Leukoencephalopathy Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells. (Human Phenotype Ontology, HP_0002352)
External Link https://www.disgenet.org/browser/0/1/0/C0023524
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Genes

261 genes associated with the disease Leukoencephalopathy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
AHI1 Abelson helper integration site 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ANXA2 annexin A2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APP amyloid beta (A4) precursor protein
AQP9 aquaporin 9
ARSF arylsulfatase F
ATG7 autophagy related 7
ATR ATR serine/threonine kinase
ATRX alpha thalassemia/mental retardation syndrome X-linked
AZIN2 antizyme inhibitor 2
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
CAMP cathelicidin antimicrobial peptide
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCDC6 coiled-coil domain containing 6
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CD6 CD6 molecule
CD9 CD9 molecule
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHP1 calcineurin-like EF-hand protein 1
CISH cytokine inducible SH2-containing protein
CLCN2 chloride channel, voltage-sensitive 2
COL11A2 collagen, type XI, alpha 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DARS1 aspartyl-tRNA synthetase 1
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DAXX death-domain associated protein
DCTN4 dynactin 4 (p62)
DCTN6 dynactin 6
DDIT4 DNA-damage-inducible transcript 4
DDR2 discoidin domain receptor tyrosine kinase 2
DEFB4A defensin, beta 4A
DEFB4B defensin, beta 4B
DISC1 disrupted in schizophrenia 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGF epidermal growth factor
EGR1 early growth response 1
EIF4E eukaryotic translation initiation factor 4E
ELANE elastase, neutrophil expressed
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EML4 echinoderm microtubule associated protein like 4
ESR2 estrogen receptor 2 (ER beta)
FAS Fas cell surface death receptor
FGFR1 fibroblast growth factor receptor 1
FOXO3 forkhead box O3
FYB1 FYN binding protein 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADL1 glutamate decarboxylase-like 1
GCN1 GCN1 activator of EIF2AK4
GFAP glial fibrillary acidic protein
GINS2 GINS complex subunit 2 (Psf2 homolog)
GKN1 gastrokine 1
GORASP1 golgi reassembly stacking protein 1, 65kDa
GRAP2 GRB2-related adaptor protein 2
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HBB hemoglobin, beta
HDAC1 histone deacetylase 1
HDAC9 histone deacetylase 9
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIRA histone cell cycle regulator
HLA-A major histocompatibility complex, class I, A
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMBOX1 homeobox containing 1
HOXD9 homeobox D9
HPGDS hematopoietic prostaglandin D synthase
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGHMBP2 immunoglobulin mu binding protein 2
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1B interleukin 1, beta
IL37 interleukin 37
IL7 interleukin 7
IRF8 interferon regulatory factor 8
ISG15 ISG15 ubiquitin-like modifier
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAG1 jagged 1
KAT5 K(lysine) acetyltransferase 5
KAT6A K(lysine) acetyltransferase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT20 keratin 20, type I
LAMC2 laminin, gamma 2
LMNB1 lamin B1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGT1 magnesium transporter 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD1 MAX dimerization protein 1
MXD4 MAX dimerization protein 4
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NCKIPSD NCK interacting protein with SH3 domain
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEFL neurofilament, light polypeptide
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NLRP2 NLR family, pyrin domain containing 2
NPB neuropeptide B
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRSN1 neurensin 1
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
NT5C3A 5'-nucleotidase, cytosolic IIIA
NUP62 nucleoporin 62kDa
ORC5 origin recognition complex, subunit 5
PADI4 peptidyl arginine deiminase, type IV
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDIK1L PDLIM1 interacting kinase 1 like
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PML promyelocytic leukemia
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRAM1 PML-RARA regulated adaptor molecule 1
PRKCD protein kinase C, delta
PRNP prion protein
PROM2 prominin 2
PRPF8 pre-mRNA processing factor 8
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTK2B protein tyrosine kinase 2 beta
PTPRH protein tyrosine phosphatase, receptor type, H
RAB40B RAB40B, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RAD51 RAD51 recombinase
RAG1 recombination activating gene 1
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RARS1 arginyl-tRNA synthetase 1
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNASET2 ribonuclease T2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNPEP arginyl aminopeptidase (aminopeptidase B)
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RXRA retinoid X receptor, alpha
SCARB1 scavenger receptor class B, member 1
SCLT1 sodium channel and clathrin linker 1
SCP2 sterol carrier protein 2
SCPEP1 serine carboxypeptidase 1
SENP1 SUMO1/sentrin specific peptidase 1
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGSM3 small G protein signaling modulator 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC5 structural maintenance of chromosomes 5
SNIP1 Smad nuclear interacting protein 1
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SP100 SP100 nuclear antigen
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SQSTM1 sequestosome 1
SRSF1 serine/arginine-rich splicing factor 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYCP1 synaptonemal complex protein 1
SYCP3 synaptonemal complex protein 3
SYT1 synaptotagmin I
TAT tyrosine aminotransferase
TBPL1 TBP-like 1
TCHP trichoplein, keratin filament binding
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THY1 Thy-1 cell surface antigen
TICAM2 toll-like receptor adaptor molecule 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMEM107 transmembrane protein 107
TMEM151B transmembrane protein 151B
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPPP tubulin polymerization promoting protein
TRAP triiodothyronine receptor auxiliary protein
TRIM69 tripartite motif containing 69
UBA1 ubiquitin-like modifier activating enzyme 1
UBA7 ubiquitin-like modifier activating enzyme 7
UCN3 urocortin 3
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
WDR4 WD repeat domain 4
WNK1 WNK lysine deficient protein kinase 1
XPO1 exportin 1
XPR1 xenotropic and polytropic retrovirus receptor 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB16 zinc finger and BTB domain containing 16
ZMYM2 zinc finger, MYM-type 2
ZNF645 zinc finger protein 645