Levobupivacaine (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.167915
EEF2 eukaryotic translation elongation factor 2 0.143063
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.112312
NUP58 nucleoporin 58 0.110408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0736445
NDRG1 N-myc downstream regulated 1 0.0729741
RPL3 ribosomal protein L3 0.0596925
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0590177
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0563387
SRRM2 serine/arginine repetitive matrix 2 0.0515734
NCKAP1 NCK-associated protein 1 0.0511407
ZNF292 zinc finger protein 292 0.0501368
MCL1 myeloid cell leukemia 1 0.0500622
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0475004
FNDC3B fibronectin type III domain containing 3B 0.0473199
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0472422
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.047025
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0462337
RBM39 RNA binding motif protein 39 0.0451167
KTN1 kinectin 1 (kinesin receptor) 0.0440357
ADAM9 ADAM metallopeptidase domain 9 0.0438146
CHD1 chromodomain helicase DNA binding protein 1 0.0433985
TRAM1 translocation associated membrane protein 1 0.0428159
PRRC2C proline-rich coiled-coil 2C 0.0423568
WDR43 WD repeat domain 43 0.0419696
KMT2E lysine (K)-specific methyltransferase 2E 0.0416698
UBA6 ubiquitin-like modifier activating enzyme 6 0.0413494
PCBP2 poly(rC) binding protein 2 0.0411971
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0406485
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.03951
YTHDC1 YTH domain containing 1 0.0389956
PCM1 pericentriolar material 1 0.0388731
LPP LIM domain containing preferred translocation partner in lipoma 0.0386025
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0384107
SRPK2 SRSF protein kinase 2 0.0383594
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0382808
AKAP9 A kinase (PRKA) anchor protein 9 0.0381098
SET SET nuclear proto-oncogene 0.037989
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0368605
TPM3 tropomyosin 3 0.0366509
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365094
TOR1AIP2 torsin A interacting protein 2 0.0364536
MYH9 myosin, heavy chain 9, non-muscle 0.0362606
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0358756
RASA2 RAS p21 protein activator 2 0.0350746
EIF4B eukaryotic translation initiation factor 4B 0.0349771
ADAM17 ADAM metallopeptidase domain 17 0.0349089
MACF1 microtubule-actin crosslinking factor 1 0.034593
MCTP1 multiple C2 domains, transmembrane 1 0.0344563
STC1 stanniocalcin 1 0.0341614
RBM33 RNA binding motif protein 33 0.034015
FLNA filamin A, alpha 0.0337919
YAP1 Yes-associated protein 1 0.0336724
RACK1 receptor for activated C kinase 1 0.0335276
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0333427
COPA coatomer protein complex, subunit alpha 0.0327129
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0324797
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0322771
GOLGA4 golgin A4 0.0322735
UGCG UDP-glucose ceramide glucosyltransferase 0.0322033
SRRM1 serine/arginine repetitive matrix 1 0.0321043
CCNL1 cyclin L1 0.0317161
POTEF POTE ankyrin domain family, member F 0.031705
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0315453
TSC22D2 TSC22 domain family, member 2 0.031535
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0315293
CALU calumenin 0.0312717
KDM6A lysine (K)-specific demethylase 6A 0.031246
SEC16A SEC16 homolog A (S. cerevisiae) 0.0301376
FXR1 fragile X mental retardation, autosomal homolog 1 0.0300116
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0299804
ZFC3H1 zinc finger, C3H1-type containing 0.0290707
HDLBP high density lipoprotein binding protein 0.0289726
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.028866
CLIC4 chloride intracellular channel 4 0.0287699
FAM91A1 family with sequence similarity 91, member A1 0.0287034
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.028672
SAMD4A sterile alpha motif domain containing 4A 0.0286472
TRA2A transformer 2 alpha homolog (Drosophila) 0.0280681
WAC WW domain containing adaptor with coiled-coil 0.0279992
PDIA6 protein disulfide isomerase family A, member 6 0.0279582
BIRC6 baculoviral IAP repeat containing 6 0.0277737
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0276621
UBXN7 UBX domain protein 7 0.0271281
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0270602
SRSF11 serine/arginine-rich splicing factor 11 0.0269999
SEC24A SEC24 family member A 0.0266254
HYOU1 hypoxia up-regulated 1 0.0264377
APP amyloid beta (A4) precursor protein 0.0263924
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0261853
ANXA5 annexin A5 0.0261107
KMT2C lysine (K)-specific methyltransferase 2C 0.0260774
ITCH itchy E3 ubiquitin protein ligase 0.0257939
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0257307
ACBD3 acyl-CoA binding domain containing 3 0.0255121
C1ORF52 chromosome 1 open reading frame 52 0.0253523
YBX1 Y box binding protein 1 0.0253455
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0253246
PRRC2B proline-rich coiled-coil 2B 0.0253195
GARS1 glycyl-tRNA synthetase 1 0.0253179

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.16854
DLC1 DLC1 Rho GTPase activating protein -0.160381
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.119871
RPS6 ribosomal protein S6 -0.0877612
ZNF438 zinc finger protein 438 -0.0772675
RPLP1 ribosomal protein, large, P1 -0.0763647
RPL35A ribosomal protein L35a -0.0760668
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0693806
ACTG1 actin gamma 1 -0.0681932
RPL37A ribosomal protein L37a -0.0670259
NAP1L1 nucleosome assembly protein 1-like 1 -0.0645565
ARHGAP22 Rho GTPase activating protein 22 -0.0635223
IFI16 interferon, gamma-inducible protein 16 -0.0632119
TPT1 tumor protein, translationally-controlled 1 -0.0616738
TMSB10 thymosin beta 10 -0.0594261
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0574255
PTMA prothymosin, alpha -0.0564638
LAMB3 laminin, beta 3 -0.055727
HMGA2 high mobility group AT-hook 2 -0.0542019
RPLP2 ribosomal protein, large, P2 -0.053792
FTL ferritin, light polypeptide -0.0537675
RPL12 ribosomal protein L12 -0.053552
RPS3 ribosomal protein S3 -0.0516637
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0504751
RPL8 ribosomal protein L8 -0.0504609
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0493077
C2CD2 C2 calcium-dependent domain containing 2 -0.0473544
RPL34 ribosomal protein L34 -0.047115
RPS24 ribosomal protein S24 -0.0462746
RSL1D1 ribosomal L1 domain containing 1 -0.0459355
RPS27A ribosomal protein S27a -0.0456266
RPL13A ribosomal protein L13a -0.0448395
RPL31 ribosomal protein L31 -0.0443581
NAV3 neuron navigator 3 -0.0442866
RPL35 ribosomal protein L35 -0.042792
RPL26 ribosomal protein L26 -0.0420633
RPS29 ribosomal protein S29 -0.0412469
S100A2 S100 calcium binding protein A2 -0.0409859
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0400366
RPL23 ribosomal protein L23 -0.0390394
RPL32 ribosomal protein L32 -0.0378456
FRMD4A FERM domain containing 4A -0.037295
CD63 CD63 molecule -0.0362176
PGK1 phosphoglycerate kinase 1 -0.0357711
SCLT1 sodium channel and clathrin linker 1 -0.033045
RPL7A ribosomal protein L7a -0.0316218
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0315819
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313818
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0311806
RPS13 ribosomal protein S13 -0.0311448
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.030786
RPS16 ribosomal protein S16 -0.0301837
RPLP0 ribosomal protein, large, P0 -0.0298736
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0292792
SP100 SP100 nuclear antigen -0.0289029
RPL38 ribosomal protein L38 -0.028329
RPS25 ribosomal protein S25 -0.0283255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0277693
RPL9 ribosomal protein L9 -0.0272874
ANTXR2 anthrax toxin receptor 2 -0.0268764
RPL28 ribosomal protein L28 -0.0263477
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0258839
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0254632
IFITM2 interferon induced transmembrane protein 2 -0.0253459
PKM pyruvate kinase, muscle -0.0245867
SBF2 SET binding factor 2 -0.024363
RPL27A ribosomal protein L27a -0.0242708
CLIP1 CAP-GLY domain containing linker protein 1 -0.024016
RPL19 ribosomal protein L19 -0.0237921
FLNB filamin B, beta -0.0237346
AGO2 argonaute RISC catalytic component 2 -0.0237153
MT1X metallothionein 1X -0.0236469
RPS21 ribosomal protein S21 -0.0234794
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0233966
MYL12B myosin, light chain 12B, regulatory -0.0232353
PFN1 profilin 1 -0.0229747
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0229512
NAV2 neuron navigator 2 -0.0226185
SENP5 SUMO1/sentrin specific peptidase 5 -0.0224955
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0224407
EFNB2 ephrin-B2 -0.0222339
RPS23 ribosomal protein S23 -0.0221952
RPL36 ribosomal protein L36 -0.0221543
TUBB4B tubulin, beta 4B class IVb -0.0220043
RRBP1 ribosome binding protein 1 -0.0219965
HDAC9 histone deacetylase 9 -0.0219469
CUL1 cullin 1 -0.0219357
RSL24D1 ribosomal L24 domain containing 1 -0.0217559
SLC38A2 solute carrier family 38, member 2 -0.0217241
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0216714
GPHN gephyrin -0.021301
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0212896
RPS5 ribosomal protein S5 -0.0212376
RIGI RNA sensor RIG-I -0.020912
EIF1 eukaryotic translation initiation factor 1 -0.0208399
RPL11 ribosomal protein L11 -0.0207055
AHNAK AHNAK nucleoprotein -0.0206408
ZC3H12B zinc finger CCCH-type containing 12B -0.0205996
TM4SF1 transmembrane 4 L six family member 1 -0.0204781
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0204162