Lidocaine (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.161796
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.151254
AHNAK AHNAK nucleoprotein 0.140265
LOC112694756 uncharaterized LOC112694756 0.132358
MYH9 myosin, heavy chain 9, non-muscle 0.0946371
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.087968
PKM pyruvate kinase, muscle 0.0792458
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0789671
EEF2 eukaryotic translation elongation factor 2 0.067109
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0632243
FLNA filamin A, alpha 0.0615926
RRM2 ribonucleotide reductase M2 0.0564658
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0560981
H1-4 H1.4 linker histone, cluster member 0.0556409
WWOX WW domain containing oxidoreductase 0.0556104
APLP2 amyloid beta (A4) precursor-like protein 2 0.0544477
MKI67 marker of proliferation Ki-67 0.0536211
HSPA8 heat shock 70kDa protein 8 0.0525095
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0515072
RPL3 ribosomal protein L3 0.0509932
INTS6 integrator complex subunit 6 0.0500385
PLEC plectin 0.0494817
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0479544
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0477905
LDHA lactate dehydrogenase A 0.0460467
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0459112
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0452541
FHIT fragile histidine triad 0.0441242
TENM3 teneurin transmembrane protein 3 0.0428197
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0417292
MACF1 microtubule-actin crosslinking factor 1 0.0412798
SMYD3 SET and MYND domain containing 3 0.0406071
KRT18 keratin 18, type I 0.0402355
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0401351
KTN1 kinectin 1 (kinesin receptor) 0.0398514
TPM3 tropomyosin 3 0.039474
ENO1 enolase 1, (alpha) 0.039228
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0391296
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0389607
CTBP2 C-terminal binding protein 2 0.0388275
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0386089
HDLBP high density lipoprotein binding protein 0.0381928
CENPF centromere protein F, 350/400kDa 0.0378662
SFPQ splicing factor proline/glutamine-rich 0.0376491
TPI1 triosephosphate isomerase 1 0.0372977
TBC1D5 TBC1 domain family, member 5 0.0370155
EZR ezrin 0.0358457
DSPP dentin sialophosphoprotein 0.0354746
DDIT4 DNA-damage-inducible transcript 4 0.0344935
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0344448
ZSWIM6 zinc finger, SWIM-type containing 6 0.0341401
MED13L mediator complex subunit 13-like 0.0339824
SAMD4A sterile alpha motif domain containing 4A 0.0336733
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0335147
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0328818
ATXN1 ataxin 1 0.0328814
TBC1D22A TBC1 domain family, member 22A 0.0327004
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0323819
ASPH aspartate beta-hydroxylase 0.032226
TRIO trio Rho guanine nucleotide exchange factor 0.0321884
MCL1 myeloid cell leukemia 1 0.031944
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0317872
CEMIP2 cell migration inducing hyaluronidase 2 0.0317151
SBF2 SET binding factor 2 0.0316199
TRAPPC9 trafficking protein particle complex 9 0.0315875
ZFAND3 zinc finger, AN1-type domain 3 0.0315478
SLC38A2 solute carrier family 38, member 2 0.0309529
SET SET nuclear proto-oncogene 0.0307051
EIF4H eukaryotic translation initiation factor 4H 0.0303582
WAC WW domain containing adaptor with coiled-coil 0.0303538
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0300385
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0300011
RUNX1 runt-related transcription factor 1 0.0298262
NQO1 NAD(P)H dehydrogenase, quinone 1 0.029787
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0295843
EGFR epidermal growth factor receptor 0.0288702
RNF213 ring finger protein 213 0.0285274
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283357
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0279939
MSI2 musashi RNA-binding protein 2 0.0279244
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0277424
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0277168
PCM1 pericentriolar material 1 0.027667
POTEF POTE ankyrin domain family, member F 0.0275804
USP34 ubiquitin specific peptidase 34 0.0271763
BRD2 bromodomain containing 2 0.0270807
FLNB filamin B, beta 0.0269904
NCKAP1 NCK-associated protein 1 0.026646
HELLS helicase, lymphoid-specific 0.0266456
KDM4C lysine (K)-specific demethylase 4C 0.0265779
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0265731
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0261365
TUBB4B tubulin, beta 4B class IVb 0.0260252
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0259666
APP amyloid beta (A4) precursor protein 0.0258722
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0258355
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0257774
CUX1 cut-like homeobox 1 0.0257235
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0251733
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0249496

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.127971
TMSB10 thymosin beta 10 -0.0974602
RPL35A ribosomal protein L35a -0.0517662
MT2A metallothionein 2A -0.0449848
TPT1 tumor protein, translationally-controlled 1 -0.0419623
RPS6 ribosomal protein S6 -0.0404554
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0332786
S100A9 S100 calcium binding protein A9 -0.0325016
RPL34 ribosomal protein L34 -0.0308258
RPLP2 ribosomal protein, large, P2 -0.0299902
RPS21 ribosomal protein S21 -0.0283369
ANKRD12 ankyrin repeat domain 12 -0.0271855
RPL26 ribosomal protein L26 -0.0269487
RPLP0 ribosomal protein, large, P0 -0.0267721
RPL37A ribosomal protein L37a -0.0262782
CANX calnexin -0.0262244
RPL9 ribosomal protein L9 -0.0261132
RPL11 ribosomal protein L11 -0.0251479
RPL12 ribosomal protein L12 -0.0244704
RAB1A RAB1A, member RAS oncogene family -0.0243502
RPL31 ribosomal protein L31 -0.0242605
VIM vimentin -0.0240332
RPS13 ribosomal protein S13 -0.0223302
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0220858
RPS14 ribosomal protein S14 -0.0211861
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0208188
RPS24 ribosomal protein S24 -0.0208168
S100A6 S100 calcium binding protein A6 -0.0206831
RPL27 ribosomal protein L27 -0.0196124
CD2AP CD2-associated protein -0.0194031
RSF1 remodeling and spacing factor 1 -0.0191769
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0190018
VMP1 vacuole membrane protein 1 -0.0187318
HMGA1 high mobility group AT-hook 1 -0.0186354
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0179048
MBNL2 muscleblind-like splicing regulator 2 -0.0176735
GOLGA4 golgin A4 -0.0176515
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0171275
RPLP1 ribosomal protein, large, P1 -0.0170897
FTH1 ferritin, heavy polypeptide 1 -0.016931
MORF4L2 mortality factor 4 like 2 -0.0166401
RPS12 ribosomal protein S12 -0.0164696
TMEM41B transmembrane protein 41B -0.0164
ITPKC inositol-trisphosphate 3-kinase C -0.0163717
S100A10 S100 calcium binding protein A10 -0.0163626
RPL30 ribosomal protein L30 -0.0157994
TMEM263 transmembrane protein 263 -0.0155589
GARS1 glycyl-tRNA synthetase 1 -0.0149796
RPS15 ribosomal protein S15 -0.0148964
AKAP9 A kinase (PRKA) anchor protein 9 -0.0147678
LCORL ligand dependent nuclear receptor corepressor-like -0.0146322
RPL36A ribosomal protein L36a -0.0145301
RPL36 ribosomal protein L36 -0.0144659
NDUFA4 NDUFA4, mitochondrial complex associated -0.014393
UBE2B ubiquitin-conjugating enzyme E2B -0.01432
RPL23 ribosomal protein L23 -0.0143043
MBD5 methyl-CpG binding domain protein 5 -0.0142661
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0140721
MON2 MON2 homolog (S. cerevisiae) -0.0138404
OSBP oxysterol binding protein -0.0137516
RPS27A ribosomal protein S27a -0.0136798
RPS17 ribosomal protein S17 -0.0136059
YME1L1 YME1-like 1 ATPase -0.0135425
RPL35 ribosomal protein L35 -0.013518
FAM162A family with sequence similarity 162, member A -0.013397
LOC102724023 ES1 protein homolog, mitochondrial -0.0133796
RPS29 ribosomal protein S29 -0.0133559
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0130226
ZBTB7A zinc finger and BTB domain containing 7A -0.012957
ARF4 ADP-ribosylation factor 4 -0.0129546
GOSR1 golgi SNAP receptor complex member 1 -0.0129156
SUB1 SUB1 homolog (S. cerevisiae) -0.0129076
FKBP2 FK506 binding protein 2, 13kDa -0.0129033
RPS23 ribosomal protein S23 -0.0126797
RSL1D1 ribosomal L1 domain containing 1 -0.0126333
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0125463
PTEN phosphatase and tensin homolog -0.0124647
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0124614
HLA-E major histocompatibility complex, class I, E -0.0124272
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.0123876
RCOR3 REST corepressor 3 -0.0123113
RBM25 RNA binding motif protein 25 -0.0122719
USP37 ubiquitin specific peptidase 37 -0.0122315
RPL36AL ribosomal protein L36a-like -0.0121251
RPS25 ribosomal protein S25 -0.0121224
SEC31A SEC31 homolog A (S. cerevisiae) -0.0119953
RPL32 ribosomal protein L32 -0.0118887
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0117876
RPS16 ribosomal protein S16 -0.0117849
ISG15 ISG15 ubiquitin-like modifier -0.0117238
KLF6 Kruppel-like factor 6 -0.0116971
GCC2 GRIP and coiled-coil domain containing 2 -0.0116701
RPL21 ribosomal protein L21 -0.0116567
HLA-B major histocompatibility complex, class I, B -0.0116158
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0115609
IFITM2 interferon induced transmembrane protein 2 -0.0115023
PIAS1 protein inhibitor of activated STAT, 1 -0.0114288
IARS1 isoleucyl-tRNA synthetase 1 -0.0113678
GUK1 guanylate kinase 1 -0.0113312
ACBD3 acyl-CoA binding domain containing 3 -0.0112648