| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.230203 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.154734 |
| NAV1 | neuron navigator 1 | 0.152378 |
| COL5A1 | collagen, type V, alpha 1 | 0.136734 |
| CDH13 | cadherin 13 | 0.121642 |
| CD44 | CD44 molecule (Indian blood group) | 0.118707 |
| POTEF | POTE ankyrin domain family, member F | 0.10915 |
| FLNA | filamin A, alpha | 0.107898 |
| LOC112694756 | uncharaterized LOC112694756 | 0.103464 |
| PODXL | podocalyxin-like | 0.102909 |
| MAP1B | microtubule-associated protein 1B | 0.102654 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0970096 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0875008 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0839277 |
| SEPTIN9 | septin 9 | 0.0690982 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0690733 |
| ASPH | aspartate beta-hydroxylase | 0.0676769 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0670315 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0658911 |
| RUNX1 | runt-related transcription factor 1 | 0.0656846 |
| PKM | pyruvate kinase, muscle | 0.0644167 |
| FSTL1 | follistatin-like 1 | 0.0641541 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0631726 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0629595 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0621089 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0619934 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0597698 |
| AHNAK | AHNAK nucleoprotein | 0.0593275 |
| MSN | moesin | 0.0591346 |
| TPM3 | tropomyosin 3 | 0.0563948 |
| EGFR | epidermal growth factor receptor | 0.0557039 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.054762 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.05208 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0515774 |
| EFNA5 | ephrin-A5 | 0.0511008 |
| PLXNA2 | plexin A2 | 0.0505493 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0500331 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0495307 |
| MYOF | myoferlin | 0.0486853 |
| VCL | vinculin | 0.0484976 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.048398 |
| HDAC9 | histone deacetylase 9 | 0.0481988 |
| PLEC | plectin | 0.0477711 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0471013 |
| S100A10 | S100 calcium binding protein A10 | 0.0468439 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0458972 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0454134 |
| FLNB | filamin B, beta | 0.0445055 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0443484 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0441517 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0441116 |
| LDHA | lactate dehydrogenase A | 0.0429029 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0427928 |
| CYTH3 | cytohesin 3 | 0.0420848 |
| APP | amyloid beta (A4) precursor protein | 0.0417576 |
| CENPF | centromere protein F, 350/400kDa | 0.0408457 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0407362 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0406939 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0399322 |
| FN1 | fibronectin 1 | 0.0396567 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0394525 |
| TMSB4X | thymosin beta 4, X-linked | 0.0394187 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0392935 |
| RNF213 | ring finger protein 213 | 0.0389077 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0388761 |
| SMAD3 | SMAD family member 3 | 0.0387546 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0386778 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.037416 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0373344 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0369326 |
| MB21D2 | Mab-21 domain containing 2 | 0.0366694 |
| DOCK5 | dedicator of cytokinesis 5 | 0.035927 |
| CDK6 | cyclin-dependent kinase 6 | 0.0359173 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0358935 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0357334 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0356649 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.035659 |
| CUX1 | cut-like homeobox 1 | 0.0355053 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0351976 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0348202 |
| KIAA1549L | KIAA1549-like | 0.0346789 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0346295 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0345239 |
| GSE1 | Gse1 coiled-coil protein | 0.0341517 |
| SMYD3 | SET and MYND domain containing 3 | 0.034016 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0335935 |
| RRM2 | ribonucleotide reductase M2 | 0.0334817 |
| DST | dystonin | 0.0327637 |
| NCKAP1 | NCK-associated protein 1 | 0.0323327 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0320011 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0318419 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0313888 |
| PRSS23 | protease, serine, 23 | 0.0313865 |
| GLIS3 | GLIS family zinc finger 3 | 0.0313386 |
| DCLK2 | doublecortin-like kinase 2 | 0.0312138 |
| CCND1 | cyclin D1 | 0.0311808 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0310944 |
| FNIP2 | folliculin interacting protein 2 | 0.030847 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.030557 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0300844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.187662 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.168027 |
| TMSB10 | thymosin beta 10 | -0.142614 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0890943 |
| FBN1 | fibrillin 1 | -0.0842309 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0743235 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0741276 |
| COL1A2 | collagen, type I, alpha 2 | -0.0645131 |
| VIM | vimentin | -0.0629923 |
| HLA-B | major histocompatibility complex, class I, B | -0.0567402 |
| LOXL2 | lysyl oxidase-like 2 | -0.0557364 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0557085 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0556909 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0527685 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0504551 |
| PTMA | prothymosin, alpha | -0.0497464 |
| NDRG1 | N-myc downstream regulated 1 | -0.0491938 |
| THBS2 | thrombospondin 2 | -0.048874 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0472283 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0470791 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0433593 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0323786 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0316979 |
| CANX | calnexin | -0.0315351 |
| S100A6 | S100 calcium binding protein A6 | -0.0314888 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0300825 |
| STC1 | stanniocalcin 1 | -0.0292966 |
| HLA-E | major histocompatibility complex, class I, E | -0.0287636 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0286979 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0278842 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0274419 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0272114 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0271008 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.026825 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.026344 |
| LOX | lysyl oxidase | -0.0261693 |
| FRMD5 | FERM domain containing 5 | -0.0261494 |
| INSIG1 | insulin induced gene 1 | -0.0259496 |
| GOLGA4 | golgin A4 | -0.0259132 |
| PRRX1 | paired related homeobox 1 | -0.0252522 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0247472 |
| CD99 | CD99 molecule | -0.0238024 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0235265 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0233276 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0232004 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0230289 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0229471 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0220318 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0219067 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0214747 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0211461 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0209357 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0205961 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0200857 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0197819 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0197226 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0197057 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0189397 |
| TMOD1 | tropomodulin 1 | -0.0188877 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0188442 |
| MEIS2 | Meis homeobox 2 | -0.0182754 |
| FTL | ferritin, light polypeptide | -0.0181542 |
| LRRC49 | leucine rich repeat containing 49 | -0.0181385 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0180744 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0176053 |
| MT2A | metallothionein 2A | -0.0175941 |
| SUCNR1 | succinate receptor 1 | -0.0175631 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0175174 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0173899 |
| NGLY1 | N-glycanase 1 | -0.0170675 |
| SBF2 | SET binding factor 2 | -0.0164697 |
| MMP12 | matrix metallopeptidase 12 | -0.0162239 |
| RAB1A | RAB1A, member RAS oncogene family | -0.016119 |
| RPL35A | ribosomal protein L35a | -0.01571 |
| AUTS2 | autism susceptibility candidate 2 | -0.0155693 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0154722 |
| GPC6 | glypican 6 | -0.0154423 |
| EGR1 | early growth response 1 | -0.015377 |
| SLFN5 | schlafen family member 5 | -0.015204 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0147796 |
| RRBP1 | ribosome binding protein 1 | -0.014757 |
| CD109 | CD109 molecule | -0.0147074 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0145327 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0144684 |
| SYT1 | synaptotagmin I | -0.0141444 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0140653 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0140269 |
| MAP4 | microtubule-associated protein 4 | -0.0139743 |
| S100A9 | S100 calcium binding protein A9 | -0.0138643 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0138458 |
| WTAP | Wilms tumor 1 associated protein | -0.0137993 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0137447 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0137444 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0137293 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0137233 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.013677 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0132464 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0132324 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0131486 |
| ANK2 | ankyrin 2, neuronal | -0.0130942 |
