Levobupivacaine (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.107151
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.102409
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0971854
RACK1 receptor for activated C kinase 1 0.080808
IGFBP3 insulin-like growth factor binding protein 3 0.0745368
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0651499
JARID2 jumonji, AT rich interactive domain 2 0.0570071
LAMB3 laminin, beta 3 0.0512667
SEPTIN9 septin 9 0.0465854
CDH13 cadherin 13 0.0457923
FN1 fibronectin 1 0.0438877
COL6A3 collagen, type VI, alpha 3 0.0432723
COL5A1 collagen, type V, alpha 1 0.0387549
PRELID2 PRELI domain containing 2 0.0372705
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.035776
RPL35A ribosomal protein L35a 0.03254
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0295942
EFNA5 ephrin-A5 0.0293522
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0286927
HPCAL1 hippocalcin-like 1 0.0281052
GRB10 growth factor receptor-bound protein 10 0.02806
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0273847
FLNA filamin A, alpha 0.0273219
PLEC plectin 0.0271471
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0269512
CENPF centromere protein F, 350/400kDa 0.0266432
TNS1 tensin 1 0.0263124
MT2A metallothionein 2A 0.0254542
AKAP12 A kinase (PRKA) anchor protein 12 0.0254005
NAV1 neuron navigator 1 0.025216
VEGFA vascular endothelial growth factor A 0.0250104
EEF2 eukaryotic translation elongation factor 2 0.0247499
RASA3 RAS p21 protein activator 3 0.0247252
RPL23 ribosomal protein L23 0.0245122
PDE10A phosphodiesterase 10A 0.0245088
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0243342
RPL37A ribosomal protein L37a 0.0242627
RAI1 retinoic acid induced 1 0.0235534
MYH9 myosin, heavy chain 9, non-muscle 0.0233503
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0229059
NAV2 neuron navigator 2 0.0228246
SDK1 sidekick cell adhesion molecule 1 0.0227457
SHB Src homology 2 domain containing adaptor protein B 0.0222607
TPI1 triosephosphate isomerase 1 0.0221793
ANKRD11 ankyrin repeat domain 11 0.0213982
RPS8 ribosomal protein S8 0.0213481
RPS12 ribosomal protein S12 0.0210845
G0S2 G0/G1 switch 2 0.021079
CAVIN1 caveolae associated protein 1 0.0210364
HJURP Holliday junction recognition protein 0.0202433
PRSS23 protease, serine, 23 0.0201894
RPL30 ribosomal protein L30 0.0199601
TRIO trio Rho guanine nucleotide exchange factor 0.0199493
DDIT4 DNA-damage-inducible transcript 4 0.019934
MACF1 microtubule-actin crosslinking factor 1 0.0192791
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0190117
STC1 stanniocalcin 1 0.0187414
RPL26 ribosomal protein L26 0.0186422
BACE2 beta-site APP-cleaving enzyme 2 0.0185249
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0183477
RPS4X ribosomal protein S4, X-linked 0.0181758
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0181582
RPL11 ribosomal protein L11 0.0181358
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0179468
ANGPTL4 angiopoietin-like 4 0.0178465
YBX1 Y box binding protein 1 0.0177206
COL6A2 collagen, type VI, alpha 2 0.0176848
AFF3 AF4/FMR2 family, member 3 0.0172745
RPL7 ribosomal protein L7 0.0170962
ATXN1 ataxin 1 0.0168121
RPL34 ribosomal protein L34 0.0167697
CFAP20DC CFAP20 domain containing 0.0165222
SERF2 small EDRK-rich factor 2 0.0159986
RPL9 ribosomal protein L9 0.0159674
LGALS1 lectin, galactoside-binding, soluble, 1 0.0158408
FRMD4A FERM domain containing 4A 0.0158168
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.015724
ARHGAP22 Rho GTPase activating protein 22 0.0156104
CD59 CD59 molecule, complement regulatory protein 0.0155549
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0153498
RPS19 ribosomal protein S19 0.0153059
RPL3 ribosomal protein L3 0.0152261
MKI67 marker of proliferation Ki-67 0.0147825
EPN2 epsin 2 0.0147623
MTSS1 metastasis suppressor 1 0.0146869
RPS3 ribosomal protein S3 0.01464
UBE2O ubiquitin-conjugating enzyme E2O 0.0143929
NACA nascent polypeptide-associated complex alpha subunit 0.0141934
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0139248
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0138693
MYO10 myosin X 0.0138578
ZMYND8 zinc finger, MYND-type containing 8 0.0138347
WDFY2 WD repeat and FYVE domain containing 2 0.0135943
FMN1 formin 1 0.0135619
F3 coagulation factor III (thromboplastin, tissue factor) 0.013523
SPAG5 sperm associated antigen 5 0.0135098
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0134202
CEP250 centrosomal protein 250kDa 0.0132929
MPRIP myosin phosphatase Rho interacting protein 0.0132657
RPL12 ribosomal protein L12 0.0132013

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.716917
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.127208
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105892
CD44 CD44 molecule (Indian blood group) -0.0897979
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0801323
UBC ubiquitin C -0.0791614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0709512
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0545974
AHNAK AHNAK nucleoprotein -0.0531499
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0507854
RTN4 reticulon 4 -0.0498725
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0480945
VIM vimentin -0.0480335
LDHA lactate dehydrogenase A -0.0478892
ENO1 enolase 1, (alpha) -0.0462463
FNDC3B fibronectin type III domain containing 3B -0.0458045
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0451172
PDIA3 protein disulfide isomerase family A, member 3 -0.0449824
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0445098
ELL2 elongation factor, RNA polymerase II, 2 -0.0440718
PKM pyruvate kinase, muscle -0.0431054
ASPH aspartate beta-hydroxylase -0.0380571
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0360695
VMP1 vacuole membrane protein 1 -0.0358209
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0356758
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0351229
RPS27A ribosomal protein S27a -0.0348597
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.034624
EGR1 early growth response 1 -0.0344255
VCL vinculin -0.0343452
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0341963
CANX calnexin -0.0339437
ZFAND3 zinc finger, AN1-type domain 3 -0.0339293
PCBP2 poly(rC) binding protein 2 -0.0335403
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0332359
PDIA4 protein disulfide isomerase family A, member 4 -0.0329079
JUN jun proto-oncogene -0.0328462
IER3 immediate early response 3 -0.0327478
NAMPT nicotinamide phosphoribosyltransferase -0.031477
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0314253
PDIA6 protein disulfide isomerase family A, member 6 -0.0295233
THBS1 thrombospondin 1 -0.0287429
RAB1A RAB1A, member RAS oncogene family -0.028174
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.028169
TXNRD1 thioredoxin reductase 1 -0.0270406
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0267933
TXNIP thioredoxin interacting protein -0.0257863
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0253383
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0248214
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0242927
ANKRD28 ankyrin repeat domain 28 -0.0242445
BICD1 bicaudal D homolog 1 (Drosophila) -0.0241318
EXT1 exostosin glycosyltransferase 1 -0.0241081
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0239018
RYBP RING1 and YY1 binding protein -0.0238487
QKI QKI, KH domain containing, RNA binding -0.0234625
ACTN4 actinin, alpha 4 -0.0232991
KDM2A lysine (K)-specific demethylase 2A -0.0230798
SETD5 SET domain containing 5 -0.0226942
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0226915
CLIC4 chloride intracellular channel 4 -0.0226773
CCND1 cyclin D1 -0.0224286
TIMP1 TIMP metallopeptidase inhibitor 1 -0.022289
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0221029
TSC22D2 TSC22 domain family, member 2 -0.0220797
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0218144
SFPQ splicing factor proline/glutamine-rich -0.0215396
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0213819
ZNF207 zinc finger protein 207 -0.0211249
CCNI cyclin I -0.0210442
RAB7A RAB7A, member RAS oncogene family -0.0210321
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.020948
UGCG UDP-glucose ceramide glucosyltransferase -0.0208488
WASF2 WAS protein family, member 2 -0.0207495
CALU calumenin -0.020293
TFRC transferrin receptor -0.0202848
SYAP1 synapse associated protein 1 -0.0202164
BHLHE40 basic helix-loop-helix family, member e40 -0.0199779
HELZ helicase with zinc finger -0.0199293
RLF rearranged L-myc fusion -0.0199172
USP3 ubiquitin specific peptidase 3 -0.0198021
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0189466
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0187359
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0187338
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0185078
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0183166
BRD2 bromodomain containing 2 -0.0183101
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0182972
RHEB Ras homolog enriched in brain -0.0182852
KDM3A lysine (K)-specific demethylase 3A -0.0181244
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0181042
ADAM9 ADAM metallopeptidase domain 9 -0.0180539
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.017992
ANXA2 annexin A2 -0.0179136
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0177795
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0177224
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0176628
LOC112694756 uncharaterized LOC112694756 -0.0176199
COPA coatomer protein complex, subunit alpha -0.0175227
ZNF292 zinc finger protein 292 -0.017449