Lewy Body Disease Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities. (Human Disease Ontology, DOID_12217)
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Genes

30 genes associated with the Lewy Body Disease phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
COMT catechol-O-methyltransferase
CST3 cystatin C
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
GBA glucosidase, beta, acid
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
LRRK2 leucine-rich repeat kinase 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARK7 parkinson protein 7
PSEN1 presenilin 1
SEPT3 septin 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPP1 secreted phosphoprotein 1
TFAM transcription factor A, mitochondrial
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
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