| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lidocaine (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.245731 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.127544 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.110865 |
| KYNU | kynureninase | 0.103017 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0978869 |
| PLEC | plectin | 0.0939166 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0858376 |
| LOX | lysyl oxidase | 0.074532 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0730426 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0711863 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0704458 |
| COL5A1 | collagen, type V, alpha 1 | 0.0622912 |
| NAV2 | neuron navigator 2 | 0.0601814 |
| H1-4 | H1.4 linker histone, cluster member | 0.0587325 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0584304 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0575811 |
| FLNA | filamin A, alpha | 0.0562072 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0561433 |
| NLGN1 | neuroligin 1 | 0.0548409 |
| CD44 | CD44 molecule (Indian blood group) | 0.0544139 |
| SQSTM1 | sequestosome 1 | 0.0537789 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0534416 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0516272 |
| APP | amyloid beta (A4) precursor protein | 0.0508839 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0504816 |
| FN1 | fibronectin 1 | 0.0504564 |
| TNS3 | tensin 3 | 0.0493184 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0483964 |
| DST | dystonin | 0.0469194 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0461222 |
| ASPH | aspartate beta-hydroxylase | 0.0459491 |
| WWOX | WW domain containing oxidoreductase | 0.0457684 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0456498 |
| PKM | pyruvate kinase, muscle | 0.0455544 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.04504 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0446817 |
| LDHA | lactate dehydrogenase A | 0.0442072 |
| FTL | ferritin, light polypeptide | 0.044157 |
| NAV1 | neuron navigator 1 | 0.0437011 |
| RUNX1 | runt-related transcription factor 1 | 0.043361 |
| RPL3 | ribosomal protein L3 | 0.042717 |
| INTS6 | integrator complex subunit 6 | 0.0415642 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0414993 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0410924 |
| TPI1 | triosephosphate isomerase 1 | 0.0409211 |
| MKI67 | marker of proliferation Ki-67 | 0.0404767 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0391223 |
| RACK1 | receptor for activated C kinase 1 | 0.0391018 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0376958 |
| FLNB | filamin B, beta | 0.0369592 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0367113 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0366846 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0364108 |
| SEPTIN9 | septin 9 | 0.0361311 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0354449 |
| FSTL1 | follistatin-like 1 | 0.0352016 |
| MYO10 | myosin X | 0.034658 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0346399 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0345952 |
| ECE1 | endothelin converting enzyme 1 | 0.0344386 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0342631 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0339266 |
| FNIP1 | folliculin interacting protein 1 | 0.0337606 |
| CALN1 | calneuron 1 | 0.0337544 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.033738 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.033477 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0333136 |
| AHNAK | AHNAK nucleoprotein | 0.0328005 |
| MCL1 | myeloid cell leukemia 1 | 0.0322272 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0321678 |
| DIAPH3 | diaphanous-related formin 3 | 0.0319862 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0319293 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0316781 |
| H1-5 | H1.5 linker histone, cluster member | 0.0313471 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0312072 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0311998 |
| ANLN | anillin, actin binding protein | 0.0311946 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0310536 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0309941 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0305455 |
| PTK2 | protein tyrosine kinase 2 | 0.0304433 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.030248 |
| H1-10 | H1.10 linker histone | 0.02996 |
| RPS4X | ribosomal protein S4, X-linked | 0.0298058 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0297211 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0296859 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0294804 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0292267 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0292181 |
| RPLP0 | ribosomal protein, large, P0 | 0.0291847 |
| HIP1 | huntingtin interacting protein 1 | 0.0291494 |
| RPS3 | ribosomal protein S3 | 0.0288081 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0288024 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0286217 |
| NCKAP1 | NCK-associated protein 1 | 0.0285548 |
| C1S | complement component 1, s subcomponent | 0.028553 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0283839 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0282282 |
| RPL23 | ribosomal protein L23 | 0.0282193 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0280297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.171091 |
| TMSB10 | thymosin beta 10 | -0.108272 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.105605 |
| VIM | vimentin | -0.0802262 |
| SBF2 | SET binding factor 2 | -0.0643143 |
| NDRG1 | N-myc downstream regulated 1 | -0.0490105 |
| TPM4 | tropomyosin 4 | -0.0473259 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0436807 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0355093 |
| RPL35A | ribosomal protein L35a | -0.0340473 |
| COG5 | component of oligomeric golgi complex 5 | -0.0315561 |
| GOLGA4 | golgin A4 | -0.0315555 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.031236 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0309073 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0306157 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0290053 |
| HMGA1 | high mobility group AT-hook 1 | -0.0286683 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0279505 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0279129 |
| GOLGB1 | golgin B1 | -0.0276572 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0265783 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0264264 |
| TNNC1 | troponin C type 1 (slow) | -0.025796 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0253016 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0252416 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.024631 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0246053 |
| ATP13A3 | ATPase type 13A3 | -0.0245383 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0245253 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0237983 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0237778 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0237554 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0235651 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0235202 |
| CALD1 | caldesmon 1 | -0.0233817 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0232187 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0231236 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0229633 |
| PCNX4 | pecanex 4 | -0.022488 |
| NUCB2 | nucleobindin 2 | -0.0222044 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | -0.0217673 |
| SCFD2 | sec1 family domain containing 2 | -0.0215194 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0210053 |
| FAF2 | Fas associated factor family member 2 | -0.0206815 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0204994 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0202176 |
| CADM1 | cell adhesion molecule 1 | -0.0201315 |
| ATM | ATM serine/threonine kinase | -0.0197138 |
| SMARCAD1 | SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 | -0.01967 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0195992 |
| S100A6 | S100 calcium binding protein A6 | -0.0192401 |
| MAP1B | microtubule-associated protein 1B | -0.0190961 |
| LRRC49 | leucine rich repeat containing 49 | -0.0189116 |
| ZNF652 | zinc finger protein 652 | -0.0188655 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181788 |
| IL7R | interleukin 7 receptor | -0.0180309 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0179634 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0178875 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0177653 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0177195 |
| GNAS | GNAS complex locus | -0.0176803 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0175645 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0174777 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0173921 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0172971 |
| GOLGA2 | golgin A2 | -0.0172274 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0171064 |
| TMEM263 | transmembrane protein 263 | -0.0169722 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0169645 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0168991 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0168552 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0167651 |
| MMP12 | matrix metallopeptidase 12 | -0.0165408 |
| TMSB4X | thymosin beta 4, X-linked | -0.0164965 |
| TMEM39A | transmembrane protein 39A | -0.0164608 |
| ATN1 | atrophin 1 | -0.016358 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0163053 |
| HLA-B | major histocompatibility complex, class I, B | -0.0162618 |
| SEPTIN7 | septin 7 | -0.0161389 |
| USP47 | ubiquitin specific peptidase 47 | -0.016125 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0159646 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0159595 |
| ZNF432 | zinc finger protein 432 | -0.0159256 |
| SRP54 | signal recognition particle 54kDa | -0.0158442 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0158359 |
| WASF2 | WAS protein family, member 2 | -0.0156766 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0153663 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0152811 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.015212 |
| CLMP | CXADR-like membrane protein | -0.0151672 |
| MYO9A | myosin IXA | -0.0150751 |
| INSIG2 | insulin induced gene 2 | -0.0150469 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0150442 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0149225 |
| CIRSR | corepressor of RBPJ and splicing regulator | -0.0148056 |
| HM13 | histocompatibility (minor) 13 | -0.0147927 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0147552 |
| TCF12 | transcription factor 12 | -0.0146023 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0145503 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0145426 |
