypeptide -1.37621
LYZL4 lysozyme-like 4 -1.37584
L3MBTL3 l(3)mbt-like 3 (Drosophila) -1.37521
ZNF771 zinc finger protein 771 -1.37438
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -1.37396
Funding