Levobupivacaine (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.140369
EZR ezrin 0.133108
FLNB filamin B, beta 0.114279
BAIAP2L1 BAI1-associated protein 2-like 1 0.112763
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.107893
PLEC plectin 0.107299
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0988273
EEF2 eukaryotic translation elongation factor 2 0.0857056
FTH1 ferritin, heavy polypeptide 1 0.0853469
IGFBP3 insulin-like growth factor binding protein 3 0.0818005
RACK1 receptor for activated C kinase 1 0.0743936
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0719936
VIM vimentin 0.0713108
PRRC2C proline-rich coiled-coil 2C 0.0695268
DSPP dentin sialophosphoprotein 0.0692288
MYH9 myosin, heavy chain 9, non-muscle 0.0688126
NDRG1 N-myc downstream regulated 1 0.0665482
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0630834
TPM3 tropomyosin 3 0.0629749
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0622553
POTEF POTE ankyrin domain family, member F 0.0621129
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0615142
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0604813
APLP2 amyloid beta (A4) precursor-like protein 2 0.0584189
LAMB3 laminin, beta 3 0.0572819
PCBP2 poly(rC) binding protein 2 0.0558863
KIF5B kinesin family member 5B 0.0548881
CD59 CD59 molecule, complement regulatory protein 0.0534067
ACTG1 actin gamma 1 0.0521727
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0512409
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0505967
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0503306
FAM107B family with sequence similarity 107, member B 0.0494245
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.047247
KCMF1 potassium channel modulatory factor 1 0.0457496
S100A6 S100 calcium binding protein A6 0.0448196
ESYT2 extended synaptotagmin-like protein 2 0.04442
CAPRIN2 caprin family member 2 0.0436894
ADAM9 ADAM metallopeptidase domain 9 0.0435962
TRA2A transformer 2 alpha homolog (Drosophila) 0.0412727
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0410953
B2M beta-2-microglobulin 0.0397778
RPL26 ribosomal protein L26 0.0388442
LOC112694756 uncharaterized LOC112694756 0.037866
TPT1 tumor protein, translationally-controlled 1 0.0377928
RBM39 RNA binding motif protein 39 0.0374571
PARD3 par-3 family cell polarity regulator 0.0373451
OPTN optineurin 0.0368716
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0368615
TMSB4X thymosin beta 4, X-linked 0.0364257
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0363593
ITGA6 integrin, alpha 6 0.0362056
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0361291
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0360639
RPS12 ribosomal protein S12 0.0358118
RB1CC1 RB1-inducible coiled-coil 1 0.0355391
MCL1 myeloid cell leukemia 1 0.0347872
UBC ubiquitin C 0.034429
RPL36A ribosomal protein L36a 0.0341748
NCOR2 nuclear receptor corepressor 2 0.0337804
CUL3 cullin 3 0.0333212
RPS4X ribosomal protein S4, X-linked 0.0327182
LAMC2 laminin, gamma 2 0.0326411
SLMAP sarcolemma associated protein 0.0326183
ZFC3H1 zinc finger, C3H1-type containing 0.0325505
NIBAN2 niban apoptosis regulator 2 0.032288
KRT8 keratin 8, type II 0.0320994
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0318782
GOLGA4 golgin A4 0.0317037
ARRDC3 arrestin domain containing 3 0.0316346
RPL30 ribosomal protein L30 0.0313612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0309216
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0307977
RSRC2 arginine/serine-rich coiled-coil 2 0.0305246
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0304332
OGA O-GlcNAcase 0.0303903
MPRIP myosin phosphatase Rho interacting protein 0.0302794
NACA nascent polypeptide-associated complex alpha subunit 0.0301237
THOC2 THO complex 2 0.030089
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0297143
SEC31A SEC31 homolog A (S. cerevisiae) 0.0294051
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0293974
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0292223
ZNF292 zinc finger protein 292 0.0292191
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0291403
RPL23 ribosomal protein L23 0.0290716
ANXA5 annexin A5 0.0289931
YTHDC1 YTH domain containing 1 0.0289818
RPS3 ribosomal protein S3 0.028642
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0286061
KRT18 keratin 18, type I 0.0285266
KLK10 kallikrein-related peptidase 10 0.0284234
RAB1A RAB1A, member RAS oncogene family 0.0282853
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281609
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0279912
HSPA8 heat shock 70kDa protein 8 0.0279859
MATR3 matrin 3 0.027734
TSC22D2 TSC22 domain family, member 2 0.0275671
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0274162
KIF2A kinesin heavy chain member 2A 0.0273272

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.0812441
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0779902
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0695805
VCAN versican -0.0687024
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0653704
SLC35F3 solute carrier family 35, member F3 -0.0596667
MAML2 mastermind-like 2 (Drosophila) -0.0555302
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0531404
FNDC3B fibronectin type III domain containing 3B -0.0488679
PTPRR protein tyrosine phosphatase, receptor type, R -0.0472984
AKAP12 A kinase (PRKA) anchor protein 12 -0.0460718
LMO7 LIM domain 7 -0.0455862
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0454884
F3 coagulation factor III (thromboplastin, tissue factor) -0.0430091
DIAPH2 diaphanous-related formin 2 -0.0415842
LAMA4 laminin, alpha 4 -0.0396354
HMGA2 high mobility group AT-hook 2 -0.0394765
RIGI RNA sensor RIG-I -0.0376883
NPSR1 neuropeptide S receptor 1 -0.037025
PRSS3 protease, serine, 3 -0.0352735
ANXA2 annexin A2 -0.0348187
RASAL2 RAS protein activator like 2 -0.0343685
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0339621
PDE4D phosphodiesterase 4D, cAMP-specific -0.0339207
OSBPL3 oxysterol binding protein-like 3 -0.0330462
EHBP1 EH domain binding protein 1 -0.0317927
PRELID2 PRELI domain containing 2 -0.0316693
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.031297
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.030861
ARHGAP42 Rho GTPase activating protein 42 -0.0307791
DOCK5 dedicator of cytokinesis 5 -0.0292217
MX1 MX dynamin-like GTPase 1 -0.0289031
SERINC5 serine incorporator 5 -0.0287639
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0287427
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0278027
IFI16 interferon, gamma-inducible protein 16 -0.027584
PLA2R1 phospholipase A2 receptor 1, 180kDa -0.0273084
SAMD9 sterile alpha motif domain containing 9 -0.0272123
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271798
FOXP2 forkhead box P2 -0.0269469
FERMT1 fermitin family member 1 -0.0266553
DSG2 desmoglein 2 -0.0260541
ANTXR2 anthrax toxin receptor 2 -0.0259059
AKAP13 A kinase (PRKA) anchor protein 13 -0.0258664
ASPH aspartate beta-hydroxylase -0.0258442
FOXO1 forkhead box O1 -0.0255383
STAT1 signal transducer and activator of transcription 1, 91kDa -0.02542
TNRC18 trinucleotide repeat containing 18 -0.0251644
NBEAL1 neurobeachin-like 1 -0.0250962
RABGAP1L RAB GTPase activating protein 1-like -0.0244938
ZBTB20 zinc finger and BTB domain containing 20 -0.0241611
TXNIP thioredoxin interacting protein -0.024126
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0241219
TRRAP transformation/transcription domain-associated protein -0.0236889
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0236131
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0231679
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0228676
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0227302
ACTN4 actinin, alpha 4 -0.0226666
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0226095
SNRK SNF related kinase -0.0225296
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0224431
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0222696
PTBP3 polypyrimidine tract binding protein 3 -0.0220316
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0220083
CDK13 cyclin-dependent kinase 13 -0.0218681
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0217439
ITGB8 integrin, beta 8 -0.0217411
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0213655
MYOF myoferlin -0.0210595
THSD4 thrombospondin, type I, domain containing 4 -0.021049
RAD51B RAD51 paralog B -0.0210031
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209501
DUSP6 dual specificity phosphatase 6 -0.0208976
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0208685
GREB1L growth regulation by estrogen in breast cancer-like -0.0207724
SKAP2 src kinase associated phosphoprotein 2 -0.0207698
NAMPT nicotinamide phosphoribosyltransferase -0.0206826
LPP LIM domain containing preferred translocation partner in lipoma -0.0198557
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0197561
BMAL2 basic helix-loop-helix ARNT like 2 -0.0195308
CD2AP CD2-associated protein -0.0193244
ZEB1 zinc finger E-box binding homeobox 1 -0.0191549
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0191549
H1-0 H1.0 linker histone -0.0186627
CORO1C coronin, actin binding protein, 1C -0.0186124
LPIN2 lipin 2 -0.0182822
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0181983
FAM3C family with sequence similarity 3, member C -0.0181969
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0181263
ITGB4 integrin, beta 4 -0.0180429
TMSB10 thymosin beta 10 -0.018028
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0180276
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0179229
RHEB Ras homolog enriched in brain -0.0178552
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0177978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.01769
S100A4 S100 calcium binding protein A4 -0.0176446
AHNAK AHNAK nucleoprotein -0.0175995
SDC4 syndecan 4 -0.0175577