| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Levobupivacaine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Levobupivacaine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0682503 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0661724 |
| MCL1 | myeloid cell leukemia 1 | 0.0622163 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0584318 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0485456 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0479588 |
| RBM39 | RNA binding motif protein 39 | 0.0468584 |
| CCNL1 | cyclin L1 | 0.046681 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0460202 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0456581 |
| RTN4 | reticulon 4 | 0.044691 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0440565 |
| PCBP2 | poly(rC) binding protein 2 | 0.0434549 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0420409 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0400429 |
| COPA | coatomer protein complex, subunit alpha | 0.0393097 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0389505 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0383692 |
| TPM3 | tropomyosin 3 | 0.0372855 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0366601 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0361673 |
| ATP11A | ATPase, class VI, type 11A | 0.0355039 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0341733 |
| PDE10A | phosphodiesterase 10A | 0.0332882 |
| MSN | moesin | 0.032133 |
| TXNRD1 | thioredoxin reductase 1 | 0.0317707 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0313528 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0303075 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0293333 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280843 |
| PLEC | plectin | 0.0278674 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0273074 |
| ANXA5 | annexin A5 | 0.027269 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0269026 |
| POTEF | POTE ankyrin domain family, member F | 0.0268393 |
| BRD4 | bromodomain containing 4 | 0.0266501 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0266245 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265249 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0264383 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0261567 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0261505 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0257893 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0257612 |
| UBC | ubiquitin C | 0.025374 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.025069 |
| NUP58 | nucleoporin 58 | 0.0248717 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0248365 |
| CRY1 | cryptochrome circadian clock 1 | 0.0248016 |
| ZNF207 | zinc finger protein 207 | 0.0246228 |
| ARF4 | ADP-ribosylation factor 4 | 0.0245383 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0239467 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0238832 |
| RPL3 | ribosomal protein L3 | 0.0238743 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.023466 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0233032 |
| MEF2D | myocyte enhancer factor 2D | 0.0231171 |
| VMP1 | vacuole membrane protein 1 | 0.0230962 |
| NBAS | neuroblastoma amplified sequence | 0.0228918 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0225914 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0225585 |
| OGA | O-GlcNAcase | 0.0224144 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0218693 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0217759 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0217577 |
| FOXO3 | forkhead box O3 | 0.021697 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0214417 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0214415 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0211498 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0211259 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0209058 |
| SMAD3 | SMAD family member 3 | 0.0208669 |
| SRP54 | signal recognition particle 54kDa | 0.0207995 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0207697 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0207515 |
| PREPL | prolyl endopeptidase-like | 0.0206517 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0206294 |
| ANO6 | anoctamin 6 | 0.0203384 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0202516 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0202015 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0200871 |
| WWOX | WW domain containing oxidoreductase | 0.0200417 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0198805 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0198093 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0197342 |
| USP15 | ubiquitin specific peptidase 15 | 0.0195434 |
| FAM168B | family with sequence similarity 168, member B | 0.0194862 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0193372 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.019279 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0192444 |
| BRD2 | bromodomain containing 2 | 0.0188436 |
| SAP30BP | SAP30 binding protein | 0.0188322 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0187745 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0186943 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0186154 |
| HYOU1 | hypoxia up-regulated 1 | 0.018519 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.018509 |
| OSMR | oncostatin M receptor | 0.0184825 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0184799 |
| OSBPL2 | oxysterol binding protein-like 2 | 0.0184477 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0184467 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.107715 |
| RAD51B | RAD51 paralog B | -0.104684 |
| PTMA | prothymosin, alpha | -0.0921737 |
| RPS3 | ribosomal protein S3 | -0.0760765 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0714818 |
| MT2A | metallothionein 2A | -0.0647553 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0602044 |
| TPI1 | triosephosphate isomerase 1 | -0.0566638 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0548687 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0530776 |
| YBX3 | Y box binding protein 3 | -0.0523239 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0461234 |
| RPS27A | ribosomal protein S27a | -0.0455251 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.044426 |
| RPL12 | ribosomal protein L12 | -0.0436223 |
| HMGA2 | high mobility group AT-hook 2 | -0.0429025 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0427012 |
| RPS8 | ribosomal protein S8 | -0.0425212 |
| RPL23 | ribosomal protein L23 | -0.0421149 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0418769 |
| VIM | vimentin | -0.0399921 |
| EXOC4 | exocyst complex component 4 | -0.0398277 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0388804 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0388236 |
| RPL26 | ribosomal protein L26 | -0.0377257 |
| ACTG1 | actin gamma 1 | -0.0375602 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0374721 |
| RPL35A | ribosomal protein L35a | -0.0372313 |
| RACK1 | receptor for activated C kinase 1 | -0.0371432 |
| RPS29 | ribosomal protein S29 | -0.0367348 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0354634 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0353606 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0351162 |
| MKI67 | marker of proliferation Ki-67 | -0.034297 |
| CAVIN1 | caveolae associated protein 1 | -0.033157 |
| FTL | ferritin, light polypeptide | -0.0328384 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0325826 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0322969 |
| AHNAK | AHNAK nucleoprotein | -0.032264 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0319504 |
| RPLP1 | ribosomal protein, large, P1 | -0.0319421 |
| GRAMD1B | GRAM domain containing 1B | -0.0318088 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0311956 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0309172 |
| RPL34 | ribosomal protein L34 | -0.0297123 |
| RPS21 | ribosomal protein S21 | -0.0296713 |
| RPL5 | ribosomal protein L5 | -0.0295361 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0285031 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0275574 |
| RPS10 | ribosomal protein S10 | -0.0275232 |
| RPL19 | ribosomal protein L19 | -0.0272769 |
| THOC2 | THO complex 2 | -0.0272011 |
| RPL32 | ribosomal protein L32 | -0.0269739 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0265752 |
| DENND5B | DENN/MADD domain containing 5B | -0.0257094 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0255921 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0255155 |
| KIF5B | kinesin family member 5B | -0.025472 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.02546 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0251452 |
| BPTF | bromodomain PHD finger transcription factor | -0.0251289 |
| GNAS | GNAS complex locus | -0.0251188 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0250807 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0248498 |
| RPL31 | ribosomal protein L31 | -0.0245909 |
| CENPF | centromere protein F, 350/400kDa | -0.0241102 |
| TPX2 | TPX2, microtubule-associated | -0.0240222 |
| CUX1 | cut-like homeobox 1 | -0.0239901 |
| RPL36 | ribosomal protein L36 | -0.0238823 |
| RRM2 | ribonucleotide reductase M2 | -0.0238541 |
| RPL37 | ribosomal protein L37 | -0.0238244 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0238236 |
| RPS12 | ribosomal protein S12 | -0.0237396 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0236138 |
| RPLP2 | ribosomal protein, large, P2 | -0.0235922 |
| TRIM56 | tripartite motif containing 56 | -0.0235666 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0235385 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0232952 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0227964 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0225865 |
| PHF20 | PHD finger protein 20 | -0.022279 |
| BRCA1 | breast cancer 1, early onset | -0.0221133 |
| S100A11 | S100 calcium binding protein A11 | -0.0220482 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0216654 |
| RPS6 | ribosomal protein S6 | -0.0215745 |
| RPL37A | ribosomal protein L37a | -0.0211589 |
| DST | dystonin | -0.0209131 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0208885 |
| NLGN1 | neuroligin 1 | -0.020851 |
| ETV6 | ets variant 6 | -0.0207561 |
| RPL18 | ribosomal protein L18 | -0.0207512 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.020724 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0207171 |
| SSH2 | slingshot protein phosphatase 2 | -0.0205908 |
| RPL9 | ribosomal protein L9 | -0.0205724 |
| IGF1R | insulin-like growth factor 1 receptor | -0.020421 |
| BBX | bobby sox homolog (Drosophila) | -0.0204093 |
| SRP72 | signal recognition particle 72kDa | -0.0203367 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0202732 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0202483 |
