Levobupivacaine (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Levobupivacaine (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Levobupivacaine (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.106742
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0936174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.063102
ACTG1 actin gamma 1 0.0610691
RPL3 ribosomal protein L3 0.0592989
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0573757
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0560584
HSPA8 heat shock 70kDa protein 8 0.0559136
RACK1 receptor for activated C kinase 1 0.0553117
FRAS1 Fraser extracellular matrix complex subunit 1 0.0489414
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462415
DSPP dentin sialophosphoprotein 0.0450094
EGR1 early growth response 1 0.0435532
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0401552
ANXA2 annexin A2 0.0379043
FLOT1 flotillin 1 0.0345553
NDRG1 N-myc downstream regulated 1 0.0343381
RPS12 ribosomal protein S12 0.0333579
FHIT fragile histidine triad 0.0330409
IGFBP3 insulin-like growth factor binding protein 3 0.0292844
EZR ezrin 0.0276467
RPS17 ribosomal protein S17 0.027363
KLF5 Kruppel-like factor 5 (intestinal) 0.0269196
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0264419
KRT18 keratin 18, type I 0.0263203
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0259972
FTH1 ferritin, heavy polypeptide 1 0.0257343
ENO1 enolase 1, (alpha) 0.0253582
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0248352
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0246445
RPS8 ribosomal protein S8 0.0245465
SET SET nuclear proto-oncogene 0.0245151
ITGA6 integrin, alpha 6 0.0243404
CD9 CD9 molecule 0.0239803
ITGB4 integrin, beta 4 0.0230268
PRELID2 PRELI domain containing 2 0.0228046
SRRM2 serine/arginine repetitive matrix 2 0.0225797
TPM3 tropomyosin 3 0.0223642
ACTN4 actinin, alpha 4 0.0221648
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220102
VEGFA vascular endothelial growth factor A 0.0219645
LDHA lactate dehydrogenase A 0.0218589
MYH9 myosin, heavy chain 9, non-muscle 0.0217845
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0215794
HDLBP high density lipoprotein binding protein 0.0213893
GPC5 glypican 5 0.0207746
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0207277
YBX1 Y box binding protein 1 0.0206884
FLNA filamin A, alpha 0.0206753
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0205484
MKI67 marker of proliferation Ki-67 0.020399
FERMT1 fermitin family member 1 0.0202284
APLP2 amyloid beta (A4) precursor-like protein 2 0.0202283
RAD51B RAD51 paralog B 0.0199529
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0194764
CREB5 cAMP responsive element binding protein 5 0.0190632
AKAP12 A kinase (PRKA) anchor protein 12 0.0189461
MPRIP myosin phosphatase Rho interacting protein 0.0184885
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.018117
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0181026
KRT8 keratin 8, type II 0.0179644
SLK STE20-like kinase 0.0177196
ZBTB7C zinc finger and BTB domain containing 7C 0.0174662
MYO5B myosin VB 0.0174076
HMGA2 high mobility group AT-hook 2 0.0166835
RPL23 ribosomal protein L23 0.0166608
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0164777
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0164583
S100A6 S100 calcium binding protein A6 0.016314
DENND1A DENN/MADD domain containing 1A 0.0160467
RPL37A ribosomal protein L37a 0.0158249
RPS2 ribosomal protein S2 0.0157339
ASPH aspartate beta-hydroxylase 0.0154568
NCOR2 nuclear receptor corepressor 2 0.0153587
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0153569
MYO1B myosin IB 0.0148805
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0146794
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0146237
FN1 fibronectin 1 0.0143985
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0142822
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0141156
EMP1 epithelial membrane protein 1 0.0137648
EPHA2 EPH receptor A2 0.0136541
PTPRG protein tyrosine phosphatase, receptor type, G 0.0136247
EXT1 exostosin glycosyltransferase 1 0.0134519
PARD3 par-3 family cell polarity regulator 0.0133258
HDGF hepatoma-derived growth factor 0.0132589
LAMA4 laminin, alpha 4 0.0131895
EEF1G eukaryotic translation elongation factor 1 gamma 0.013176
RCOR1 REST corepressor 1 0.0131052
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0130374
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0129582
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0129387
GRB10 growth factor receptor-bound protein 10 0.0129172
EFNB2 ephrin-B2 0.0128326
RPL37 ribosomal protein L37 0.0126124
STIP1 stress-induced phosphoprotein 1 0.0124018
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0123611
KRT19 keratin 19, type I 0.0123379
CANX calnexin 0.0122943

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.130134
LMO7 LIM domain 7 -0.0990072
AREG amphiregulin -0.0728758
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0633551
EGFR epidermal growth factor receptor -0.0629205
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0567887
OXR1 oxidation resistance 1 -0.056414
CD36 CD36 molecule (thrombospondin receptor) -0.0532171
RBM25 RNA binding motif protein 25 -0.0506117
TMSB10 thymosin beta 10 -0.0485605
NCEH1 neutral cholesterol ester hydrolase 1 -0.0431156
PDE4B phosphodiesterase 4B, cAMP-specific -0.0385059
RPS24 ribosomal protein S24 -0.0367525
SERINC5 serine incorporator 5 -0.03608
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0353523
ITPRID2 ITPR interacting domain containing 2 -0.0336943
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0324899
PDLIM5 PDZ and LIM domain 5 -0.0319766
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0317984
IER3 immediate early response 3 -0.0316902
GOLGA4 golgin A4 -0.0311384
ATXN1 ataxin 1 -0.0310137
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0309055
TPT1 tumor protein, translationally-controlled 1 -0.0305071
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0296643
NEMF nuclear export mediator factor -0.0291429
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0289289
YAP1 Yes-associated protein 1 -0.0289004
VCL vinculin -0.0288781
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0281613
IARS1 isoleucyl-tRNA synthetase 1 -0.028081
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0277405
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0277197
KITLG KIT ligand -0.0269806
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0268581
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0264932
FAM3C family with sequence similarity 3, member C -0.0263114
EIF1 eukaryotic translation initiation factor 1 -0.0261881
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0255954
STRN3 striatin, calmodulin binding protein 3 -0.0250916
EVA1C eva-1 homolog C (C. elegans) -0.0250051
GARS1 glycyl-tRNA synthetase 1 -0.0239894
CDK13 cyclin-dependent kinase 13 -0.023951
ARHGAP32 Rho GTPase activating protein 32 -0.0238772
PTBP2 polypyrimidine tract binding protein 2 -0.0234876
RAB10 RAB10, member RAS oncogene family -0.023324
RUNX2 runt-related transcription factor 2 -0.0231805
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0231611
AXIN2 axin 2 -0.0227721
TNPO1 transportin 1 -0.0225205
PTMA prothymosin, alpha -0.0223789
ANXA1 annexin A1 -0.0223223
MTAP methylthioadenosine phosphorylase -0.022159
RNF43 ring finger protein 43 -0.0219874
DSCAM Down syndrome cell adhesion molecule -0.0217709
NIPBL Nipped-B homolog (Drosophila) -0.0213869
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.021179
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0211497
ADNP activity-dependent neuroprotector homeobox -0.0210504
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0210019
USP34 ubiquitin specific peptidase 34 -0.0209413
NKTR natural killer cell triggering receptor -0.0208764
ATL2 atlastin GTPase 2 -0.0207828
PUM2 pumilio RNA-binding family member 2 -0.0205476
ARL5B ADP-ribosylation factor-like 5B -0.0205431
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0204115
EIF5B eukaryotic translation initiation factor 5B -0.020381
NCOR1 nuclear receptor corepressor 1 -0.0200814
JMJD1C jumonji domain containing 1C -0.0200272
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0200115
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0198221
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0197291
ZMYM2 zinc finger, MYM-type 2 -0.0196986
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0194447
ADGRA3 adhesion G protein-coupled receptor A3 -0.0193322
RPLP0 ribosomal protein, large, P0 -0.0193175
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0193099
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0192076
PHF14 PHD finger protein 14 -0.0187803
NAP1L1 nucleosome assembly protein 1-like 1 -0.0187293
MED13L mediator complex subunit 13-like -0.0183816
TCF12 transcription factor 12 -0.0183059
OGA O-GlcNAcase -0.018184
GPHN gephyrin -0.0181623
MED13 mediator complex subunit 13 -0.0181621
FNDC3A fibronectin type III domain containing 3A -0.0179521
BIRC6 baculoviral IAP repeat containing 6 -0.0178666
FHL2 four and a half LIM domains 2 -0.0178595
BIRC3 baculoviral IAP repeat containing 3 -0.0176407
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0176365
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0176307
ZNRF3 zinc and ring finger 3 -0.0173907
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0173241
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0172497
TXNRD1 thioredoxin reductase 1 -0.0172022
ARL15 ADP-ribosylation factor-like 15 -0.0171061
CTSB cathepsin B -0.0169848
SRSF11 serine/arginine-rich splicing factor 11 -0.016955
PAXBP1 PAX3 and PAX7 binding protein 1 -0.0169375
MTUS1 microtubule associated tumor suppressor 1 -0.0167697