Levobupivacaine (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEPTIN11 septin 11 0.0812892
TMSB4X thymosin beta 4, X-linked 0.0748306
TSHZ2 teashirt zinc finger homeobox 2 0.0514996
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0503804
MACF1 microtubule-actin crosslinking factor 1 0.0497045
MEOX2 mesenchyme homeobox 2 0.0492459
SMYD3 SET and MYND domain containing 3 0.0482966
THSD4 thrombospondin, type I, domain containing 4 0.0468775
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0468461
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0462065
HSPA8 heat shock 70kDa protein 8 0.0448557
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0422679
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0422248
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0412747
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0411497
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0391016
TPM4 tropomyosin 4 0.0376889
FGFR1 fibroblast growth factor receptor 1 0.037203
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0351512
EEF2 eukaryotic translation elongation factor 2 0.0350859
PDE4D phosphodiesterase 4D, cAMP-specific 0.0347847
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0340379
SOD2 superoxide dismutase 2, mitochondrial 0.0336397
USP34 ubiquitin specific peptidase 34 0.0332451
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0330303
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0324308
HIPK2 homeodomain interacting protein kinase 2 0.0322552
SOBP sine oculis binding protein homolog (Drosophila) 0.0315224
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0315128
MGP matrix Gla protein 0.0314572
DLG1 discs, large homolog 1 (Drosophila) 0.0308466
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0305343
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0304751
BIRC6 baculoviral IAP repeat containing 6 0.0302054
SIK3 SIK family kinase 3 0.0298592
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0297547
TXNRD1 thioredoxin reductase 1 0.0295566
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.02907
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0288729
NCOA3 nuclear receptor coactivator 3 0.0284292
MARCHF6 membrane associated ring-CH-type finger 6 0.0280983
SHROOM3 shroom family member 3 0.0279761
KANK1 KN motif and ankyrin repeat domains 1 0.0279334
GTF2I general transcription factor IIi 0.0277657
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0275446
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0274546
BLTP1 bridge-like lipid transfer protein family member 1 0.0271581
CSDE1 cold shock domain containing E1, RNA-binding 0.0271106
PIBF1 progesterone immunomodulatory binding factor 1 0.026719
EGFR epidermal growth factor receptor 0.0267038
TOP2B topoisomerase (DNA) II beta 180kDa 0.0266639
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0264277
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0263842
XRN1 5'-3' exoribonuclease 1 0.0258812
SOX6 SRY (sex determining region Y)-box 6 0.0255926
NBEA neurobeachin 0.025465
TRIP12 thyroid hormone receptor interactor 12 0.0251725
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0248421
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0247756
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0247077
ARL15 ADP-ribosylation factor-like 15 0.024563
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.024504
MYO1B myosin IB 0.0242393
RBM26 RNA binding motif protein 26 0.0237094
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0231789
RHOA ras homolog family member A 0.0230125
PRELID2 PRELI domain containing 2 0.0229459
USP22 ubiquitin specific peptidase 22 0.0229389
DBN1 drebrin 1 0.0228936
CSNK1G3 casein kinase 1, gamma 3 0.0226627
MSRB3 methionine sulfoxide reductase B3 0.0225642
EVI5 ecotropic viral integration site 5 0.0224356
FBXL7 F-box and leucine-rich repeat protein 7 0.0223026
TBC1D5 TBC1 domain family, member 5 0.0222836
COL1A2 collagen, type I, alpha 2 0.0222621
CEP250 centrosomal protein 250kDa 0.0222606
RPS15A ribosomal protein S15a 0.0222452
FGFR2 fibroblast growth factor receptor 2 0.0220993
TAS2R14 taste receptor, type 2, member 14 0.022094
TM9SF3 transmembrane 9 superfamily member 3 0.0220643
TOR1AIP2 torsin A interacting protein 2 0.0217752
ZNF37A zinc finger protein 37A 0.0216459
FBN1 fibrillin 1 0.0215842
KIAA1549 KIAA1549 0.0215452
PLEC plectin 0.0215353
TTC3 tetratricopeptide repeat domain 3 0.0215066
BTBD3 BTB (POZ) domain containing 3 0.021479
ATG5 autophagy related 5 0.0214715
PCM1 pericentriolar material 1 0.0213961
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0213725
ZNF106 zinc finger protein 106 0.0212369
UBC ubiquitin C 0.0212043
STX18 syntaxin 18 0.0211452
MYH10 myosin, heavy chain 10, non-muscle 0.0210193
AHNAK AHNAK nucleoprotein 0.0210033
GOLM2 golgi membrane protein 2 0.0208519
MTAP methylthioadenosine phosphorylase 0.0208185
UBQLN1 ubiquilin 1 0.020748
CANX calnexin 0.0207449
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0207382

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117863
CADM2 cell adhesion molecule 2 -0.0794716
RPS6 ribosomal protein S6 -0.0728683
JMJD1C jumonji domain containing 1C -0.0676352
RPLP1 ribosomal protein, large, P1 -0.0621116
MT2A metallothionein 2A -0.0613747
VIM vimentin -0.0586309
RAB7A RAB7A, member RAS oncogene family -0.0503974
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0502106
RPS19 ribosomal protein S19 -0.0466772
SOX4 SRY (sex determining region Y)-box 4 -0.0458185
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0437967
IER3 immediate early response 3 -0.0414424
PHF3 PHD finger protein 3 -0.0404832
SSBP2 single-stranded DNA binding protein 2 -0.037839
KMT2E lysine (K)-specific methyltransferase 2E -0.0359644
RPL35A ribosomal protein L35a -0.0358268
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0357128
RPL12 ribosomal protein L12 -0.0354153
PKM pyruvate kinase, muscle -0.0352969
RPL32 ribosomal protein L32 -0.0349843
RPL37A ribosomal protein L37a -0.0346307
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0343347
WAC WW domain containing adaptor with coiled-coil -0.0341528
SBF2 SET binding factor 2 -0.034049
ANKRD12 ankyrin repeat domain 12 -0.0333293
NAP1L1 nucleosome assembly protein 1-like 1 -0.0326328
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0321611
RPS24 ribosomal protein S24 -0.0320286
RPS8 ribosomal protein S8 -0.0319646
FNIP1 folliculin interacting protein 1 -0.0313519
RPLP2 ribosomal protein, large, P2 -0.0311748
RPL34 ribosomal protein L34 -0.030464
PHIP pleckstrin homology domain interacting protein -0.0299624
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298415
TRA2A transformer 2 alpha homolog (Drosophila) -0.0298233
CREBRF CREB3 regulatory factor -0.0292242
RYBP RING1 and YY1 binding protein -0.0292203
IGF2 insulin-like growth factor 2 -0.0291722
FTL ferritin, light polypeptide -0.029121
ZNF292 zinc finger protein 292 -0.0290324
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0286558
FNDC3B fibronectin type III domain containing 3B -0.0285086
TMSB10 thymosin beta 10 -0.0277995
RPL18 ribosomal protein L18 -0.0270907
GOLGA4 golgin A4 -0.0266133
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0265438
NKTR natural killer cell triggering receptor -0.0264116
RPS29 ribosomal protein S29 -0.0261872
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0261095
TULP4 tubby like protein 4 -0.0260527
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0258857
SMAD3 SMAD family member 3 -0.0253031
MED13L mediator complex subunit 13-like -0.0250915
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -0.0244636
RPS14 ribosomal protein S14 -0.0242999
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0242868
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -0.0242427
NCOA2 nuclear receptor coactivator 2 -0.0241276
RPL23 ribosomal protein L23 -0.0240039
ZNF395 zinc finger protein 395 -0.0237715
PUM2 pumilio RNA-binding family member 2 -0.0236982
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0236927
GPBP1 GC-rich promoter binding protein 1 -0.0236731
FAM162A family with sequence similarity 162, member A -0.0234376
NDUFA4 NDUFA4, mitochondrial complex associated -0.0234336
UBE3A ubiquitin protein ligase E3A -0.0233839
DEK DEK proto-oncogene -0.0233753
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0233598
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0230697
FAM13A family with sequence similarity 13, member A -0.0227713
RBM25 RNA binding motif protein 25 -0.0227611
NUCB2 nucleobindin 2 -0.022747
POU2F1 POU class 2 homeobox 1 -0.0226861
ARHGAP12 Rho GTPase activating protein 12 -0.0226329
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.022443
OGA O-GlcNAcase -0.0221077
SQSTM1 sequestosome 1 -0.0220888
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0220346
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0218837
S100A9 S100 calcium binding protein A9 -0.0217748
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0216442
HMGA1 high mobility group AT-hook 1 -0.021523
MED13 mediator complex subunit 13 -0.0213332
TPST1 tyrosylprotein sulfotransferase 1 -0.0211565
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0211085
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0209759
RSRC1 arginine/serine-rich coiled-coil 1 -0.0209635
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0208697
CREBBP CREB binding protein -0.0208499
RPS3 ribosomal protein S3 -0.0207201
KDM3B lysine (K)-specific demethylase 3B -0.020661
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.020647
SGO2 shugoshin 2 -0.0206403
CDK19 cyclin-dependent kinase 19 -0.0205714
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0204874
PNISR PNN-interacting serine/arginine-rich protein -0.0203939
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -0.0203766
RPS10 ribosomal protein S10 -0.0203714
SMAP1 small ArfGAP 1 -0.0202508