Levobupivacaine (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RACK1 receptor for activated C kinase 1 0.0860879
FLNA filamin A, alpha 0.0852243
IGFBP3 insulin-like growth factor binding protein 3 0.0833173
MYH9 myosin, heavy chain 9, non-muscle 0.0821983
EEF2 eukaryotic translation elongation factor 2 0.0690119
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0593832
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.057267
SMAD3 SMAD family member 3 0.0499948
PLEC plectin 0.043958
RPL3 ribosomal protein L3 0.0408665
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0381143
FTH1 ferritin, heavy polypeptide 1 0.0368734
HSPA8 heat shock 70kDa protein 8 0.0362641
AFDN afadin, adherens junction formation factor 0.0358848
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0356334
USP9X ubiquitin specific peptidase 9, X-linked 0.0335888
ANKRD36 ankyrin repeat domain 36 0.0310127
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0308568
TMSB4X thymosin beta 4, X-linked 0.0299837
MPRIP myosin phosphatase Rho interacting protein 0.0282939
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0280593
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.02789
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0275093
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0273381
DSPP dentin sialophosphoprotein 0.0273074
FNDC3B fibronectin type III domain containing 3B 0.0272121
SLTM SAFB-like, transcription modulator 0.0270106
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263561
EIF4H eukaryotic translation initiation factor 4H 0.0250322
APP amyloid beta (A4) precursor protein 0.0238968
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0235898
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0235534
SET SET nuclear proto-oncogene 0.0230099
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0227056
WAC WW domain containing adaptor with coiled-coil 0.0225736
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223474
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0222971
CTBP2 C-terminal binding protein 2 0.0221497
BCAR3 breast cancer anti-estrogen resistance 3 0.0220817
RANBP2 RAN binding protein 2 0.0220514
OSBPL10 oxysterol binding protein-like 10 0.0218308
TPM3 tropomyosin 3 0.0216618
LPP LIM domain containing preferred translocation partner in lipoma 0.0215831
AFF1 AF4/FMR2 family, member 1 0.0210781
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0208898
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0208889
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0208349
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0207713
KDM6A lysine (K)-specific demethylase 6A 0.0205839
BIRC6 baculoviral IAP repeat containing 6 0.0205709
RHOA ras homolog family member A 0.0202046
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0199835
MACF1 microtubule-actin crosslinking factor 1 0.0198812
GOLGA4 golgin A4 0.0196914
NCKAP1 NCK-associated protein 1 0.0196052
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0195345
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0194568
CSNK1A1 casein kinase 1, alpha 1 0.0194152
SFPQ splicing factor proline/glutamine-rich 0.0190244
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0190076
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0189811
CALR calreticulin 0.0189553
VEGFA vascular endothelial growth factor A 0.0189254
TNIP1 TNFAIP3 interacting protein 1 0.0188661
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0188564
AFF4 AF4/FMR2 family, member 4 0.0186393
YBX1 Y box binding protein 1 0.0185717
SARS1 seryl-tRNA synthetase 1 0.018549
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0185071
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0182151
PSD3 pleckstrin and Sec7 domain containing 3 0.0181293
DOCK3 dedicator of cytokinesis 3 0.0181251
LAMC2 laminin, gamma 2 0.018048
NBAS neuroblastoma amplified sequence 0.0179151
RAD23B RAD23 homolog B (S. cerevisiae) 0.0178388
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0177324
RBM26 RNA binding motif protein 26 0.0176085
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0175533
PUM2 pumilio RNA-binding family member 2 0.0175244
SCAF8 SR-related CTD-associated factor 8 0.0173408
ZNF148 zinc finger protein 148 0.0173192
HELZ helicase with zinc finger 0.0169671
SEPTIN9 septin 9 0.0168993
SREBF2 sterol regulatory element binding transcription factor 2 0.016881
AUH AU RNA binding protein/enoyl-CoA hydratase 0.016827
CHD9 chromodomain helicase DNA binding protein 9 0.0168246
PUM1 pumilio RNA-binding family member 1 0.0167734
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0166771
AHNAK2 AHNAK nucleoprotein 2 0.0166484
UBXN7 UBX domain protein 7 0.016492
SBF2 SET binding factor 2 0.016318
MBNL2 muscleblind-like splicing regulator 2 0.016312
UBQLN1 ubiquilin 1 0.0162298
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0162186
PITPNB phosphatidylinositol transfer protein, beta 0.0161487
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0159664
KDM3B lysine (K)-specific demethylase 3B 0.0157442
NFE2L1 nuclear factor, erythroid 2-like 1 0.0157385
NCOR1 nuclear receptor corepressor 1 0.0156559
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0155995

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.320694
MT2A metallothionein 2A -0.19474
TMSB10 thymosin beta 10 -0.178895
FTL ferritin, light polypeptide -0.166849
RPS19 ribosomal protein S19 -0.0958917
ACTG1 actin gamma 1 -0.0923273
RPL35A ribosomal protein L35a -0.0854692
RPS6 ribosomal protein S6 -0.0839677
TPT1 tumor protein, translationally-controlled 1 -0.0820025
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0720644
PTMA prothymosin, alpha -0.0706295
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0643792
RPL19 ribosomal protein L19 -0.0628084
CCND1 cyclin D1 -0.0625637
RPL32 ribosomal protein L32 -0.062419
RPLP2 ribosomal protein, large, P2 -0.0604942
RPL12 ribosomal protein L12 -0.0601223
RPL28 ribosomal protein L28 -0.0594766
RPL31 ribosomal protein L31 -0.0575372
RPLP1 ribosomal protein, large, P1 -0.0569558
S100A9 S100 calcium binding protein A9 -0.0554295
RPS8 ribosomal protein S8 -0.0521995
RPL9 ribosomal protein L9 -0.0516177
PKM pyruvate kinase, muscle -0.047714
MT1X metallothionein 1X -0.0472146
RPS29 ribosomal protein S29 -0.0464022
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0463172
RPS11 ribosomal protein S11 -0.0458643
S100A10 S100 calcium binding protein A10 -0.0457313
RPS14 ribosomal protein S14 -0.0448034
RPLP0 ribosomal protein, large, P0 -0.0447834
EGR1 early growth response 1 -0.0440583
RPS27A ribosomal protein S27a -0.0437245
TUBB4B tubulin, beta 4B class IVb -0.04297
RPS24 ribosomal protein S24 -0.0419654
B2M beta-2-microglobulin -0.0419607
RPL34 ribosomal protein L34 -0.0418149
RPS13 ribosomal protein S13 -0.0401911
RPS5 ribosomal protein S5 -0.0394109
H1-0 H1.0 linker histone -0.0389704
S100A6 S100 calcium binding protein A6 -0.0384975
EIF5B eukaryotic translation initiation factor 5B -0.0383882
RPS23 ribosomal protein S23 -0.037707
RPS16 ribosomal protein S16 -0.0375699
RPL35 ribosomal protein L35 -0.0372695
RPL36 ribosomal protein L36 -0.0360526
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0356989
POTEF POTE ankyrin domain family, member F -0.0356237
RPS15 ribosomal protein S15 -0.0353181
EIF1 eukaryotic translation initiation factor 1 -0.0352157
CCNI cyclin I -0.0342668
RPL38 ribosomal protein L38 -0.0334584
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0333235
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0331102
RPS21 ribosomal protein S21 -0.032977
SEPTIN7 septin 7 -0.0329096
ENO1 enolase 1, (alpha) -0.0327282
RPS25 ribosomal protein S25 -0.0322776
DEK DEK proto-oncogene -0.03212
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0319835
ALCAM activated leukocyte cell adhesion molecule -0.0313999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030756
RPL7A ribosomal protein L7a -0.0306194
WSB1 WD repeat and SOCS box containing 1 -0.030291
RPL18 ribosomal protein L18 -0.0301241
RPL11 ribosomal protein L11 -0.0299935
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0297986
ANLN anillin, actin binding protein -0.0297658
RPL37A ribosomal protein L37a -0.0296178
MACROD2 MACRO domain containing 2 -0.0294239
VIM vimentin -0.0287988
ENO2 enolase 2 (gamma, neuronal) -0.0283276
TUBA1B tubulin, alpha 1b -0.0278977
RPS3 ribosomal protein S3 -0.0278342
DLG1 discs, large homolog 1 (Drosophila) -0.0276014
MKI67 marker of proliferation Ki-67 -0.0275768
IER3 immediate early response 3 -0.0274285
RPL23 ribosomal protein L23 -0.027353
MYL12B myosin, light chain 12B, regulatory -0.0272391
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269103
RAD51B RAD51 paralog B -0.0264776
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0261823
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.02603
RPS10 ribosomal protein S10 -0.0258411
RPS27 ribosomal protein S27 -0.025616
BPTF bromodomain PHD finger transcription factor -0.0253438
PFN1 profilin 1 -0.0253192
RPS20 ribosomal protein S20 -0.0249888
DSG2 desmoglein 2 -0.024729
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0244481
VDAC1 voltage-dependent anion channel 1 -0.0243016
RPL8 ribosomal protein L8 -0.0240745
GNAS GNAS complex locus -0.023879
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0236438
HMGB1 high mobility group box 1 -0.0236206
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0235788
S100A11 S100 calcium binding protein A11 -0.0234141
PTBP3 polypyrimidine tract binding protein 3 -0.0233646
DARS1 aspartyl-tRNA synthetase 1 -0.0233419
FOSL1 FOS-like antigen 1 -0.0233307