| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.174364 |
| CEP250 | centrosomal protein 250kDa | 0.14331 |
| RPL19 | ribosomal protein L19 | 0.124542 |
| CLTC | clathrin, heavy chain (Hc) | 0.117722 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.101681 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0968764 |
| CDK12 | cyclin-dependent kinase 12 | 0.0966524 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0865115 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0841408 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0804362 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0739736 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0733527 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0725947 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0708363 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0677329 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0675643 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0673575 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0667529 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0667325 |
| RPL23 | ribosomal protein L23 | 0.0661167 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0628344 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0616933 |
| AHNAK | AHNAK nucleoprotein | 0.0614741 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0604873 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0602886 |
| SHROOM3 | shroom family member 3 | 0.0600651 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0598089 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0595838 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0585255 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.055806 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0555909 |
| INTS6 | integrator complex subunit 6 | 0.0552955 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0546841 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0517838 |
| RUNX1 | runt-related transcription factor 1 | 0.0504247 |
| PTK2 | protein tyrosine kinase 2 | 0.0502359 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0501807 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.050131 |
| ATXN1 | ataxin 1 | 0.0499929 |
| PLEC | plectin | 0.0493304 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.049302 |
| DUSP16 | dual specificity phosphatase 16 | 0.0489558 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0483938 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0467839 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0462339 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0456801 |
| DSPP | dentin sialophosphoprotein | 0.0455086 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0454876 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.0446899 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0439953 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0431002 |
| YAP1 | Yes-associated protein 1 | 0.0430264 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0422353 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.041956 |
| MYOF | myoferlin | 0.0417509 |
| NEBL | nebulette | 0.041531 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0415177 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0415049 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0414355 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.0410064 |
| RPL3 | ribosomal protein L3 | 0.0407471 |
| SMYD3 | SET and MYND domain containing 3 | 0.0405996 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0403479 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0401673 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0400553 |
| VCP | valosin containing protein | 0.0387896 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0385748 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.03841 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0383811 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0377986 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0374964 |
| ENAH | enabled homolog (Drosophila) | 0.0373874 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0364587 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0363994 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0363097 |
| ACSF2 | acyl-CoA synthetase family member 2 | 0.0362667 |
| MYO10 | myosin X | 0.0359135 |
| AEBP2 | AE binding protein 2 | 0.03575 |
| FAM168A | family with sequence similarity 168, member A | 0.0353521 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.0343925 |
| SEPTIN9 | septin 9 | 0.0337656 |
| RBM33 | RNA binding motif protein 33 | 0.0335372 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0331726 |
| PRLR | prolactin receptor | 0.0325815 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0323805 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0321841 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0321619 |
| SGMS1 | sphingomyelin synthase 1 | 0.0321475 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0320048 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0319158 |
| PRKCA | protein kinase C, alpha | 0.0317596 |
| FLNA | filamin A, alpha | 0.0315818 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0313363 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0310092 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0308638 |
| MSI2 | musashi RNA-binding protein 2 | 0.0308184 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0307185 |
| FAM219A | family with sequence similarity 219, member A | 0.0304444 |
| FOXN3 | forkhead box N3 | 0.0303146 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0302686 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | -0.100285 |
| PTMA | prothymosin, alpha | -0.0682606 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0477611 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0466103 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.042453 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0423842 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0414027 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0403089 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0402536 |
| S100A8 | S100 calcium binding protein A8 | -0.0397773 |
| RPL35A | ribosomal protein L35a | -0.0395626 |
| TMSB10 | thymosin beta 10 | -0.0381491 |
| B2M | beta-2-microglobulin | -0.0380106 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0368067 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0361511 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0356505 |
| S100A9 | S100 calcium binding protein A9 | -0.0329339 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0328132 |
| FTL | ferritin, light polypeptide | -0.0319824 |
| S100A6 | S100 calcium binding protein A6 | -0.0311788 |
| RPL12 | ribosomal protein L12 | -0.0310991 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0308021 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0299264 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0295239 |
| TMEM41B | transmembrane protein 41B | -0.0284074 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0279969 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0279163 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0267268 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0266768 |
| MIEN1 | migration and invasion enhancer 1 | -0.0265934 |
| RPL34 | ribosomal protein L34 | -0.0252587 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0250105 |
| RPL31 | ribosomal protein L31 | -0.0249411 |
| RPL9 | ribosomal protein L9 | -0.0247888 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0247254 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0242066 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.023598 |
| AREG | amphiregulin | -0.0234326 |
| DSTN | destrin (actin depolymerizing factor) | -0.0230866 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0225209 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0224935 |
| S100A14 | S100 calcium binding protein A14 | -0.0224215 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0224166 |
| TMEM165 | transmembrane protein 165 | -0.0218755 |
| GATA3 | GATA binding protein 3 | -0.0214939 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0213792 |
| TMC5 | transmembrane channel-like 5 | -0.0213675 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0210651 |
| LDLR | low density lipoprotein receptor | -0.0210279 |
| S100A7 | S100 calcium binding protein A7 | -0.0209291 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0208852 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0204045 |
| RPS8 | ribosomal protein S8 | -0.0204035 |
| RTN4 | reticulon 4 | -0.0204016 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0203059 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0201331 |
| EGR1 | early growth response 1 | -0.0199459 |
| CCNI | cyclin I | -0.0197775 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0197389 |
| CD44 | CD44 molecule (Indian blood group) | -0.0194854 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0194744 |
| TPM4 | tropomyosin 4 | -0.019408 |
| HLA-B | major histocompatibility complex, class I, B | -0.0192208 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0189164 |
| PCBP2 | poly(rC) binding protein 2 | -0.0187929 |
| PERP | PERP, TP53 apoptosis effector | -0.0187744 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0186828 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0184769 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.018431 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0184186 |
| FDPS | farnesyl diphosphate synthase | -0.0180739 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0179502 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0177057 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0176932 |
| CD63 | CD63 molecule | -0.0176524 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0174782 |
| FHL2 | four and a half LIM domains 2 | -0.0173132 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0172722 |
| MT2A | metallothionein 2A | -0.017226 |
| IER3 | immediate early response 3 | -0.0171922 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.016794 |
| TPM1 | tropomyosin 1 (alpha) | -0.0166449 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0166364 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0165879 |
| HLA-C | major histocompatibility complex, class I, C | -0.0164897 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0163943 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0163544 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0162677 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0162448 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.0160432 |
| HLA-E | major histocompatibility complex, class I, E | -0.015605 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0155932 |
| ANXA3 | annexin A3 | -0.0155581 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0155325 |
| VIM | vimentin | -0.0152915 |
| KITLG | KIT ligand | -0.0152702 |
| CFB | complement factor B | -0.0151698 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0151133 |
| CBX3 | chromobox homolog 3 | -0.0150691 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0150213 |
