| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.28557 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.178707 |
| EXT1 | exostosin glycosyltransferase 1 | 0.157051 |
| CDH13 | cadherin 13 | 0.150731 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.141305 |
| FNDC3B | fibronectin type III domain containing 3B | 0.131097 |
| COL5A1 | collagen, type V, alpha 1 | 0.10902 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.105205 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0966424 |
| PLEC | plectin | 0.0869562 |
| FN1 | fibronectin 1 | 0.0848417 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0812671 |
| CD44 | CD44 molecule (Indian blood group) | 0.0798595 |
| NDRG1 | N-myc downstream regulated 1 | 0.0770357 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0715667 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0689427 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0668323 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0638052 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0633772 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0628988 |
| MYO10 | myosin X | 0.0625192 |
| IL6ST | interleukin 6 signal transducer | 0.0620797 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0613854 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0606783 |
| CALD1 | caldesmon 1 | 0.060648 |
| EGFR | epidermal growth factor receptor | 0.0595866 |
| NAV1 | neuron navigator 1 | 0.0572439 |
| FLNA | filamin A, alpha | 0.0551575 |
| FBN1 | fibrillin 1 | 0.0550783 |
| RUNX1 | runt-related transcription factor 1 | 0.0548099 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0523127 |
| SDC2 | syndecan 2 | 0.0514065 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0508272 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0500427 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.049867 |
| LOX | lysyl oxidase | 0.0495873 |
| ATXN1 | ataxin 1 | 0.0478269 |
| HDAC9 | histone deacetylase 9 | 0.0477485 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0463615 |
| AHNAK | AHNAK nucleoprotein | 0.0462555 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.045864 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0455637 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0452544 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0452531 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0451286 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0449563 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0447276 |
| GLIS3 | GLIS family zinc finger 3 | 0.0447246 |
| CNTN5 | contactin 5 | 0.0439575 |
| SQSTM1 | sequestosome 1 | 0.0426282 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0424373 |
| ASPH | aspartate beta-hydroxylase | 0.0423805 |
| CADM1 | cell adhesion molecule 1 | 0.0421881 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0408205 |
| VEGFA | vascular endothelial growth factor A | 0.0395083 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0380313 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0376851 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0366011 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.036045 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.035685 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0355539 |
| NAV2 | neuron navigator 2 | 0.035311 |
| JAG1 | jagged 1 | 0.0350364 |
| ACTG1 | actin gamma 1 | 0.0350035 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0349564 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0349449 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0347176 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0345337 |
| HMGA2 | high mobility group AT-hook 2 | 0.0344965 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0339719 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0336307 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.03332 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0331633 |
| MTSS1 | metastasis suppressor 1 | 0.0328468 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0325862 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0324422 |
| NEK10 | NIMA-related kinase 10 | 0.0322886 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0321171 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0310786 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0308476 |
| CUX1 | cut-like homeobox 1 | 0.0301147 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0299758 |
| CALU | calumenin | 0.0298353 |
| LDHA | lactate dehydrogenase A | 0.0297241 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0296137 |
| VCL | vinculin | 0.0294289 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0293229 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0292655 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0291235 |
| INTS6 | integrator complex subunit 6 | 0.0290744 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0289647 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0287115 |
| MRTFA | myocardin related transcription factor A | 0.0286453 |
| ACTN1 | actinin, alpha 1 | 0.0286319 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0284224 |
| STC2 | stanniocalcin 2 | 0.028046 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0277721 |
| ECE1 | endothelin converting enzyme 1 | 0.0277478 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0276497 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0275552 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.138767 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0971635 |
| TMSB10 | thymosin beta 10 | -0.0740325 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0659923 |
| PTMA | prothymosin, alpha | -0.0506412 |
| VIM | vimentin | -0.0494968 |
| STC1 | stanniocalcin 1 | -0.0406479 |
| MT2A | metallothionein 2A | -0.0395816 |
| RRBP1 | ribosome binding protein 1 | -0.0383779 |
| CANX | calnexin | -0.0346884 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0341496 |
| LMAN1 | lectin, mannose-binding, 1 | -0.030773 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0307192 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0305555 |
| MAP1B | microtubule-associated protein 1B | -0.0287686 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0284884 |
| ATP13A3 | ATPase type 13A3 | -0.0281258 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0280336 |
| FTL | ferritin, light polypeptide | -0.0279565 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0279299 |
| GOLGA4 | golgin A4 | -0.027494 |
| POSTN | periostin, osteoblast specific factor | -0.0253985 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0252665 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0248453 |
| TPM4 | tropomyosin 4 | -0.0247663 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0217634 |
| S100A6 | S100 calcium binding protein A6 | -0.0214645 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0205154 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0200811 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0198911 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.018466 |
| CALR | calreticulin | -0.0177132 |
| COL1A2 | collagen, type I, alpha 2 | -0.0174408 |
| PALLD | palladin, cytoskeletal associated protein | -0.0168508 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0166569 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0164888 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0162382 |
| RPS19 | ribosomal protein S19 | -0.0162079 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0160748 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0157379 |
| LOXL2 | lysyl oxidase-like 2 | -0.0156017 |
| B2M | beta-2-microglobulin | -0.0150271 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0150107 |
| SBF2 | SET binding factor 2 | -0.0146611 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0145388 |
| WASF2 | WAS protein family, member 2 | -0.0144667 |
| COG5 | component of oligomeric golgi complex 5 | -0.0141067 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0136626 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0134401 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0131468 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0130161 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0129995 |
| RPL35A | ribosomal protein L35a | -0.0129513 |
| SULF1 | sulfatase 1 | -0.0125095 |
| USP3 | ubiquitin specific peptidase 3 | -0.0122901 |
| TMEM41B | transmembrane protein 41B | -0.012166 |
| URI1 | URI1, prefoldin-like chaperone | -0.0121648 |
| EGR1 | early growth response 1 | -0.0120203 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0118464 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0117818 |
| INSIG1 | insulin induced gene 1 | -0.0115964 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.0113887 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0113712 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | -0.0113421 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0112644 |
| SQLE | squalene epoxidase | -0.0110915 |
| KIF5B | kinesin family member 5B | -0.0110862 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0110313 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0110058 |
| S100A9 | S100 calcium binding protein A9 | -0.0109407 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0108953 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0108855 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0108269 |
| PYGL | phosphorylase, glycogen, liver | -0.0108227 |
| CAVIN1 | caveolae associated protein 1 | -0.0107029 |
| RAI14 | retinoic acid induced 14 | -0.0106677 |
| PFN1 | profilin 1 | -0.0106452 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.0105848 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0105696 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0105299 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0104862 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0104255 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.010398 |
| IKBIP | IKBKB interacting protein | -0.0103541 |
| COL3A1 | collagen, type III, alpha 1 | -0.0102216 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0101568 |
| CKAP2L | cytoskeleton associated protein 2-like | -0.0101328 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0100982 |
| HMGA1 | high mobility group AT-hook 1 | -0.0100527 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.00996985 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.00993592 |
| SCFD2 | sec1 family domain containing 2 | -0.0099129 |
| CFB | complement factor B | -0.00990726 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.00986123 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00985253 |
| ARRDC3 | arrestin domain containing 3 | -0.00985232 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.00974104 |
| HLA-E | major histocompatibility complex, class I, E | -0.00960602 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -0.00960062 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00959894 |
