Leukemia Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.|A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)|A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. (Experimental Factor Ontology, EFO_0000565)
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Genes

189 genes associated with the disease Leukemia in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
RTKN2 rhotekin 2 2.049
ARID5B AT rich interactive domain 5B (MRF1-like) 2.049
GRAMD1B GRAM domain containing 1B 2.047
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.034
FIGNL1 fidgetin-like 1 2.034
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.034
ACOXL acyl-CoA oxidase-like 2.033
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.027
IRF8 interferon regulatory factor 8 2.022
IRF4 interferon regulatory factor 4 2.005
DUSP22 dual specificity phosphatase 22 2.005
EXOC2 exocyst complex component 2 2.005
SP140 SP140 nuclear body protein 2.003
SP110 SP110 nuclear body protein 2.003
SP140L SP140 nuclear body protein-like 2.003
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.999
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.985
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.985
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.956
ACTA2 actin, alpha 2, smooth muscle, aorta 1.926
FAS Fas cell surface death receptor 1.926
STAMBPL1 STAM binding protein-like 1 1.926
ZNF280D zinc finger protein 280D 1.925
TEX9 testis expressed 9 1.925
MNS1 meiosis-specific nuclear structural 1 1.925
EMC8 ER membrane protein complex subunit 8 1.911
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.887
BAK1 BCL2-antagonist/killer 1 1.887
SPAG6 sperm associated antigen 6 1.817
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 1.817
BCL2 B-cell CLL/lymphoma 2 1.807
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1.807
KDSR 3-ketodihydrosphingosine reductase 1.79
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.775
CFLAR CASP8 and FADD-like apoptosis regulator 1.753
CASP10 caspase 10, apoptosis-related cysteine peptidase 1.714
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.714
CDH24 cadherin 24, type 2 1.682
RNF212B ring finger protein 212B 1.682
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.682
ACIN1 apoptotic chromatin condensation inducer 1 1.682
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.682
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11 1.682
C14ORF119 chromosome 14 open reading frame 119 1.682
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 1.682
ASCL2 achaete-scute family bHLH transcription factor 2 1.659
C11ORF21 chromosome 11 open reading frame 21 1.659
CD81 CD81 molecule 1.659
TSPAN32 tetraspanin 32 1.659
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 1.601
OPRM1 opioid receptor, mu 1 1.567
IPCEF1 interaction protein for cytohesin exchange factors 1 1.567
LEF1 lymphoid enhancer-binding factor 1 1.529
HADH hydroxyacyl-CoA dehydrogenase 1.529
E2F2 E2F transcription factor 2 1.487
RPL11 ribosomal protein L11 1.487
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.487
ACTRT3 actin-related protein T3 1.478
LRRC31 leucine rich repeat containing 31 1.478
MYNN myoneurin 1.478
LRRC34 leucine rich repeat containing 34 1.478
LRRIQ4 leucine-rich repeats and IQ motif containing 4 1.478
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 1.45
CLPTM1L CLPTM1-like 1.45
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 1.45
TERT telomerase reverse transcriptase 1.45
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.429
PRKD2 protein kinase D2 1.429
STRN4 striatin, calmodulin binding protein 4 1.429
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 1.429
GNG8 guanine nucleotide binding protein (G protein), gamma 8 1.429
DACT3 dishevelled-binding antagonist of beta-catenin 3 1.429
FKRP fukutin related protein 1.429
FLACC1 flagellum associated containing coiled-coil domains 1 1.418
GATA3 GATA binding protein 3 1.383
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 1.383
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 1.339
SPDEF SAM pointed domain containing ETS transcription factor 1.339
POT1 protection of telomeres 1 1.337
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 1.337
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.306
ARSJ arylsulfatase family, member J 1.306
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.29
RHOU ras homolog family member U 1.29
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.269
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 1.269
LRRC3C leucine rich repeat containing 3C 1.269
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 1.269
GSDMA gasdermin A 1.269
ZPBP2 zona pellucida binding protein 2 1.269
GSDMB gasdermin B 1.269
BTBD16 BTB (POZ) domain containing 16 1.239
TACC2 transforming, acidic coiled-coil containing protein 2 1.239
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 1.239
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.218
MTAP methylthioadenosine phosphorylase 1.19
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.19
CDKN2A cyclin-dependent kinase inhibitor 2A 1.19
ABHD12B abhydrolase domain containing 12B 1.169
PYGL phosphorylase, glycogen, liver 1.169
TRIM9 tripartite motif containing 9 1.169
TPRG1 tumor protein p63 regulated 1 1.11
TP63 tumor protein p63 1.11
BMF Bcl2 modifying factor 1.105
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 1.105
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 1.105
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.105
SP4 Sp4 transcription factor 1.095
DNAH11 dynein, axonemal, heavy chain 11 1.095
GRB10 growth factor receptor-bound protein 10 1.071
VMP1 vacuole membrane protein 1 1.055
NQO2 NAD(P)H dehydrogenase, quinone 2 1.032
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.032
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.032
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 1.032
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1.023
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 1.023
GPSM3 G-protein signaling modulator 3 0.986
NOTCH4 notch 4 0.986
TSBP1 testis expressed basic protein 1 0.986
PBX2 pre-B-cell leukemia homeobox 2 0.986
ORC2 origin recognition complex, subunit 2 0.985
LPP LIM domain containing preferred translocation partner in lipoma 0.952
RREB1 ras responsive element binding protein 1 0.908
SSR1 signal sequence receptor, alpha 0.908
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.889
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.889
RPH3A rabphilin 3A 0.889
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.889
TUBD1 tubulin, delta 1 0.841
PTRH2 peptidyl-tRNA hydrolase 2 0.841
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.841
RNFT1 ring finger protein, transmembrane 1 0.841
CLTC clathrin, heavy chain (Hc) 0.841
WSB1 WD repeat and SOCS box containing 1 0.75
SEPTIN2 septin 2 0.732
HDLBP high density lipoprotein binding protein 0.732
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.732
ARSA arylsulfatase A 0.715
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.715
ADM2 adrenomedullin 2 0.715
SYCE3 synaptonemal complex central element protein 3 0.715
SBF1 SET binding factor 1 0.715
CHKB choline kinase beta 0.715
CPT1B carnitine palmitoyltransferase 1B (muscle) 0.715
TYMP thymidine phosphorylase 0.715
KLHDC7B kelch domain containing 7B 0.715
NCAPH2 non-SMC condensin II complex, subunit H2 0.715
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.715
MIOX myo-inositol oxygenase 0.715
LMF2 lipase maturation factor 2 0.715
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.708
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.708
CCDC171 coiled-coil domain containing 171 0.697
EOMES eomesodermin 0.673
TMPRSS5 transmembrane protease, serine 5 0.631
ZW10 zw10 kinetochore protein 0.631
DRD2 dopamine receptor D2 0.631
EXOC6 exocyst complex component 6 0.587
KIF11 kinesin family member 11 0.587
HHEX hematopoietically expressed homeobox 0.587
DMRTA1 DMRT-like family A1 0.567
OR5M8 olfactory receptor, family 5, subfamily M, member 8 0.559
OR5M3 olfactory receptor, family 5, subfamily M, member 3 0.559
OR8K1 olfactory receptor, family 8, subfamily K, member 1 0.559
OR8K3 olfactory receptor, family 8, subfamily K, member 3 (gene/pseudogene) 0.559
OR8J1 olfactory receptor, family 8, subfamily J, member 1 0.559
OR5M9 olfactory receptor, family 5, subfamily M, member 9 0.559
OR8U1 olfactory receptor, family 8, subfamily U, member 1 0.559
MBD1 methyl-CpG binding domain protein 1 0.551
CXXC1 CXXC finger protein 1 0.551
SKA1 spindle and kinetochore associated complex subunit 1 0.551
CFAP53 cilia and flagella associated protein 53 0.551
IRF2 interferon regulatory factor 2 0.548
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.541
ODF1 outer dense fiber of sperm tails 1 0.54
KLF10 Kruppel-like factor 10 0.54
ZBTB7A zinc finger and BTB domain containing 7A 0.53
MAP2K2 mitogen-activated protein kinase kinase 2 0.53
CREB3L3 cAMP responsive element binding protein 3-like 3 0.53
PIAS4 protein inhibitor of activated STAT, 4 0.53
EEF2 eukaryotic translation elongation factor 2 0.53
DAPK3 death-associated protein kinase 3 0.53
QPCT glutaminyl-peptide cyclotransferase 0.525
PRKD3 protein kinase D3 0.525
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.521
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.521
THEMIS thymocyte selection associated 0.512
PTPRK protein tyrosine phosphatase, receptor type, K 0.512