Leukostasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

205 genes co-occuring with the disease Leukostasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ICAM1 intercellular adhesion molecule 1 2.989
VCAM1 vascular cell adhesion molecule 1 2.533
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.453
CCL2 chemokine (C-C motif) ligand 2 2.361
IL1B interleukin 1, beta 2.355
IL6 interleukin 6 2.195
TNF tumor necrosis factor 2.16
SELE selectin E 2.088
OCLN occludin 2.064
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.995
CXCL8 chemokine (C-X-C motif) ligand 8 1.969
CDH5 cadherin 5, type 2 (vascular endothelium) 1.9
PGF placental growth factor 1.873
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.866
TJP1 tight junction protein 1 1.85
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.839
ANGPT2 angiopoietin 2 1.838
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.827
NOS3 nitric oxide synthase 3 (endothelial cell) 1.817
FLT1 fms-related tyrosine kinase 1 1.817
PPARA peroxisome proliferator-activated receptor alpha 1.808
FLT3 fms-related tyrosine kinase 3 1.803
RMC1 regulator of MON1-CCZ1 1.796
KDR kinase insert domain receptor 1.787
ALB albumin 1.771
INS insulin 1.769
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.763
PRKCB protein kinase C, beta 1.76
SORD sorbitol dehydrogenase 1.74
CYBB cytochrome b-245, beta polypeptide 1.738
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.728
PTPRC protein tyrosine phosphatase, receptor type, C 1.712
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.707
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.687
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.678
REN renin 1.671
AGER advanced glycosylation end product-specific receptor 1.666
VLDLR very low density lipoprotein receptor 1.647
CXCL12 chemokine (C-X-C motif) ligand 12 1.619
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.614
FGF2 fibroblast growth factor 2 (basic) 1.611
RBP3 retinol binding protein 3, interstitial 1.601
TLR4 toll-like receptor 4 1.598
TEK TEK tyrosine kinase, endothelial 1.594
MMP9 matrix metallopeptidase 9 1.578
PECAM1 platelet/endothelial cell adhesion molecule 1 1.575
CXCL10 chemokine (C-X-C motif) ligand 10 1.573
AIF1 allograft inflammatory factor 1 1.573
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.565
ACTB actin, beta 1.565
VEGFB vascular endothelial growth factor B 1.564
CD34 CD34 molecule 1.562
IL1A interleukin 1, alpha 1.551
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.55
ANGPT1 angiopoietin 1 1.545
RHO rhodopsin 1.54
FAM209B family with sequence similarity 209, member B 1.539
MPO myeloperoxidase 1.533
TXNIP thioredoxin interacting protein 1.529
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.526
HMGB1 high mobility group box 1 1.525
EDN1 endothelin 1 1.514
KNG1 kininogen 1 1.506
IFNG interferon, gamma 1.503
TGFB1 transforming growth factor, beta 1 1.501
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.491
SNAP47 synaptosomal-associated protein, 47kDa 1.485
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.485
CD40 CD40 molecule, TNF receptor superfamily member 5 1.484
F3 coagulation factor III (thromboplastin, tissue factor) 1.482
THBD thrombomodulin 1.482
NOS1 nitric oxide synthase 1 (neuronal) 1.481
CLDN5 claudin 5 1.472
AGTR1 angiotensin II receptor, type 1 1.467
IGF1 insulin-like growth factor 1 (somatomedin C) 1.465
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.454
CCL5 chemokine (C-C motif) ligand 5 1.446
PPARG peroxisome proliferator-activated receptor gamma 1.444
RPE65 retinal pigment epithelium-specific protein 65kDa 1.433
NOX4 NADPH oxidase 4 1.431
CSF3 colony stimulating factor 3 (granulocyte) 1.427
CCL3 chemokine (C-C motif) ligand 3 1.417
IL10 interleukin 10 1.415
FASLG Fas ligand (TNF superfamily, member 6) 1.401
PPARD peroxisome proliferator-activated receptor delta 1.4
CD33 CD33 molecule 1.399
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.389
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.366
EPO erythropoietin 1.36
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.355
SOCS3 suppressor of cytokine signaling 3 1.35
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.343
ANPEP alanyl (membrane) aminopeptidase 1.341
NOS2 nitric oxide synthase 2, inducible 1.33
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.327
FN1 fibronectin 1 1.322
ACE angiotensin I converting enzyme 1.321
PLG plasminogen 1.319
PTPRB protein tyrosine phosphatase, receptor type, B 1.314
PXDN peroxidasin 1.31
F2 coagulation factor II (thrombin) 1.306
PXDNL peroxidasin-like 1.305
BCR breakpoint cluster region 1.305
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 1.302
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.291
CD40LG CD40 ligand 1.289
POU4F1 POU class 4 homeobox 1 1.285
IL18 interleukin 18 1.28
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 1.277
SELPLG selectin P ligand 1.273
CXCR4 chemokine (C-X-C motif) receptor 4 1.271
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.269
AOC3 amine oxidase, copper containing 3 1.264
SIRT1 sirtuin 1 1.262
LRP6 low density lipoprotein receptor-related protein 6 1.262
BDKRB2 bradykinin receptor B2 1.257
BDNF brain-derived neurotrophic factor 1.253
RARA retinoic acid receptor, alpha 1.24
HMOX1 heme oxygenase 1 1.239
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.238
CCL4 chemokine (C-C motif) ligand 4 1.236
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 1.235
BDKRB1 bradykinin receptor B1 1.232
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.227
GPX3 glutathione peroxidase 3 1.214
EGR1 early growth response 1 1.212
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.211
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.201
NOX1 NADPH oxidase 1 1.2
RLBP1 retinaldehyde binding protein 1 1.193
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 1.191
IL17A interleukin 17A 1.188
GPX6 glutathione peroxidase 6 1.186
GPX5 glutathione peroxidase 5 1.185
GPX8 glutathione peroxidase 8 (putative) 1.184
CFH complement factor H 1.184
NGF nerve growth factor (beta polypeptide) 1.182
GPX7 glutathione peroxidase 7 1.181
BCL2 B-cell CLL/lymphoma 2 1.178
CRP C-reactive protein, pentraxin-related 1.176
GPX2 glutathione peroxidase 2 1.172
IL1R1 interleukin 1 receptor, type I 1.17
ALOX15 arachidonate 15-lipoxygenase 1.165
JUN jun proto-oncogene 1.159
TXN thioredoxin 1.157
PRKCZ protein kinase C, zeta 1.155
GFAP glial fibrillary acidic protein 1.155
SELL selectin L 1.152
NCF1 neutrophil cytosolic factor 1 1.151
LOX lysyl oxidase 1.14
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.13
CCN2 cellular communication network factor 2 1.129
CCL8 chemokine (C-C motif) ligand 8 1.129
SCGB1D1 secretoglobin, family 1D, member 1 1.126
GFPT2 glutamine-fructose-6-phosphate transaminase 2 1.125
CD4 CD4 molecule 1.125
MAPK3 mitogen-activated protein kinase 3 1.124
NLRP3 NLR family, pyrin domain containing 3 1.118
SST somatostatin 1.115
CD59 CD59 molecule, complement regulatory protein 1.105
TLR2 toll-like receptor 2 1.098
PDGFC platelet derived growth factor C 1.091
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.09
STAP2 signal transducing adaptor family member 2 1.085
CCR2 chemokine (C-C motif) receptor 2 1.083
COL18A1 collagen, type XVIII, alpha 1 1.082
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.079
BMP8A bone morphogenetic protein 8a 1.075
DNTT DNA nucleotidylexotransferase 1.07
TP53 tumor protein p53 1.069
CYBA cytochrome b-245, alpha polypeptide 1.068
CYCS cytochrome c, somatic 1.067
CD19 CD19 molecule 1.067
IL2 interleukin 2 1.064
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.06
ARG2 arginase 2 1.06
DUOX1 dual oxidase 1 1.056
RUNX1 runt-related transcription factor 1 1.055
PDGFB platelet-derived growth factor beta polypeptide 1.05
CD38 CD38 molecule 1.05
MYD88 myeloid differentiation primary response 88 1.046
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.043
IL3 interleukin 3 1.042
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.041
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.041
CD44 CD44 molecule (Indian blood group) 1.039
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.038
NFE2L2 nuclear factor, erythroid 2-like 2 1.034
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.032
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.031
NCAM1 neural cell adhesion molecule 1 1.031
ASPG asparaginase 1.028
KLK2 kallikrein-related peptidase 2 1.024
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.023
ASXL1 additional sex combs like transcriptional regulator 1 1.023
C3 complement component 3 1.019
FLT4 fms-related tyrosine kinase 4 1.018
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 1.013
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.012
APOE apolipoprotein E 1.011
VEGFD vascular endothelial growth factor D 1.007
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.006
VEGFC vascular endothelial growth factor C 1.005
ADIPOQ adiponectin, C1Q and collagen domain containing 1.005
GFPT1 glutamine--fructose-6-phosphate transaminase 1 1.0