| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Levobupivacaine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Levobupivacaine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.132465 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.094507 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0930392 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0906584 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0784038 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0778353 |
| POTEF | POTE ankyrin domain family, member F | 0.0639552 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0598179 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0594462 |
| PTK2 | protein tyrosine kinase 2 | 0.0559179 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0544512 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0543716 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0519077 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.051155 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0492189 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0489819 |
| FAT1 | FAT atypical cadherin 1 | 0.0488416 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0477472 |
| VIM | vimentin | 0.046678 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0461534 |
| ATP13A3 | ATPase type 13A3 | 0.0456764 |
| MSN | moesin | 0.0454418 |
| SP3 | Sp3 transcription factor | 0.0447441 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0445698 |
| ITGAV | integrin, alpha V | 0.0440482 |
| TXNRD1 | thioredoxin reductase 1 | 0.0438564 |
| VEGFA | vascular endothelial growth factor A | 0.0433354 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0432151 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.04258 |
| SRPK2 | SRSF protein kinase 2 | 0.0422554 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0419226 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0417908 |
| RPL3 | ribosomal protein L3 | 0.0414847 |
| ARRDC3 | arrestin domain containing 3 | 0.0413198 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0411839 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0402727 |
| TPM3 | tropomyosin 3 | 0.0400963 |
| FLNA | filamin A, alpha | 0.0395466 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0394117 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0393897 |
| WDR43 | WD repeat domain 43 | 0.0384646 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0384174 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0383999 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0380884 |
| USP3 | ubiquitin specific peptidase 3 | 0.0379645 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0375685 |
| ANKRD33B | ankyrin repeat domain 33B | 0.037241 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0371902 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0357945 |
| VCAN | versican | 0.0357318 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0356465 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.03554 |
| APOL1 | apolipoprotein L, 1 | 0.0353906 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0350541 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0347929 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0343393 |
| HPCAL1 | hippocalcin-like 1 | 0.0341256 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0339123 |
| TRAM1 | translocation associated membrane protein 1 | 0.0326976 |
| QKI | QKI, KH domain containing, RNA binding | 0.032517 |
| DENND2B | DENN domain containing 2B | 0.0322161 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0318918 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0316578 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0315723 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0315433 |
| RTN4 | reticulon 4 | 0.0312926 |
| RHEB | Ras homolog enriched in brain | 0.0310676 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0307941 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0306882 |
| ANXA5 | annexin A5 | 0.0306665 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0306142 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0303688 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0302514 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0302185 |
| UBC | ubiquitin C | 0.0300685 |
| G0S2 | G0/G1 switch 2 | 0.0298192 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0296549 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0295429 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0294506 |
| NUP58 | nucleoporin 58 | 0.0294384 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0291141 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0289264 |
| SEPTIN9 | septin 9 | 0.0288776 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0286753 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0286014 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0285432 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0283662 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0282433 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0281616 |
| TFG | TRK-fused gene | 0.0281176 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0279426 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0279161 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0278503 |
| RPS4X | ribosomal protein S4, X-linked | 0.0278344 |
| APP | amyloid beta (A4) precursor protein | 0.0273301 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0269949 |
| INSIG1 | insulin induced gene 1 | 0.0269799 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0269781 |
| LDHA | lactate dehydrogenase A | 0.0266458 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0265641 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.123361 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.12294 |
| FRMD4A | FERM domain containing 4A | -0.10515 |
| EXT1 | exostosin glycosyltransferase 1 | -0.101807 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0914208 |
| TMSB10 | thymosin beta 10 | -0.0910828 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0893565 |
| RIGI | RNA sensor RIG-I | -0.0872715 |
| ASPH | aspartate beta-hydroxylase | -0.0750438 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0648561 |
| RRBP1 | ribosome binding protein 1 | -0.0648473 |
| INTS6 | integrator complex subunit 6 | -0.0637506 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0617135 |
| FTL | ferritin, light polypeptide | -0.0542783 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0524943 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0484111 |
| SP100 | SP100 nuclear antigen | -0.0459503 |
| EXOC4 | exocyst complex component 4 | -0.0457493 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0455106 |
| FRMD5 | FERM domain containing 5 | -0.0443508 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0438143 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0433968 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0424523 |
| CREB5 | cAMP responsive element binding protein 5 | -0.041274 |
| RNF213 | ring finger protein 213 | -0.0407458 |
| RAI14 | retinoic acid induced 14 | -0.0390045 |
| GOLGB1 | golgin B1 | -0.0377442 |
| HLA-B | major histocompatibility complex, class I, B | -0.0370715 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0365514 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0356139 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0355388 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0351871 |
| IFI44L | interferon-induced protein 44-like | -0.0350531 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0341879 |
| RAD51B | RAD51 paralog B | -0.0341809 |
| HM13 | histocompatibility (minor) 13 | -0.0335336 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0333448 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.033106 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.0330748 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0330379 |
| HDAC9 | histone deacetylase 9 | -0.03221 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0321772 |
| PMM2 | phosphomannomutase 2 | -0.031018 |
| CUX1 | cut-like homeobox 1 | -0.0305948 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0305082 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.029998 |
| UBAP2 | ubiquitin associated protein 2 | -0.0297169 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0296035 |
| TUT7 | terminal uridylyl transferase 7 | -0.0295642 |
| HKDC1 | hexokinase domain containing 1 | -0.0294757 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0293995 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0289298 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286912 |
| NUP98 | nucleoporin 98kDa | -0.028506 |
| EGFR | epidermal growth factor receptor | -0.0276933 |
| NABP1 | nucleic acid binding protein 1 | -0.0272922 |
| RPS3 | ribosomal protein S3 | -0.0272918 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0272678 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0272214 |
| DIAPH3 | diaphanous-related formin 3 | -0.0268592 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.026853 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0267705 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0265398 |
| DGKI | diacylglycerol kinase, iota | -0.026501 |
| RNF220 | ring finger protein 220 | -0.0263732 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.026307 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0262444 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0261194 |
| EFNA5 | ephrin-A5 | -0.0260258 |
| VCL | vinculin | -0.0257033 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0256195 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0255191 |
| MORF4L2 | mortality factor 4 like 2 | -0.0254595 |
| MT2A | metallothionein 2A | -0.0253542 |
| PALLD | palladin, cytoskeletal associated protein | -0.0248388 |
| SQSTM1 | sequestosome 1 | -0.0247534 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246206 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0246127 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0244362 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0239733 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0238658 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0234032 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0233285 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0232603 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.023258 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0228555 |
| PLSCR1 | phospholipid scramblase 1 | -0.0223832 |
| IFI44 | interferon-induced protein 44 | -0.0220133 |
| MTFR1 | mitochondrial fission regulator 1 | -0.021941 |
| NAV2 | neuron navigator 2 | -0.0218893 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0217768 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0216096 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0215274 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0213549 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0213001 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.021148 |
| HMGA1 | high mobility group AT-hook 1 | -0.0210733 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0210358 |
| PRKCA | protein kinase C, alpha | -0.0209352 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.0207753 |
