| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.227799 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.185643 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.152867 |
| HMGA2 | high mobility group AT-hook 2 | 0.140941 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.132448 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.125576 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.122342 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.103477 |
| PCDH7 | protocadherin 7 | 0.103048 |
| DST | dystonin | 0.0985852 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0907656 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0831375 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0761012 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0750285 |
| ACTG1 | actin gamma 1 | 0.0750261 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0730293 |
| TENM3 | teneurin transmembrane protein 3 | 0.0699579 |
| MKI67 | marker of proliferation Ki-67 | 0.0688351 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0678112 |
| CCN2 | cellular communication network factor 2 | 0.0672875 |
| SMC4 | structural maintenance of chromosomes 4 | 0.066574 |
| YAP1 | Yes-associated protein 1 | 0.0663978 |
| MMP12 | matrix metallopeptidase 12 | 0.0640662 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0632693 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0612378 |
| RRM2 | ribonucleotide reductase M2 | 0.0598346 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0597575 |
| ADIPOR2 | adiponectin receptor 2 | 0.0579596 |
| ANXA1 | annexin A1 | 0.0577025 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.057211 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0565183 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0548366 |
| NHSL1 | NHS-like 1 | 0.0548211 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0519784 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0502585 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0489559 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0477127 |
| CLTC | clathrin, heavy chain (Hc) | 0.04765 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0470778 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0467695 |
| CMIP | c-Maf inducing protein | 0.0448856 |
| CENPF | centromere protein F, 350/400kDa | 0.0445523 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0443944 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0430326 |
| RASAL2 | RAS protein activator like 2 | 0.0426751 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0408339 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0402408 |
| CDK6 | cyclin-dependent kinase 6 | 0.0391849 |
| LOC112694756 | uncharaterized LOC112694756 | 0.039055 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0389179 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0389136 |
| VMP1 | vacuole membrane protein 1 | 0.038171 |
| LMO7 | LIM domain 7 | 0.0375126 |
| RPL3 | ribosomal protein L3 | 0.0372964 |
| CALR | calreticulin | 0.0364841 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0362141 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0361997 |
| EDARADD | EDAR-associated death domain | 0.0361151 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0360995 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0356081 |
| USP34 | ubiquitin specific peptidase 34 | 0.0355874 |
| PDGFC | platelet derived growth factor C | 0.0354502 |
| TUBB | tubulin, beta class I | 0.0354345 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0350021 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0348045 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0347802 |
| MTAP | methylthioadenosine phosphorylase | 0.0347393 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0346792 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0342641 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0341947 |
| TPI1 | triosephosphate isomerase 1 | 0.0341535 |
| FUS | FUS RNA binding protein | 0.0338681 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0337657 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0333903 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.033383 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0331679 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0327365 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0326658 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.032243 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0322112 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.032199 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0321416 |
| DIAPH3 | diaphanous-related formin 3 | 0.0321081 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0321065 |
| ECT2 | epithelial cell transforming 2 | 0.0320632 |
| IPO7 | importin 7 | 0.0316267 |
| ZNF804A | zinc finger protein 804A | 0.0315198 |
| WWOX | WW domain containing oxidoreductase | 0.0312763 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0300939 |
| CCND1 | cyclin D1 | 0.0300903 |
| SPAG9 | sperm associated antigen 9 | 0.0299064 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0297869 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0293036 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.029082 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0290628 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0290389 |
| BRD2 | bromodomain containing 2 | 0.0290144 |
| AREG | amphiregulin | 0.0289677 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0286858 |
| TPX2 | TPX2, microtubule-associated | 0.0284071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS27A | ribosomal protein S27a | -0.0486136 |
| PTMA | prothymosin, alpha | -0.0370187 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0302783 |
| VIM | vimentin | -0.0267612 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0255914 |
| TMSB10 | thymosin beta 10 | -0.0245399 |
| EHBP1 | EH domain binding protein 1 | -0.0240165 |
| UBC | ubiquitin C | -0.0227537 |
| RPS8 | ribosomal protein S8 | -0.0226591 |
| YEATS2 | YEATS domain containing 2 | -0.0222225 |
| SESN2 | sestrin 2 | -0.0218494 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0188241 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0180268 |
| ZNF292 | zinc finger protein 292 | -0.0179836 |
| KLHL24 | kelch-like family member 24 | -0.0166532 |
| RPS19 | ribosomal protein S19 | -0.0161027 |
| RPS13 | ribosomal protein S13 | -0.0160323 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0159058 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0157939 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -0.0155998 |
| RPL9 | ribosomal protein L9 | -0.0155495 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0154905 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0154812 |
| RBM27 | RNA binding motif protein 27 | -0.0154594 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0150658 |
| S100A6 | S100 calcium binding protein A6 | -0.0145713 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0144839 |
| RPL23 | ribosomal protein L23 | -0.0138698 |
| PREPL | prolyl endopeptidase-like | -0.0138614 |
| ANK2 | ankyrin 2, neuronal | -0.0137477 |
| RPL31 | ribosomal protein L31 | -0.0136301 |
| NCK1 | NCK adaptor protein 1 | -0.0134225 |
| PHF3 | PHD finger protein 3 | -0.0130478 |
| SNX14 | sorting nexin 14 | -0.0129796 |
| RPS3 | ribosomal protein S3 | -0.0127797 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0126764 |
| PLPP1 | phospholipid phosphatase 1 | -0.0125367 |
| FTL | ferritin, light polypeptide | -0.0124572 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0124506 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0123921 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0122253 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0121313 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0121226 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0119651 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0117829 |
| RAB30 | RAB30, member RAS oncogene family | -0.0116919 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0115824 |
| CACUL1 | CDK2-associated, cullin domain 1 | -0.0115653 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0114942 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0114267 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0113701 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0113202 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0110257 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0110078 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0109217 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0108316 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0106241 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0105887 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0104458 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.010427 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0103833 |
| VGLL4 | vestigial-like family member 4 | -0.0103441 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.0103137 |
| NUP54 | nucleoporin 54kDa | -0.0102614 |
| YY1AP1 | YY1 associated protein 1 | -0.0102513 |
| CFDP1 | craniofacial development protein 1 | -0.0102248 |
| REST | RE1-silencing transcription factor | -0.0101302 |
| FBXO11 | F-box protein 11 | -0.0100897 |
| RPL37A | ribosomal protein L37a | -0.010039 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0100343 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.00995355 |
| TRIM33 | tripartite motif containing 33 | -0.00994443 |
| RYK | receptor-like tyrosine kinase | -0.00994101 |
| NKTR | natural killer cell triggering receptor | -0.00986489 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.00986153 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00973207 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.00970515 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.00970293 |
| NDRG1 | N-myc downstream regulated 1 | -0.00968729 |
| RPL30 | ribosomal protein L30 | -0.00968036 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.00967665 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00966871 |
| RNF130 | ring finger protein 130 | -0.00966011 |
| PTEN | phosphatase and tensin homolog | -0.00963932 |
| ARRDC3 | arrestin domain containing 3 | -0.00958258 |
| TLK1 | tousled-like kinase 1 | -0.00954336 |
| DDX19B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B | -0.0095357 |
| RPL12 | ribosomal protein L12 | -0.00946515 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0093626 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.00921997 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00921298 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.00916624 |
| RPS16 | ribosomal protein S16 | -0.00914332 |
| RPS12 | ribosomal protein S12 | -0.00912936 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.00903937 |
| RPL37 | ribosomal protein L37 | -0.00903253 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00902801 |
| MED23 | mediator complex subunit 23 | -0.00899505 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.00896469 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0089347 |
