Levobupivacaine (hydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.380239
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0891442
EEF2 eukaryotic translation elongation factor 2 0.0799255
MYH9 myosin, heavy chain 9, non-muscle 0.0759602
SOD2 superoxide dismutase 2, mitochondrial 0.0740535
TIMP3 TIMP metallopeptidase inhibitor 3 0.0698763
CEMIP cell migration inducing protein, hyaluronan binding 0.0600913
CD109 CD109 molecule 0.0569487
FLNA filamin A, alpha 0.0511926
RACK1 receptor for activated C kinase 1 0.0468932
FTH1 ferritin, heavy polypeptide 1 0.0451902
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0389754
KLF7 Kruppel-like factor 7 (ubiquitous) 0.03763
PGK1 phosphoglycerate kinase 1 0.0366486
YBX1 Y box binding protein 1 0.034762
PSD3 pleckstrin and Sec7 domain containing 3 0.034299
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0338041
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0337385
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0331242
TMEM178B transmembrane protein 178B 0.0330354
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0325508
COL7A1 collagen, type VII, alpha 1 0.0299575
PLEC plectin 0.0298565
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0289495
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0269628
RAD23B RAD23 homolog B (S. cerevisiae) 0.0263345
FKBP1A FK506 binding protein 1A, 12kDa 0.0262667
IGFBP3 insulin-like growth factor binding protein 3 0.0258149
TPM3 tropomyosin 3 0.0258115
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254588
SH3RF3 SH3 domain containing ring finger 3 0.0249363
COL4A2 collagen, type IV, alpha 2 0.0249274
HILPDA hypoxia inducible lipid droplet-associated 0.0247957
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246473
TUBB tubulin, beta class I 0.0241172
GRB10 growth factor receptor-bound protein 10 0.0229859
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0229423
CEP250 centrosomal protein 250kDa 0.0228691
MEF2A myocyte enhancer factor 2A 0.0223948
FAM13A family with sequence similarity 13, member A 0.0222646
CALR calreticulin 0.0222175
FMNL2 formin-like 2 0.021883
PER1 period circadian clock 1 0.0217545
COL5A1 collagen, type V, alpha 1 0.0217484
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0216479
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0216227
INHBA inhibin, beta A 0.0214532
ZFC3H1 zinc finger, C3H1-type containing 0.0214011
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0211906
ZNF148 zinc finger protein 148 0.0211046
RPS4X ribosomal protein S4, X-linked 0.0210574
NUP58 nucleoporin 58 0.0209011
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0206026
GYS1 glycogen synthase 1 (muscle) 0.0202766
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0201874
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0200099
PABPN1 poly(A) binding protein, nuclear 1 0.0199715
MIDEAS mitotic deacetylase associated SANT domain protein 0.0199608
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0199327
CALD1 caldesmon 1 0.0198622
PGM3 phosphoglucomutase 3 0.0197898
MSI2 musashi RNA-binding protein 2 0.0192884
LOC112694756 uncharaterized LOC112694756 0.0189106
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0186998
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0186556
TMEM39A transmembrane protein 39A 0.0186223
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.01855
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0183342
NPTN neuroplastin 0.018143
RANBP2 RAN binding protein 2 0.0181246
ARHGAP12 Rho GTPase activating protein 12 0.0179025
ACTN1 actinin, alpha 1 0.0178138
NIBAN2 niban apoptosis regulator 2 0.0177541
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0176407
RLIM ring finger protein, LIM domain interacting 0.0175607
PDE10A phosphodiesterase 10A 0.0175409
ITCH itchy E3 ubiquitin protein ligase 0.0175345
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0174645
RAB18 RAB18, member RAS oncogene family 0.0173441
RPL3 ribosomal protein L3 0.0172393
COL6A2 collagen, type VI, alpha 2 0.0171891
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0170113
GARS1 glycyl-tRNA synthetase 1 0.0168832
SERF2 small EDRK-rich factor 2 0.0167174
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.01659
BHLHE40 basic helix-loop-helix family, member e40 0.0164895
ZMIZ1 zinc finger, MIZ-type containing 1 0.0162674
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0161726
PRC1 protein regulator of cytokinesis 1 0.0161033
VIM vimentin 0.0160177
EML5 echinoderm microtubule associated protein like 5 0.0160153
NUMA1 nuclear mitotic apparatus protein 1 0.015961
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0159371
EPAS1 endothelial PAS domain protein 1 0.0158985
DENND5A DENN/MADD domain containing 5A 0.0158462
KDM5B lysine (K)-specific demethylase 5B 0.0158133
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0157393
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0157178
MMP2 matrix metallopeptidase 2 0.0156009
SFPQ splicing factor proline/glutamine-rich 0.0155867

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.361623
MT2A metallothionein 2A -0.192991
STC1 stanniocalcin 1 -0.118172
HLA-B major histocompatibility complex, class I, B -0.115254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100536
FTL ferritin, light polypeptide -0.0889039
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0714906
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0705819
PTMA prothymosin, alpha -0.0686744
ASPH aspartate beta-hydroxylase -0.0667125
CDCP1 CUB domain containing protein 1 -0.061218
RPS6 ribosomal protein S6 -0.0592765
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0589931
B2M beta-2-microglobulin -0.058722
IFI6 interferon, alpha-inducible protein 6 -0.0580814
CD44 CD44 molecule (Indian blood group) -0.0532121
GOLGA4 golgin A4 -0.0517347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0513731
PKM pyruvate kinase, muscle -0.0493341
TMSB10 thymosin beta 10 -0.0489751
USP34 ubiquitin specific peptidase 34 -0.0468934
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0442736
IER3 immediate early response 3 -0.0441034
WWTR1 WW domain containing transcription regulator 1 -0.0429428
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0427372
H1-0 H1.0 linker histone -0.0419891
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0412864
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0398156
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0390014
SETD5 SET domain containing 5 -0.0385026
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0363554
SP100 SP100 nuclear antigen -0.0349639
TPT1 tumor protein, translationally-controlled 1 -0.0345831
SEPTIN7 septin 7 -0.034396
ZBTB38 zinc finger and BTB domain containing 38 -0.0340316
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0335095
ENO1 enolase 1, (alpha) -0.0333482
RPL28 ribosomal protein L28 -0.0329095
RPLP1 ribosomal protein, large, P1 -0.0325651
EIF1 eukaryotic translation initiation factor 1 -0.0321521
NKTR natural killer cell triggering receptor -0.0316724
ANLN anillin, actin binding protein -0.031511
IFI16 interferon, gamma-inducible protein 16 -0.0309369
MBNL1 muscleblind-like splicing regulator 1 -0.0307129
RPS19 ribosomal protein S19 -0.0303382
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0300877
RPS13 ribosomal protein S13 -0.0300276
RPS27A ribosomal protein S27a -0.0300045
DSCAM Down syndrome cell adhesion molecule -0.02981
GOLGB1 golgin B1 -0.0293135
RPL31 ribosomal protein L31 -0.0292846
TFPI2 tissue factor pathway inhibitor 2 -0.0291664
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0291048
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0288706
RPS25 ribosomal protein S25 -0.0288626
ANXA2 annexin A2 -0.0284826
RPS5 ribosomal protein S5 -0.0284626
RAB1A RAB1A, member RAS oncogene family -0.0280047
KMT2E lysine (K)-specific methyltransferase 2E -0.0277987
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.027683
RAD21 RAD21 homolog (S. pombe) -0.027418
CTSB cathepsin B -0.0274098
RPL38 ribosomal protein L38 -0.0269916
S100A10 S100 calcium binding protein A10 -0.0267004
RPS24 ribosomal protein S24 -0.026384
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0261535
RPL37A ribosomal protein L37a -0.0260883
NRIP1 nuclear receptor interacting protein 1 -0.0260257
RPS3 ribosomal protein S3 -0.0259578
ICAM1 intercellular adhesion molecule 1 -0.0258865
SVIL supervillin -0.0254207
WSB1 WD repeat and SOCS box containing 1 -0.0253792
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0252885
RPS21 ribosomal protein S21 -0.0251658
DST dystonin -0.0251256
PLAUR plasminogen activator, urokinase receptor -0.0250981
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0250925
KDM3A lysine (K)-specific demethylase 3A -0.0250299
CDK13 cyclin-dependent kinase 13 -0.0249439
ZBTB20 zinc finger and BTB domain containing 20 -0.0247068
RPL32 ribosomal protein L32 -0.0246897
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0246376
ANKRD12 ankyrin repeat domain 12 -0.0245904
STAU1 staufen double-stranded RNA binding protein 1 -0.0245005
RPS17 ribosomal protein S17 -0.0243181
RAB5A RAB5A, member RAS oncogene family -0.0242023
EXOC6B exocyst complex component 6B -0.0237507
RYBP RING1 and YY1 binding protein -0.0236463
DARS1 aspartyl-tRNA synthetase 1 -0.0235973
NT5E 5'-nucleotidase, ecto (CD73) -0.0235058
IL1B interleukin 1, beta -0.0234001
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0230313
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0229564
CST3 cystatin C -0.0225156
RPL9 ribosomal protein L9 -0.0223832
LDHA lactate dehydrogenase A -0.0223424
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0222997
DOCK5 dedicator of cytokinesis 5 -0.0222625
RDX radixin -0.0221776
RUNX1 runt-related transcription factor 1 -0.0221775