Lidocaine (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.141952
MYOF myoferlin 0.10513
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0953246
LOC112694756 uncharaterized LOC112694756 0.0812312
MYH9 myosin, heavy chain 9, non-muscle 0.0803106
MT2A metallothionein 2A 0.0746619
TRIO trio Rho guanine nucleotide exchange factor 0.071325
LMO7 LIM domain 7 0.0693921
ANXA1 annexin A1 0.0656781
RPS6 ribosomal protein S6 0.065404
TMSB4X thymosin beta 4, X-linked 0.063923
HMGA2 high mobility group AT-hook 2 0.0616821
AHNAK AHNAK nucleoprotein 0.0615916
ESYT2 extended synaptotagmin-like protein 2 0.0573083
APLP2 amyloid beta (A4) precursor-like protein 2 0.056647
CLU clusterin 0.0545559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0543798
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0536497
KRT17 keratin 17, type I 0.0524295
CD44 CD44 molecule (Indian blood group) 0.0523571
SMAD3 SMAD family member 3 0.0521868
FNDC3B fibronectin type III domain containing 3B 0.0492765
RPS8 ribosomal protein S8 0.0491095
MTSS1 metastasis suppressor 1 0.0485923
EEF2 eukaryotic translation elongation factor 2 0.0477579
S100A10 S100 calcium binding protein A10 0.0465234
ENO1 enolase 1, (alpha) 0.0462199
MACF1 microtubule-actin crosslinking factor 1 0.0453219
KRT6A keratin 6A, type II 0.0444641
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0435911
RPL3 ribosomal protein L3 0.0429599
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0420002
TPT1 tumor protein, translationally-controlled 1 0.0415881
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0413674
EZR ezrin 0.0412517
RPL19 ribosomal protein L19 0.0407153
RPL37 ribosomal protein L37 0.038666
TGM2 transglutaminase 2 0.0384032
RPS4X ribosomal protein S4, X-linked 0.0383461
RPLP2 ribosomal protein, large, P2 0.0374504
TOP1 topoisomerase (DNA) I 0.0368018
RPS12 ribosomal protein S12 0.0367303
RPL23 ribosomal protein L23 0.0361626
FLNA filamin A, alpha 0.0357866
BCAR3 breast cancer anti-estrogen resistance 3 0.0353756
NAP1L1 nucleosome assembly protein 1-like 1 0.035312
LMNA lamin A/C 0.0350148
DST dystonin 0.0340537
HSPA8 heat shock 70kDa protein 8 0.0338186
TMSB10 thymosin beta 10 0.0335655
ZSWIM6 zinc finger, SWIM-type containing 6 0.0334973
STC1 stanniocalcin 1 0.033142
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.032171
RPL11 ribosomal protein L11 0.031772
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0316735
DSCAM Down syndrome cell adhesion molecule 0.0314453
AKAP13 A kinase (PRKA) anchor protein 13 0.0304001
RPL8 ribosomal protein L8 0.0303279
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0299611
RPL5 ribosomal protein L5 0.0296225
CAV1 caveolin 1, caveolae protein, 22kDa 0.0293258
MBNL2 muscleblind-like splicing regulator 2 0.0290862
RPLP1 ribosomal protein, large, P1 0.0287521
DOCK5 dedicator of cytokinesis 5 0.0285125
RPS3 ribosomal protein S3 0.0281163
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0280904
RPS24 ribosomal protein S24 0.0276898
ITGA6 integrin, alpha 6 0.0275601
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0273008
RPS25 ribosomal protein S25 0.0272915
H1-0 H1.0 linker histone 0.0271652
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0271406
TPR translocated promoter region, nuclear basket protein 0.0271118
INTS6 integrator complex subunit 6 0.027015
UBC ubiquitin C 0.0267725
EIF1 eukaryotic translation initiation factor 1 0.0265244
APP amyloid beta (A4) precursor protein 0.0264319
RPL7A ribosomal protein L7a 0.0262537
RPS11 ribosomal protein S11 0.026249
DSTN destrin (actin depolymerizing factor) 0.0262152
BARX2 BARX homeobox 2 0.0258467
ASPH aspartate beta-hydroxylase 0.0258185
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0255156
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0254813
RPS27 ribosomal protein S27 0.025372
YBX1 Y box binding protein 1 0.0249554
TKT transketolase 0.0248137
RPS19 ribosomal protein S19 0.023859
UBE2H ubiquitin-conjugating enzyme E2H 0.0233751
ARRDC3 arrestin domain containing 3 0.0233057
KLF5 Kruppel-like factor 5 (intestinal) 0.0231537
PGK1 phosphoglycerate kinase 1 0.0230597
ITCH itchy E3 ubiquitin protein ligase 0.0229578
ANGPTL4 angiopoietin-like 4 0.0228457
RPS13 ribosomal protein S13 0.0228299
RPS17 ribosomal protein S17 0.0227781
TXNIP thioredoxin interacting protein 0.0226669
ARHGAP21 Rho GTPase activating protein 21 0.0226416
CEMIP cell migration inducing protein, hyaluronan binding 0.0224119
ANKRD11 ankyrin repeat domain 11 0.0223771

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.250029
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0768643
DPYD dihydropyrimidine dehydrogenase -0.0683285
SULF1 sulfatase 1 -0.0494406
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0439529
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.043222
PODXL podocalyxin-like -0.0382916
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0356724
ZEB1 zinc finger E-box binding homeobox 1 -0.0331847
ABI3BP ABI family, member 3 (NESH) binding protein -0.0306295
SLC35F3 solute carrier family 35, member F3 -0.0298907
C4BPB complement component 4 binding protein, beta -0.0288661
MECOM MDS1 and EVI1 complex locus -0.0279136
HSPG2 heparan sulfate proteoglycan 2 -0.0266849
FOSL1 FOS-like antigen 1 -0.0247382
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.024699
BCL2L1 BCL2-like 1 -0.0241755
SAMD9 sterile alpha motif domain containing 9 -0.0235271
EGR1 early growth response 1 -0.023408
IGF2 insulin-like growth factor 2 -0.0223999
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0222323
UTRN utrophin -0.022012
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0211491
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0211321
DSG2 desmoglein 2 -0.0195877
LAMC2 laminin, gamma 2 -0.0188607
NEK7 NIMA-related kinase 7 -0.0184326
PTHLH parathyroid hormone-like hormone -0.0176391
MEF2A myocyte enhancer factor 2A -0.0164814
SYN3 synapsin III -0.0159936
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0159183
THBD thrombomodulin -0.0158401
DUSP5 dual specificity phosphatase 5 -0.0158131
NDRG1 N-myc downstream regulated 1 -0.0146944
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0146833
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0144165
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -0.0143322
OXR1 oxidation resistance 1 -0.0142824
RAB7A RAB7A, member RAS oncogene family -0.0142732
BLCAP bladder cancer associated protein -0.0142466
CNTNAP3 contactin associated protein-like 3 -0.0142351
MEIS2 Meis homeobox 2 -0.0139034
IFI44L interferon-induced protein 44-like -0.0137218
HDAC9 histone deacetylase 9 -0.0135804
ZMYND8 zinc finger, MYND-type containing 8 -0.013518
PDGFA platelet-derived growth factor alpha polypeptide -0.0133282
SOX7 SRY (sex determining region Y)-box 7 -0.0131411
TPM4 tropomyosin 4 -0.0130206
CDCP1 CUB domain containing protein 1 -0.0127986
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0127541
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0125775
RAI1 retinoic acid induced 1 -0.012428
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0123294
PPARG peroxisome proliferator-activated receptor gamma -0.0118264
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0115612
LAMB3 laminin, beta 3 -0.0111091
AGMO alkylglycerol monooxygenase -0.0108749
DPYSL2 dihydropyrimidinase-like 2 -0.0108585
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0108293
RAP1B RAP1B, member of RAS oncogene family -0.0105983
RIGI RNA sensor RIG-I -0.0105009
PTPRB protein tyrosine phosphatase, receptor type, B -0.0104435
FER fer (fps/fes related) tyrosine kinase -0.0103832
PTPRE protein tyrosine phosphatase, receptor type, E -0.010374
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0103578
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0102901
CDK6 cyclin-dependent kinase 6 -0.0102363
LRP1B low density lipoprotein receptor-related protein 1B -0.010223
SAMD9L sterile alpha motif domain containing 9-like -0.0101957
RHEB Ras homolog enriched in brain -0.0101927
IRF1 interferon regulatory factor 1 -0.010168
PDLIM5 PDZ and LIM domain 5 -0.0101188
DENND2C DENN/MADD domain containing 2C -0.0100659
TTC28 tetratricopeptide repeat domain 28 -0.01004
SOX5 SRY (sex determining region Y)-box 5 -0.0100162
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.00999134
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.00996397
TMEM41B transmembrane protein 41B -0.00995961
ZNFX1 zinc finger, NFX1-type containing 1 -0.00976622
PLSCR1 phospholipid scramblase 1 -0.00976007
STAT1 signal transducer and activator of transcription 1, 91kDa -0.00975108
NANOS3 nanos homolog 3 (Drosophila) -0.00972268
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.00968311
CPM carboxypeptidase M -0.0096714
PCDH9 protocadherin 9 -0.00966155
RHOJ ras homolog family member J -0.00955524
MAML2 mastermind-like 2 (Drosophila) -0.00952068
KDSR 3-ketodihydrosphingosine reductase -0.00945378
CD9 CD9 molecule -0.00936439
PDGFB platelet-derived growth factor beta polypeptide -0.00923117
HMGA1 high mobility group AT-hook 1 -0.00918471
ARHGAP26 Rho GTPase activating protein 26 -0.00915858
WARS1 tryptophanyl-tRNA synthetase 1 -0.00912855
NECTIN2 nectin cell adhesion molecule 2 -0.00905013
DGKB diacylglycerol kinase, beta 90kDa -0.0089401
KLF13 Kruppel-like factor 13 -0.0088378
MX2 MX dynamin-like GTPase 2 -0.00880552
CLIC4 chloride intracellular channel 4 -0.00875961
CDC42 cell division cycle 42 -0.00871426
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.00871305