Lidocaine (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.135149
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.133357
TRIO trio Rho guanine nucleotide exchange factor 0.119744
CD44 CD44 molecule (Indian blood group) 0.109491
FLNB filamin B, beta 0.0977665
MYH9 myosin, heavy chain 9, non-muscle 0.0948348
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0816052
FNDC3B fibronectin type III domain containing 3B 0.0768517
TXNRD1 thioredoxin reductase 1 0.0745197
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0731728
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0729156
SLC12A8 solute carrier family 12, member 8 0.0666209
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0654171
LOC112694756 uncharaterized LOC112694756 0.0591422
ERBIN erbb2 interacting protein 0.0589335
EXT1 exostosin glycosyltransferase 1 0.0581186
HEG1 heart development protein with EGF-like domains 1 0.0565391
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0557318
UBA6 ubiquitin-like modifier activating enzyme 6 0.0533237
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0488696
TPM3 tropomyosin 3 0.0488365
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0476686
DST dystonin 0.0467308
PICALM phosphatidylinositol binding clathrin assembly protein 0.045927
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0455516
FLNA filamin A, alpha 0.0440739
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.043976
MSN moesin 0.0428741
COL5A1 collagen, type V, alpha 1 0.0423176
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.041474
PKM pyruvate kinase, muscle 0.0397198
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0392871
ZNF841 zinc finger protein 841 0.0391071
NAV1 neuron navigator 1 0.0390123
FN1 fibronectin 1 0.0387823
OSMR oncostatin M receptor 0.0387005
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0383703
PDIA3 protein disulfide isomerase family A, member 3 0.0380496
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.038047
SEPTIN9 septin 9 0.0380104
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0373157
AFAP1 actin filament associated protein 1 0.0363365
ACTN1 actinin, alpha 1 0.0361896
EGFR epidermal growth factor receptor 0.0360451
MAP1B microtubule-associated protein 1B 0.035073
CALU calumenin 0.0349594
H1-4 H1.4 linker histone, cluster member 0.0340164
LDHA lactate dehydrogenase A 0.033358
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0332735
AXL AXL receptor tyrosine kinase 0.0327557
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0318555
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0318474
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0317052
PTK2 protein tyrosine kinase 2 0.0308539
TNIP1 TNFAIP3 interacting protein 1 0.0304508
ELL2 elongation factor, RNA polymerase II, 2 0.0298076
IQGAP1 IQ motif containing GTPase activating protein 1 0.029548
ENO1 enolase 1, (alpha) 0.0295347
CENPF centromere protein F, 350/400kDa 0.0295244
ANO6 anoctamin 6 0.0293867
GLS2 glutaminase 2 (liver, mitochondrial) 0.0291126
BCL2L1 BCL2-like 1 0.0289788
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.028741
ASPH aspartate beta-hydroxylase 0.0285868
IL6ST interleukin 6 signal transducer 0.0285614
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0284319
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0274418
SET SET nuclear proto-oncogene 0.0269677
AKAP12 A kinase (PRKA) anchor protein 12 0.0269543
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.026741
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0267025
NEK7 NIMA-related kinase 7 0.0266715
SMAD3 SMAD family member 3 0.026624
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0265886
MACF1 microtubule-actin crosslinking factor 1 0.0263684
TPX2 TPX2, microtubule-associated 0.0259052
ZEB2 zinc finger E-box binding homeobox 2 0.0256801
PTBP3 polypyrimidine tract binding protein 3 0.0256758
CSDE1 cold shock domain containing E1, RNA-binding 0.0255462
ADAM9 ADAM metallopeptidase domain 9 0.02542
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0252091
FOSL1 FOS-like antigen 1 0.0250576
ATP13A3 ATPase type 13A3 0.0249032
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0248703
CD59 CD59 molecule, complement regulatory protein 0.0246089
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0244665
RNF213 ring finger protein 213 0.0244577
CLTC clathrin, heavy chain (Hc) 0.0243469
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.024333
MT1X metallothionein 1X 0.0240663
RPL3 ribosomal protein L3 0.0240599
AHNAK AHNAK nucleoprotein 0.0239955
SAMD12 sterile alpha motif domain containing 12 0.0239936
SETD5 SET domain containing 5 0.0238828
SULF1 sulfatase 1 0.0237481
PLEC plectin 0.0237447
ITGAV integrin, alpha V 0.0235303
SMYD3 SET and MYND domain containing 3 0.0234908
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0234837
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.023442

decreased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B -0.165741
FTL ferritin, light polypeptide -0.141674
MT2A metallothionein 2A -0.0923107
RPL35A ribosomal protein L35a -0.0884321
TMSB10 thymosin beta 10 -0.0873147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0844081
PTMA prothymosin, alpha -0.0837718
TPT1 tumor protein, translationally-controlled 1 -0.0712947
ABI3BP ABI family, member 3 (NESH) binding protein -0.0627878
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0498795
RPLP2 ribosomal protein, large, P2 -0.042878
RPLP1 ribosomal protein, large, P1 -0.0412013
CAVIN1 caveolae associated protein 1 -0.0409913
RPS6 ribosomal protein S6 -0.0382787
VIM vimentin -0.0352925
RPL34 ribosomal protein L34 -0.0346622
INTS6 integrator complex subunit 6 -0.0339652
RPL11 ribosomal protein L11 -0.0326252
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0311439
NDRG1 N-myc downstream regulated 1 -0.030854
RPL12 ribosomal protein L12 -0.0304661
HMGB1 high mobility group box 1 -0.0301632
RPS19 ribosomal protein S19 -0.0301049
RPS21 ribosomal protein S21 -0.0299161
ADM adrenomedullin -0.0299126
RPS24 ribosomal protein S24 -0.029647
GNAS GNAS complex locus -0.0293806
HLA-A major histocompatibility complex, class I, A -0.0293521
RPS8 ribosomal protein S8 -0.0290984
WSB1 WD repeat and SOCS box containing 1 -0.028649
PHACTR1 phosphatase and actin regulator 1 -0.0282674
RPL26 ribosomal protein L26 -0.0274082
IER3 immediate early response 3 -0.0270192
S100A9 S100 calcium binding protein A9 -0.0267178
TLE4 transducin-like enhancer of split 4 -0.0264567
RPL27A ribosomal protein L27a -0.0262729
RPL23 ribosomal protein L23 -0.0249755
RPL9 ribosomal protein L9 -0.0246219
RPL31 ribosomal protein L31 -0.0244748
IGFBP5 insulin-like growth factor binding protein 5 -0.0228737
RPS29 ribosomal protein S29 -0.0227268
RPS23 ribosomal protein S23 -0.0226455
RPL38 ribosomal protein L38 -0.020553
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0201488
ZNF804A zinc finger protein 804A -0.0197793
RPL37A ribosomal protein L37a -0.0197193
LOC102724023 ES1 protein homolog, mitochondrial -0.019696
RPS14 ribosomal protein S14 -0.0194941
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0194491
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0192028
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0190866
MYL12B myosin, light chain 12B, regulatory -0.0190509
LMNA lamin A/C -0.0189461
RPL32 ribosomal protein L32 -0.0189234
B2M beta-2-microglobulin -0.0185114
EIF5B eukaryotic translation initiation factor 5B -0.0184045
HLA-C major histocompatibility complex, class I, C -0.0178824
EIF1 eukaryotic translation initiation factor 1 -0.0177444
RPL36 ribosomal protein L36 -0.0175149
RPS27A ribosomal protein S27a -0.0169979
IFITM3 interferon induced transmembrane protein 3 -0.0169513
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0166769
RPL37 ribosomal protein L37 -0.0166429
RPS17 ribosomal protein S17 -0.0165653
ENO2 enolase 2 (gamma, neuronal) -0.0165225
RPL35 ribosomal protein L35 -0.0163603
RPS15 ribosomal protein S15 -0.0163501
SLIT2 slit homolog 2 (Drosophila) -0.01623
S100A11 S100 calcium binding protein A11 -0.0162228
S100A6 S100 calcium binding protein A6 -0.0162008
SERF2 small EDRK-rich factor 2 -0.0155307
RPL5 ribosomal protein L5 -0.0155093
RPL27 ribosomal protein L27 -0.0152683
TM4SF1 transmembrane 4 L six family member 1 -0.0152181
NAP1L1 nucleosome assembly protein 1-like 1 -0.0150659
RPS13 ribosomal protein S13 -0.015028
RPL28 ribosomal protein L28 -0.0148943
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0148921
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0148433
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0146619
RPL7A ribosomal protein L7a -0.014551
KDM3A lysine (K)-specific demethylase 3A -0.0145502
ANKRD10 ankyrin repeat domain 10 -0.0144314
SDCBP syndecan binding protein (syntenin) -0.0143156
IFITM1 interferon induced transmembrane protein 1 -0.0143034
TBCA tubulin folding cofactor A -0.0140075
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0137784
RPS25 ribosomal protein S25 -0.0137759
PDCD5 programmed cell death 5 -0.0137418
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0134471
ISG15 ISG15 ubiquitin-like modifier -0.0134117
ACTG1 actin gamma 1 -0.0131642
LRRC23 leucine rich repeat containing 23 -0.0131465
RPL30 ribosomal protein L30 -0.0129959
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0129764
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0129517
RPL36A ribosomal protein L36a -0.0128554
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0127391
RPS27 ribosomal protein S27 -0.0126759
LAMP1 lysosomal-associated membrane protein 1 -0.0125804