Levobupivacaine (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.256669
LAMB3 laminin, beta 3 0.179326
RACK1 receptor for activated C kinase 1 0.138713
FTH1 ferritin, heavy polypeptide 1 0.129208
NDRG1 N-myc downstream regulated 1 0.0943619
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0856611
MYH9 myosin, heavy chain 9, non-muscle 0.0841916
F3 coagulation factor III (thromboplastin, tissue factor) 0.0817751
EEF2 eukaryotic translation elongation factor 2 0.0787867
EZR ezrin 0.0779622
RPL23 ribosomal protein L23 0.0759995
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0746744
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0700181
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0697655
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0694235
ENO1 enolase 1, (alpha) 0.0666569
YBX1 Y box binding protein 1 0.0639859
PGK1 phosphoglycerate kinase 1 0.0611175
AHNAK2 AHNAK nucleoprotein 2 0.0587373
FLNA filamin A, alpha 0.0580446
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0578517
FLNB filamin B, beta 0.0573494
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.056937
CALR calreticulin 0.0559964
B2M beta-2-microglobulin 0.0543656
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0542524
G0S2 G0/G1 switch 2 0.0539846
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0539793
PLEC plectin 0.0520208
STC2 stanniocalcin 2 0.0476484
NUP58 nucleoporin 58 0.0473406
LASP1 LIM and SH3 protein 1 0.0466865
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0464819
MMP7 matrix metallopeptidase 7 0.046473
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0458543
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0453412
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0453109
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0449965
GRB10 growth factor receptor-bound protein 10 0.0447233
AKAP12 A kinase (PRKA) anchor protein 12 0.044112
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0439388
HLA-C major histocompatibility complex, class I, C 0.0420041
CCNY cyclin Y 0.041673
TRIO trio Rho guanine nucleotide exchange factor 0.0402333
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0396048
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0395849
HLA-A major histocompatibility complex, class I, A 0.0389608
DSPP dentin sialophosphoprotein 0.0382665
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0379537
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.037344
VEGFA vascular endothelial growth factor A 0.0371378
TMSB10 thymosin beta 10 0.0369769
NPEPPS aminopeptidase puromycin sensitive 0.036475
ACTN4 actinin, alpha 4 0.0358361
HSPA8 heat shock 70kDa protein 8 0.0355688
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0347229
HDLBP high density lipoprotein binding protein 0.0346279
LOC112694756 uncharaterized LOC112694756 0.0346003
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0341422
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0338505
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0334055
TNIP1 TNFAIP3 interacting protein 1 0.0329319
ADAM9 ADAM metallopeptidase domain 9 0.0326246
SERF2 small EDRK-rich factor 2 0.0325391
TMSB4X thymosin beta 4, X-linked 0.0325104
NPTN neuroplastin 0.0321428
RPL35A ribosomal protein L35a 0.0317872
RPS4X ribosomal protein S4, X-linked 0.0315575
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0314841
BIRC3 baculoviral IAP repeat containing 3 0.0310471
RPL3 ribosomal protein L3 0.0307802
RAB6A RAB6A, member RAS oncogene family 0.0306827
HILPDA hypoxia inducible lipid droplet-associated 0.0301842
SOD2 superoxide dismutase 2, mitochondrial 0.029522
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0294748
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0288397
NIBAN2 niban apoptosis regulator 2 0.0287515
ESYT2 extended synaptotagmin-like protein 2 0.0287254
GBP2 guanylate binding protein 2, interferon-inducible 0.0286776
LPP LIM domain containing preferred translocation partner in lipoma 0.0286347
KDM5B lysine (K)-specific demethylase 5B 0.0285291
PADI1 peptidyl arginine deiminase, type I 0.0284096
UBA6 ubiquitin-like modifier activating enzyme 6 0.0283607
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0282655
ANKRD11 ankyrin repeat domain 11 0.0282564
CCNL1 cyclin L1 0.0281077
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0279475
ZMIZ1 zinc finger, MIZ-type containing 1 0.0278467
DAPK1 death-associated protein kinase 1 0.0273726
JUP junction plakoglobin 0.0271106
PRPF38B pre-mRNA processing factor 38B 0.0270883
TMED2 transmembrane emp24 domain trafficking protein 2 0.0270283
MCL1 myeloid cell leukemia 1 0.0265754
FAT1 FAT atypical cadherin 1 0.0265617
HSPG2 heparan sulfate proteoglycan 2 0.026153
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0260336
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0259927
BZW1 basic leucine zipper and W2 domains 1 0.0258898
TPM3 tropomyosin 3 0.0256348
RAI1 retinoic acid induced 1 0.0254659

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266613
MT2A metallothionein 2A -0.165784
ASPH aspartate beta-hydroxylase -0.144712
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.133925
CDCP1 CUB domain containing protein 1 -0.0671123
NAMPT nicotinamide phosphoribosyltransferase -0.0655093
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0650631
DSG2 desmoglein 2 -0.0630982
BRD2 bromodomain containing 2 -0.0554944
RPS2 ribosomal protein S2 -0.0554203
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.055313
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0520201
ARHGAP5 Rho GTPase activating protein 5 -0.0513928
EIF1 eukaryotic translation initiation factor 1 -0.0502965
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0479594
WWTR1 WW domain containing transcription regulator 1 -0.0454349
FAM3C family with sequence similarity 3, member C -0.0445607
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0437466
ALCAM activated leukocyte cell adhesion molecule -0.0434982
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0421984
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0419542
SYNRG synergin, gamma -0.0418628
HLA-B major histocompatibility complex, class I, B -0.0386995
PTMA prothymosin, alpha -0.0380632
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0380204
RTN4 reticulon 4 -0.0374463
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0367405
C15ORF48 chromosome 15 open reading frame 48 -0.0365299
FNDC3B fibronectin type III domain containing 3B -0.0362268
ANXA2 annexin A2 -0.0359437
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0357674
NABP1 nucleic acid binding protein 1 -0.0350215
MYO1E myosin IE -0.0343977
NRIP1 nuclear receptor interacting protein 1 -0.0343106
APOL1 apolipoprotein L, 1 -0.0336992
IFI16 interferon, gamma-inducible protein 16 -0.0332023
NUMB numb homolog (Drosophila) -0.0331222
DSCAM Down syndrome cell adhesion molecule -0.0330355
MT1X metallothionein 1X -0.0329737
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0328045
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0325248
RPS6 ribosomal protein S6 -0.0321893
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0319098
DOCK5 dedicator of cytokinesis 5 -0.031862
TXNIP thioredoxin interacting protein -0.0317197
ADAM28 ADAM metallopeptidase domain 28 -0.0308342
CD2AP CD2-associated protein -0.0307508
FNIP1 folliculin interacting protein 1 -0.0299531
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0293664
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.029308
EFNA5 ephrin-A5 -0.0290476
TMEM165 transmembrane protein 165 -0.0284956
PKM pyruvate kinase, muscle -0.0284485
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0282957
IL6ST interleukin 6 signal transducer -0.0282349
MBNL1 muscleblind-like splicing regulator 1 -0.0282288
RPS24 ribosomal protein S24 -0.0281396
S100A10 S100 calcium binding protein A10 -0.0276846
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0276229
RPL19 ribosomal protein L19 -0.0273829
CCNI cyclin I -0.0263427
RPS29 ribosomal protein S29 -0.0260998
GCC2 GRIP and coiled-coil domain containing 2 -0.0255264
JAK1 Janus kinase 1 -0.024988
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0248839
JMJD1C jumonji domain containing 1C -0.0246751
IER3 immediate early response 3 -0.0245946
CSTB cystatin B (stefin B) -0.0244687
LAMA4 laminin, alpha 4 -0.0243592
MX2 MX dynamin-like GTPase 2 -0.0241849
STAU1 staufen double-stranded RNA binding protein 1 -0.0239317
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0238986
PMP22 peripheral myelin protein 22 -0.0236353
BICC1 BicC family RNA binding protein 1 -0.0232658
AREG amphiregulin -0.0232475
TFPI2 tissue factor pathway inhibitor 2 -0.023202
ZBTB20 zinc finger and BTB domain containing 20 -0.023152
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0230876
GLRX glutaredoxin (thioltransferase) -0.0225488
LAMB1 laminin, beta 1 -0.0225377
GOLM2 golgi membrane protein 2 -0.0224822
WDR26 WD repeat domain 26 -0.0223124
USP53 ubiquitin specific peptidase 53 -0.0222676
AKAP13 A kinase (PRKA) anchor protein 13 -0.0220333
ANO6 anoctamin 6 -0.0218684
GOLGB1 golgin B1 -0.0217972
PLAUR plasminogen activator, urokinase receptor -0.0217336
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0213794
SUCO SUN domain containing ossification factor -0.0213359
FAM107B family with sequence similarity 107, member B -0.0212854
ACTG1 actin gamma 1 -0.0212763
ANKRD17 ankyrin repeat domain 17 -0.0211454
RPL28 ribosomal protein L28 -0.020955
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0209426
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0204613
RPS21 ribosomal protein S21 -0.020442
STRN3 striatin, calmodulin binding protein 3 -0.0203939
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0202538
OSMR oncostatin M receptor -0.0202172
UGDH UDP-glucose 6-dehydrogenase -0.0201416