Levobupivacaine (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0866201
EXT1 exostosin glycosyltransferase 1 0.0641118
HYOU1 hypoxia up-regulated 1 0.060401
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0601581
ADARB1 adenosine deaminase, RNA-specific, B1 0.0585776
RACK1 receptor for activated C kinase 1 0.0567284
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0536716
EEF2 eukaryotic translation elongation factor 2 0.0525729
GCLC glutamate-cysteine ligase, catalytic subunit 0.0518393
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0493858
ATXN1 ataxin 1 0.0469403
INTS6 integrator complex subunit 6 0.0453616
TXNRD1 thioredoxin reductase 1 0.0404399
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0375483
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0365264
DST dystonin 0.0343818
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0325275
SMAD3 SMAD family member 3 0.0324435
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0306793
RPL3 ribosomal protein L3 0.030005
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0297078
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0293562
TRA2A transformer 2 alpha homolog (Drosophila) 0.0292807
PTEN phosphatase and tensin homolog 0.0290683
GOLGA4 golgin A4 0.0289746
HM13 histocompatibility (minor) 13 0.0284943
NUP58 nucleoporin 58 0.028115
MBNL2 muscleblind-like splicing regulator 2 0.0280892
PGM3 phosphoglucomutase 3 0.0280497
VEGFA vascular endothelial growth factor A 0.0274174
CSNK1A1 casein kinase 1, alpha 1 0.0271214
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0270859
RBM39 RNA binding motif protein 39 0.0270675
CEMIP2 cell migration inducing hyaluronidase 2 0.0269956
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0265985
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0264392
SUCO SUN domain containing ossification factor 0.0262802
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0260106
SND1 staphylococcal nuclease and tudor domain containing 1 0.0256377
FAM91A1 family with sequence similarity 91, member A1 0.0256117
USP9X ubiquitin specific peptidase 9, X-linked 0.0255641
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0253405
OGA O-GlcNAcase 0.0250689
EIF4B eukaryotic translation initiation factor 4B 0.0235868
TUFT1 tuftelin 1 0.0230637
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0229732
TMF1 TATA element modulatory factor 1 0.0228998
NCKAP1 NCK-associated protein 1 0.0228677
DSPP dentin sialophosphoprotein 0.0227283
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.022428
TMCO3 transmembrane and coiled-coil domains 3 0.0222435
GIGYF2 GRB10 interacting GYF protein 2 0.0222115
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0221378
SBF2 SET binding factor 2 0.0221018
SRRM1 serine/arginine repetitive matrix 1 0.0220692
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0220567
FNIP1 folliculin interacting protein 1 0.0220054
CALR calreticulin 0.021929
BTBD9 BTB (POZ) domain containing 9 0.0219114
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0219024
PSPC1 paraspeckle component 1 0.0218703
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218287
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0213478
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0212387
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0211724
XPOT exportin, tRNA 0.0209506
TMED2 transmembrane emp24 domain trafficking protein 2 0.0208231
HSPA8 heat shock 70kDa protein 8 0.020805
TRPS1 trichorhinophalangeal syndrome I 0.0207686
PDIA6 protein disulfide isomerase family A, member 6 0.0205899
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0202991
MKRN1 makorin ring finger protein 1 0.0202809
UBN2 ubinuclein 2 0.0202661
HELZ helicase with zinc finger 0.0202594
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.020231
LIN7C lin-7 homolog C (C. elegans) 0.0201919
PHF20L1 PHD finger protein 20-like 1 0.0200416
PDIA4 protein disulfide isomerase family A, member 4 0.0198697
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0198582
GLS2 glutaminase 2 (liver, mitochondrial) 0.0198576
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0198488
KMT2C lysine (K)-specific methyltransferase 2C 0.0197862
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.019317
IARS1 isoleucyl-tRNA synthetase 1 0.0192179
NFE2L1 nuclear factor, erythroid 2-like 1 0.0191748
KDM6A lysine (K)-specific demethylase 6A 0.0191636
CTBP2 C-terminal binding protein 2 0.0187933
SFPQ splicing factor proline/glutamine-rich 0.0185388
CLTC clathrin, heavy chain (Hc) 0.0185342
PDIA3 protein disulfide isomerase family A, member 3 0.0184037
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0183604
ZMYM2 zinc finger, MYM-type 2 0.018328
YBX1 Y box binding protein 1 0.0182913
DSCAM Down syndrome cell adhesion molecule 0.0180442
FUBP1 far upstream element (FUSE) binding protein 1 0.0178421
ZFC3H1 zinc finger, C3H1-type containing 0.0177858
ARHGAP29 Rho GTPase activating protein 29 0.0176867
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0176749
LARP1B La ribonucleoprotein domain family, member 1B 0.0175366
APLP2 amyloid beta (A4) precursor-like protein 2 0.0173046

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209666
TPT1 tumor protein, translationally-controlled 1 -0.20187
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.138648
LOC102724023 ES1 protein homolog, mitochondrial -0.136802
PTMA prothymosin, alpha -0.118245
ITPKC inositol-trisphosphate 3-kinase C -0.11327
FTL ferritin, light polypeptide -0.105692
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.105088
KRT20 keratin 20, type I -0.104576
RPS6 ribosomal protein S6 -0.10043
MYH14 myosin, heavy chain 14, non-muscle -0.0911203
TMSB10 thymosin beta 10 -0.0885324
AHNAK AHNAK nucleoprotein -0.083305
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0795628
NECTIN2 nectin cell adhesion molecule 2 -0.0769242
ACTG1 actin gamma 1 -0.0762773
RPLP1 ribosomal protein, large, P1 -0.0695035
S100A10 S100 calcium binding protein A10 -0.0678963
PGK1 phosphoglycerate kinase 1 -0.0663806
LYZ lysozyme -0.0624554
KRT19 keratin 19, type I -0.0612141
EGR1 early growth response 1 -0.0602798
PLAUR plasminogen activator, urokinase receptor -0.060113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0593655
B2M beta-2-microglobulin -0.0588185
RPS19 ribosomal protein S19 -0.0581231
RPS24 ribosomal protein S24 -0.0576241
S100A6 S100 calcium binding protein A6 -0.0572785
EZR ezrin -0.0566519
ANXA2 annexin A2 -0.0560533
ZMYND8 zinc finger, MYND-type containing 8 -0.0554362
TMEM123 transmembrane protein 123 -0.0550164
POTEF POTE ankyrin domain family, member F -0.0535118
ACTN4 actinin, alpha 4 -0.0522731
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0515801
LMO7 LIM domain 7 -0.0506777
RPS16 ribosomal protein S16 -0.0503093
RPL35A ribosomal protein L35a -0.0499118
CD2AP CD2-associated protein -0.0493579
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0485574
FRY furry homolog (Drosophila) -0.048394
JUN jun proto-oncogene -0.0479034
RPS13 ribosomal protein S13 -0.0464521
KRT18 keratin 18, type I -0.0463281
RPS11 ribosomal protein S11 -0.0461562
RAB7A RAB7A, member RAS oncogene family -0.0459672
RPLP0 ribosomal protein, large, P0 -0.0459532
WASF2 WAS protein family, member 2 -0.0445498
RPLP2 ribosomal protein, large, P2 -0.0439844
TMC5 transmembrane channel-like 5 -0.0437968
MUC13 mucin 13, cell surface associated -0.0436881
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0436424
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0429013
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0424344
KLF3 Kruppel-like factor 3 (basic) -0.0420356
SAMD12 sterile alpha motif domain containing 12 -0.0420084
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0416578
PKM pyruvate kinase, muscle -0.0416257
RPL34 ribosomal protein L34 -0.0409205
RPL28 ribosomal protein L28 -0.0407556
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0404371
RPS8 ribosomal protein S8 -0.0403047
DIAPH2 diaphanous-related formin 2 -0.0402179
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0389921
LDHA lactate dehydrogenase A -0.0387091
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0379172
RAD21 RAD21 homolog (S. pombe) -0.0378162
RPS23 ribosomal protein S23 -0.0376041
RPS5 ribosomal protein S5 -0.0370515
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0367149
ENO1 enolase 1, (alpha) -0.0366919
KRT8 keratin 8, type II -0.0365457
STK24 serine/threonine kinase 24 -0.0363678
GCC2 GRIP and coiled-coil domain containing 2 -0.0356068
LMNA lamin A/C -0.0355639
RPL31 ribosomal protein L31 -0.0355509
WDR45B WD repeat domain 45B -0.0354764
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0347338
JUP junction plakoglobin -0.0345013
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0341553
TRIB1 tribbles pseudokinase 1 -0.0340536
RPS21 ribosomal protein S21 -0.0340087
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0339123
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0334424
ETV6 ets variant 6 -0.0333984
RPL7A ribosomal protein L7a -0.0326067
RNF213 ring finger protein 213 -0.0323097
RPL27A ribosomal protein L27a -0.0320869
RPS25 ribosomal protein S25 -0.0316941
RPL19 ribosomal protein L19 -0.0313889
TRIM56 tripartite motif containing 56 -0.0313519
RPS27A ribosomal protein S27a -0.0311331
MMP7 matrix metallopeptidase 7 -0.0310661
RHEB Ras homolog enriched in brain -0.030885
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0307754
NPEPPS aminopeptidase puromycin sensitive -0.0307456
C6ORF132 chromosome 6 open reading frame 132 -0.0307086
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.030398
ACACA acetyl-CoA carboxylase alpha -0.0303386
NPC1 Niemann-Pick disease, type C1 -0.030232