Lewy Body Disease Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0752347
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Genes

237 genes associated with the disease Lewy Body Disease in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABI3 ABI family, member 3
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
AFF1 AF4/FMR2 family, member 1
AFM afamin
AGER advanced glycosylation end product-specific receptor
AIF1 allograft inflammatory factor 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANK1 ankyrin 1, erythrocytic
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG7 autophagy related 7
BACE1 beta-site APP-cleaving enzyme 1
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL7C B-cell CLL/lymphoma 7C
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BHLHE22 basic helix-loop-helix family, member e22
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BPIFA2 BPI fold containing family A, member 2
BRAP BRCA1 associated protein
BRCA2 breast cancer 2, early onset
C9ORF72 chromosome 9 open reading frame 72
CALB1 calbindin 1, 28kDa
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAPN1 calpain 1, (mu/I) large subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP2B charged multivesicular body protein 2B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHP1 calcineurin-like EF-hand protein 1
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CLU clusterin
COMT catechol-O-methyltransferase
COX2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST3 cystatin C
CTSB cathepsin B
CTSD cathepsin D
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCTN4 dynactin 4 (p62)
DCX doublecortin
DLD dihydrolipoamide dehydrogenase
DLG4 discs, large homolog 4 (Drosophila)
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECD ecdysoneless homolog (Drosophila)
ECE1 endothelin converting enzyme 1
ECE2 endothelin converting enzyme 2
EDN1 endothelin 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELK1 ELK1, member of ETS oncogene family
ENO2 enolase 2 (gamma, neuronal)
EPHX2 epoxide hydrolase 2, cytoplasmic
F11 coagulation factor XI
FABP3 fatty acid binding protein 3, muscle and heart
FAM188B family with sequence similarity 188, member B
FANCD2 Fanconi anemia, complementation group D2
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FOXO1 forkhead box O1
FUS FUS RNA binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAL galanin/GMAP prepropeptide
GBA glucosidase, beta, acid
GDF15 growth differentiation factor 15
GFAP glial fibrillary acidic protein
GPR78 G protein-coupled receptor 78
GRK2 G protein-coupled receptor kinase 2
GRK5 G protein-coupled receptor kinase 5
GRM5 glutamate receptor, metabotropic 5
GRN granulin
GSN gelsolin
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HTRA2 HtrA serine peptidase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INS insulin
INSR insulin receptor
INSRR insulin receptor-related receptor
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLK6 kallikrein-related peptidase 6
LAD1 ladinin 1
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LMTK2 lemur tyrosine kinase 2
LRP10 low density lipoprotein receptor-related protein 10
LRRK2 leucine-rich repeat kinase 2
MAG myelin associated glycoprotein
MAOB monoamine oxidase B
MAP1A microtubule-associated protein 1A
MAP2 microtubule-associated protein 2
MAPT microtubule-associated protein tau
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein
MMP9 matrix metallopeptidase 9
MOAP1 modulator of apoptosis 1
MSMB microseminoprotein, beta-
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO5C myosin VC
NANOS3 nanos homolog 3 (Drosophila)
NBEAL1 neurobeachin-like 1
NEFL neurofilament, light polypeptide
NEUROD6 neuronal differentiation 6
NGF nerve growth factor (beta polypeptide)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUB1 negative regulator of ubiquitin-like proteins 1
NUP62 nucleoporin 62kDa
OGA O-GlcNAcase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLK2 polo-like kinase 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRNP prion protein
PRSS2 protease, serine, 2 (trypsin 2)
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPH phosphoserine phosphatase
PSPN persephin
PTCRA pre T-cell antigen receptor alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB39B RAB39B, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
REM1 RAS (RAD and GEM)-like GTP-binding 1
REST RE1-silencing transcription factor
RIDA reactive intermediate imine deaminase A homolog
RMC1 regulator of MON1-CCZ1
RPH3A rabphilin 3A
RPS27A ribosomal protein S27a
S100B S100 calcium binding protein B
SCARB2 scavenger receptor class B, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SESN3 sestrin 3
SFN stratifin
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SNCB synuclein, beta
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STXBP3 syntaxin binding protein 3
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SYNM synemin, intermediate filament protein
SYNPO synaptopodin
TARDBP TAR DNA binding protein
TF transferrin
TFAM transcription factor A, mitochondrial
TFEB transcription factor EB
TGFB2 transforming growth factor, beta 2
TH tyrosine hydroxylase
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM230 transmembrane protein 230
TNF tumor necrosis factor
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TPO thyroid peroxidase
TPPP tubulin polymerization promoting protein
TPSG1 tryptase gamma 1
TRIM9 tripartite motif containing 9
TSC2 tuberous sclerosis 2
TSHZ1 teashirt zinc finger homeobox 1
TSPO translocator protein (18kDa)
UBB ubiquitin B
UBC ubiquitin C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGF VGF nerve growth factor inducible
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VSNL1 visinin-like 1
ZFPM1 zinc finger protein, FOG family member 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF645 zinc finger protein 645