Levobupivacaine (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0731067
NAV2 neuron navigator 2 0.0546216
MACF1 microtubule-actin crosslinking factor 1 0.0519331
MYH9 myosin, heavy chain 9, non-muscle 0.0451672
TRIO trio Rho guanine nucleotide exchange factor 0.0436558
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0414551
DSCAM Down syndrome cell adhesion molecule 0.0375435
NUP58 nucleoporin 58 0.0366575
ERRFI1 ERBB receptor feedback inhibitor 1 0.0354186
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0347361
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0341566
TAS2R14 taste receptor, type 2, member 14 0.0334114
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0331511
ZFAND3 zinc finger, AN1-type domain 3 0.0324721
MSN moesin 0.032194
BIRC3 baculoviral IAP repeat containing 3 0.0320843
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.030333
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0296479
FLNB filamin B, beta 0.0291761
PBX3 pre-B-cell leukemia homeobox 3 0.0286398
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0283996
IGFBP3 insulin-like growth factor binding protein 3 0.0276925
CEP250 centrosomal protein 250kDa 0.0272257
EEF2 eukaryotic translation elongation factor 2 0.0270971
RAD51B RAD51 paralog B 0.0270933
PRELID2 PRELI domain containing 2 0.0267589
ANKRD36 ankyrin repeat domain 36 0.0267258
DNER delta/notch-like EGF repeat containing 0.0264592
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262742
PYGL phosphorylase, glycogen, liver 0.0262279
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0256667
ATXN1 ataxin 1 0.0256075
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0254253
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0249094
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0245258
DYNC2I1 dynein 2 intermediate chain 1 0.0233319
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0226013
NBAS neuroblastoma amplified sequence 0.0225837
ATP13A3 ATPase type 13A3 0.022454
NCEH1 neutral cholesterol ester hydrolase 1 0.0222952
OSMR oncostatin M receptor 0.0222145
HSPA8 heat shock 70kDa protein 8 0.0220492
CAPRIN2 caprin family member 2 0.0220175
ASXL2 additional sex combs like transcriptional regulator 2 0.0218093
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0214205
MYOF myoferlin 0.0213589
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0210363
DST dystonin 0.0207421
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0205822
SNX14 sorting nexin 14 0.0202401
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201065
ZNF292 zinc finger protein 292 0.0200827
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0197279
ZFC3H1 zinc finger, C3H1-type containing 0.0194199
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0194114
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0192524
RACK1 receptor for activated C kinase 1 0.0191709
PRKCE protein kinase C, epsilon 0.0191695
CUL4B cullin 4B 0.018985
MCL1 myeloid cell leukemia 1 0.0189075
FMN1 formin 1 0.0188351
SNX13 sorting nexin 13 0.0187784
TTC28 tetratricopeptide repeat domain 28 0.0184864
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0182089
GSK3B glycogen synthase kinase 3 beta 0.0182017
UBE2O ubiquitin-conjugating enzyme E2O 0.0181293
PTBP3 polypyrimidine tract binding protein 3 0.0181275
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0181203
MBD5 methyl-CpG binding domain protein 5 0.0179249
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0178839
PRSS23 protease, serine, 23 0.0176839
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.01761
DOCK1 dedicator of cytokinesis 1 0.0175254
NGLY1 N-glycanase 1 0.0174823
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0172179
SEPTIN2 septin 2 0.0171507
KTN1 kinectin 1 (kinesin receptor) 0.0170384
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0169841
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0167892
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0167866
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0167793
RANBP2 RAN binding protein 2 0.0166552
FOXJ3 forkhead box J3 0.0166105
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0165249
AURKA aurora kinase A 0.0163063
TARDBP TAR DNA binding protein 0.0162723
SEPTIN9 septin 9 0.0162107
DOCK5 dedicator of cytokinesis 5 0.0161432
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0160277
TPM3 tropomyosin 3 0.0156947
KDM5A lysine (K)-specific demethylase 5A 0.0156581
TBC1D5 TBC1 domain family, member 5 0.0156284
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0155311
ARRDC3 arrestin domain containing 3 0.0153886
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0153587
VCL vinculin 0.0151593
RNF145 ring finger protein 145 0.0151145
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0150614
ATM ATM serine/threonine kinase 0.0148778
THSD4 thrombospondin, type I, domain containing 4 0.0148234

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.406006
VIM vimentin -0.0981666
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0644997
TPT1 tumor protein, translationally-controlled 1 -0.0552477
GNAS GNAS complex locus -0.0479908
RPLP1 ribosomal protein, large, P1 -0.0427794
SQSTM1 sequestosome 1 -0.0415249
GOLGA4 golgin A4 -0.040787
RPS8 ribosomal protein S8 -0.0367286
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0361206
EIF1 eukaryotic translation initiation factor 1 -0.0345982
RPS13 ribosomal protein S13 -0.0328418
RPL12 ribosomal protein L12 -0.0293759
PTMA prothymosin, alpha -0.0276403
TMSB10 thymosin beta 10 -0.0273775
HMGA1 high mobility group AT-hook 1 -0.0266114
RPLP0 ribosomal protein, large, P0 -0.0255663
RPS23 ribosomal protein S23 -0.0254835
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0239129
SETD5 SET domain containing 5 -0.0236544
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0234763
RPS6 ribosomal protein S6 -0.0231077
FTL ferritin, light polypeptide -0.0228666
RPL32 ribosomal protein L32 -0.0222807
RPLP2 ribosomal protein, large, P2 -0.0216141
AKAP9 A kinase (PRKA) anchor protein 9 -0.0210527
EGR1 early growth response 1 -0.0207659
ADIPOR2 adiponectin receptor 2 -0.0205085
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0202588
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0199757
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0199193
CCNI cyclin I -0.0198693
RPS11 ribosomal protein S11 -0.0196704
RPL30 ribosomal protein L30 -0.0195941
SMC4 structural maintenance of chromosomes 4 -0.0193524
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.019251
SETX senataxin -0.0192345
RAB7A RAB7A, member RAS oncogene family -0.0191812
RPS29 ribosomal protein S29 -0.0189541
ANXA2 annexin A2 -0.0187332
RPS19 ribosomal protein S19 -0.0186037
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0184281
RPL35A ribosomal protein L35a -0.0184033
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0182847
ANXA1 annexin A1 -0.0181984
RPL36 ribosomal protein L36 -0.0179271
RTN3 reticulon 3 -0.0177908
TP53 tumor protein p53 -0.0175972
RPL31 ribosomal protein L31 -0.0174624
RPS16 ribosomal protein S16 -0.017271
RPL35 ribosomal protein L35 -0.0167983
SRRM1 serine/arginine repetitive matrix 1 -0.0167821
RPL4 ribosomal protein L4 -0.0165775
IFITM3 interferon induced transmembrane protein 3 -0.0163267
RPS14 ribosomal protein S14 -0.0162316
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0161773
ZC3H12B zinc finger CCCH-type containing 12B -0.0160815
IARS1 isoleucyl-tRNA synthetase 1 -0.0160428
NPR2 natriuretic peptide receptor 2 -0.0159462
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0159241
RPL11 ribosomal protein L11 -0.0158641
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0158151
MORF4L2 mortality factor 4 like 2 -0.0157938
ZC3H12C zinc finger CCCH-type containing 12C -0.0157316
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.0157121
NIN ninein (GSK3B interacting protein) -0.0155614
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0154923
RASAL2 RAS protein activator like 2 -0.015414
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0152913
TUBB4B tubulin, beta 4B class IVb -0.015287
TMEM263 transmembrane protein 263 -0.0152846
SH3KBP1 SH3-domain kinase binding protein 1 -0.0151828
RPL34 ribosomal protein L34 -0.0151674
BSG basigin (Ok blood group) -0.0151551
EPAS1 endothelial PAS domain protein 1 -0.0151023
ARF1 ADP-ribosylation factor 1 -0.0150987
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0148605
HLA-C major histocompatibility complex, class I, C -0.0147117
PFN1 profilin 1 -0.0147062
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0147001
SEPTIN7 septin 7 -0.0146309
CENPP centromere protein P -0.01453
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0143813
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0143462
CCND1 cyclin D1 -0.0142532
HMGB1 high mobility group box 1 -0.0140504
RPS20 ribosomal protein S20 -0.0139888
RPS3 ribosomal protein S3 -0.013682
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0136539
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.013618
FKBP10 FK506 binding protein 10, 65 kDa -0.0135796
BLM Bloom syndrome, RecQ helicase-like -0.0135737
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0135575
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0135126
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0133256
RPS21 ribosomal protein S21 -0.0133223
MED13 mediator complex subunit 13 -0.0133196
NAMPT nicotinamide phosphoribosyltransferase -0.0133164
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0131963
TUBA1B tubulin, alpha 1b -0.0131088