Lidocaine (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 0.11371
DSPP dentin sialophosphoprotein 0.112395
RPL3 ribosomal protein L3 0.110831
MYO1E myosin IE 0.108878
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105477
TPT1 tumor protein, translationally-controlled 1 0.0992004
ITPRID2 ITPR interacting domain containing 2 0.0990193
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0913839
FAT1 FAT atypical cadherin 1 0.0873528
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0796361
PTPRR protein tyrosine phosphatase, receptor type, R 0.0788181
AKAP13 A kinase (PRKA) anchor protein 13 0.0733408
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0700377
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0616597
LMO7 LIM domain 7 0.0611547
LDHA lactate dehydrogenase A 0.058598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0581407
MYH9 myosin, heavy chain 9, non-muscle 0.0532598
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0528545
HSPA8 heat shock 70kDa protein 8 0.0520083
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0516874
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0506607
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0506049
FRMD5 FERM domain containing 5 0.0505509
ABHD17C abhydrolase domain containing 17C 0.049569
PDIA3 protein disulfide isomerase family A, member 3 0.0481847
WWOX WW domain containing oxidoreductase 0.0481198
EIF4A2 eukaryotic translation initiation factor 4A2 0.047068
EGFR epidermal growth factor receptor 0.0464865
FHIT fragile histidine triad 0.0464198
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0460504
PELI1 pellino E3 ubiquitin protein ligase 1 0.0459537
PDE4D phosphodiesterase 4D, cAMP-specific 0.0456601
KRT18 keratin 18, type I 0.0449375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0446016
DOCK5 dedicator of cytokinesis 5 0.0438294
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0434965
SERINC5 serine incorporator 5 0.0432296
LPP LIM domain containing preferred translocation partner in lipoma 0.0429862
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0424839
KLF5 Kruppel-like factor 5 (intestinal) 0.0423331
MYO5B myosin VB 0.042228
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0420635
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0418361
UBE2H ubiquitin-conjugating enzyme E2H 0.0418026
DST dystonin 0.0416825
RPLP0 ribosomal protein, large, P0 0.0413547
ZSWIM6 zinc finger, SWIM-type containing 6 0.041299
FOXO1 forkhead box O1 0.0412979
PKM pyruvate kinase, muscle 0.0408574
SLC38A2 solute carrier family 38, member 2 0.0407687
PDZD8 PDZ domain containing 8 0.0406573
RPS18 ribosomal protein S18 0.0406155
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0405389
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0404091
PLEC plectin 0.0398357
EEF2 eukaryotic translation elongation factor 2 0.0398035
RHOA ras homolog family member A 0.0395866
SLTM SAFB-like, transcription modulator 0.0390342
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0390101
RIMKLB ribosomal modification protein rimK-like family member B 0.0383468
UBC ubiquitin C 0.0382779
PRELID2 PRELI domain containing 2 0.0377686
EZR ezrin 0.0375776
CLIC5 chloride intracellular channel 5 0.0370366
USP34 ubiquitin specific peptidase 34 0.0369869
RPL4 ribosomal protein L4 0.0358607
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.035777
CUX1 cut-like homeobox 1 0.0354425
KTN1 kinectin 1 (kinesin receptor) 0.0350528
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0349226
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0347651
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.034302
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0341583
MACF1 microtubule-actin crosslinking factor 1 0.0337691
LGALS12 lectin, galactoside-binding, soluble, 12 0.0333148
KRT8 keratin 8, type II 0.0332287
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0331943
ASPH aspartate beta-hydroxylase 0.0329377
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0328192
ITGA6 integrin, alpha 6 0.0324431
APP amyloid beta (A4) precursor protein 0.032303
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0321313
PTK2 protein tyrosine kinase 2 0.0316522
FER fer (fps/fes related) tyrosine kinase 0.0314523
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0313201
FLNB filamin B, beta 0.0312378
MUC13 mucin 13, cell surface associated 0.0311636
ARRDC3 arrestin domain containing 3 0.0310028
PTBP3 polypyrimidine tract binding protein 3 0.030995
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0309794
JMJD1C jumonji domain containing 1C 0.0309458
MPRIP myosin phosphatase Rho interacting protein 0.0308329
AREG amphiregulin 0.0306146
SSR1 signal sequence receptor, alpha 0.0306086
PDIA6 protein disulfide isomerase family A, member 6 0.0305619
RACK1 receptor for activated C kinase 1 0.0304883
ADAR adenosine deaminase, RNA-specific 0.0303502
EXT1 exostosin glycosyltransferase 1 0.0300092
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0295248

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.165225
RPLP1 ribosomal protein, large, P1 -0.0900658
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0891506
RPS19 ribosomal protein S19 -0.0800393
RPL35A ribosomal protein L35a -0.0646273
RPLP2 ribosomal protein, large, P2 -0.0639801
THSD4 thrombospondin, type I, domain containing 4 -0.0637017
RPS14 ribosomal protein S14 -0.0582721
PTMA prothymosin, alpha -0.0572355
GMDS GDP-mannose 4,6-dehydratase -0.0520613
RPL34 ribosomal protein L34 -0.050739
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0493654
RPL36 ribosomal protein L36 -0.0484851
RPS21 ribosomal protein S21 -0.0481079
RIGI RNA sensor RIG-I -0.0433856
MT2A metallothionein 2A -0.0428069
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0412418
MON2 MON2 homolog (S. cerevisiae) -0.0395462
RPS13 ribosomal protein S13 -0.0391312
RPL26 ribosomal protein L26 -0.0385283
MX2 MX dynamin-like GTPase 2 -0.0380988
HMGA1 high mobility group AT-hook 1 -0.0370239
RPS29 ribosomal protein S29 -0.0368551
RRBP1 ribosome binding protein 1 -0.0360636
S100P S100 calcium binding protein P -0.0354574
RPL11 ribosomal protein L11 -0.0347749
RPS23 ribosomal protein S23 -0.0343302
RPS2 ribosomal protein S2 -0.0309181
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0306848
MYOF myoferlin -0.0298514
GDF15 growth differentiation factor 15 -0.0297265
S100A14 S100 calcium binding protein A14 -0.0295874
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0294689
RPL28 ribosomal protein L28 -0.0293606
MATR3 matrin 3 -0.0278585
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0274664
RPL23 ribosomal protein L23 -0.0272224
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0268736
CLDN4 claudin 4 -0.0262633
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0259605
RPL31 ribosomal protein L31 -0.0249511
RPS6 ribosomal protein S6 -0.0242427
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0240153
NSUN6 NOP2/Sun domain family, member 6 -0.0235971
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0232538
RPL32 ribosomal protein L32 -0.0228585
PCDHB16 protocadherin beta 16 -0.0223457
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.022318
LARP1B La ribonucleoprotein domain family, member 1B -0.0221737
EGR1 early growth response 1 -0.0213304
ANKRD11 ankyrin repeat domain 11 -0.0210814
NCOA7 nuclear receptor coactivator 7 -0.0206378
SEPTIN7 septin 7 -0.0206155
TBCA tubulin folding cofactor A -0.0204236
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0198983
RPS15 ribosomal protein S15 -0.0198974
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0198874
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0195347
ATF4 activating transcription factor 4 -0.0193834
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0193747
CCDC138 coiled-coil domain containing 138 -0.0193523
WARS1 tryptophanyl-tRNA synthetase 1 -0.0193162
MKI67 marker of proliferation Ki-67 -0.019154
S100A9 S100 calcium binding protein A9 -0.0189897
RPL27 ribosomal protein L27 -0.0184629
CENPF centromere protein F, 350/400kDa -0.0183207
FTH1 ferritin, heavy polypeptide 1 -0.0182569
CLINT1 clathrin interactor 1 -0.0181486
IRF1 interferon regulatory factor 1 -0.0180646
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0179435
NAP1L1 nucleosome assembly protein 1-like 1 -0.0179239
ZNF638 zinc finger protein 638 -0.0179143
GPX2 glutathione peroxidase 2 -0.0179099
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0177885
RPS3 ribosomal protein S3 -0.0176358
RPL13A ribosomal protein L13a -0.0176246
DMGDH dimethylglycine dehydrogenase -0.0176088
RIN2 Ras and Rab interactor 2 -0.0175912
RPL5 ribosomal protein L5 -0.0175892
DGKD diacylglycerol kinase, delta 130kDa -0.0175707
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0175377
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0174948
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0174762
COX5A cytochrome c oxidase subunit Va -0.0172607
MORF4L2 mortality factor 4 like 2 -0.0172596
UGDH UDP-glucose 6-dehydrogenase -0.0172109
PLCB4 phospholipase C, beta 4 -0.0170973
EP400 E1A binding protein p400 -0.0170899
CBX3 chromobox homolog 3 -0.0168839
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0166875
BTBD9 BTB (POZ) domain containing 9 -0.0164023
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0163196
PLAC8 placenta-specific 8 -0.0161415
SPDYA speedy/RINGO cell cycle regulator family member A -0.0161031
POTEF POTE ankyrin domain family, member F -0.0158701
S100A6 S100 calcium binding protein A6 -0.0155279
SEC61G Sec61 gamma subunit -0.0154014
TMEM41B transmembrane protein 41B -0.0154005
JMY junction mediating and regulatory protein, p53 cofactor -0.0153327
GARS1 glycyl-tRNA synthetase 1 -0.0153306