Lidocaine (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0895277
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0861113
TPT1 tumor protein, translationally-controlled 1 0.0726634
AHNAK AHNAK nucleoprotein 0.0723001
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0708785
SAMD12 sterile alpha motif domain containing 12 0.0699935
ACTN4 actinin, alpha 4 0.0699844
TRAPPC9 trafficking protein particle complex 9 0.0661964
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0618608
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0598393
SEPTIN9 septin 9 0.057563
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0571377
PRKN parkin RBR E3 ubiquitin protein ligase 0.0564994
PATJ PATJ crumbs cell polarity complex component 0.053296
CCSER1 coiled-coil serine-rich protein 1 0.0520812
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0519409
STK24 serine/threonine kinase 24 0.0510762
PTK2 protein tyrosine kinase 2 0.0499296
MYH14 myosin, heavy chain 14, non-muscle 0.0488191
NECTIN2 nectin cell adhesion molecule 2 0.0470142
SLC45A4 solute carrier family 45, member 4 0.0469981
ARHGAP32 Rho GTPase activating protein 32 0.0464598
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0460721
ASPH aspartate beta-hydroxylase 0.0459736
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0452717
PGK1 phosphoglycerate kinase 1 0.0449935
TMC5 transmembrane channel-like 5 0.0442105
ZBTB20 zinc finger and BTB domain containing 20 0.0436375
ZMYND8 zinc finger, MYND-type containing 8 0.0426642
LOC112694756 uncharaterized LOC112694756 0.0424418
CTNND1 catenin (cadherin-associated protein), delta 1 0.042052
LAMA4 laminin, alpha 4 0.041729
MYH9 myosin, heavy chain 9, non-muscle 0.0413041
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0410388
LMO7 LIM domain 7 0.0402795
LPP LIM domain containing preferred translocation partner in lipoma 0.0400957
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0397872
ATXN1 ataxin 1 0.0395827
KRT8 keratin 8, type II 0.0393663
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0392205
FLNB filamin B, beta 0.0388626
EXOC4 exocyst complex component 4 0.0388454
CTBP2 C-terminal binding protein 2 0.038452
PLEC plectin 0.0377815
FAT1 FAT atypical cadherin 1 0.0375277
ETV6 ets variant 6 0.0371051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0370667
VCL vinculin 0.0362262
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.036224
PDIA4 protein disulfide isomerase family A, member 4 0.0352527
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0345217
PICALM phosphatidylinositol binding clathrin assembly protein 0.033949
FRY furry homolog (Drosophila) 0.033751
AGO2 argonaute RISC catalytic component 2 0.0335514
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0332922
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0331892
SERINC5 serine incorporator 5 0.0329207
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.032415
KIAA0232 KIAA0232 0.0323406
UTRN utrophin 0.0322117
DST dystonin 0.0320565
RAD21 RAD21 homolog (S. pombe) 0.0318316
BCL2L1 BCL2-like 1 0.0316904
SPRED2 sprouty-related, EVH1 domain containing 2 0.0315172
RNF213 ring finger protein 213 0.0314562
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0310484
H1-4 H1.4 linker histone, cluster member 0.0310305
MACF1 microtubule-actin crosslinking factor 1 0.0308579
TCF12 transcription factor 12 0.0305914
MAML3 mastermind-like 3 (Drosophila) 0.0304976
WWC1 WW and C2 domain containing 1 0.0304894
CD2AP CD2-associated protein 0.0304882
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0304116
KRT18 keratin 18, type I 0.0300793
ARHGAP23 Rho GTPase activating protein 23 0.0297517
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0297009
PPL periplakin 0.029579
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0295615
CYRIB CYFIP related Rac1 interactor B 0.0294852
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0289476
ATAD2 ATPase family, AAA domain containing 2 0.0288647
HDLBP high density lipoprotein binding protein 0.0286077
CUX1 cut-like homeobox 1 0.0284741
PRELID2 PRELI domain containing 2 0.0283011
RAD51B RAD51 paralog B 0.028116
GMDS GDP-mannose 4,6-dehydratase 0.0280346
NIBAN2 niban apoptosis regulator 2 0.0280301
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0279188
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0278614
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0277262
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0273961
PTPRK protein tyrosine phosphatase, receptor type, K 0.027218
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0272023
KLF3 Kruppel-like factor 3 (basic) 0.0269707
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0267429
AKAP13 A kinase (PRKA) anchor protein 13 0.0266421
MYO1E myosin IE 0.026627
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0264615
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0262761
NUP98 nucleoporin 98kDa 0.0257828

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.143138
FTH1 ferritin, heavy polypeptide 1 -0.131396
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104275
NDRG1 N-myc downstream regulated 1 -0.089489
RPS19 ribosomal protein S19 -0.082157
TMSB10 thymosin beta 10 -0.0812131
POTEF POTE ankyrin domain family, member F -0.0754359
RPL23 ribosomal protein L23 -0.0750806
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0737276
RPLP1 ribosomal protein, large, P1 -0.06953
RPS6 ribosomal protein S6 -0.0608018
RPL21 ribosomal protein L21 -0.0588062
RPL35A ribosomal protein L35a -0.0561617
RPLP2 ribosomal protein, large, P2 -0.0532856
PCBP2 poly(rC) binding protein 2 -0.0517556
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0502321
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0455701
HMGA1 high mobility group AT-hook 1 -0.0432573
TSC22D2 TSC22 domain family, member 2 -0.0422777
GOLGA4 golgin A4 -0.0408026
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0402101
RPS5 ribosomal protein S5 -0.0396371
RPS8 ribosomal protein S8 -0.038096
RPS11 ribosomal protein S11 -0.0376885
RPS21 ribosomal protein S21 -0.0375654
MORF4L2 mortality factor 4 like 2 -0.0371682
RPL28 ribosomal protein L28 -0.036621
LYZ lysozyme -0.0341171
FBXO32 F-box protein 32 -0.0335484
RPS23 ribosomal protein S23 -0.0324997
RPS16 ribosomal protein S16 -0.032033
KMT2C lysine (K)-specific methyltransferase 2C -0.0315902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314084
BRD2 bromodomain containing 2 -0.0309444
RPL12 ribosomal protein L12 -0.0304576
YBX1 Y box binding protein 1 -0.0284621
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0283941
VEGFA vascular endothelial growth factor A -0.028241
RPS13 ribosomal protein S13 -0.028147
RPL37A ribosomal protein L37a -0.0280292
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0276786
EGR1 early growth response 1 -0.0276563
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0267663
RNF145 ring finger protein 145 -0.0264147
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0261428
PDIA3 protein disulfide isomerase family A, member 3 -0.0259447
AREG amphiregulin -0.0259023
RPL32 ribosomal protein L32 -0.0257216
RPS12 ribosomal protein S12 -0.0255584
RPS25 ribosomal protein S25 -0.0253952
ARF4 ADP-ribosylation factor 4 -0.0253043
RPL18 ribosomal protein L18 -0.0251673
RPS2 ribosomal protein S2 -0.0246823
PFN1 profilin 1 -0.0240997
RPS14 ribosomal protein S14 -0.0236734
ASTN2 astrotactin 2 -0.0228528
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0228025
RPL5 ribosomal protein L5 -0.0224721
LDHA lactate dehydrogenase A -0.0222158
RPS27 ribosomal protein S27 -0.0216867
RPL9 ribosomal protein L9 -0.0212265
RPS17 ribosomal protein S17 -0.0211675
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0211075
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0210683
RPL31 ribosomal protein L31 -0.0210571
ATF4 activating transcription factor 4 -0.0210369
CEMIP2 cell migration inducing hyaluronidase 2 -0.0210326
HBP1 HMG-box transcription factor 1 -0.0210165
RPL19 ribosomal protein L19 -0.0207883
RPL11 ribosomal protein L11 -0.020672
RPL34 ribosomal protein L34 -0.0205985
CLDN4 claudin 4 -0.0200986
CNRIP1 cannabinoid receptor interacting protein 1 -0.0198984
PNPLA8 patatin-like phospholipase domain containing 8 -0.0198636
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0198066
S100A9 S100 calcium binding protein A9 -0.0195046
RPL8 ribosomal protein L8 -0.0193548
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0193397
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0192803
NUP58 nucleoporin 58 -0.0192445
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0192333
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.019155
HLA-A major histocompatibility complex, class I, A -0.0190582
S100A6 S100 calcium binding protein A6 -0.0190458
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -0.0189101
GARS1 glycyl-tRNA synthetase 1 -0.0188787
TRAM1 translocation associated membrane protein 1 -0.018728
TJP1 tight junction protein 1 -0.0186952
RPS10 ribosomal protein S10 -0.0186363
EIF1 eukaryotic translation initiation factor 1 -0.0185321
ADM adrenomedullin -0.0184795
RPL36 ribosomal protein L36 -0.01831
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0182924
ZFP36 ZFP36 ring finger protein -0.0182462
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0180326
SPAG9 sperm associated antigen 9 -0.0179578
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0178693
PAWR PRKC, apoptosis, WT1, regulator -0.0176734
RBM25 RNA binding motif protein 25 -0.0173173
S100P S100 calcium binding protein P -0.0170437