Levobupivacaine (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.209007
AKAP12 A kinase (PRKA) anchor protein 12 0.116953
EEF2 eukaryotic translation elongation factor 2 0.106535
FRMD4A FERM domain containing 4A 0.0965987
LSAMP limbic system-associated membrane protein 0.0838337
FLNA filamin A, alpha 0.0817936
LINGO2 leucine rich repeat and Ig domain containing 2 0.0811011
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0756223
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0689518
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.068901
FNDC3B fibronectin type III domain containing 3B 0.068857
TXNRD1 thioredoxin reductase 1 0.0580168
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0579573
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0566457
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0555922
SLC39A11 solute carrier family 39, member 11 0.0534806
SOD2 superoxide dismutase 2, mitochondrial 0.0533827
NAV2 neuron navigator 2 0.0521179
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0501491
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0479307
SPTBN1 spectrin, beta, non-erythrocytic 1 0.046339
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0463289
GOLGA4 golgin A4 0.0463132
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0455955
TPM3 tropomyosin 3 0.0450153
SREBF2 sterol regulatory element binding transcription factor 2 0.0446981
RPL3 ribosomal protein L3 0.0432353
HDAC9 histone deacetylase 9 0.0428894
PABPC1 poly(A) binding protein, cytoplasmic 1 0.042328
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0418545
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0408402
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0398153
ICAM1 intercellular adhesion molecule 1 0.0384917
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0384868
HSPA8 heat shock 70kDa protein 8 0.0383929
CD59 CD59 molecule, complement regulatory protein 0.0383118
CXCL8 chemokine (C-X-C motif) ligand 8 0.0377509
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0377104
FSTL5 follistatin-like 5 0.0373329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0366734
ERBIN erbb2 interacting protein 0.0365728
CANX calnexin 0.0363282
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0355719
GOLGB1 golgin B1 0.0342835
TCF20 transcription factor 20 (AR1) 0.0337163
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0334584
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0321562
FMNL2 formin-like 2 0.0318278
FRMD5 FERM domain containing 5 0.0316181
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0312053
FHIT fragile histidine triad 0.0304953
PLEC plectin 0.0304945
KAZN kazrin, periplakin interacting protein 0.0304611
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0304464
PRELID2 PRELI domain containing 2 0.0304408
SMYD3 SET and MYND domain containing 3 0.0303175
COG5 component of oligomeric golgi complex 5 0.0297943
CAMTA1 calmodulin binding transcription activator 1 0.0295721
RB1CC1 RB1-inducible coiled-coil 1 0.0293758
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0290002
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0287706
NF1 neurofibromin 1 0.0287193
LOC112694756 uncharaterized LOC112694756 0.0286608
SRRM2 serine/arginine repetitive matrix 2 0.0282924
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0282885
EHBP1 EH domain binding protein 1 0.0282327
CALD1 caldesmon 1 0.0282197
YEATS2 YEATS domain containing 2 0.0281176
DENND1A DENN/MADD domain containing 1A 0.0280962
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0280408
SFTPA2 surfactant protein A2 0.0277576
NOTCH2 notch 2 0.0277037
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0276088
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0272736
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0272187
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0268517
FAM219A family with sequence similarity 219, member A 0.0267897
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.026655
TRIO trio Rho guanine nucleotide exchange factor 0.0264109
PTPRG protein tyrosine phosphatase, receptor type, G 0.0263976
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.026136
RUNX1 runt-related transcription factor 1 0.0258196
SEPTIN9 septin 9 0.0257637
TBC1D5 TBC1 domain family, member 5 0.0255471
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0251543
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0250735
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0250531
MYH9 myosin, heavy chain 9, non-muscle 0.0250224
TRIM33 tripartite motif containing 33 0.0249341
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0247995
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0245929
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 0.0244548
ZC3H12B zinc finger CCCH-type containing 12B 0.0243498
SNX9 sorting nexin 9 0.0243086
RHOA ras homolog family member A 0.0241769
CALU calumenin 0.0240104
MACF1 microtubule-actin crosslinking factor 1 0.0239452
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0238268
ACTN1 actinin, alpha 1 0.0238114
DIAPH1 diaphanous-related formin 1 0.0236869

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133666
NLGN1 neuroligin 1 -0.113486
FTL ferritin, light polypeptide -0.110314
MT2A metallothionein 2A -0.105305
TMSB10 thymosin beta 10 -0.0690299
PTMA prothymosin, alpha -0.0602696
NRG3 neuregulin 3 -0.0520998
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0511869
RPL35A ribosomal protein L35a -0.0497781
RPS6 ribosomal protein S6 -0.0467567
IFI6 interferon, alpha-inducible protein 6 -0.0466473
B2M beta-2-microglobulin -0.0439219
RPLP1 ribosomal protein, large, P1 -0.0409972
RPS19 ribosomal protein S19 -0.040218
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0395044
RPS3 ribosomal protein S3 -0.038198
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0358861
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.033787
ENO2 enolase 2 (gamma, neuronal) -0.0336403
NAP1L1 nucleosome assembly protein 1-like 1 -0.0332862
VIM vimentin -0.0313115
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0302928
RPLP2 ribosomal protein, large, P2 -0.0301928
RPL32 ribosomal protein L32 -0.0290448
ACTG1 actin gamma 1 -0.0276726
RPL23 ribosomal protein L23 -0.0276587
PKM pyruvate kinase, muscle -0.027504
S100A9 S100 calcium binding protein A9 -0.0274391
APOD apolipoprotein D -0.0273094
QKI QKI, KH domain containing, RNA binding -0.0269858
S100A10 S100 calcium binding protein A10 -0.0264561
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0264157
RPL34 ribosomal protein L34 -0.0255597
RPS27 ribosomal protein S27 -0.0255287
TRA2A transformer 2 alpha homolog (Drosophila) -0.0254285
WSB1 WD repeat and SOCS box containing 1 -0.0253028
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0252308
IFIH1 interferon induced with helicase C domain 1 -0.0242827
TPI1 triosephosphate isomerase 1 -0.0242527
LITAF lipopolysaccharide-induced TNF factor -0.0239585
SLC38A2 solute carrier family 38, member 2 -0.0239028
IFITM3 interferon induced transmembrane protein 3 -0.0238702
BZW2 basic leucine zipper and W2 domains 2 -0.0237491
S100A6 S100 calcium binding protein A6 -0.02355
ENO1 enolase 1, (alpha) -0.0232854
HDAC3 histone deacetylase 3 -0.0227823
KDM5B lysine (K)-specific demethylase 5B -0.0227521
TOP2A topoisomerase (DNA) II alpha 170kDa -0.022614
RPS5 ribosomal protein S5 -0.0225824
IGFBP3 insulin-like growth factor binding protein 3 -0.022438
RPL37A ribosomal protein L37a -0.0222126
WDR45B WD repeat domain 45B -0.0221899
RPS23 ribosomal protein S23 -0.0216339
TPT1 tumor protein, translationally-controlled 1 -0.0214858
RPL11 ribosomal protein L11 -0.0213254
RNF213 ring finger protein 213 -0.0210719
RPL35 ribosomal protein L35 -0.0206424
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.020555
DDIT4 DNA-damage-inducible transcript 4 -0.0201259
AUTS2 autism susceptibility candidate 2 -0.0201
IFI44L interferon-induced protein 44-like -0.0198691
LEF1 lymphoid enhancer-binding factor 1 -0.0196709
RPS29 ribosomal protein S29 -0.0196283
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0195439
IER3 immediate early response 3 -0.0194048
INTS6 integrator complex subunit 6 -0.0192733
RPL31 ribosomal protein L31 -0.0191839
ANGPTL4 angiopoietin-like 4 -0.0190412
HMGA1 high mobility group AT-hook 1 -0.0189979
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0188771
CENPF centromere protein F, 350/400kDa -0.0188499
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0188118
MT1X metallothionein 1X -0.0187509
INSIG2 insulin induced gene 2 -0.0185691
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0184614
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0182705
RPL36 ribosomal protein L36 -0.018184
KDM3A lysine (K)-specific demethylase 3A -0.0181425
RPL28 ribosomal protein L28 -0.0180948
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0180831
ECT2 epithelial cell transforming 2 -0.0179877
ASTN2 astrotactin 2 -0.0178338
RPL8 ribosomal protein L8 -0.0177049
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0176158
CLEC1B C-type lectin domain family 1, member B -0.017477
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0172822
RPS21 ribosomal protein S21 -0.0171268
EGR1 early growth response 1 -0.016952
DUSP6 dual specificity phosphatase 6 -0.0166031
RPS8 ribosomal protein S8 -0.0165859
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0164312
SLC38A1 solute carrier family 38, member 1 -0.0164119
RPL19 ribosomal protein L19 -0.0164039
SSBP3 single stranded DNA binding protein 3 -0.0163718
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0163459
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0162526
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0162396
MBD5 methyl-CpG binding domain protein 5 -0.0161953
RPL12 ribosomal protein L12 -0.0160632
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0159821