Levobupivacaine (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RACK1 receptor for activated C kinase 1 0.0638863
EEF2 eukaryotic translation elongation factor 2 0.0500347
SMAD3 SMAD family member 3 0.0479308
TPT1 tumor protein, translationally-controlled 1 0.0476778
MEF2A myocyte enhancer factor 2A 0.0464812
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0440332
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0437407
KRT6A keratin 6A, type II 0.0383201
PLEC plectin 0.0372917
TPM3 tropomyosin 3 0.0363142
KTN1 kinectin 1 (kinesin receptor) 0.0354241
FLNA filamin A, alpha 0.0348262
INTS6 integrator complex subunit 6 0.0344764
RPS8 ribosomal protein S8 0.0335992
RPL37 ribosomal protein L37 0.0330674
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0327966
RPS12 ribosomal protein S12 0.0324528
RPS4X ribosomal protein S4, X-linked 0.0324388
ANO6 anoctamin 6 0.0307786
HSPA8 heat shock 70kDa protein 8 0.0288094
RPL11 ribosomal protein L11 0.0286937
RPL30 ribosomal protein L30 0.0280869
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0279844
RPLP1 ribosomal protein, large, P1 0.027106
KIAA1217 KIAA1217 0.0263015
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0255692
PDE4D phosphodiesterase 4D, cAMP-specific 0.0254781
YBX1 Y box binding protein 1 0.0251708
RPL26 ribosomal protein L26 0.0249724
ARHGAP21 Rho GTPase activating protein 21 0.0245123
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0242739
RPL3 ribosomal protein L3 0.0240957
RPL23 ribosomal protein L23 0.0237836
LMNA lamin A/C 0.0232204
SEPTIN9 septin 9 0.0229659
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229565
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0228078
KIAA1671 KIAA1671 0.0227918
MYH9 myosin, heavy chain 9, non-muscle 0.0226842
NRIP1 nuclear receptor interacting protein 1 0.0225709
VCL vinculin 0.0223248
CD59 CD59 molecule, complement regulatory protein 0.0222831
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0222583
PRELID2 PRELI domain containing 2 0.0220581
HMGA2 high mobility group AT-hook 2 0.0219999
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0216933
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.021442
RPL37A ribosomal protein L37a 0.0213382
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0213188
FTH1 ferritin, heavy polypeptide 1 0.021188
RPL7 ribosomal protein L7 0.0211613
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.020681
CAPN2 calpain 2, (m/II) large subunit 0.020266
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0199699
ZNF292 zinc finger protein 292 0.0199034
ARRDC3 arrestin domain containing 3 0.0198648
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197913
KLF5 Kruppel-like factor 5 (intestinal) 0.0197628
FNDC3B fibronectin type III domain containing 3B 0.0197031
BZW1 basic leucine zipper and W2 domains 1 0.0192176
SET SET nuclear proto-oncogene 0.0191182
HSPH1 heat shock 105kDa/110kDa protein 1 0.0188787
RPS6 ribosomal protein S6 0.0188719
RPL39 ribosomal protein L39 0.0186416
BARX2 BARX homeobox 2 0.0185633
LOC112694756 uncharaterized LOC112694756 0.0184982
RPS15A ribosomal protein S15a 0.0182577
SIK3 SIK family kinase 3 0.0181278
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0181078
EHBP1L1 EH domain binding protein 1-like 1 0.0181051
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0180757
KDM4C lysine (K)-specific demethylase 4C 0.0180175
ANGPTL4 angiopoietin-like 4 0.0177367
GSN gelsolin 0.0176259
B2M beta-2-microglobulin 0.01746
LHFPL6 LHFPL tetraspan subfamily member 6 0.0173766
RAI14 retinoic acid induced 14 0.0173658
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.017146
RPS2 ribosomal protein S2 0.0171062
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0170403
EXT1 exostosin glycosyltransferase 1 0.0169571
OSMR oncostatin M receptor 0.0169088
ACTN1 actinin, alpha 1 0.0168885
BACE2 beta-site APP-cleaving enzyme 2 0.0167922
LRP1B low density lipoprotein receptor-related protein 1B 0.0167467
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0166105
CREBBP CREB binding protein 0.0163833
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0160745
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0160241
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0159699
TMSB4X thymosin beta 4, X-linked 0.0157353
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0155957
RPS24 ribosomal protein S24 0.0154671
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0154555
SENP5 SUMO1/sentrin specific peptidase 5 0.0153712
PMP22 peripheral myelin protein 22 0.0153166
ATG7 autophagy related 7 0.015314
SFPQ splicing factor proline/glutamine-rich 0.0153065
RPL4 ribosomal protein L4 0.0152755
COL17A1 collagen, type XVII, alpha 1 0.0151563

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.164999
TIMP3 TIMP metallopeptidase inhibitor 3 -0.1367
SULF1 sulfatase 1 -0.12083
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.110944
IGF2 insulin-like growth factor 2 -0.0786708
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0742132
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0720222
TMSB10 thymosin beta 10 -0.0660287
ITGA6 integrin, alpha 6 -0.0609685
PGK1 phosphoglycerate kinase 1 -0.0559614
MBNL1 muscleblind-like splicing regulator 1 -0.0541993
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0511386
DPYD dihydropyrimidine dehydrogenase -0.0507582
CLU clusterin -0.0506439
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0506333
WASF2 WAS protein family, member 2 -0.0479434
MYO10 myosin X -0.0465308
BCL2L1 BCL2-like 1 -0.0454154
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0432044
FN1 fibronectin 1 -0.0430426
ZEB1 zinc finger E-box binding homeobox 1 -0.0419499
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0415846
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0403543
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0397002
EMP1 epithelial membrane protein 1 -0.039173
SEC31A SEC31 homolog A (S. cerevisiae) -0.0374047
PTMA prothymosin, alpha -0.0370469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0354165
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0353854
RTN4 reticulon 4 -0.0351992
DLG1 discs, large homolog 1 (Drosophila) -0.0350096
MT2A metallothionein 2A -0.034676
LDHA lactate dehydrogenase A -0.0344885
TXNIP thioredoxin interacting protein -0.0344701
NAMPT nicotinamide phosphoribosyltransferase -0.0341139
EZR ezrin -0.0326733
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0326557
NEK7 NIMA-related kinase 7 -0.0321598
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0321476
ACTN4 actinin, alpha 4 -0.0316678
S100A11 S100 calcium binding protein A11 -0.0316593
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313499
TMEM165 transmembrane protein 165 -0.0311777
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0311281
MORF4L2 mortality factor 4 like 2 -0.0304529
SQLE squalene epoxidase -0.0298766
TXNRD1 thioredoxin reductase 1 -0.0289526
CYB5R3 cytochrome b5 reductase 3 -0.0288599
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.028803
ARF4 ADP-ribosylation factor 4 -0.0286316
PODXL podocalyxin-like -0.0285609
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0284648
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0284178
COPB1 coatomer protein complex, subunit beta 1 -0.0283753
TAGLN2 transgelin 2 -0.028303
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0282342
OXR1 oxidation resistance 1 -0.0280169
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0279889
DOCK5 dedicator of cytokinesis 5 -0.0279031
FOXO1 forkhead box O1 -0.0278078
GLG1 golgi glycoprotein 1 -0.0275561
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0270936
C4BPB complement component 4 binding protein, beta -0.0263242
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0261023
ITSN1 intersectin 1 (SH3 domain protein) -0.0257766
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0254965
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0254309
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0249152
SRPK2 SRSF protein kinase 2 -0.0247976
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0246445
ZMYND8 zinc finger, MYND-type containing 8 -0.0243062
RUNX1 runt-related transcription factor 1 -0.0242886
EVI5 ecotropic viral integration site 5 -0.0242428
TMEM263 transmembrane protein 263 -0.0240364
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0239292
DGKH diacylglycerol kinase, eta -0.0238466
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0236257
PDIA3 protein disulfide isomerase family A, member 3 -0.0234283
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.023183
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0229125
MAML2 mastermind-like 2 (Drosophila) -0.0229002
CAPRIN2 caprin family member 2 -0.0228454
SERINC3 serine incorporator 3 -0.0225987
LMAN1 lectin, mannose-binding, 1 -0.0225739
ASPH aspartate beta-hydroxylase -0.0225004
ENO1 enolase 1, (alpha) -0.0224607
SEC23A Sec23 homolog A (S. cerevisiae) -0.0223103
TTC3 tetratricopeptide repeat domain 3 -0.0223065
RBM39 RNA binding motif protein 39 -0.0219686
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0219054
WSB1 WD repeat and SOCS box containing 1 -0.0215021
KDM5B lysine (K)-specific demethylase 5B -0.0214663
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0213239
CALU calumenin -0.0210971
GRB10 growth factor receptor-bound protein 10 -0.0209323
TRAM1 translocation associated membrane protein 1 -0.0208064
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0206345
SLC38A2 solute carrier family 38, member 2 -0.0205922
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0202751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0202016