Lidocaine (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.167867
SAMD4A sterile alpha motif domain containing 4A 0.12006
ATXN1 ataxin 1 0.0971876
DSPP dentin sialophosphoprotein 0.094519
SLC38A2 solute carrier family 38, member 2 0.08968
FRMD5 FERM domain containing 5 0.0828754
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0778106
PDLIM5 PDZ and LIM domain 5 0.0769011
MYH9 myosin, heavy chain 9, non-muscle 0.0768799
DST dystonin 0.0756053
EXT1 exostosin glycosyltransferase 1 0.0752247
ASPH aspartate beta-hydroxylase 0.0690496
TPT1 tumor protein, translationally-controlled 1 0.0686714
FAM107B family with sequence similarity 107, member B 0.0644448
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0640786
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0635077
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0617974
IGFBP1 insulin-like growth factor binding protein 1 0.0608712
LRMDA leucine rich melanocyte differentiation associated 0.0602261
INTS6 integrator complex subunit 6 0.059968
FMNL2 formin-like 2 0.0582693
GMDS GDP-mannose 4,6-dehydratase 0.0562938
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0560338
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0547872
GPC6 glypican 6 0.0540229
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0526532
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0524524
LOC112694756 uncharaterized LOC112694756 0.05009
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0449494
MACF1 microtubule-actin crosslinking factor 1 0.0443821
RNF213 ring finger protein 213 0.0438523
H1-0 H1.0 linker histone 0.0423644
SVIL supervillin 0.0421386
MBNL2 muscleblind-like splicing regulator 2 0.0418418
FLNB filamin B, beta 0.0414294
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0408236
APLP2 amyloid beta (A4) precursor-like protein 2 0.0406537
MT2A metallothionein 2A 0.0405557
LPP LIM domain containing preferred translocation partner in lipoma 0.0402535
SEPTIN9 septin 9 0.039982
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0395368
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0392722
DOCK4 dedicator of cytokinesis 4 0.0392495
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0390605
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0380198
NDRG1 N-myc downstream regulated 1 0.0369927
RPS12 ribosomal protein S12 0.0368994
PLEC plectin 0.0367529
ERRFI1 ERBB receptor feedback inhibitor 1 0.0363465
FLNA filamin A, alpha 0.036208
KYNU kynureninase 0.0356416
EEF2 eukaryotic translation elongation factor 2 0.0347098
RPS24 ribosomal protein S24 0.0341109
RPL23 ribosomal protein L23 0.0338222
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0331635
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0330397
TLE4 transducin-like enhancer of split 4 0.0326521
ACTG1 actin gamma 1 0.0316614
SORBS1 sorbin and SH3 domain containing 1 0.0316133
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.031238
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0307869
RAD51B RAD51 paralog B 0.0307471
TRIO trio Rho guanine nucleotide exchange factor 0.0304434
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0302171
ZBTB20 zinc finger and BTB domain containing 20 0.0296807
CTNND1 catenin (cadherin-associated protein), delta 1 0.0296721
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0293107
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0290925
LMO7 LIM domain 7 0.0289378
AFF1 AF4/FMR2 family, member 1 0.0285362
MCL1 myeloid cell leukemia 1 0.0275196
PRELID2 PRELI domain containing 2 0.027375
HPCAL1 hippocalcin-like 1 0.0266499
LIMS1 LIM and senescent cell antigen-like domains 1 0.0262882
TIMP2 TIMP metallopeptidase inhibitor 2 0.0260282
PTPRK protein tyrosine phosphatase, receptor type, K 0.0258345
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0258276
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0253373
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0252132
MAML2 mastermind-like 2 (Drosophila) 0.025176
CMIP c-Maf inducing protein 0.0251253
AHNAK AHNAK nucleoprotein 0.0248222
RNASET2 ribonuclease T2 0.024403
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0240813
CFLAR CASP8 and FADD-like apoptosis regulator 0.0240682
ACTN4 actinin, alpha 4 0.0240673
NABP1 nucleic acid binding protein 1 0.0240608
USP34 ubiquitin specific peptidase 34 0.0240167
TMSB10 thymosin beta 10 0.0238386
ITGA6 integrin, alpha 6 0.0235842
HOOK2 hook microtubule-tethering protein 2 0.0233519
RPL3 ribosomal protein L3 0.0232057
KIF21A kinesin family member 21A 0.0231874
ENO1 enolase 1, (alpha) 0.0231633
MYO1E myosin IE 0.0231242
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0230942
PKM pyruvate kinase, muscle 0.0228219
MBNL1 muscleblind-like splicing regulator 1 0.0227646
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0227113
KDM4B lysine (K)-specific demethylase 4B 0.0225958

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.178078
IGF2 insulin-like growth factor 2 -0.150052
FBF1 Fas (TNFRSF6) binding factor 1 -0.11473
C3 complement component 3 -0.0826991
APOB apolipoprotein B -0.0783383
RBM39 RNA binding motif protein 39 -0.0618856
ELL2 elongation factor, RNA polymerase II, 2 -0.0564167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0482308
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0475877
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0455669
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0442606
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0412667
EGR1 early growth response 1 -0.0395877
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0380733
EML4 echinoderm microtubule associated protein like 4 -0.0380496
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0380468
CFB complement factor B -0.0354669
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0350291
JMJD1C jumonji domain containing 1C -0.033505
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0327171
NKD1 naked cuticle homolog 1 (Drosophila) -0.0318702
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0306019
TM9SF3 transmembrane 9 superfamily member 3 -0.0295783
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0294591
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0293689
CP ceruloplasmin (ferroxidase) -0.0292143
FTH1 ferritin, heavy polypeptide 1 -0.0289592
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0281789
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0270283
MATR3 matrin 3 -0.0268805
RAI14 retinoic acid induced 14 -0.0268611
RPL35A ribosomal protein L35a -0.0265617
A2M alpha-2-macroglobulin -0.0259354
KLF10 Kruppel-like factor 10 -0.0258666
KIF5B kinesin family member 5B -0.0258096
GDF15 growth differentiation factor 15 -0.0249052
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0247121
KTN1 kinectin 1 (kinesin receptor) -0.0246797
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0246597
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0245947
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0244833
CANX calnexin -0.0239258
KPNB1 karyopherin (importin) beta 1 -0.0237569
RAB1A RAB1A, member RAS oncogene family -0.0236175
GPC3 glypican 3 -0.0233872
WDR43 WD repeat domain 43 -0.0233638
GCC2 GRIP and coiled-coil domain containing 2 -0.0230918
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0230282
ZEB1 zinc finger E-box binding homeobox 1 -0.0225044
AFDN afadin, adherens junction formation factor -0.0223771
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0221864
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0220921
CPE carboxypeptidase E -0.0219212
FNDC3B fibronectin type III domain containing 3B -0.0213544
TLK1 tousled-like kinase 1 -0.0212037
DLC1 DLC1 Rho GTPase activating protein -0.0206854
TMEM41B transmembrane protein 41B -0.0202408
LMCD1 LIM and cysteine-rich domains 1 -0.0201148
NCOA7 nuclear receptor coactivator 7 -0.0201128
SELENOP selenoprotein P -0.0200002
DENND4A DENN/MADD domain containing 4A -0.0199682
KCMF1 potassium channel modulatory factor 1 -0.0198109
PLAC8 placenta-specific 8 -0.0198009
FN1 fibronectin 1 -0.0194871
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0194743
EPAS1 endothelial PAS domain protein 1 -0.0193291
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0193236
LMAN1 lectin, mannose-binding, 1 -0.0193172
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0190886
ANKRD10 ankyrin repeat domain 10 -0.0187662
ZNF33A zinc finger protein 33A -0.018433
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0182895
RRBP1 ribosome binding protein 1 -0.0182649
ANXA5 annexin A5 -0.0178883
BHLHE40 basic helix-loop-helix family, member e40 -0.0178071
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0175819
IGFBP3 insulin-like growth factor binding protein 3 -0.0175358
PTBP3 polypyrimidine tract binding protein 3 -0.0175321
FERMT1 fermitin family member 1 -0.017297
MRTFA myocardin related transcription factor A -0.017218
YAF2 YY1 associated factor 2 -0.0171546
TGFBI transforming growth factor, beta-induced, 68kDa -0.0169402
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0169304
FNBP1L formin binding protein 1-like -0.0168746
LONP2 lon peptidase 2, peroxisomal -0.016732
IER3 immediate early response 3 -0.0167267
PDGFB platelet-derived growth factor beta polypeptide -0.0166541
FILIP1L filamin A interacting protein 1-like -0.0165823
PUM2 pumilio RNA-binding family member 2 -0.0164457
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.016406
FOXK2 forkhead box K2 -0.0163664
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0160375
SRSF10 serine/arginine-rich splicing factor 10 -0.0159755
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0159616
AMBRA1 autophagy/beclin-1 regulator 1 -0.0159355
MBNL3 muscleblind-like splicing regulator 3 -0.0156757
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0155706
RBM25 RNA binding motif protein 25 -0.0155217
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0153978
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0153615