Levobupivacaine (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.168319
RACK1 receptor for activated C kinase 1 0.152029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0936966
NRIP1 nuclear receptor interacting protein 1 0.0809775
GOLGA4 golgin A4 0.0809005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0807985
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0765969
NAV2 neuron navigator 2 0.0763446
SMC4 structural maintenance of chromosomes 4 0.0629301
DSPP dentin sialophosphoprotein 0.0618017
KRT17 keratin 17, type I 0.0599619
RPL23 ribosomal protein L23 0.0593748
GOLGB1 golgin B1 0.0564884
EEF2 eukaryotic translation elongation factor 2 0.0551839
CALR calreticulin 0.0500712
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0495087
AKAP9 A kinase (PRKA) anchor protein 9 0.0479527
B2M beta-2-microglobulin 0.0475889
PABPC1 poly(A) binding protein, cytoplasmic 1 0.046369
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.045692
BIRC3 baculoviral IAP repeat containing 3 0.0455462
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0446808
RB1CC1 RB1-inducible coiled-coil 1 0.0446153
MKI67 marker of proliferation Ki-67 0.0445194
CENPF centromere protein F, 350/400kDa 0.0440035
TMSB4X thymosin beta 4, X-linked 0.0411238
RPL26 ribosomal protein L26 0.0410945
IRS2 insulin receptor substrate 2 0.0410683
OGA O-GlcNAcase 0.0409963
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0405314
ARRDC3 arrestin domain containing 3 0.0405186
KTN1 kinectin 1 (kinesin receptor) 0.0402395
EZR ezrin 0.0391316
NACA nascent polypeptide-associated complex alpha subunit 0.0384007
ESYT2 extended synaptotagmin-like protein 2 0.0381409
TMF1 TATA element modulatory factor 1 0.0377182
TPR translocated promoter region, nuclear basket protein 0.0367842
MBNL2 muscleblind-like splicing regulator 2 0.0366065
OPTN optineurin 0.0348664
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0346434
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0344749
LAMC2 laminin, gamma 2 0.0344369
RPS8 ribosomal protein S8 0.0340325
NDRG1 N-myc downstream regulated 1 0.0339715
RBM25 RNA binding motif protein 25 0.0339699
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0337854
GSN gelsolin 0.0335924
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0335281
CEP350 centrosomal protein 350kDa 0.0332905
TNIP1 TNFAIP3 interacting protein 1 0.0332251
RPL37 ribosomal protein L37 0.0331914
KMT2C lysine (K)-specific methyltransferase 2C 0.0331461
MYO6 myosin VI 0.0328595
EIF1 eukaryotic translation initiation factor 1 0.032602
EMP1 epithelial membrane protein 1 0.0325555
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0323073
SMAD3 SMAD family member 3 0.0322904
PCLO piccolo presynaptic cytomatrix protein 0.0321859
MTAP methylthioadenosine phosphorylase 0.0320544
LOC112694756 uncharaterized LOC112694756 0.0316647
GIGYF2 GRB10 interacting GYF protein 2 0.0311744
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031165
RPL30 ribosomal protein L30 0.0310561
SET SET nuclear proto-oncogene 0.0302876
PRRC2C proline-rich coiled-coil 2C 0.029995
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0298955
RPS4X ribosomal protein S4, X-linked 0.0298368
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0298075
DDIT4 DNA-damage-inducible transcript 4 0.0296542
RPL34 ribosomal protein L34 0.0294959
PDE8A phosphodiesterase 8A 0.0294954
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0290404
RPL35A ribosomal protein L35a 0.0290152
SDC4 syndecan 4 0.0289645
HLA-B major histocompatibility complex, class I, B 0.028929
AFDN afadin, adherens junction formation factor 0.0289183
RPL13A ribosomal protein L13a 0.0283924
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0280479
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0280418
RUNX1 runt-related transcription factor 1 0.027915
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0277792
HMGB2 high mobility group box 2 0.0276232
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.027478
ITSN2 intersectin 2 0.0271662
HLA-A major histocompatibility complex, class I, A 0.0270901
SAMD4A sterile alpha motif domain containing 4A 0.0269745
YBX1 Y box binding protein 1 0.0269718
FRMD6 FERM domain containing 6 0.0267517
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0266332
KPNB1 karyopherin (importin) beta 1 0.0265306
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0261395
RIOK3 RIO kinase 3 0.0261221
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0258774
SKAP2 src kinase associated phosphoprotein 2 0.0257937
FOXO3 forkhead box O3 0.0256354
DIAPH3 diaphanous-related formin 3 0.0255906
AFF4 AF4/FMR2 family, member 4 0.0255692
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0253658
RPL11 ribosomal protein L11 0.0252773
PCM1 pericentriolar material 1 0.0251828

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149573
MUC4 mucin 4, cell surface associated -0.0990384
FN1 fibronectin 1 -0.0898279
LMO7 LIM domain 7 -0.082916
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0691339
F3 coagulation factor III (thromboplastin, tissue factor) -0.0644242
MUC16 mucin 16, cell surface associated -0.0612528
SVIL supervillin -0.0590481
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0579235
LAMA4 laminin, alpha 4 -0.0572657
ASPH aspartate beta-hydroxylase -0.0543096
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0539211
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0502428
IGFBP3 insulin-like growth factor binding protein 3 -0.0499811
MX2 MX dynamin-like GTPase 2 -0.0495422
RASAL2 RAS protein activator like 2 -0.0495384
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0490188
ZBTB20 zinc finger and BTB domain containing 20 -0.0489857
FTL ferritin, light polypeptide -0.0483829
LY6E lymphocyte antigen 6 complex, locus E -0.0476601
RNF213 ring finger protein 213 -0.0473983
INTS6 integrator complex subunit 6 -0.0470478
PARD3 par-3 family cell polarity regulator -0.0468431
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0456116
PICALM phosphatidylinositol binding clathrin assembly protein -0.0433091
SH3KBP1 SH3-domain kinase binding protein 1 -0.0422428
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0417631
TMSB10 thymosin beta 10 -0.0408191
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0400594
PLSCR1 phospholipid scramblase 1 -0.0390259
MYO1E myosin IE -0.0387236
POTEF POTE ankyrin domain family, member F -0.0383966
GATAD2A GATA zinc finger domain containing 2A -0.0378577
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0378203
OSMR oncostatin M receptor -0.0377858
RCOR1 REST corepressor 1 -0.037499
SLC38A2 solute carrier family 38, member 2 -0.0373855
OXSR1 oxidative stress responsive 1 -0.0366291
MX1 MX dynamin-like GTPase 1 -0.0366247
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0366097
EFNA5 ephrin-A5 -0.0360455
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.035809
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.035337
ZFAND3 zinc finger, AN1-type domain 3 -0.0347997
AHNAK AHNAK nucleoprotein -0.0346471
IFI27 interferon, alpha-inducible protein 27 -0.0345633
ANXA2 annexin A2 -0.034303
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0341535
IFI44L interferon-induced protein 44-like -0.0337088
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0331533
HMGA2 high mobility group AT-hook 2 -0.0329745
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0326804
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0322881
EPSTI1 epithelial stromal interaction 1 (breast) -0.0318818
DLC1 DLC1 Rho GTPase activating protein -0.0318346
EXT1 exostosin glycosyltransferase 1 -0.0315915
PGK1 phosphoglycerate kinase 1 -0.0312907
TM4SF1 transmembrane 4 L six family member 1 -0.0310048
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0302036
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0301155
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0299201
PTK2 protein tyrosine kinase 2 -0.0297368
SIK3 SIK family kinase 3 -0.0295713
IFITM1 interferon induced transmembrane protein 1 -0.0295332
RIGI RNA sensor RIG-I -0.0294241
ATF7IP activating transcription factor 7 interacting protein -0.0291115
ETV6 ets variant 6 -0.0290351
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289072
ENO1 enolase 1, (alpha) -0.0287589
IFI6 interferon, alpha-inducible protein 6 -0.0281962
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0280107
WWC1 WW and C2 domain containing 1 -0.0279865
RPS6 ribosomal protein S6 -0.0279204
ACTG1 actin gamma 1 -0.027819
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0277513
RAD51B RAD51 paralog B -0.0275594
SMOC1 SPARC related modular calcium binding 1 -0.0274872
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0272069
TSC22D1 TSC22 domain family, member 1 -0.0271719
SOX4 SRY (sex determining region Y)-box 4 -0.0270219
RIMKLB ribosomal modification protein rimK-like family member B -0.0268648
TCF12 transcription factor 12 -0.0267974
ACTN4 actinin, alpha 4 -0.0265558
HMGA1 high mobility group AT-hook 1 -0.0263582
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0263263
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0262609
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0262085
SULF2 sulfatase 2 -0.0260214
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0260138
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0258676
WAC WW domain containing adaptor with coiled-coil -0.0258594
PTPRE protein tyrosine phosphatase, receptor type, E -0.0256629
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0256496
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0252688
TMEM123 transmembrane protein 123 -0.024909
ZNF207 zinc finger protein 207 -0.0247028
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0246808
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0246624
PKM pyruvate kinase, muscle -0.0244532
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.024397