Levobupivacaine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.131167
SLIT2 slit homolog 2 (Drosophila) 0.0959975
EEF2 eukaryotic translation elongation factor 2 0.0743633
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0679924
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0499795
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0480876
HSPA8 heat shock 70kDa protein 8 0.0443733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.039716
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0393109
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0379252
RPL3 ribosomal protein L3 0.037838
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0370903
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0365415
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0349296
GNPDA1 glucosamine-6-phosphate deaminase 1 0.033078
DENND1A DENN/MADD domain containing 1A 0.0318737
CNN2 calponin 2 0.0318648
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0309008
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0308447
FLNA filamin A, alpha 0.0304354
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0304057
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0300526
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0295094
CADM2 cell adhesion molecule 2 0.0289797
RACK1 receptor for activated C kinase 1 0.028969
OSBPL10 oxysterol binding protein-like 10 0.0276619
TUBB tubulin, beta class I 0.0273098
CTBP2 C-terminal binding protein 2 0.0265696
GAB2 GRB2-associated binding protein 2 0.0259193
EIF4B eukaryotic translation initiation factor 4B 0.0256515
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0251766
PYGL phosphorylase, glycogen, liver 0.0251725
SLF1 SMC5-SMC6 complex localization factor 1 0.0247034
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0245771
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0244515
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0243655
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0242162
FNDC3B fibronectin type III domain containing 3B 0.0239853
KIF1A kinesin family member 1A 0.0239193
NPAS3 neuronal PAS domain protein 3 0.023905
DNAH14 dynein, axonemal, heavy chain 14 0.0233835
USP9X ubiquitin specific peptidase 9, X-linked 0.0233807
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0231083
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0230136
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0229936
GJA1 gap junction protein, alpha 1, 43kDa 0.0227758
CAPZB capping protein (actin filament) muscle Z-line, beta 0.022548
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0223619
EMP1 epithelial membrane protein 1 0.0222654
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0220968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0220194
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0216689
ARHGAP32 Rho GTPase activating protein 32 0.0215848
QRICH1 glutamine-rich 1 0.021323
ELOVL5 ELOVL fatty acid elongase 5 0.0207084
MYH9 myosin, heavy chain 9, non-muscle 0.0205242
ATP9A ATPase, class II, type 9A 0.0204486
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0204453
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0204218
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0204056
UBAP2L ubiquitin associated protein 2-like 0.0203885
TXNRD1 thioredoxin reductase 1 0.0203574
PLCG1 phospholipase C, gamma 1 0.0203269
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0202818
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0199436
GCN1 GCN1 activator of EIF2AK4 0.0198253
EWSR1 EWS RNA-binding protein 1 0.0197549
ATP11A ATPase, class VI, type 11A 0.0195736
SPIDR scaffolding protein involved in DNA repair 0.019551
ANXA2 annexin A2 0.0194173
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.0191361
CORO1C coronin, actin binding protein, 1C 0.0191354
LIMS1 LIM and senescent cell antigen-like domains 1 0.0191002
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0190298
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.0187372
RPS4X ribosomal protein S4, X-linked 0.0186611
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0185306
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0185125
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0184432
COL11A1 collagen, type XI, alpha 1 0.0182399
TMEM117 transmembrane protein 117 0.0182329
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0181647
ITCH itchy E3 ubiquitin protein ligase 0.0179401
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0178662
HILPDA hypoxia inducible lipid droplet-associated 0.0178397
BLTP2 bridge-like lipid transfer protein family member 2 0.0177569
TCF12 transcription factor 12 0.0177281
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0176892
MDN1 MDN1, midasin homolog (yeast) 0.0176787
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0176667
EXOC4 exocyst complex component 4 0.017566
GMDS GDP-mannose 4,6-dehydratase 0.0175641
RNF4 ring finger protein 4 0.0175558
USP3 ubiquitin specific peptidase 3 0.0175065
DCTN1 dynactin 1 0.0174917
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.017444
DHFR dihydrofolate reductase 0.017236
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.017174
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0171608
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0171362

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144077
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.110663
RPS6 ribosomal protein S6 -0.110417
WSB1 WD repeat and SOCS box containing 1 -0.103813
KTN1 kinectin 1 (kinesin receptor) -0.0946011
RPL11 ribosomal protein L11 -0.072951
RPS8 ribosomal protein S8 -0.071181
NFIA nuclear factor I/A -0.0684571
PTMA prothymosin, alpha -0.0651359
SETD5 SET domain containing 5 -0.0608228
RPS3 ribosomal protein S3 -0.060458
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598354
RPS2 ribosomal protein S2 -0.0592279
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0583634
TOX thymocyte selection-associated high mobility group box -0.0583544
COL5A2 collagen, type V, alpha 2 -0.0579745
ZNF608 zinc finger protein 608 -0.0575336
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0575086
ANKRD12 ankyrin repeat domain 12 -0.0559343
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0541315
RPS12 ribosomal protein S12 -0.0540827
STAT1 signal transducer and activator of transcription 1, 91kDa -0.050499
NEBL nebulette -0.04817
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0476061
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0472236
RPS24 ribosomal protein S24 -0.0467692
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0465537
MED13 mediator complex subunit 13 -0.0455569
NKTR natural killer cell triggering receptor -0.0455297
DSCAM Down syndrome cell adhesion molecule -0.0454947
RPLP1 ribosomal protein, large, P1 -0.0454876
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0448353
SEPTIN7 septin 7 -0.0440563
ZNF292 zinc finger protein 292 -0.0438871
ACTG1 actin gamma 1 -0.0438432
JMJD1C jumonji domain containing 1C -0.0436901
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0436086
NAP1L1 nucleosome assembly protein 1-like 1 -0.0421121
KMT2C lysine (K)-specific methyltransferase 2C -0.0419773
RPL31 ribosomal protein L31 -0.041771
KIAA1958 KIAA1958 -0.0415724
RPL26 ribosomal protein L26 -0.0409129
TAOK1 TAO kinase 1 -0.0406997
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0405073
CCDC88A coiled-coil domain containing 88A -0.0398664
RPL37A ribosomal protein L37a -0.0397006
USP34 ubiquitin specific peptidase 34 -0.0395942
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.038595
PNISR PNN-interacting serine/arginine-rich protein -0.0385259
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0378653
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0377755
TTC3 tetratricopeptide repeat domain 3 -0.0375582
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.037406
WDR45B WD repeat domain 45B -0.03711
RPL18 ribosomal protein L18 -0.0369064
SNX14 sorting nexin 14 -0.0368802
PHF3 PHD finger protein 3 -0.0368719
RPL7A ribosomal protein L7a -0.0366656
RPS5 ribosomal protein S5 -0.036658
RPLP2 ribosomal protein, large, P2 -0.036387
FAM162A family with sequence similarity 162, member A -0.0363546
NBEAL1 neurobeachin-like 1 -0.0361175
RPL13A ribosomal protein L13a -0.0359865
RPL9 ribosomal protein L9 -0.0359341
RPS21 ribosomal protein S21 -0.035888
NCOR1 nuclear receptor corepressor 1 -0.0358427
RPS27A ribosomal protein S27a -0.0357398
RPL28 ribosomal protein L28 -0.0356053
TNRC6B trinucleotide repeat containing 6B -0.0354698
KMT2E lysine (K)-specific methyltransferase 2E -0.0354387
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0353898
HELZ helicase with zinc finger -0.035258
IFI6 interferon, alpha-inducible protein 6 -0.0351988
PCNX4 pecanex 4 -0.0347244
PDIA3 protein disulfide isomerase family A, member 3 -0.0344356
BPTF bromodomain PHD finger transcription factor -0.0341596
OGA O-GlcNAcase -0.0340192
TUT4 terminal uridylyl transferase 4 -0.0339047
RPL34 ribosomal protein L34 -0.0338998
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0337084
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0336308
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0333337
SEC63 SEC63 homolog (S. cerevisiae) -0.0329617
RPL38 ribosomal protein L38 -0.0329223
SCAF11 SR-related CTD-associated factor 11 -0.0328312
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.032457
RPL7 ribosomal protein L7 -0.0320866
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0316217
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0315611
MBD5 methyl-CpG binding domain protein 5 -0.0313553
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0311834
RBM25 RNA binding motif protein 25 -0.0305512
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0303847
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0303393
CDC27 cell division cycle 27 -0.0301047
MYO9A myosin IXA -0.0300958
KIF13A kinesin family member 13A -0.0300664
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0299687
RPL21 ribosomal protein L21 -0.0299263
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0298384