| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.198032 |
| MCL1 | myeloid cell leukemia 1 | 0.129216 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.112245 |
| GRAMD1B | GRAM domain containing 1B | 0.106472 |
| YBX3 | Y box binding protein 3 | 0.104733 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.099694 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0994965 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0868332 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0853624 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0833434 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0784215 |
| ATP11A | ATPase, class VI, type 11A | 0.0777279 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0737167 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0728267 |
| BRD2 | bromodomain containing 2 | 0.0634916 |
| RRM2 | ribonucleotide reductase M2 | 0.0630601 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0625979 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0623965 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0608525 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0600486 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0571142 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.056579 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0556652 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0527523 |
| PCBP2 | poly(rC) binding protein 2 | 0.0523303 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0521906 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0517691 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0497171 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0472454 |
| TPM3 | tropomyosin 3 | 0.0469381 |
| PRELID2 | PRELI domain containing 2 | 0.0461421 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0458798 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0458293 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0454 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0453372 |
| IPO7 | importin 7 | 0.0452538 |
| WWOX | WW domain containing oxidoreductase | 0.0443065 |
| RPL3 | ribosomal protein L3 | 0.0439859 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0436306 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0429783 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0429538 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0427334 |
| INTS6 | integrator complex subunit 6 | 0.0425761 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0413114 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0412723 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0412624 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0411811 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0409419 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0407232 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406587 |
| HOMER1 | homer scaffolding protein 1 | 0.0401183 |
| PDE10A | phosphodiesterase 10A | 0.0394276 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0391972 |
| FLNA | filamin A, alpha | 0.0381147 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0368254 |
| VCP | valosin containing protein | 0.0367257 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0365231 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0363585 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0353693 |
| GPHN | gephyrin | 0.0346619 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.034646 |
| SET | SET nuclear proto-oncogene | 0.0337026 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0337002 |
| SPAG9 | sperm associated antigen 9 | 0.0336284 |
| POTEF | POTE ankyrin domain family, member F | 0.0335647 |
| SVIL | supervillin | 0.0333758 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0332274 |
| TPI1 | triosephosphate isomerase 1 | 0.0331973 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0328755 |
| RCOR1 | REST corepressor 1 | 0.032874 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0328589 |
| AEBP2 | AE binding protein 2 | 0.0326311 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0325575 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0315041 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0313386 |
| CALD1 | caldesmon 1 | 0.0312066 |
| CLTC | clathrin, heavy chain (Hc) | 0.0311565 |
| RTN4 | reticulon 4 | 0.0309398 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0308198 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0306673 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0303307 |
| FUS | FUS RNA binding protein | 0.0298643 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0296663 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0294009 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0290425 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0288192 |
| UBC | ubiquitin C | 0.0282176 |
| NEK10 | NIMA-related kinase 10 | 0.0281802 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0280493 |
| MYPN | myopalladin | 0.0279832 |
| YAP1 | Yes-associated protein 1 | 0.0279531 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0276778 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0276285 |
| USP34 | ubiquitin specific peptidase 34 | 0.0275161 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0275065 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0274943 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0272057 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.026609 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0265234 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0265189 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.113037 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106623 |
| TMSB10 | thymosin beta 10 | -0.103847 |
| PTMA | prothymosin, alpha | -0.0774238 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0638796 |
| CANX | calnexin | -0.0589675 |
| VIM | vimentin | -0.0529565 |
| AHNAK | AHNAK nucleoprotein | -0.0526841 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0437008 |
| RPL35A | ribosomal protein L35a | -0.0379796 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0378039 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0376154 |
| RAD51B | RAD51 paralog B | -0.0371463 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0355469 |
| MT2A | metallothionein 2A | -0.0332083 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0324014 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0321178 |
| RPS21 | ribosomal protein S21 | -0.0320917 |
| PHF21A | PHD finger protein 21A | -0.0314933 |
| WASF2 | WAS protein family, member 2 | -0.0307149 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0293698 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0293399 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0291921 |
| ZNF292 | zinc finger protein 292 | -0.0279574 |
| EGFR | epidermal growth factor receptor | -0.0278785 |
| RSF1 | remodeling and spacing factor 1 | -0.027815 |
| ETV6 | ets variant 6 | -0.0276858 |
| BBX | bobby sox homolog (Drosophila) | -0.0274786 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0262399 |
| EGR1 | early growth response 1 | -0.0259814 |
| MAP4 | microtubule-associated protein 4 | -0.0257117 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0254916 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0251187 |
| RPL36A | ribosomal protein L36a | -0.0250369 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0249357 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0248856 |
| RPL34 | ribosomal protein L34 | -0.0247887 |
| RPS27 | ribosomal protein S27 | -0.0245716 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0241861 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0240068 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.024005 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.023618 |
| DENND5B | DENN/MADD domain containing 5B | -0.0234626 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0229329 |
| RPL23 | ribosomal protein L23 | -0.0227469 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.022386 |
| RGS17 | regulator of G-protein signaling 17 | -0.0223349 |
| IGF2 | insulin-like growth factor 2 | -0.0222727 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0222186 |
| HMGA2 | high mobility group AT-hook 2 | -0.0221085 |
| TPM4 | tropomyosin 4 | -0.0219637 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0217744 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0216502 |
| FTL | ferritin, light polypeptide | -0.0216238 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0216188 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.021318 |
| RPS29 | ribosomal protein S29 | -0.0213007 |
| EHBP1 | EH domain binding protein 1 | -0.0212909 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0208566 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0207581 |
| RNF169 | ring finger protein 169 | -0.0207264 |
| TLK1 | tousled-like kinase 1 | -0.0206936 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0205564 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0204283 |
| PATJ | PATJ crumbs cell polarity complex component | -0.02042 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0203764 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0203279 |
| RPL32 | ribosomal protein L32 | -0.0199928 |
| RPLP2 | ribosomal protein, large, P2 | -0.019915 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0197358 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0195079 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0194261 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0194174 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0192435 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0191204 |
| S100A10 | S100 calcium binding protein A10 | -0.0190814 |
| ZFR | zinc finger RNA binding protein | -0.0188789 |
| FMN1 | formin 1 | -0.0188497 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0187471 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0184319 |
| FAM13A | family with sequence similarity 13, member A | -0.0183891 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0182163 |
| TULP3 | tubby like protein 3 | -0.0179676 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0179188 |
| RAD21 | RAD21 homolog (S. pombe) | -0.017681 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.0174907 |
| HMGA1 | high mobility group AT-hook 1 | -0.0174738 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0174735 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0173038 |
| S100A6 | S100 calcium binding protein A6 | -0.0172999 |
| SRPK2 | SRSF protein kinase 2 | -0.0169801 |
| RPS6 | ribosomal protein S6 | -0.0169702 |
| TRIM56 | tripartite motif containing 56 | -0.0169067 |
| NFIA | nuclear factor I/A | -0.0169043 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0168386 |
| TRERF1 | transcriptional regulating factor 1 | -0.0168022 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0167741 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0167557 |
| GLG1 | golgi glycoprotein 1 | -0.0166609 |
| RPL31 | ribosomal protein L31 | -0.0165021 |
