| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.176036 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0952565 |
| RPL3 | ribosomal protein L3 | 0.0898255 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0869411 |
| WWOX | WW domain containing oxidoreductase | 0.0824429 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0818575 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0742752 |
| PLEC | plectin | 0.0682845 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0675509 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0659434 |
| FLNA | filamin A, alpha | 0.065512 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0643585 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0613044 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0609451 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0590391 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0588155 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0586352 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0546648 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0546106 |
| FAM107B | family with sequence similarity 107, member B | 0.0541036 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0530113 |
| ATXN1 | ataxin 1 | 0.0525215 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0523336 |
| ANGPTL4 | angiopoietin-like 4 | 0.0514729 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0510631 |
| RPL23 | ribosomal protein L23 | 0.0506765 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0502165 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0464759 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0462463 |
| MCL1 | myeloid cell leukemia 1 | 0.046094 |
| BRD2 | bromodomain containing 2 | 0.0442829 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0441669 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0431409 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0430475 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0417635 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0411274 |
| MYOF | myoferlin | 0.0399801 |
| AHNAK | AHNAK nucleoprotein | 0.0378956 |
| RPS12 | ribosomal protein S12 | 0.0375785 |
| BMP6 | bone morphogenetic protein 6 | 0.036898 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0367193 |
| MSN | moesin | 0.0366523 |
| ACTN1 | actinin, alpha 1 | 0.0359685 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0357114 |
| TPM3 | tropomyosin 3 | 0.0355814 |
| ATP11A | ATPase, class VI, type 11A | 0.035355 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0349845 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0345879 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0344149 |
| FLNB | filamin B, beta | 0.0343947 |
| USP34 | ubiquitin specific peptidase 34 | 0.0342762 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0336278 |
| H1-4 | H1.4 linker histone, cluster member | 0.0333289 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0330304 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0326135 |
| PFKP | phosphofructokinase, platelet | 0.0317541 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0317317 |
| ACTG1 | actin gamma 1 | 0.0312073 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.031179 |
| RAD51B | RAD51 paralog B | 0.0309685 |
| SFPQ | splicing factor proline/glutamine-rich | 0.030767 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.030343 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0301281 |
| PKM | pyruvate kinase, muscle | 0.0297396 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0295663 |
| FHIT | fragile histidine triad | 0.029418 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0291835 |
| HDLBP | high density lipoprotein binding protein | 0.0289257 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0289075 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0288774 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0283962 |
| TOP1 | topoisomerase (DNA) I | 0.0283751 |
| MT1X | metallothionein 1X | 0.0281294 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0276377 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0274096 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0272699 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.027237 |
| CTBP2 | C-terminal binding protein 2 | 0.0270784 |
| PDE10A | phosphodiesterase 10A | 0.0269135 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0267622 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0264697 |
| RNF213 | ring finger protein 213 | 0.0264284 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0260054 |
| RPL31 | ribosomal protein L31 | 0.0258498 |
| SEPTIN9 | septin 9 | 0.0256488 |
| INTS6 | integrator complex subunit 6 | 0.0255933 |
| RPS27A | ribosomal protein S27a | 0.025531 |
| NNMT | nicotinamide N-methyltransferase | 0.0255102 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0254473 |
| H1-10 | H1.10 linker histone | 0.0253703 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0252328 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0250944 |
| IER3 | immediate early response 3 | 0.0249854 |
| CREBBP | CREB binding protein | 0.0249521 |
| TPI1 | triosephosphate isomerase 1 | 0.0249387 |
| NCKAP1 | NCK-associated protein 1 | 0.0249024 |
| RPS18 | ribosomal protein S18 | 0.0248975 |
| SMAD3 | SMAD family member 3 | 0.0248578 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0248133 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0247165 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.145782 |
| TXNRD1 | thioredoxin reductase 1 | -0.143227 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.134354 |
| IGF2 | insulin-like growth factor 2 | -0.118181 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.113266 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.113151 |
| FTL | ferritin, light polypeptide | -0.100418 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.096449 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0862998 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0841779 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0806744 |
| GRAMD1B | GRAM domain containing 1B | -0.0731703 |
| FGB | fibrinogen beta chain | -0.0580344 |
| NEGR1 | neuronal growth regulator 1 | -0.0528392 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0517574 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0498106 |
| HDAC9 | histone deacetylase 9 | -0.048913 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0478496 |
| S100A6 | S100 calcium binding protein A6 | -0.0463851 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0445206 |
| AHR | aryl hydrocarbon receptor | -0.0441547 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0427116 |
| PYGL | phosphorylase, glycogen, liver | -0.0425333 |
| BICC1 | BicC family RNA binding protein 1 | -0.0420611 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0411062 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0408935 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0405591 |
| EGR1 | early growth response 1 | -0.0399742 |
| RTN4 | reticulon 4 | -0.0375521 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0362228 |
| PFN1 | profilin 1 | -0.0345595 |
| PLS3 | plastin 3 | -0.0327551 |
| TPM4 | tropomyosin 4 | -0.0321853 |
| PTMA | prothymosin, alpha | -0.0321654 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0313622 |
| HMGA1 | high mobility group AT-hook 1 | -0.0303966 |
| ERBIN | erbb2 interacting protein | -0.0300889 |
| WDR43 | WD repeat domain 43 | -0.0300059 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0298319 |
| USP3 | ubiquitin specific peptidase 3 | -0.0288789 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0286555 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0285938 |
| POTEF | POTE ankyrin domain family, member F | -0.0279657 |
| RBM39 | RNA binding motif protein 39 | -0.027403 |
| CHN1 | chimerin 1 | -0.0271102 |
| PFDN2 | prefoldin subunit 2 | -0.0264094 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0259564 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.025281 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0252188 |
| VIM | vimentin | -0.0247792 |
| NAV3 | neuron navigator 3 | -0.0247608 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0247073 |
| RPL35A | ribosomal protein L35a | -0.0245821 |
| MORF4L1 | mortality factor 4 like 1 | -0.0244059 |
| RNF217 | ring finger protein 217 | -0.0243753 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.024277 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0242689 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0241582 |
| EFNA5 | ephrin-A5 | -0.0241487 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0240153 |
| OSMR | oncostatin M receptor | -0.0239963 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0238813 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0237835 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0233509 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0227113 |
| CCNL1 | cyclin L1 | -0.0225744 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0221856 |
| PRR16 | proline rich 16 | -0.0221169 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0220346 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0216618 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0214837 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0212734 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0210718 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0208905 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0208145 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0207096 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0205975 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0205756 |
| ZNF804A | zinc finger protein 804A | -0.0204326 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0204123 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0203997 |
| NUP58 | nucleoporin 58 | -0.0201646 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0201608 |
| YBX1 | Y box binding protein 1 | -0.0200122 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0199567 |
| TFG | TRK-fused gene | -0.0199444 |
| THBS1 | thrombospondin 1 | -0.0199125 |
| RNF145 | ring finger protein 145 | -0.0195913 |
| AK1 | adenylate kinase 1 | -0.0193566 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0192119 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.019147 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0190987 |
| RHEB | Ras homolog enriched in brain | -0.0190287 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0190117 |
| TBC1D19 | TBC1 domain family, member 19 | -0.0188706 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0187756 |
| TMEM123 | transmembrane protein 123 | -0.0187215 |
| WBP11 | WW domain binding protein 11 | -0.0186842 |
| CANX | calnexin | -0.0186642 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0185292 |
