| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LOC112694756 | uncharaterized LOC112694756 | 0.158617 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.107804 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.105413 |
| VGF | VGF nerve growth factor inducible | 0.0936983 |
| DST | dystonin | 0.0919092 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0817086 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0770249 |
| MACROD2 | MACRO domain containing 2 | 0.0698444 |
| EXOC4 | exocyst complex component 4 | 0.0635623 |
| RNF213 | ring finger protein 213 | 0.0629915 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.058865 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0570244 |
| NAV1 | neuron navigator 1 | 0.0559022 |
| PLEC | plectin | 0.0534685 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0528637 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0509918 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0503966 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0487391 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0478391 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0471267 |
| CABIN1 | calcineurin binding protein 1 | 0.0459236 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0442366 |
| FLNA | filamin A, alpha | 0.0440531 |
| AHNAK | AHNAK nucleoprotein | 0.0434713 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0429128 |
| SETBP1 | SET binding protein 1 | 0.0423655 |
| TSC22D1 | TSC22 domain family, member 1 | 0.04223 |
| RPL3 | ribosomal protein L3 | 0.0419724 |
| ACTN1 | actinin, alpha 1 | 0.041833 |
| LMNA | lamin A/C | 0.0414677 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0412569 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0408843 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0408783 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0406515 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0394975 |
| PKM | pyruvate kinase, muscle | 0.039305 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0392586 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0388785 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0387788 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0386705 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0386678 |
| FLNB | filamin B, beta | 0.0385345 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.038187 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0376762 |
| ACTN4 | actinin, alpha 4 | 0.0373038 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0370852 |
| MT2A | metallothionein 2A | 0.036595 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0363321 |
| ATP11A | ATPase, class VI, type 11A | 0.035974 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0355193 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0351276 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0351253 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0350756 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0344407 |
| NRP2 | neuropilin 2 | 0.0344272 |
| SEPTIN9 | septin 9 | 0.0341028 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0339931 |
| BRD2 | bromodomain containing 2 | 0.0339795 |
| CD44 | CD44 molecule (Indian blood group) | 0.0339119 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0332082 |
| APP | amyloid beta (A4) precursor protein | 0.0329633 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.032961 |
| UTRN | utrophin | 0.0325883 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0316367 |
| GAS7 | growth arrest-specific 7 | 0.0312066 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0310749 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0309138 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0308963 |
| ARRDC3 | arrestin domain containing 3 | 0.0304157 |
| LAMB1 | laminin, beta 1 | 0.0301119 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0294438 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0292835 |
| ATXN1 | ataxin 1 | 0.029258 |
| AFAP1 | actin filament associated protein 1 | 0.0288156 |
| MSN | moesin | 0.0286858 |
| SMYD3 | SET and MYND domain containing 3 | 0.0286518 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0286268 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0285734 |
| SMAD3 | SMAD family member 3 | 0.0284148 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0281563 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0280567 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0277168 |
| TMEM178B | transmembrane protein 178B | 0.0275489 |
| GSN | gelsolin | 0.027304 |
| WWOX | WW domain containing oxidoreductase | 0.0272347 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0271998 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0268091 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0267412 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.026649 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0266246 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0265506 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0264023 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0263748 |
| MCL1 | myeloid cell leukemia 1 | 0.0254197 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0253568 |
| FRMD4A | FERM domain containing 4A | 0.0252381 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0250614 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0250345 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.024628 |
| FBXO7 | F-box protein 7 | 0.0245962 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0966688 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0947293 |
| FN1 | fibronectin 1 | -0.0937237 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0832535 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0819544 |
| GDF15 | growth differentiation factor 15 | -0.0705764 |
| TMEM123 | transmembrane protein 123 | -0.0650505 |
| TMSB10 | thymosin beta 10 | -0.0564714 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.047083 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0469497 |
| PTMA | prothymosin, alpha | -0.0466537 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0437916 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0411227 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0405593 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0386916 |
| ZNF292 | zinc finger protein 292 | -0.03794 |
| ITGB8 | integrin, beta 8 | -0.0376648 |
| PHF21A | PHD finger protein 21A | -0.0350069 |
| CANX | calnexin | -0.0341238 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0330059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0317842 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0316878 |
| OXR1 | oxidation resistance 1 | -0.0311739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0307368 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0304094 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0301786 |
| SCFD2 | sec1 family domain containing 2 | -0.0294573 |
| RPL35A | ribosomal protein L35a | -0.029062 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0280515 |
| SBF2 | SET binding factor 2 | -0.0279711 |
| CDC73 | cell division cycle 73 | -0.0279344 |
| DCT | dopachrome tautomerase | -0.0277773 |
| S100A6 | S100 calcium binding protein A6 | -0.0276494 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0267099 |
| HELZ | helicase with zinc finger | -0.026606 |
| PLIN2 | perilipin 2 | -0.0265235 |
| GHR | growth hormone receptor | -0.0250392 |
| HBP1 | HMG-box transcription factor 1 | -0.0249774 |
| S100A9 | S100 calcium binding protein A9 | -0.0245752 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0239897 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0239446 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.023847 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0236934 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.023569 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0234932 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0229769 |
| ENO1 | enolase 1, (alpha) | -0.0228076 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0227686 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0227128 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0226136 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0225667 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0223432 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0221663 |
| PGK1 | phosphoglycerate kinase 1 | -0.0220557 |
| RNF145 | ring finger protein 145 | -0.0219573 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0218521 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0217721 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.021167 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.021131 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0208658 |
| TRIM2 | tripartite motif containing 2 | -0.0207683 |
| NPR2 | natriuretic peptide receptor 2 | -0.0205997 |
| HLA-A | major histocompatibility complex, class I, A | -0.0205389 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0205127 |
| ATF4 | activating transcription factor 4 | -0.0197579 |
| UBE3C | ubiquitin protein ligase E3C | -0.0195346 |
| PUM2 | pumilio RNA-binding family member 2 | -0.01948 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.0194617 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0193092 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.019092 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0189978 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0189666 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0184941 |
| BBX | bobby sox homolog (Drosophila) | -0.0183678 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0182909 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0182562 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0180424 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0179636 |
| INSYN2B | inhibitory synaptic factor family member 2B | -0.0174407 |
| PNLIPRP3 | pancreatic lipase-related protein 3 | -0.0173504 |
| MEF2A | myocyte enhancer factor 2A | -0.0171626 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0169932 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | -0.0168916 |
| PTCHD4 | patched domain containing 4 | -0.0167844 |
| GPC6 | glypican 6 | -0.0167672 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.016722 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.016581 |
| TNPO3 | transportin 3 | -0.0165734 |
| NEK7 | NIMA-related kinase 7 | -0.0165161 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0163122 |
| CERT1 | ceramide transporter 1 | -0.0162414 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0161989 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0160964 |
| RPLP1 | ribosomal protein, large, P1 | -0.0158561 |
| PRAME | preferentially expressed antigen in melanoma | -0.0156031 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0155909 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0154829 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0154127 |
| CENPF | centromere protein F, 350/400kDa | -0.0151655 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0149941 |
