| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3033825 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Levosimendan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.95 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.57 |
| DENND4B | DENN/MADD domain containing 4B | 0.5 |
| FN1 | fibronectin 1 | 0.5 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.48 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.47 |
| TMEM199 | transmembrane protein 199 | 0.46 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.46 |
| HLA-F | major histocompatibility complex, class I, F | 0.44 |
| ZNF142 | zinc finger protein 142 | 0.42 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.42 |
| NAV3 | neuron navigator 3 | 0.42 |
| ARSD | arylsulfatase D | 0.41 |
| VIM | vimentin | 0.39 |
| FAM135B | family with sequence similarity 135, member B | 0.37 |
| RANBP6 | RAN binding protein 6 | 0.37 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.36 |
| CLTA | clathrin, light chain A | 0.36 |
| STC2 | stanniocalcin 2 | 0.36 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | 0.36 |
| NAGS | N-acetylglutamate synthase | 0.35 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.35 |
| ODC1 | ornithine decarboxylase 1 | 0.35 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.34 |
| FBXO44 | F-box protein 44 | 0.34 |
| SCNM1 | sodium channel modifier 1 | 0.33 |
| SPHK2 | sphingosine kinase 2 | 0.33 |
| CLK1 | CDC-like kinase 1 | 0.32 |
| E4F1 | E4F transcription factor 1 | 0.32 |
| REXO1 | REX1, RNA exonuclease 1 homolog (S. cerevisiae) | 0.31 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.31 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.31 |
| MYCBP | MYC binding protein | 0.31 |
| TMEM185B | transmembrane protein 185B | 0.3 |
| ZNF354A | zinc finger protein 354A | 0.3 |
| CDC37 | cell division cycle 37 | 0.3 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.29 |
| TUSC2 | tumor suppressor candidate 2 | 0.29 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.29 |
| PTK2B | protein tyrosine kinase 2 beta | 0.29 |
| MATR3 | matrin 3 | 0.29 |
| CHAC2 | ChaC, cation transport regulator homolog 2 (E. coli) | 0.29 |
| MKRN1 | makorin ring finger protein 1 | 0.28 |
| TMEM248 | transmembrane protein 248 | 0.28 |
| PLAUR | plasminogen activator, urokinase receptor | 0.28 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.28 |
| ZNF721 | zinc finger protein 721 | 0.28 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.28 |
| PDCD2L | programmed cell death 2-like | 0.28 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.27 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.27 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.27 |
| STK36 | serine/threonine kinase 36 | 0.27 |
| GID8 | GID complex subunit 8 | 0.26 |
| TUBA4A | tubulin, alpha 4a | 0.26 |
| TRIML2 | tripartite motif family-like 2 | 0.26 |
| METTL26 | methyltransferase like 26 | 0.26 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.25 |
| FAM241A | family with sequence similarity 241 member A | 0.25 |
| KMT5C | lysine methyltransferase 5C | 0.25 |
| MTFR1L | mitochondrial fission regulator 1-like | 0.25 |
| PLD6 | phospholipase D family, member 6 | 0.25 |
| FKBPL | FK506 binding protein like | 0.25 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.25 |
| COX18 | COX18 cytochrome c oxidase assembly factor | 0.25 |
| TFR2 | transferrin receptor 2 | 0.25 |
| CCDC84 | coiled-coil domain containing 84 | 0.24 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.24 |
| SP110 | SP110 nuclear body protein | 0.24 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.24 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.24 |
| ARHGAP45 | Rho GTPase activating protein 45 | 0.24 |
| FAM122B | family with sequence similarity 122B | 0.23 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.23 |
| SESN2 | sestrin 2 | 0.23 |
| ZNF384 | zinc finger protein 384 | 0.23 |
| LRRC58 | leucine rich repeat containing 58 | 0.23 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.23 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.23 |
| RPL10 | ribosomal protein L10 | 0.23 |
| BAG1 | BCL2-associated athanogene | 0.23 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | 0.23 |
| PVR | poliovirus receptor | 0.23 |
| HPCAL4 | hippocalcin like 4 | 0.23 |
| GLRX | glutaredoxin (thioltransferase) | 0.23 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.23 |
| CLPP | caseinolytic mitochondrial matrix peptidase proteolytic subunit | 0.22 |
| OIP5 | Opa interacting protein 5 | 0.22 |
| FDX1 | ferredoxin 1 | 0.22 |
| ZNF557 | zinc finger protein 557 | 0.22 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.22 |
| RBM4 | RNA binding motif protein 4 | 0.22 |
| GRPEL1 | GrpE-like 1, mitochondrial (E. coli) | 0.22 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.22 |
| RMI2 | RecQ mediated genome instability 2 | 0.22 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | 0.22 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.22 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.22 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.21 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.43 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -1.32 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.88 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.83 |
| ZNF525 | zinc finger protein 525 | -0.65 |
| STK17A | serine/threonine kinase 17a | -0.65 |
| PRSS23 | protease, serine, 23 | -0.59 |
| RNF185 | ring finger protein 185 | -0.55 |
| KLHL24 | kelch-like family member 24 | -0.55 |
| ENO1 | enolase 1, (alpha) | -0.54 |
| PMF1 | polyamine-modulated factor 1 | -0.53 |
| MIGA2 | mitoguardin 2 | -0.51 |
| JRKL | JRK-like | -0.49 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.49 |
| ZNF362 | zinc finger protein 362 | -0.49 |
| CENPH | centromere protein H | -0.47 |
| DMD | dystrophin | -0.45 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -0.45 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.44 |
| MT1F | metallothionein 1F | -0.43 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.42 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | -0.42 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.4 |
| NCOA6 | nuclear receptor coactivator 6 | -0.39 |
| ATP9B | ATPase, class II, type 9B | -0.39 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.38 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.38 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.38 |
| ALKBH6 | alkB, alkylation repair homolog 6 (E. coli) | -0.38 |
| PLEC | plectin | -0.38 |
| TCTN2 | tectonic family member 2 | -0.37 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.37 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | -0.37 |
| DNM1L | dynamin 1-like | -0.36 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.36 |
| ZNF669 | zinc finger protein 669 | -0.36 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.36 |
| SPATA2 | spermatogenesis associated 2 | -0.36 |
| HDAC4 | histone deacetylase 4 | -0.36 |
| FAM102B | family with sequence similarity 102, member B | -0.35 |
| PTGES | prostaglandin E synthase | -0.35 |
| ABHD18 | abhydrolase domain containing 18 | -0.35 |
| BOK | BCL2-related ovarian killer | -0.35 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -0.35 |
| STRIP2 | striatin interacting protein 2 | -0.34 |
| TRAIP | TRAF interacting protein | -0.34 |
| MADD | MAP-kinase activating death domain | -0.34 |
| MRNIP | MRN complex interacting protein | -0.34 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.34 |
| ZNF280D | zinc finger protein 280D | -0.34 |
| SP6 | Sp6 transcription factor | -0.34 |
| RNF130 | ring finger protein 130 | -0.34 |
| NPNT | nephronectin | -0.34 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.33 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.33 |
| RAB37 | RAB37, member RAS oncogene family | -0.33 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.33 |
| RNF141 | ring finger protein 141 | -0.33 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.32 |
| CDK10 | cyclin-dependent kinase 10 | -0.32 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.32 |
| SHROOM1 | shroom family member 1 | -0.32 |
| CCNF | cyclin F | -0.31 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.31 |
| HPS4 | Hermansky-Pudlak syndrome 4 | -0.31 |
| TBC1D30 | TBC1 domain family, member 30 | -0.31 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.31 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.31 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.31 |
| ANXA6 | annexin A6 | -0.31 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.3 |
| MT2A | metallothionein 2A | -0.3 |
| H1-2 | H1.2 linker histone, cluster member | -0.3 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.3 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.3 |
| SUCO | SUN domain containing ossification factor | -0.3 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.3 |
| FAAH | fatty acid amide hydrolase | -0.29 |
| PIMREG | PICALM interacting mitotic regulator | -0.29 |
| FANCA | Fanconi anemia, complementation group A | -0.29 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.29 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.29 |
| EEF2K | eukaryotic elongation factor 2 kinase | -0.29 |
| TTC39B | tetratricopeptide repeat domain 39B | -0.29 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | -0.29 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.29 |
| BMP4 | bone morphogenetic protein 4 | -0.28 |
| KLK6 | kallikrein-related peptidase 6 | -0.28 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.28 |
| SLC2A4RG | SLC2A4 regulator | -0.28 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.28 |
| SLC38A7 | solute carrier family 38, member 7 | -0.28 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.28 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.28 |
| ANKRD44 | ankyrin repeat domain 44 | -0.27 |
| KIAA1210 | KIAA1210 | -0.27 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.27 |
| LMF1 | lipase maturation factor 1 | -0.27 |
| ELMO1 | engulfment and cell motility 1 | -0.27 |
| FCSK | fucose kinase | -0.27 |
