Levobupivacaine (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.152495
RACK1 receptor for activated C kinase 1 0.107656
FAT1 FAT atypical cadherin 1 0.0958806
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0827509
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0812228
RPL3 ribosomal protein L3 0.0750679
FLNB filamin B, beta 0.0749162
PRELID2 PRELI domain containing 2 0.0540419
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0527416
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0524462
TXNRD1 thioredoxin reductase 1 0.051572
ITGA6 integrin, alpha 6 0.0496178
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0475489
MYH9 myosin, heavy chain 9, non-muscle 0.0451842
MYOF myoferlin 0.043878
THSD4 thrombospondin, type I, domain containing 4 0.0416136
CALB1 calbindin 1, 28kDa 0.0408154
RAD51B RAD51 paralog B 0.0396418
SHROOM3 shroom family member 3 0.0375417
DSPP dentin sialophosphoprotein 0.0373849
SRRM2 serine/arginine repetitive matrix 2 0.0354825
EPHA2 EPH receptor A2 0.0343671
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0341114
PKP2 plakophilin 2 0.0334913
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0334003
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0330783
ARHGAP26 Rho GTPase activating protein 26 0.0330263
CEMIP cell migration inducing protein, hyaluronan binding 0.0323647
TNRC18 trinucleotide repeat containing 18 0.0319224
EIF4B eukaryotic translation initiation factor 4B 0.0318853
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0318675
PCBP2 poly(rC) binding protein 2 0.0314415
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0308386
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.02997
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0298345
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0289179
PTPRG protein tyrosine phosphatase, receptor type, G 0.0288039
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286631
TRIM2 tripartite motif containing 2 0.0281951
RPS2 ribosomal protein S2 0.0276108
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0268122
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0266374
SMAD3 SMAD family member 3 0.0265202
KMT2C lysine (K)-specific methyltransferase 2C 0.0263747
WWC1 WW and C2 domain containing 1 0.0261505
AFDN afadin, adherens junction formation factor 0.0260038
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0252901
PLAC8 placenta-specific 8 0.0248035
NRDC nardilysin convertase 0.0247402
CSNK1A1 casein kinase 1, alpha 1 0.0240081
MKI67 marker of proliferation Ki-67 0.0238473
SFPQ splicing factor proline/glutamine-rich 0.0236272
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0232593
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0231838
KIF5B kinesin family member 5B 0.0229101
CDK19 cyclin-dependent kinase 19 0.0228731
CENPF centromere protein F, 350/400kDa 0.0226328
SMYD3 SET and MYND domain containing 3 0.0224839
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224752
MED13L mediator complex subunit 13-like 0.0222206
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0221245
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0219479
TRIO trio Rho guanine nucleotide exchange factor 0.0217145
AKAP9 A kinase (PRKA) anchor protein 9 0.0216761
AUTS2 autism susceptibility candidate 2 0.0215482
FOXO1 forkhead box O1 0.0215175
EZR ezrin 0.0213517
TNIP1 TNFAIP3 interacting protein 1 0.0212113
KDM7A lysine (K)-specific demethylase 7A 0.0210825
AVL9 AVL9 homolog (S. cerevisiase) 0.0210102
PDE8A phosphodiesterase 8A 0.020941
PTEN phosphatase and tensin homolog 0.02057
DSCAM Down syndrome cell adhesion molecule 0.0205109
RNF145 ring finger protein 145 0.0205096
RNF213 ring finger protein 213 0.0203351
MPRIP myosin phosphatase Rho interacting protein 0.0202802
SH3RF2 SH3 domain containing ring finger 2 0.020165
SLTM SAFB-like, transcription modulator 0.0200392
ETV6 ets variant 6 0.0200131
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0199598
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0199355
AKAP13 A kinase (PRKA) anchor protein 13 0.0198603
ESYT2 extended synaptotagmin-like protein 2 0.0198485
ANXA11 annexin A11 0.0197852
DYNC2I1 dynein 2 intermediate chain 1 0.0195835
ABHD17C abhydrolase domain containing 17C 0.0195068
ZNF292 zinc finger protein 292 0.0194311
PCDHB16 protocadherin beta 16 0.019416
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0192357
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0191717
PSAT1 phosphoserine aminotransferase 1 0.0191251
CCNL1 cyclin L1 0.0190445
LRP6 low density lipoprotein receptor-related protein 6 0.0187572
YEATS2 YEATS domain containing 2 0.0187122
KDM4C lysine (K)-specific demethylase 4C 0.01866
KMT2D lysine (K)-specific methyltransferase 2D 0.0185713
ZNF638 zinc finger protein 638 0.0183735
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0183683
FOXP1 forkhead box P1 0.0182784
TPM3 tropomyosin 3 0.0181933

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.23872
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.157422
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137351
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129765
RPLP1 ribosomal protein, large, P1 -0.116469
RPS6 ribosomal protein S6 -0.110884
PTMA prothymosin, alpha -0.0778454
RPS8 ribosomal protein S8 -0.0718126
RPS24 ribosomal protein S24 -0.0715687
RPLP0 ribosomal protein, large, P0 -0.0701501
TMSB10 thymosin beta 10 -0.0680254
RPL34 ribosomal protein L34 -0.0631889
LMO7 LIM domain 7 -0.0603042
RPS23 ribosomal protein S23 -0.0538067
RPS25 ribosomal protein S25 -0.0529093
RPL31 ribosomal protein L31 -0.0515734
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0510848
RPS27A ribosomal protein S27a -0.0492307
RPL35A ribosomal protein L35a -0.0491996
KLF5 Kruppel-like factor 5 (intestinal) -0.0475211
CANX calnexin -0.0474903
RPS13 ribosomal protein S13 -0.0447486
RPS19 ribosomal protein S19 -0.0445491
GMDS GDP-mannose 4,6-dehydratase -0.0437897
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0436549
RPLP2 ribosomal protein, large, P2 -0.0425891
RPL38 ribosomal protein L38 -0.0421938
ACTG1 actin gamma 1 -0.0407597
MYO1E myosin IE -0.0403473
AGR2 anterior gradient 2 -0.0403358
RPL19 ribosomal protein L19 -0.0403105
PDIA3 protein disulfide isomerase family A, member 3 -0.0399114
HLA-B major histocompatibility complex, class I, B -0.0394653
KRT18 keratin 18, type I -0.0391383
DSG2 desmoglein 2 -0.0390159
RPL37A ribosomal protein L37a -0.0387565
RPL32 ribosomal protein L32 -0.0382685
RPS21 ribosomal protein S21 -0.0369023
FRMD5 FERM domain containing 5 -0.0341835
RPS29 ribosomal protein S29 -0.0335183
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0333775
PALLD palladin, cytoskeletal associated protein -0.0328032
RPS11 ribosomal protein S11 -0.0317075
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0314669
RPS16 ribosomal protein S16 -0.0310833
RPL12 ribosomal protein L12 -0.0309052
SLC38A2 solute carrier family 38, member 2 -0.030453
SERINC5 serine incorporator 5 -0.0302073
ITPRID2 ITPR interacting domain containing 2 -0.0294867
RPL28 ribosomal protein L28 -0.0291176
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.02902
RPL27A ribosomal protein L27a -0.0289019
RPS5 ribosomal protein S5 -0.028758
IFI6 interferon, alpha-inducible protein 6 -0.0287573
RPS14 ribosomal protein S14 -0.0286628
RPL8 ribosomal protein L8 -0.0278279
RPL4 ribosomal protein L4 -0.0275247
NPSR1 neuropeptide S receptor 1 -0.0272258
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0271011
RRBP1 ribosome binding protein 1 -0.0269807
RPL36A ribosomal protein L36a -0.0262106
S100A10 S100 calcium binding protein A10 -0.0254852
S100A9 S100 calcium binding protein A9 -0.0253978
CCNI cyclin I -0.0247141
RPS15 ribosomal protein S15 -0.0246668
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0246206
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0244116
IER3 immediate early response 3 -0.0243846
FBXO11 F-box protein 11 -0.0243717
CATSPERB catsper channel auxiliary subunit beta -0.0243336
KDM3A lysine (K)-specific demethylase 3A -0.0237691
RPL7A ribosomal protein L7a -0.023646
RPL6 ribosomal protein L6 -0.0232337
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231398
XAF1 XIAP associated factor 1 -0.0226349
MTDH metadherin -0.0225739
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.02224
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221727
TSPAN8 tetraspanin 8 -0.0220749
CUX1 cut-like homeobox 1 -0.021973
AHNAK AHNAK nucleoprotein -0.0219555
RPL37 ribosomal protein L37 -0.0217767
STAU1 staufen double-stranded RNA binding protein 1 -0.0213239
PDIA4 protein disulfide isomerase family A, member 4 -0.0211922
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0205576
HDLBP high density lipoprotein binding protein -0.0205067
INTS6 integrator complex subunit 6 -0.0202352
SP100 SP100 nuclear antigen -0.0201624
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0201059
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0200011
RTN3 reticulon 3 -0.0199539
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0199527
ANXA2 annexin A2 -0.0196472
S100A6 S100 calcium binding protein A6 -0.0195428
RPL35 ribosomal protein L35 -0.0193377
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0190742
PERP PERP, TP53 apoptosis effector -0.0190172
FTL ferritin, light polypeptide -0.0189658
VDAC1 voltage-dependent anion channel 1 -0.0187817