Lidocaine (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.145518
LOC112694756 uncharaterized LOC112694756 0.114634
GRAMD1B GRAM domain containing 1B 0.103064
SLTM SAFB-like, transcription modulator 0.099288
ELL2 elongation factor, RNA polymerase II, 2 0.092689
MCL1 myeloid cell leukemia 1 0.0860704
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0781996
PDE4D phosphodiesterase 4D, cAMP-specific 0.0740076
CEMIP cell migration inducing protein, hyaluronan binding 0.0597818
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0594904
PM20D1 peptidase M20 domain containing 1 0.0593277
THSD4 thrombospondin, type I, domain containing 4 0.0575822
AGO2 argonaute RISC catalytic component 2 0.0573807
TBC1D22A TBC1 domain family, member 22A 0.0569748
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0559888
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0517821
DOCK5 dedicator of cytokinesis 5 0.0507631
DSCAM Down syndrome cell adhesion molecule 0.0491736
INTS6 integrator complex subunit 6 0.0483519
SAMD4A sterile alpha motif domain containing 4A 0.0477067
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0470154
PLEC plectin 0.0469757
SPAG9 sperm associated antigen 9 0.0445724
MYOF myoferlin 0.0442154
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0441999
RUNX1 runt-related transcription factor 1 0.0416345
TOP1 topoisomerase (DNA) I 0.0413697
BCAR3 breast cancer anti-estrogen resistance 3 0.04114
MAP7 microtubule-associated protein 7 0.0409002
HSPA8 heat shock 70kDa protein 8 0.040291
MYH9 myosin, heavy chain 9, non-muscle 0.040176
SMAD3 SMAD family member 3 0.0382637
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0378148
HOMER1 homer scaffolding protein 1 0.0373985
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0371112
CXCL8 chemokine (C-X-C motif) ligand 8 0.0369033
MT2A metallothionein 2A 0.0366208
CSNK1A1 casein kinase 1, alpha 1 0.0342946
VCL vinculin 0.0333605
CES1 carboxylesterase 1 0.033284
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330536
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0330121
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0329886
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0326088
BMP6 bone morphogenetic protein 6 0.0325935
DOCK1 dedicator of cytokinesis 1 0.032388
MCTP1 multiple C2 domains, transmembrane 1 0.032326
GPHN gephyrin 0.0322048
NABP1 nucleic acid binding protein 1 0.0320798
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.032008
ATP11A ATPase, class VI, type 11A 0.0316879
USP34 ubiquitin specific peptidase 34 0.0311755
EPAS1 endothelial PAS domain protein 1 0.0311748
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0311228
ZSWIM6 zinc finger, SWIM-type containing 6 0.0310976
TRAPPC9 trafficking protein particle complex 9 0.0310919
SMYD3 SET and MYND domain containing 3 0.0309513
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0304693
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.03011
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0296464
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0296036
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0293551
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0293459
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0291533
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0290941
ERRFI1 ERBB receptor feedback inhibitor 1 0.0284396
IRS2 insulin receptor substrate 2 0.0281941
RNF213 ring finger protein 213 0.0279739
RAD51B RAD51 paralog B 0.0275987
EXT1 exostosin glycosyltransferase 1 0.0263623
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0260209
ANXA2 annexin A2 0.0257305
MYO1E myosin IE 0.0255296
KIAA1217 KIAA1217 0.0253311
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0251404
NAP1L1 nucleosome assembly protein 1-like 1 0.0248473
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0248132
IGF1R insulin-like growth factor 1 receptor 0.0243712
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0242237
FNDC3A fibronectin type III domain containing 3A 0.0235436
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0233927
SLC38A2 solute carrier family 38, member 2 0.0233558
RPL3 ribosomal protein L3 0.023028
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0228295
RAB7A RAB7A, member RAS oncogene family 0.0226818
TSC22D2 TSC22 domain family, member 2 0.0225687
MACF1 microtubule-actin crosslinking factor 1 0.0218534
GLS2 glutaminase 2 (liver, mitochondrial) 0.0216046
ZC3H12B zinc finger CCCH-type containing 12B 0.0215915
BMAL2 basic helix-loop-helix ARNT like 2 0.0213741
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0211239
MAP2K1 mitogen-activated protein kinase kinase 1 0.0210436
SIK3 SIK family kinase 3 0.021018
CUL4A cullin 4A 0.0207598
TRIP12 thyroid hormone receptor interactor 12 0.0207283
NAMPT nicotinamide phosphoribosyltransferase 0.0207205
BABAM2 BRISC and BRCA1 A complex member 2 0.0206568
JMJD1C jumonji domain containing 1C 0.0206191
RPLP0 ribosomal protein, large, P0 0.0204957
EFNA5 ephrin-A5 0.0203004

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.175855
TMSB10 thymosin beta 10 -0.113425
NDRG1 N-myc downstream regulated 1 -0.0785148
ASPH aspartate beta-hydroxylase -0.0534352
PTMA prothymosin, alpha -0.0432262
RAB27B RAB27B, member RAS oncogene family -0.0334582
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0308711
ZMYND8 zinc finger, MYND-type containing 8 -0.0293647
FTL ferritin, light polypeptide -0.0287377
ACTG1 actin gamma 1 -0.0282076
CST3 cystatin C -0.0258999
IGFBP3 insulin-like growth factor binding protein 3 -0.0251152
FAM13A family with sequence similarity 13, member A -0.0250551
TXNRD1 thioredoxin reductase 1 -0.0249026
TMEM165 transmembrane protein 165 -0.0240158
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.023449
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0233603
LMO7 LIM domain 7 -0.0232261
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0232047
S100A6 S100 calcium binding protein A6 -0.0226903
RIN2 Ras and Rab interactor 2 -0.0226763
SEC61G Sec61 gamma subunit -0.0223772
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0223127
HMGA1 high mobility group AT-hook 1 -0.0222641
AKR1C1 aldo-keto reductase family 1, member C1 -0.0221323
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0220874
ARHGAP32 Rho GTPase activating protein 32 -0.0220111
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0213344
S100A10 S100 calcium binding protein A10 -0.0213041
PATJ PATJ crumbs cell polarity complex component -0.0204851
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0204193
BRWD1 bromodomain and WD repeat domain containing 1 -0.020255
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0202338
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0197611
DSG2 desmoglein 2 -0.0190339
BMP7 bone morphogenetic protein 7 -0.0187813
EGR1 early growth response 1 -0.0187442
WASF2 WAS protein family, member 2 -0.0184141
ADGRF1 adhesion G protein-coupled receptor F1 -0.0177077
HDLBP high density lipoprotein binding protein -0.017662
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0174447
AGR2 anterior gradient 2 -0.0172843
SPIRE1 spire-type actin nucleation factor 1 -0.0171167
SEC31A SEC31 homolog A (S. cerevisiae) -0.0165904
SRP54 signal recognition particle 54kDa -0.0163286
GARS1 glycyl-tRNA synthetase 1 -0.0162263
KRT19 keratin 19, type I -0.0161149
KRT18 keratin 18, type I -0.0160613
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0159996
FTH1 ferritin, heavy polypeptide 1 -0.0158819
SLC38A1 solute carrier family 38, member 1 -0.0158748
PDIA3 protein disulfide isomerase family A, member 3 -0.0157443
CAV2 caveolin 2 -0.0156434
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0156072
TPD52 tumor protein D52 -0.0155224
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.015461
CAMTA1 calmodulin binding transcription activator 1 -0.0150859
PERP PERP, TP53 apoptosis effector -0.0149258
RAB1A RAB1A, member RAS oncogene family -0.0147269
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0145177
SLMAP sarcolemma associated protein -0.0145164
ESRP1 epithelial splicing regulatory protein 1 -0.014496
PDIA6 protein disulfide isomerase family A, member 6 -0.0143812
DSPP dentin sialophosphoprotein -0.0137229
PDE8A phosphodiesterase 8A -0.013593
HLA-B major histocompatibility complex, class I, B -0.0133991
CCNY cyclin Y -0.0133837
RAB10 RAB10, member RAS oncogene family -0.0132812
LMAN1 lectin, mannose-binding, 1 -0.0132639
B2M beta-2-microglobulin -0.0132342
ENO2 enolase 2 (gamma, neuronal) -0.0129315
PKP2 plakophilin 2 -0.0127923
LAMB3 laminin, beta 3 -0.0126797
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0125752
RIOK3 RIO kinase 3 -0.0125089
S100A11 S100 calcium binding protein A11 -0.0124859
CANX calnexin -0.0124039
SREBF2 sterol regulatory element binding transcription factor 2 -0.0122952
TJP2 tight junction protein 2 -0.0122273
PARD3 par-3 family cell polarity regulator -0.0122177
CP ceruloplasmin (ferroxidase) -0.0120405
KPNB1 karyopherin (importin) beta 1 -0.0119112
KDM5B lysine (K)-specific demethylase 5B -0.0117473
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0117006
RSF1 remodeling and spacing factor 1 -0.011554
SCEL sciellin -0.0112168
CPNE8 copine VIII -0.0112115
NIBAN1 niban apoptosis regulator 1 -0.0111718
IARS1 isoleucyl-tRNA synthetase 1 -0.0111641
ACBD3 acyl-CoA binding domain containing 3 -0.0111258
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.011043
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.011002
NCOA3 nuclear receptor coactivator 3 -0.0109834
S100A9 S100 calcium binding protein A9 -0.0108725
RNF217 ring finger protein 217 -0.0107744
STC2 stanniocalcin 2 -0.0107347
ARF4 ADP-ribosylation factor 4 -0.0106954
ZMYM2 zinc finger, MYM-type 2 -0.0106553
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0106007
SEPTIN2 septin 2 -0.0105705