| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.128665 |
| SMAD3 | SMAD family member 3 | 0.128392 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.101144 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0936542 |
| CA12 | carbonic anhydrase XII | 0.0812046 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.080665 |
| FLNB | filamin B, beta | 0.0794548 |
| FAM107B | family with sequence similarity 107, member B | 0.0753633 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0745262 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0707082 |
| VIM | vimentin | 0.0707009 |
| ASPH | aspartate beta-hydroxylase | 0.0670527 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0651486 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0579821 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0578181 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0562529 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0562069 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0545627 |
| AHNAK | AHNAK nucleoprotein | 0.0530447 |
| EFNA5 | ephrin-A5 | 0.0516225 |
| PLEC | plectin | 0.0516144 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0508856 |
| LAMC2 | laminin, gamma 2 | 0.0503433 |
| LOC112694756 | uncharaterized LOC112694756 | 0.049749 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0494801 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0476525 |
| ANXA2 | annexin A2 | 0.0473396 |
| ACTG1 | actin gamma 1 | 0.046462 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0462772 |
| EGFR | epidermal growth factor receptor | 0.0455152 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0440665 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0431546 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0427525 |
| LDHA | lactate dehydrogenase A | 0.0420661 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0414935 |
| MYO10 | myosin X | 0.0395471 |
| MCL1 | myeloid cell leukemia 1 | 0.0393457 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0382116 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0381355 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0376232 |
| UBC | ubiquitin C | 0.0375069 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0368478 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0361123 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0357292 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0351234 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.034553 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0344146 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.034357 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0342128 |
| PRELID2 | PRELI domain containing 2 | 0.033674 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0335192 |
| MYOF | myoferlin | 0.0334115 |
| TXNRD1 | thioredoxin reductase 1 | 0.0333765 |
| RPS2 | ribosomal protein S2 | 0.0332956 |
| PDE10A | phosphodiesterase 10A | 0.0328225 |
| CD44 | CD44 molecule (Indian blood group) | 0.0326412 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0322223 |
| MYO1E | myosin IE | 0.0319396 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0317477 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0316299 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0315935 |
| PGK1 | phosphoglycerate kinase 1 | 0.0314355 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0313729 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0307672 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0307323 |
| HIP1 | huntingtin interacting protein 1 | 0.0305633 |
| FLNA | filamin A, alpha | 0.0304784 |
| RPL7 | ribosomal protein L7 | 0.0301671 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0297884 |
| SMYD3 | SET and MYND domain containing 3 | 0.0297272 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0294968 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0291241 |
| APP | amyloid beta (A4) precursor protein | 0.0287057 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0286611 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282275 |
| SET | SET nuclear proto-oncogene | 0.0281588 |
| FA2H | fatty acid 2-hydroxylase | 0.0280375 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0275073 |
| MSN | moesin | 0.0274253 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.027348 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0269236 |
| ANXA4 | annexin A4 | 0.0266504 |
| TMSB4X | thymosin beta 4, X-linked | 0.0266284 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0265462 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0264617 |
| SQSTM1 | sequestosome 1 | 0.026394 |
| NGLY1 | N-glycanase 1 | 0.0261506 |
| RPL37 | ribosomal protein L37 | 0.0259611 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0258519 |
| SPAG9 | sperm associated antigen 9 | 0.0255155 |
| PDE8A | phosphodiesterase 8A | 0.0255065 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0254521 |
| NAV2 | neuron navigator 2 | 0.0254132 |
| KLF6 | Kruppel-like factor 6 | 0.0253729 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0252862 |
| RPS3 | ribosomal protein S3 | 0.0252412 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0249943 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0248885 |
| GRAMD1B | GRAM domain containing 1B | 0.0246373 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0245825 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | -0.120076 |
| TMSB10 | thymosin beta 10 | -0.118422 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0685057 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0597828 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0546523 |
| RPS19 | ribosomal protein S19 | -0.0427829 |
| PFN1 | profilin 1 | -0.0367773 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0358279 |
| EGR1 | early growth response 1 | -0.0304497 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0285084 |
| HMGA1 | high mobility group AT-hook 1 | -0.0278056 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0244204 |
| RPL35A | ribosomal protein L35a | -0.0243207 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0209737 |
| LAMA5 | laminin, alpha 5 | -0.0204875 |
| USP3 | ubiquitin specific peptidase 3 | -0.0203898 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0191688 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0190584 |
| HELZ | helicase with zinc finger | -0.0186041 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0181228 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0176715 |
| RPS29 | ribosomal protein S29 | -0.0168574 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0166067 |
| USP15 | ubiquitin specific peptidase 15 | -0.0165264 |
| FTL | ferritin, light polypeptide | -0.0165055 |
| BSG | basigin (Ok blood group) | -0.0163503 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0160793 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0156387 |
| CLINT1 | clathrin interactor 1 | -0.014849 |
| USP47 | ubiquitin specific peptidase 47 | -0.0140351 |
| VMP1 | vacuole membrane protein 1 | -0.0140068 |
| QKI | QKI, KH domain containing, RNA binding | -0.0139466 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0138584 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0134357 |
| MYADM | myeloid-associated differentiation marker | -0.0132546 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.013244 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0128915 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0128037 |
| MORF4L2 | mortality factor 4 like 2 | -0.0126482 |
| NF1 | neurofibromin 1 | -0.0125014 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0121458 |
| RPLP2 | ribosomal protein, large, P2 | -0.0120912 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0117433 |
| NABP1 | nucleic acid binding protein 1 | -0.011738 |
| NTN4 | netrin 4 | -0.011282 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0112343 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0111959 |
| SAP30BP | SAP30 binding protein | -0.0109269 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0108559 |
| SP100 | SP100 nuclear antigen | -0.0107837 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.010734 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0107045 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.010657 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0106215 |
| RPL28 | ribosomal protein L28 | -0.0105784 |
| GOLGB1 | golgin B1 | -0.0105407 |
| UBAP1 | ubiquitin associated protein 1 | -0.0105276 |
| TBK1 | TANK-binding kinase 1 | -0.0103499 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0102841 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | -0.0102835 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0102666 |
| PALLD | palladin, cytoskeletal associated protein | -0.0101775 |
| PGM3 | phosphoglucomutase 3 | -0.0101212 |
| ZFP36 | ZFP36 ring finger protein | -0.00990806 |
| YAF2 | YY1 associated factor 2 | -0.00986953 |
| CDV3 | CDV3 homolog (mouse) | -0.00982582 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.00978431 |
| FOSL1 | FOS-like antigen 1 | -0.00977271 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.00972649 |
| TMEM87A | transmembrane protein 87A | -0.0097098 |
| TRIB1 | tribbles pseudokinase 1 | -0.00954768 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.00951858 |
| SIK3 | SIK family kinase 3 | -0.00943657 |
| RHCG | Rh family, C glycoprotein | -0.00933924 |
| TUBB | tubulin, beta class I | -0.00933302 |
| AGO3 | argonaute RISC catalytic component 3 | -0.00931877 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00924945 |
| RPLP1 | ribosomal protein, large, P1 | -0.00923665 |
| SEC24A | SEC24 family member A | -0.00914223 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.00909349 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00908795 |
| ABLIM1 | actin binding LIM protein 1 | -0.00906755 |
| HM13 | histocompatibility (minor) 13 | -0.00898635 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.00895042 |
| COG6 | component of oligomeric golgi complex 6 | -0.00894591 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.00887273 |
| BMS1 | BMS1 ribosome biogenesis factor | -0.00880965 |
| CRY1 | cryptochrome circadian clock 1 | -0.00880465 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00879135 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.00872418 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.00871677 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.00869877 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.00860924 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.00859086 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -0.00858926 |
| ATXN2L | ataxin 2-like | -0.00858464 |
| EVI5 | ecotropic viral integration site 5 | -0.0085844 |
| RSPO3 | R-spondin 3 | -0.00855947 |
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | -0.00851463 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.00851437 |
