Levobupivacaine (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.25749
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.239154
NDRG1 N-myc downstream regulated 1 0.212296
RACK1 receptor for activated C kinase 1 0.157732
FN1 fibronectin 1 0.145641
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.133335
EEF2 eukaryotic translation elongation factor 2 0.0998115
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0967786
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0910453
S100A6 S100 calcium binding protein A6 0.0858264
ASPH aspartate beta-hydroxylase 0.0756286
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0725836
RPS8 ribosomal protein S8 0.0676742
CALR calreticulin 0.0675588
HMGB2 high mobility group box 2 0.0659556
GOLGA4 golgin A4 0.0641243
ARRDC3 arrestin domain containing 3 0.0628491
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0605633
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0596251
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0589527
TMSB4X thymosin beta 4, X-linked 0.0586923
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0578457
RPL26 ribosomal protein L26 0.0566573
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0556821
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0552172
EIF1 eukaryotic translation initiation factor 1 0.0549667
ELL2 elongation factor, RNA polymerase II, 2 0.0544945
RPL8 ribosomal protein L8 0.0540251
LAMB3 laminin, beta 3 0.0537753
RPL12 ribosomal protein L12 0.0525135
RPL23 ribosomal protein L23 0.0524867
RNF145 ring finger protein 145 0.0523364
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0515163
UBA6 ubiquitin-like modifier activating enzyme 6 0.0510072
FTH1 ferritin, heavy polypeptide 1 0.0506964
PTMA prothymosin, alpha 0.0502878
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0496402
SLC38A1 solute carrier family 38, member 1 0.0481987
RPL30 ribosomal protein L30 0.0465724
MARCHF6 membrane associated ring-CH-type finger 6 0.0459729
MYH9 myosin, heavy chain 9, non-muscle 0.0458844
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0458201
RPS12 ribosomal protein S12 0.0456005
NUP58 nucleoporin 58 0.0455367
RAD21 RAD21 homolog (S. pombe) 0.045518
RPL11 ribosomal protein L11 0.0454018
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0449298
NACA nascent polypeptide-associated complex alpha subunit 0.0443964
EZR ezrin 0.0443696
YBX1 Y box binding protein 1 0.0441604
FAM13A family with sequence similarity 13, member A 0.043247
NPEPPS aminopeptidase puromycin sensitive 0.0431688
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0429025
RPLP1 ribosomal protein, large, P1 0.0427698
RSRC2 arginine/serine-rich coiled-coil 2 0.042764
RBM25 RNA binding motif protein 25 0.0416275
TXNRD1 thioredoxin reductase 1 0.0412524
RPL37 ribosomal protein L37 0.0408386
EEF1G eukaryotic translation elongation factor 1 gamma 0.0406521
BHLHE40 basic helix-loop-helix family, member e40 0.0406124
RPL32 ribosomal protein L32 0.0405486
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0404907
MATR3 matrin 3 0.0403657
SET SET nuclear proto-oncogene 0.040286
HSPA8 heat shock 70kDa protein 8 0.0398528
RPL37A ribosomal protein L37a 0.0398149
RPL3 ribosomal protein L3 0.0396923
CANX calnexin 0.0389059
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0385741
RPS6 ribosomal protein S6 0.0385716
PLEC plectin 0.0377717
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0375253
IGFBP3 insulin-like growth factor binding protein 3 0.0374761
RPS3 ribosomal protein S3 0.0372437
RPS19 ribosomal protein S19 0.0371943
ANXA1 annexin A1 0.0367656
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0359845
NAMPT nicotinamide phosphoribosyltransferase 0.0358565
RHOA ras homolog family member A 0.0357765
RPS13 ribosomal protein S13 0.0357308
TPM3 tropomyosin 3 0.0356537
RPS4X ribosomal protein S4, X-linked 0.0353296
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0349991
TRIO trio Rho guanine nucleotide exchange factor 0.0348124
KMT2E lysine (K)-specific methyltransferase 2E 0.0345989
RPLP0 ribosomal protein, large, P0 0.034449
NCKAP1 NCK-associated protein 1 0.0337203
NAP1L1 nucleosome assembly protein 1-like 1 0.0336236
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0335202
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0334161
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0327433
PRRC2C proline-rich coiled-coil 2C 0.0326758
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0326405
TPT1 tumor protein, translationally-controlled 1 0.0324595
VEGFA vascular endothelial growth factor A 0.0324269
KTN1 kinectin 1 (kinesin receptor) 0.0323217
CCNL1 cyclin L1 0.03212
VIM vimentin 0.0313515
UPP1 uridine phosphorylase 1 0.0310281
TRA2A transformer 2 alpha homolog (Drosophila) 0.0310163

decreased expression

Symbol Name Standardized Value
LPP LIM domain containing preferred translocation partner in lipoma -0.122509
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.112184
SAMD4A sterile alpha motif domain containing 4A -0.0830293
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0684137
EXT1 exostosin glycosyltransferase 1 -0.0683698
LIMCH1 LIM and calponin homology domains 1 -0.063411
FBXO32 F-box protein 32 -0.0587616
EFNA5 ephrin-A5 -0.0550684
ZBTB20 zinc finger and BTB domain containing 20 -0.0539215
IFI6 interferon, alpha-inducible protein 6 -0.0485381
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0451792
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0406664
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0381473
ARHGAP20 Rho GTPase activating protein 20 -0.0374171
MCU mitochondrial calcium uniporter -0.0356454
WSB1 WD repeat and SOCS box containing 1 -0.0346033
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0343554
MX2 MX dynamin-like GTPase 2 -0.034283
MAML2 mastermind-like 2 (Drosophila) -0.0331581
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0326766
PLSCR1 phospholipid scramblase 1 -0.0318532
RNF213 ring finger protein 213 -0.0318515
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0314883
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0314334
AKAP13 A kinase (PRKA) anchor protein 13 -0.0309923
RAI14 retinoic acid induced 14 -0.0299703
SOX4 SRY (sex determining region Y)-box 4 -0.0288374
AHNAK AHNAK nucleoprotein -0.0286565
PGBD5 piggyBac transposable element derived 5 -0.0280956
PATJ PATJ crumbs cell polarity complex component -0.0279494
PDLIM5 PDZ and LIM domain 5 -0.0279433
RIGI RNA sensor RIG-I -0.0278033
LMO7 LIM domain 7 -0.0277569
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0273311
IFI16 interferon, gamma-inducible protein 16 -0.0265794
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0263609
MYO6 myosin VI -0.0263214
VCL vinculin -0.0262859
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0259386
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0256839
IFI27 interferon, alpha-inducible protein 27 -0.0256069
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0255314
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0253971
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0247262
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0244678
FBXO34 F-box protein 34 -0.0244153
ANKRD17 ankyrin repeat domain 17 -0.0241284
BPTF bromodomain PHD finger transcription factor -0.0240212
CCND1 cyclin D1 -0.0239531
TAOK1 TAO kinase 1 -0.0238104
PICALM phosphatidylinositol binding clathrin assembly protein -0.0236024
ATXN1 ataxin 1 -0.0234883
SVIL supervillin -0.0233459
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0227479
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0227444
RASAL2 RAS protein activator like 2 -0.0226691
ETV6 ets variant 6 -0.0224059
PALLD palladin, cytoskeletal associated protein -0.022397
PTPRK protein tyrosine phosphatase, receptor type, K -0.0219898
INTS6 integrator complex subunit 6 -0.0219338
POTEF POTE ankyrin domain family, member F -0.0218301
ATOSA atos homolog A -0.0216812
ARF4 ADP-ribosylation factor 4 -0.0214259
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0212928
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0211756
NABP1 nucleic acid binding protein 1 -0.0210506
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0209636
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0208645
CDK13 cyclin-dependent kinase 13 -0.0208333
RASA2 RAS p21 protein activator 2 -0.0207732
FBXL2 F-box and leucine-rich repeat protein 2 -0.0204209
H1-0 H1.0 linker histone -0.0203776
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0203064
EXOC4 exocyst complex component 4 -0.0202813
ARHGAP5 Rho GTPase activating protein 5 -0.0199362
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0198696
RUNX1 runt-related transcription factor 1 -0.0198301
GOLGB1 golgin B1 -0.0197573
RAD51B RAD51 paralog B -0.0197172
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0192788
KAT6B K(lysine) acetyltransferase 6B -0.0191847
AFF1 AF4/FMR2 family, member 1 -0.0189615
GLS2 glutaminase 2 (liver, mitochondrial) -0.0187632
MDK midkine (neurite growth-promoting factor 2) -0.0187554
HMGA2 high mobility group AT-hook 2 -0.0187387
FNIP1 folliculin interacting protein 1 -0.0185012
CUX1 cut-like homeobox 1 -0.0184693
BLZF1 basic leucine zipper nuclear factor 1 -0.018464
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0184309
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0183984
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0183622
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0183405
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.018337
MAP4 microtubule-associated protein 4 -0.0181718
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0181509
MACC1 metastasis associated in colon cancer 1 -0.0180573
ZHX2 zinc fingers and homeoboxes 2 -0.0180477
UBE2H ubiquitin-conjugating enzyme E2H -0.0179592
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0179429
DSG2 desmoglein 2 -0.0179158